EPS-ORC-00021

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EPS-ORC-00021

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
PPM/PP2C	289.5	3.2E-86	23	293	271

Status

Unreviewed

Ensembl Protein

ENSOCUP00000004734

UniProt Accession

G1SNZ0;

Protein Name

Protein Synonyms/Alias

Gene Name

PPM1B

Gene Synonyms/Alias

PPM1B;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSOCUG00000005461	ENSOCUP00000004734	ENSOCUT00000005459
ENSOCUG00000005461	ENSOCUP00000016437	ENSOCUT00000022489

Organism

Oryctolagus cuniculus

Functional Description

Protein Length

479

Protein Sequence
(FASTA)

MGAFLDKPKT EKHNAHGAGN GLRYGLSSMQ GWRVEMEDAH TAVVGIPHGL EDWSFFAVYD 60

GHAGSRVANY CSTHLLEHIT TNEDFRAAGK SGSALEPSVE NVKNGIRTGF LKIDEYMRNF 120

SDLRNGMDRS GSTAVGVMIS PKHVYFINCG DSRAVLYRNG QVCFSTQDHK PCNPREKERI 180

QNAGGSVMIQ RVNGSLAVSR ALGDYDYKCV DGKGPTEQLV SPEPEVYEIL RAEEDEFIIL 240

ACDGIWDVMS NEELCEFVKS RLEVSDDLEN VCNWVVDTCL HKGSRDNMSI VLVCFSNAPK 300

VSDEAVKKDL ELDKHLESRV EEIMEKSGEE GMPDLAHVMR ILSAENIPNL PPGGGLAGKR 360

NVIEAVYSRL NPHRESDGAS DEAKESGSQG KLVEALRQMR INHRGNYRQL LEEMLTSYRL 420

AKVEGEESPA DPAAAATSSN SDAGSPVTMQ ESHSDSESGL AELDSCNEDA GTKRSGEKI 479

Nucleotide Sequence
(FASTA)

