EKS-ORC-00046
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-ORC-00046
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TKL/RAF413.16.4E-124412668257
StatusUnreviewed
Ensembl ProteinENSOCUP00000004763
UniProt AccessionG1SP13;
Protein Name
Protein Synonyms/Alias
Gene NameBRAF
Gene Synonyms/Alias BRAF;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSOCUG00000005487ENSOCUP00000020686ENSOCUT00000027897
ENSOCUG00000005487ENSOCUP00000004763ENSOCUT00000005491
OrganismOryctolagus cuniculus
Functional Description
Protein Length720
Protein Sequence
(FASTA)
VWNIKQMIKL TQEHIEALLD KFGGEHNPPS IYLEAYEEYT SKLDALQQRE QQLLESLGNG 60
TDFSVSSSAS MDTVTSSSSS SLSVLPSSLS VFQNPTDVSR SNPKSPQKPI VRVFLPNKQR 120
TVVPARCGVT VRDSLKKALM MRGLIPECCA VYRIQDGEKK PIGWDTDISW LTGEELHVEV 180
LENVPLTTHN FVRKTFFTLA FCDFCRKLLF QGFRCQTCGY KFHQRCSTEV PLMCVNYDQL 240
DLLFVSKFFE HHPVPQEEAS LAETALTSGS SPSAPPSDSI GHQILTSPSP SKSIPIPQSF 300
RPADEDHRNQ FGQRDRSSSA PNVHINTIEP VNIDDLIRDQ GFRGDGGSTT GLSATPPASL 360
PGSLTSVKAV QRSPGPQRER KSSSSSEDRN RMKTLGRRDS SDDWEIPDGQ ITVGQRIGSG 420
SFGTVYKGKW HGDVAVKMLN VTAPTPQQLQ AFKNEVGVLR KTRHVNILLF MGYSTKPQLA 480
IVTQWCEGSS LYHHLHIIET KFEMIKLIDI ARQTAQGMDY LHAKSIIHRD LKSNNIFLHE 540
DLTVKIGDFG LATVKSRWSG SHQFEQLSGS ILWMAPEVIR MQDKNPYSFQ SDVYAFGIVL 600
YELMTGQLPY SNINNRDQII FMVGRGYLSP DLSKVRSNCP KAMKRLMAEC LKKKRDERPL 660
FPQILASIEL LARSLPKIHR SASEPSLNRA GFQTEDFSLY ACASPKTPIQ AGGYGAFAVH 720
Nucleotide Sequence
(FASTA)
GTGTGGAATA TCAAACAAAT GATTAAGTTG ACACAGGAGC ATATAGAGGC CCTATTGGAC 60
AAATTTGGTG GGGAGCATAA TCCACCATCA ATATATCTGG AGGCCTACGA AGAATACACC 120
AGCAAGCTAG ATGCCCTCCA ACAAAGAGAA CAGCAGTTAT TGGAATCCCT GGGGAATGGA 180
ACTGATTTTT CTGTTTCTAG CTCTGCGTCA ATGGACACCG TTACGTCTTC TTCCTCTTCT 240
AGCCTTTCAG TGCTACCTTC ATCTCTTTCA GTTTTTCAAA ATCCCACAGA TGTGTCACGG 300
AGCAACCCCA AGTCACCACA AAAACCTATT GTTAGAGTCT TCCTGCCCAA CAAACAGAGG 360
ACAGTGGTAC CTGCAAGATG TGGAGTTACG GTTCGAGACA GTCTAAAGAA AGCGCTGATG 420
ATGAGAGGTC TGATCCCAGA ATGCTGTGCT GTTTACAGAA TTCAGGATGG AGAGAAGAAG 480
CCAATTGGCT GGGACACTGA TATTTCCTGG CTCACTGGAG AAGAGCTGCA TGTGGAAGTG 540
TTAGAGAATG TCCCACTCAC CACACATAAC TTTGTACGGA AAACTTTTTT CACCTTAGCA 600
TTTTGTGACT TCTGTAGAAA GCTGCTTTTC CAGGGTTTCC GCTGTCAAAC ATGTGGCTAC 660
AAATTTCACC AGCGTTGTAG TACGGAAGTT CCACTGATGT GTGTTAATTA TGACCAACTT 720
GATTTGCTGT TTGTCTCCAA GTTCTTTGAA CACCACCCAG TACCACAGGA GGAGGCCTCC 780
TTAGCAGAGA CTGCCCTCAC ATCTGGGTCA TCGCCTTCCG CACCTCCCTC AGACTCTATT 840
GGGCACCAAA TTCTCACCAG TCCGTCCCCT TCAAAATCCA TTCCGATTCC ACAGTCCTTC 900
CGACCAGCAG ATGAAGATCA TCGAAATCAG TTTGGGCAAC GAGACCGGTC TTCATCAGCG 960
CCTAATGTTC ACATTAACAC AATAGAACCT GTCAATATTG ATGACTTGAT TAGAGACCAA 1020
GGGTTTCGTG GTGATGGAGG ATCGACCACG GGTTTGTCTG CCACTCCCCC TGCCTCATTA 1080
CCTGGCTCAC TCACTAGTGT GAAAGCTGTA CAGAGATCCC CAGGACCTCA GCGAGAGAGG 1140
AAGTCGTCTT CCTCCTCAGA AGACAGGAAT CGAATGAAAA CTCTTGGTAG ACGGGATTCA 1200
AGTGATGATT GGGAGATTCC TGATGGGCAG ATCACCGTGG GACAGAGAAT TGGATCTGGA 1260
TCATTTGGAA CCGTCTACAA GGGAAAATGG CACGGTGATG TGGCAGTAAA AATGTTGAAT 1320
GTGACAGCAC CTACACCTCA GCAGTTACAG GCCTTCAAAA ATGAAGTAGG AGTACTCAGG 1380
