EKS-ORC-00104
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-ORC-00104
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
CAMK/MLCK411.21.8E-123496749254
StatusUnreviewed
Ensembl ProteinENSOCUP00000004459
UniProt AccessionG1SNA8;
Protein Name
Protein Synonyms/Alias
Gene NameMYLK3
Gene Synonyms/Alias MYLK3;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSOCUG00000005146ENSOCUP00000004459ENSOCUT00000005148
OrganismOryctolagus cuniculus
Functional Description
Protein Length798
Protein Sequence
(FASTA)
MSGASQESLG PRELPVLGKA CLTTMDRKLN MLNEKVDKLL HFQEDVTEKL QCVCQGMGHL 60
EQGLNRLEAS RLLGPVGADS ALPADTQAGW PEVLEVVRAV QQEATQHGAR LEALFRMVVA 120
VDRAIALVGA TFQNSKVVDF IMQGSVPWRK GGMADSEEES KERVEEKGAK PKHALSTRGV 180
QADIRGPWEE SQKAELPEGT VERLHPVSAS GMGAGFLTQA GASPGQGDGV PGSGQVPPDH 240
LQLPTDTEAK APTTSSENPR TDPELAVAPD RISEVPASQE AAPSAGRGTS PSKPGPQPSE 300
EPMKLTSGSR PQPSGLPGLP ASELCSADAG PRISIHVQEM DTPGELLVTR GGSPRSTPPA 360
EAAAAAPAGE QTLRGARELP SLQERSSNEA AKAEEEQGPG AEAAMAPHSA SRDTGDNAAG 420
DPGLLQDKGP GAGHPDPRMD CTAGASGKGE AEGRTPPGAE AGGVILDDSP APPAPFEHRV 480
VSVKETSISA GYTVRQHEVL GGGRFGQVHR CTEKSTGLSL AAKIIKVKSA KDREDVKNEV 540
NIMNQLSHVN LIQLYDAFES KHSCTLVMEY VDGGELFDRI TDEKYHLTEL DVVLFTKQIC 600
EGVHYLHQHY ILHLDLKPEN ILCVNQTGHQ IKIIDFGLAR RYKPREKLKV NFGTPEFLAP 660
EVVNYEFVSF PTDMWSVGVI TYMLLSGLSP FLGETDAETM NFIVNCSWDF DAETFEGLSE 720
EAKDFVSRLL VKEKSCRMSA TQCLKHEWLN HLPAKASKFK VRLKSQLLLQ KYTAQRKWKK 780
HFYVVTAANR LRKFPTCP 798
Nucleotide Sequence
(FASTA)
ATGTCAGGGG CCTCCCAGGA GAGTCTGGGG CCCCGGGAAC TGCCGGTGTT GGGCAAGGCC 60
TGCTTAACCA CCATGGACAG AAAGCTTAAC ATGTTGAATG AGAAGGTGGA CAAACTCTTG 120
CATTTCCAAG AAGACGTCAC AGAGAAACTG CAGTGCGTAT GCCAAGGCAT GGGCCACCTG 180
GAGCAAGGGC TGAACAGGCT GGAGGCCTCC CGGCTGCTCG GCCCAGTGGG GGCCGACAGT 240
GCCCTTCCGG CTGACACTCA GGCTGGGTGG CCTGAGGTCC TGGAGGTGGT GAGGGCCGTG 300
CAGCAGGAGG CCACCCAGCA CGGCGCCAGG CTTGAAGCCC TCTTCAGGAT GGTGGTGGCT 360
GTGGACAGGG CCATCGCTTT GGTGGGGGCC ACGTTCCAGA ACTCGAAAGT GGTGGATTTC 420
ATCATGCAAG GGAGCGTGCC TTGGAGGAAA GGTGGCATGG CTGACTCCGA GGAGGAGAGC 480
AAAGAGCGAG TTGAAGAGAA GGGAGCAAAA CCCAAGCATG CGTTAAGCAC CAGAGGTGTA 540
CAAGCCGACA TCAGGGGCCC CTGGGAAGAG AGCCAGAAGG CTGAGCTGCC AGAGGGGACA 600
GTGGAGAGAT TGCACCCCGT CAGCGCCTCA GGGATGGGAG CTGGCTTCCT CACACAGGCG 660
GGGGCCTCAC CAGGGCAGGG AGATGGAGTT CCTGGCTCAG GCCAGGTGCC CCCTGATCAC 720
CTGCAGCTGC CCACAGACAC AGAAGCCAAA GCTCCCACGA CATCCAGCGA GAACCCCAGG 780
ACTGACCCGG AACTGGCTGT GGCACCCGAC AGGATCAGTG AAGTTCCTGC CAGCCAGGAG 840