ATGGGTGCAT TTTTGGATAA ACCCAAAACT GAAAAACATA ATGCTCATGG TGCTGGAAAT 60

GGTTTGCGTT ATGGCCTGAG CAGCATGCAA GGATGGAGAG TGGAGATGGA AGATGCGCAC 120

ACAGCTGTTG TGGGTATTCC TCACGGCTTG GAAGACTGGT CGTTTTTTGC AGTGTATGAT 180

GGTCATGCTG GATCCCGAGT GGCAAACTAC TGCTCGACAC ATTTGTTAGA ACACATCACT 240

ACCAATGAAG ACTTTAGGGC AGCTGGAAAA TCAGGATCTG CTCTCGAGCC TTCAGTGGAA 300

AATGTCAAGA ATGGCATCAG AACTGGCTTT TTGAAAATTG ATGAATATAT GCGTAACTTT 360

TCAGACCTCA GAAATGGGAT GGACAGGAGT GGTTCTACTG CAGTGGGAGT TATGATTTCA 420

CCTAAGCATG TCTATTTCAT TAACTGTGGT GATTCACGTG CTGTTCTCTA TAGGAATGGA 480

CAAGTCTGCT TTTCTACCCA GGATCACAAA CCTTGTAATC CAAGGGAAAA GGAGCGAATT 540

CAAAACGCAG GAGGCAGCGT CATGATACAA CGCGTTAATG GTTCATTAGC GGTGTCTCGC 600

GCTCTGGGGG ACTATGATTA CAAGTGTGTT GATGGCAAGG GCCCAACAGA ACAACTTGTT 660

TCTCCAGAGC CTGAGGTTTA TGAAATTTTA AGAGCAGAAG AGGATGAATT TATCATCTTG 720

GCTTGTGATG GGATCTGGGA TGTTATGAGT AATGAGGAGC TCTGTGAATT TGTTAAATCT 780

AGGCTTGAGG TATCTGATGA CCTGGAAAAT GTGTGCAATT GGGTAGTGGA CACTTGTTTA 840

CATAAGGGAA GTCGAGATAA CATGAGTATT GTACTAGTTT GCTTTTCAAA TGCCCCCAAG 900

GTCTCAGATG AAGCAGTGAA GAAAGATTTA GAATTGGATA AACACTTGGA ATCACGGGTT 960

GAAGAAATTA TGGAGAAATC TGGTGAGGAA GGAATGCCTG ATCTTGCCCA TGTCATGCGC 1020

ATCTTGTCTG CAGAAAATAT CCCAAATTTG CCTCCTGGGG GAGGTCTTGC TGGCAAGCGC 1080

AATGTTATTG AAGCTGTTTA TAGTAGACTG AATCCACATA GAGAAAGCGA TGGGGCCTCC 1140

GATGAAGCAA AGGAAAGTGG ATCACAGGGA AAATTGGTGG AAGCTCTCAG GCAAATGAGA 1200

ATTAATCATA GGGGAAACTA CCGACAACTT CTGGAGGAGA TGCTGACTAG TTACAGGCTA 1260

GCTAAAGTAG AGGGAGAAGA AAGCCCTGCT GACCCAGCTG CTGCTGCCAC TTCTTCGAAC 1320

AGTGATGCTG GAAGCCCAGT GACAATGCAG GAAAGCCATT CTGACTCAGA AAGTGGTCTT 1380

GCTGAATTAG ACAGCTGTAA TGAAGATGCA GGGACAAAGA GGAGTGGTGA AAAAATA 1437

Domain Profile

S: 2     lvgvvsvngrrnemedavtsspnflkspekkdrlaffgvyDGhggsevakfcseklheil  61

         ++g++s++g+r emeda+t++ ++    + +d ++ff+vyDGh+gs+va++cs++l e++

Q: 23    RYGLSSMQGWRVEMEDAHTAVVGIPH--GLED-WSFFAVYDGHAGSRVANYCSTHLLEHI  79

         69****************98555444..4434.***************************

S: 62    aeele.........sseseerkvkkalakaFlstdeelkvleeksldidksGstavvali  112

         +++ +         + e++ ++vk+ ++++Fl++de ++++++ ++ +d+sGstav ++i

Q: 80    TTNEDfraagksgsALEPSVENVKNGIRTGFLKIDEYMRNFSDLRNGMDRSGSTAVGVMI  139

         ***99********999********************************************

S: 113   kdsklyvanvGdSravLcrngkavelssdHkpsredEleRieeaggsvilkdgaRvlGvL  172

         +++++y++n+GdSravL rng+++  ++dHkp +++E+eRi++aggsv+ +   Rv+G+L

Q: 140   SPKHVYFINCGDSRAVLYRNGQVCFSTQDHKPCNPREKERIQNAGGSVMIQ---RVNGSL  196

         ***************************************************...******

S: 173   avsRalGdlylk.........pyvtpePevtshrltsedefliLasDGlwdvvsneeavs  223

         avsRalGd+++k         ++v+pePev+++ + +edef+iLa+DG+wdv+snee+++

Q: 197   AVSRALGDYDYKcvdgkgpteQLVSPEPEVYEILRAEEDEFIILACDGIWDVMSNEELCE  256

         ************************************************************

S: 224   lvrdvlekkeaeqeaakkLvklalargskdnvsaivv  260

         +v+++le +++++++++ +v+++l++gs+dn+s+++v

Q: 257   FVKSRLEVSDDLENVCNWVVDTCLHKGSRDNMSIVLV  293

         ********************************98875

Domain Sequence
(FASTA)

RYGLSSMQGW RVEMEDAHTA VVGIPHGLED WSFFAVYDGH AGSRVANYCS THLLEHITTN 60

EDFRAAGKSG SALEPSVENV KNGIRTGFLK IDEYMRNFSD LRNGMDRSGS TAVGVMISPK 120

HVYFINCGDS RAVLYRNGQV CFSTQDHKPC NPREKERIQN AGGSVMIQRV NGSLAVSRAL 180

GDYDYKCVDG KGPTEQLVSP EPEVYEILRA EEDEFIILAC DGIWDVMSNE ELCEFVKSRL 240

EVSDDLENVC NWVVDTCLHK GSRDNMSIVL V 271

Keyword

Complete proteome; Hydrolase; Magnesium; Metal-binding; Protein phosphatase; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>

Gene Ontology

GO:0000287	; F:magnesium ion binding
GO:0030145	; F:manganese ion binding
GO:0004722	; F:protein serine/threonine phosphatase activity
GO:0035970	; P:peptidyl-threonine dephosphorylation

KEGG

InterPros

IPR001932	; PP2C-like.
IPR012911	; PP2C_C.
IPR000222	; PP2C_Mn2_Asp60_BS.
IPR015655	; Protein_Pase_2C.

Pfam

PF00481	; PP2C; 1.
PF07830	; PP2C_C; 1.

SMARTs

SM00331	; PP2C_SIG; 1.
SM00332	; PP2Cc; 1.

Prosites

PS01032

; PP2C; 1.

Prints

Created Date

20-Feb-2013