EKS-ORC-00249

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ORC-00249

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Other/PLK	387.9	2.6E-116	12	265	254

Status

Unreviewed

Ensembl Protein

ENSOCUP00000004339

UniProt Accession

G1SN07;

Protein Name

Protein Synonyms/Alias

Gene Name

PLK4

Gene Synonyms/Alias

PLK4;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSOCUG00000005009	ENSOCUP00000004339	ENSOCUT00000005011

Organism

Oryctolagus cuniculus

Functional Description

Protein Length

972

Protein Sequence
(FASTA)

MATCIGEKIE DFKVGNLLGK GSFAGVYRAE SIHTGLEVAI KMIDKKAMYK AGMVQRVQNE 60

VKIHCQLKHP SILELYNYFE DNNYVYLVLE MCHNGEMNRY LKNRMKPFSE NEARHFMYQI 120

ITGLLYLHSH GILHRDLTLS NLLLTRNMNI KIADFGLATQ LKMPHEKHYT LCGTPNYISP 180

EIATRSAHGL ESDVWSLGCM FYTLLIGRPP FDTDTVKNTL NKVVLADYEM PAFLSREAKD 240

LIHQLLRRNP ADRLSLSSVM DHPFMSRSSP TKNKDLGTVE DSIDSGHATI STAVTASSST 300

SMNGSLFDRR RLLIGQPLPN KMTVFPKNKN ASDFSSAGDG SSFYTQWGNQ ETGVSRRGRV 360

IQDAEERPHS RYLRRAHSSD RSETYNTQSQ AKTCTMERCH SEEMLLKSKR SEIDESEERY 420

SPTHSNVNIF HFFKEKTSNN SGSFERPDVD QALSNRLCPG KTPFPFSDQT PQAEMVQQWF 480

GNLQINGHLR ETTEPNSISP NRDFQGHPDL QKDTSRNSWT DTQAKKNFDA PDNAHCFKQL 540

NTMKYITGLH SKPEIIQQES GFGLDPVSEQ SKTRSMESKL GYLKQTLRSI TSPLIAHRLK 600

PIRQKTKKAV VSILDSEEVC VELLKEHTSQ EYVKEVLQIS SDGNTITVYY PNDGRGFPLA 660

DRPPSPTDNI SRYSFDNLPE KYWRKYQYAS RFVQLVRSKS PKITYFTKYA KCVLMENSPG 720

ADFEVWFYDG TKIHKTEDFI QVIEKTGYSY SLKGDSDVNS FKEEIRKYMD HANEQQGHRI 780

CLALESVISE EEKKSRSAPF FPIIVGRKPG ITTSPSALSP PPSVDPEYPV REAPSLNRLI 840

MSGAESLFKQ LFLKIKIVTN EGLGHTTTAS GTNISSSNLK DGLPKSAQLL KSVFVKDVGW 900

ATQLTSGAVW VQFNDGSQLV VQAGVSSISY TSPNGQTTRY GENEKLPEYI RQKLQCLSSI 960

LLMFSNATPG FQ 972

Nucleotide Sequence
(FASTA)