GCTGCTCCAA GTGCTGGGCG AGGAACATCG CCCAGCAAAC CTGGGCCACA GCCCTCAGAG 900
GAGCCCATGA AGCTGACTTC AGGGTCCAGG CCCCAGCCCT CAGGGCTCCC AGGGCTCCCA 960
GCCTCAGAGC TGTGCTCAGC AGACGCTGGC CCCAGGATCT CCATCCACGT GCAAGAGATG 1020
GATACTCCTG GGGAACTGCT TGTGACCCGA GGGGGCAGCC CCAGATCCAC ACCCCCTGCA 1080
GAGGCTGCAG CGGCTGCCCC TGCAGGAGAA CAGACCCTCA GAGGAGCCAG AGAGCTTCCC 1140
TCACTGCAGG AGAGGAGCAG CAACGAGGCT GCAAAAGCAG AGGAGGAGCA AGGGCCTGGG 1200
GCCGAGGCGG CCATGGCGCC ACACTCAGCC AGCAGGGACA CAGGAGACAA CGCTGCTGGG 1260
GACCCGGGCC TGCTGCAGGA CAAAGGCCCA GGAGCAGGAC ACCCTGACCC CAGGATGGAC 1320
TGCACAGCCG GGGCCTCTGG GAAAGGCGAA GCAGAAGGGA GGACGCCCCC CGGTGCTGAG 1380
GCTGGCGGCG TGATTCTGGA TGACAGTCCA GCCCCGCCTG CCCCTTTTGA ACACCGGGTG 1440
GTGAGCGTCA AGGAGACGTC GATCTCAGCG GGTTACACAG TGCGCCAGCA TGAAGTGTTG 1500
GGCGGGGGCC GATTTGGCCA GGTCCACAGG TGCACAGAGA AGTCCACGGG TCTTTCACTG 1560
GCAGCCAAGA TCATCAAAGT GAAGAGTGCC AAGGACCGGG AGGATGTGAA GAATGAGGTT 1620
AACATCATGA ACCAGCTCAG CCACGTGAAC CTGATCCAGC TCTACGATGC CTTCGAGAGC 1680
AAGCACAGCT GCACACTGGT CATGGAGTAT GTGGACGGAG GTGAACTCTT CGACCGGATC 1740
ACGGATGAGA AGTACCACCT GACGGAGCTG GACGTGGTCT TATTCACCAA GCAGATCTGT 1800
GAGGGGGTGC ATTACCTCCA CCAGCACTAC ATCCTGCACC TGGACCTCAA GCCAGAGAAC 1860
ATACTGTGTG TCAATCAGAC AGGACATCAA ATTAAGATCA TTGACTTTGG CCTGGCCAGA 1920
AGGTACAAGC CTCGGGAAAA GCTGAAGGTG AACTTCGGTA CTCCGGAATT CCTGGCCCCG 1980
GAAGTTGTCA ACTACGAGTT TGTCTCCTTC CCCACGGACA TGTGGAGCGT GGGCGTCATC 2040
ACCTACATGC TACTCAGTGG CTTGTCCCCG TTTCTAGGGG AAACAGATGC AGAGACCATG 2100
AATTTCATTG TGAACTGCAG CTGGGATTTC GATGCTGAGA CCTTTGAAGG GCTGTCGGAG 2160
GAGGCCAAGG ACTTTGTTTC CCGGCTGCTG GTCAAAGAGA AGAGCTGCAG AATGAGTGCC 2220
ACACAGTGCC TGAAACATGA GTGGCTCAAT CATTTGCCTG CCAAAGCTTC CAAATTCAAA 2280
GTTCGTCTCA AATCCCAACT ACTGCTGCAG AAGTACACGG CCCAGAGAAA ATGGAAGAAA 2340
CATTTCTACG TGGTGACTGC TGCCAACAGG CTAAGGAAAT TTCCAACGTG TCCCTAA 2397
Domain Profile
S: 3     ikeelgkGkfgvvvkavekstgkklaakivkvrkekdkeevkkEieilnqlrHekliqly  62
         ++e lg G+fg+v++++ekstg +laaki+kv+++kd+e+vk+E++i+nql+H +liqly
Q: 496   QHEVLGGGRFGQVHRCTEKSTGLSLAAKIIKVKSAKDREDVKNEVNIMNQLSHVNLIQLY  555
         6899********************************************************
S: 63    dafeskeeivlvlElveggelferiveedyeltEeevvlfvrqvlealeylHkkgivHld  122
         dafesk++++lv+E+v+ggelf+ri++e+y+ltE +vvlf++q++e+++ylH+++i+Hld
Q: 556   DAFESKHSCTLVMEYVDGGELFDRITDEKYHLTELDVVLFTKQICEGVHYLHQHYILHLD  615
         ************************************************************
S: 123   lkpenillqskkskqiKlidFGlarklkkkeklkvlfgtpefvaPEvvnkepvslatDmW  182
         lkpenil+++++++qiK+idFGlar++k++eklkv+fgtpef+aPEvvn+e+vs+ tDmW
Q: 616   LKPENILCVNQTGHQIKIIDFGLARRYKPREKLKVNFGTPEFLAPEVVNYEFVSFPTDMW  675
         ************************************************************
S: 183   svGvityvLlsGlsPFlgdndeetlenvssakydfdeeafkevseeakdFiskllvkekk  242
         svGvity+LlsGlsPFlg++d+et++ + ++++dfd+e+f+ +seeakdF+s+llvkek+
Q: 676   SVGVITYMLLSGLSPFLGETDAETMNFIVNCSWDFDAETFEGLSEEAKDFVSRLLVKEKS  735
         ************************************************************
S: 243   kRmsaeeaLkhkwl  256
         +Rmsa+++Lkh+wl
Q: 736   CRMSATQCLKHEWL  749
         *************8
Domain Sequence
(FASTA)
QHEVLGGGRF GQVHRCTEKS TGLSLAAKII KVKSAKDRED VKNEVNIMNQ LSHVNLIQLY 60
DAFESKHSCT LVMEYVDGGE LFDRITDEKY HLTELDVVLF TKQICEGVHY LHQHYILHLD 120
LKPENILCVN QTGHQIKIID FGLARRYKPR EKLKVNFGTP EFLAPEVVNY EFVSFPTDMW 180
SVGVITYMLL SGLSPFLGET DAETMNFIVN CSWDFDAETF EGLSEEAKDF VSRLLVKEKS 240
CRMSATQCLK HEWL 254
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Ornithorhynchus anatinus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>
EKS-AIM-00108
EKS-ANC-00104
EKS-BOT-00113
EKS-CAE-00093
EKS-CAJ-00115
EKS-CAF-00115
EKS-CAP-00109
EKS-CII-00054
EKS-CIS-00129
EKS-DAR-00366
EKS-DRM-00053
EKS-EQC-00109
EKS-ERE-00057
EKS-FEC-00106
EKS-GAG-00093
EKS-GOG-00112
EKS-HOS-00114
EKS-ICT-00106
EKS-LAC-00117
EKS-LOA-00109
EKS-MAM-00109
EKS-MEG-00088
EKS-MOD-00110
EKS-MUM-00114
EKS-MUP-00114
EKS-NOL-00107
EKS-OCP-00074
EKS-ORA-00093
EKS-OTG-00119
EKS-PAT-00102
EKS-PES-00097
EKS-PEM-00056
EKS-POA-00106
EKS-RAN-00111
EKS-SAH-00106
EKS-TAG-00142
EKS-TUT-00102
EKS-XET-00093
Gene Ontology
GO:0015629; C:actin cytoskeleton
GO:0005737; C:cytoplasm
GO:0005524; F:ATP binding
GO:0004683; F:calmodulin-dependent protein kinase activity
GO:0004687; F:myosin light chain kinase activity
GO:0071347; P:cellular response to interleukin-1
GO:0002528; P:regulation of vascular permeability involved in acute inflammatory response
GO:0045214; P:sarcomere organization
KEGG
InterPros
IPR020636; Ca/CaM-dep_Ca-dep_prot_Kinase.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR002290; Ser/Thr_dual-sp_kinase_dom.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF00069; Pkinase; 1.
SMARTs
SM00220; S_TKc; 1.
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
Prints
Created Date20-Feb-2013