ATGGCGACCT GCATCGGGGA GAAGATCGAG GATTTTAAGG TTGGAAATCT GCTCGGCAAA 60

GGATCATTTG CTGGTGTCTA TAGAGCTGAA TCCATTCATA CTGGTTTGGA AGTTGCAATC 120

AAAATGATAG ATAAGAAGGC CATGTACAAA GCTGGAATGG TACAGAGAGT GCAAAATGAG 180

GTGAAAATAC ATTGCCAATT GAAACATCCT TCGATTTTGG AGCTTTATAA TTATTTTGAA 240

GATAACAACT ATGTATACCT GGTATTAGAA ATGTGTCATA ATGGAGAAAT GAACAGGTAT 300

CTAAAAAACA GAATGAAACC CTTCTCAGAA AATGAAGCTC GACACTTCAT GTACCAGATC 360

ATCACAGGAC TGTTGTATCT TCATTCTCAT GGTATATTAC ACCGGGACCT CACACTTTCT 420

AACCTCTTAC TTACACGTAA TATGAACATC AAGATTGCCG ACTTTGGACT AGCAACACAA 480

TTGAAAATGC CTCATGAAAA GCACTATACT TTATGTGGAA CTCCTAATTA CATTTCACCA 540

GAAATTGCAA CTCGAAGTGC ACATGGACTT GAATCTGATG TTTGGTCCTT GGGTTGTATG 600

TTTTATACAT TACTTATTGG GAGACCACCT TTTGACACTG ACACAGTCAA GAACACCTTA 660

AATAAAGTAG TATTGGCAGA TTATGAAATG CCAGCTTTTT TGTCACGAGA AGCCAAGGAC 720

CTTATTCACC AATTGCTTCG TAGAAATCCA GCGGATCGCT TAAGTCTGTC TTCCGTAATG 780

GACCATCCTT TTATGTCTAG AAGTTCTCCA ACAAAAAATA AAGATTTAGG AACTGTGGAA 840

GACTCCATTG ATAGTGGACA CGCTACGATT TCTACTGCAG TTACAGCTTC TTCCAGTACC 900

AGTATGAATG GTAGCTTATT TGACAGAAGA AGACTTTTGA TTGGTCAGCC ACTCCCAAAT 960

AAAATGACTG TATTTCCAAA GAATAAAAAT GCAAGTGATT TTTCTTCTGC AGGCGATGGA 1020

AGCAGTTTTT ATACTCAGTG GGGAAATCAA GAAACTGGTG TTAGTAGAAG GGGTAGAGTA 1080

ATCCAAGACG CAGAAGAAAG GCCGCATTCT CGATACCTTC GCAGAGCCCA TTCCTCTGAC 1140

AGATCTGAGA CTTACAACAC TCAGTCTCAA GCAAAGACGT GTACAATGGA ACGGTGTCAT 1200

TCAGAAGAAA TGCTCTTGAA GTCGAAAAGA TCAGAAATAG ATGAAAGTGA AGAGAGATAC 1260

TCACCCACAC ACAGCAATGT CAATATTTTT CACTTCTTTA AAGAAAAGAC TTCCAATAAT 1320

TCTGGATCTT TTGAAAGACC TGATGTCGAT CAAGCACTCT CCAATCGCCT TTGTCCAGGA 1380

AAAACTCCGT TTCCATTTTC AGATCAGACA CCTCAGGCTG AAATGGTGCA ACAGTGGTTT 1440

GGGAATCTGC AAATAAATGG TCATTTAAGA GAAACCACTG AGCCCAACAG CATCAGTCCA 1500

AACAGAGATT TCCAGGGGCA CCCAGATTTG CAGAAAGACA CATCAAGAAA TTCTTGGACT 1560

GATACACAAG CCAAAAAGAA CTTTGATGCT CCTGATAATG CACATTGTTT TAAACAGCTG 1620

AATACTATGA AATACATCAC TGGACTTCAC AGCAAGCCTG AAATAATTCA ACAAGAATCT 1680

GGTTTTGGCT TAGATCCTGT TTCTGAACAA AGCAAAACTA GGAGTATGGA GTCAAAACTG 1740

GGTTATCTGA AGCAAACACT ACGAAGCATA ACATCTCCTT TGATTGCTCA TAGGTTAAAA 1800

CCCATCAGAC AGAAAACCAA AAAGGCTGTG GTGAGCATAC TTGATTCTGA GGAAGTGTGT 1860

GTGGAGCTTC TAAAGGAACA TACATCTCAA GAATATGTGA AAGAAGTTCT CCAAATATCT 1920

AGTGATGGAA ATACGATTAC TGTTTATTAT CCAAATGATG GAAGAGGTTT TCCTCTTGCT 1980

GACAGACCAC CTTCACCTAC TGACAACATC AGTAGATACA GCTTTGACAA TTTACCAGAA 2040

AAGTATTGGC GAAAATATCA GTATGCTTCC AGATTTGTAC AGCTTGTAAG ATCTAAATCT 2100

CCCAAAATCA CTTATTTTAC AAAATATGCT AAATGTGTTT TAATGGAGAA CTCTCCTGGT 2160

GCTGATTTTG AGGTTTGGTT TTATGATGGA ACCAAAATAC ACAAAACAGA AGATTTTATT 2220

CAGGTGATTG AAAAAACTGG GTACTCTTAC AGTTTAAAAG GTGACAGTGA TGTTAACAGT 2280

TTCAAAGAGG AAATAAGAAA GTATATGGAC CATGCTAATG AGCAACAGGG CCATCGTATT 2340

TGTTTAGCAC TGGAATCTGT AATTTCAGAA GAGGAAAAGA AAAGTAGGAG TGCCCCCTTC 2400

TTCCCAATAA TTGTAGGAAG AAAACCTGGT ATTACTACTT CACCTTCAGC CTTATCACCT 2460

CCTCCTTCAG TGGATCCAGA GTACCCAGTG AGAGAGGCAC CATCTTTGAA CAGACTGATC 2520

ATGAGTGGTG CTGAATCTTT GTTTAAGCAG TTATTTTTAA AAATTAAGAT AGTTACAAAT 2580

GAGGGACTTG GCCATACAAC TACAGCTTCT GGAACAAACA TCTCTTCTAG CAATCTAAAA 2640

GATGGTCTTC CTAAATCAGC ACAACTTTTG AAGTCTGTTT TTGTGAAAGA TGTTGGCTGG 2700

GCTACACAGT TAACTAGTGG AGCTGTGTGG GTTCAGTTCA ATGATGGATC GCAGCTGGTT 2760

GTGCAGGCAG GCGTTTCTTC TATCAGTTAT ACATCACCAA ATGGTCAAAC AACTAGGTAT 2820

GGAGAAAATG AAAAGTTACC AGAATACATC AGACAGAAAT TACAGTGTCT GTCTTCCATC 2880

CTTTTGATGT TTTCTAATGC AACTCCCGGT TTCCAATGA 2919

Domain Profile

S: 1     yergkllGkGgfakcyelkdletkevfavkvvpksllakekqrekvekeieihrslkhkn  60

         +++g+llGkG+fa +y++++++t+ ++a+k+++k++++k+ + ++v++e++ih++lkh++

Q: 12    FKVGNLLGKGSFAGVYRAESIHTGLEVAIKMIDKKAMYKAGMVQRVQNEVKIHCQLKHPS  71

         6899********************************************************

S: 61    ivklyeffedkenvylvlelcsrrslaellkrr.kaltepevryylrqivsglkylhekr  119

         i++ly++fed+++vylvle+c++++++++lk+r k+++e+e+r++++qi++gl+ylh++

Q: 72    ILELYNYFEDNNYVYLVLEMCHNGEMNRYLKNRmKPFSENEARHFMYQIITGLLYLHSHG  131

         ********************************99**************************

S: 120   ilhrdlklgnlflneelevkigdfGlatrlekeeerkktlcGtPnyiaPevlskkghsle  179

         ilhrdl+l+nl+l++++++ki+dfGlat+l++++e+++tlcGtPnyi+Pe++++++h+le

Q: 132   ILHRDLTLSNLLLTRNMNIKIADFGLATQLKMPHEKHYTLCGTPNYISPEIATRSAHGLE  191

         ************************************************************

S: 180   vdiWslGcilytllvGkPPfetkelketyekikkaeyslPsslskeaksliakllkkePe  239

         +d+WslGc++ytll+G+PPf+t+++k+t++k++ a+y++P+ ls+eak+li++ll+++P+

Q: 192   SDVWSLGCMFYTLLIGRPPFDTDTVKNTLNKVVLADYEMPAFLSREAKDLIHQLLRRNPA  251

         ************************************************************

S: 240   erpsleevlkdefl  253

         +r+sl++v++++f+

Q: 252   DRLSLSSVMDHPFM  265

         ************98

Domain Sequence
(FASTA)

FKVGNLLGKG SFAGVYRAES IHTGLEVAIK MIDKKAMYKA GMVQRVQNEV KIHCQLKHPS 60

ILELYNYFED NNYVYLVLEM CHNGEMNRYL KNRMKPFSEN EARHFMYQII TGLLYLHSHG 120

ILHRDLTLSN LLLTRNMNIK IADFGLATQL KMPHEKHYTL CGTPNYISPE IATRSAHGLE 180

SDVWSLGCMF YTLLIGRPPF DTDTVKNTLN KVVLADYEMP AFLSREAKDL IHQLLRRNPA 240

DRLSLSSVMD HPFM 254

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005814	; C:centriole
GO:0005730	; C:nucleolus
GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0004713	; F:protein tyrosine kinase activity
GO:0007099	; P:centriole replication
GO:0046601	; P:positive regulation of centriole replication
GO:0060707	; P:trophoblast giant cell differentiation

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000959	; POLO_box_duplicated_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008266	; Tyr_kinase_AS.

Pfam

PF00069	; Pkinase; 1.
PF00659	; POLO_box; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS50078	; POLO_BOX; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.

Prints

Created Date

20-Feb-2013