AAAACACGAC ATGTGAATAT CCTACTTTTC ATGGGCTATT CCACAAAGCC ACAGCTGGCT 1440
ATTGTTACCC AGTGGTGTGA GGGCTCCAGT TTATATCACC ATCTCCACAT CATTGAGACC 1500
AAATTCGAGA TGATCAAACT TATAGATATT GCACGGCAGA CTGCACAGGG CATGGATTAC 1560
TTACACGCCA AGTCAATCAT CCACAGAGAC CTCAAGAGTA ATAATATATT TCTTCATGAA 1620
GACCTCACAG TAAAAATAGG TGATTTTGGT CTAGCCACAG TGAAATCTCG ATGGAGTGGG 1680
TCCCATCAGT TTGAACAATT GTCTGGATCC ATTTTGTGGA TGGCACCAGA AGTAATCAGA 1740
ATGCAAGACA AAAACCCATA TAGCTTTCAG TCAGATGTAT ATGCATTTGG GATTGTTCTG 1800
TATGAATTGA TGACTGGGCA GTTACCTTAC TCAAACATCA ACAACAGGGA CCAGATCATT 1860
TTTATGGTGG GACGTGGCTA CCTGTCTCCA GACCTCAGTA AGGTACGGAG TAACTGTCCG 1920
AAAGCCATGA AGAGATTAAT GGCAGAGTGC CTCAAAAAGA AAAGAGATGA GAGACCACTC 1980
TTTCCCCAAA TTCTCGCCTC CATTGAGCTG CTGGCCCGCT CATTGCCAAA AATCCACCGC 2040
AGTGCATCAG AACCCTCCTT GAATCGGGCT GGTTTCCAGA CAGAGGATTT TAGTCTATAT 2100
GCTTGTGCTT CTCCAAAAAC ACCCATCCAG GCAGGGGGAT ATGGTGCGTT TGCTGTCCAC 2160
Domain Profile
S: 2     elaekiGsGrfGtvyrgkwhGdvavkllnveelseeqleaFkkevaaykktRhenivLFm  61
         +++++iGsG+fGtvy+gkwhGdvavk+lnv++++++ql+aFk+ev +++ktRh+ni+LFm
Q: 412   TVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFM  471
         7899********************************************************
S: 62    GyvskpelaivtslckgssLykllheqetkldlaklidiarqiaqgmdYLhakkilhkDl  121
         Gy +kp+laivt++c+gssLy++lh  etk+++ klidiarq+aqgmdYLhak+i+h+Dl
Q: 472   GYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDL  531
         ************************************************************
S: 122   ksknilleeglkvvitDFgllsvkrllsgrrekqleipkgwilylapeviralsidleqd  181
         ks+ni+l+e+l+v+i+DFgl++vk+++sg  ++q+e+ +g+il++apevir+      qd
Q: 532   KSNNIFLHEDLTVKIGDFGLATVKSRWSG--SHQFEQLSGSILWMAPEVIRM------QD  583
         *****************************..*********************......**
S: 182   elpfskesDvyafGivlyellarelpyke.esadqilfavgrG.lkpdlskvksklpkel  239
         ++p+s++sDvyafGivlyel++++lpy++ +++dqi+f+vgrG l+pdlskv+s++pk++
Q: 584   KNPYSFQSDVYAFGIVLYELMTGQLPYSNiNNRDQIIFMVGRGyLSPDLSKVRSNCPKAM  643
         ************************************************************
S: 240   kellleClkfekeeRPlftqilkkl  264
         k+l++eClk++++eRPlf+qil+++
Q: 644   KRLMAECLKKKRDERPLFPQILASI  668
         *********************9875
Domain Sequence
(FASTA)
TVGQRIGSGS FGTVYKGKWH GDVAVKMLNV TAPTPQQLQA FKNEVGVLRK TRHVNILLFM 60
GYSTKPQLAI VTQWCEGSSL YHHLHIIETK FEMIKLIDIA RQTAQGMDYL HAKSIIHRDL 120
KSNNIFLHED LTVKIGDFGL ATVKSRWSGS HQFEQLSGSI LWMAPEVIRM QDKNPYSFQS 180
DVYAFGIVLY ELMTGQLPYS NINNRDQIIF MVGRGYLSPD LSKVRSNCPK AMKRLMAECL 240
KKKRDERPLF PQILASI 257
KeywordATP-binding; Complete proteome; Kinase; Metal-binding; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase; Zinc.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ornithorhynchus anatinus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00046
EKS-ANC-00043
EKS-BOT-00051
EKS-CAJ-00051
EKS-CAF-00052
EKS-CAP-00053
EKS-CII-00019
EKS-DAR-00064
EKS-EQC-00048
EKS-FEC-00048
EKS-GAG-00041
EKS-GAA-00067
EKS-GOG-00049
EKS-HOS-00052
EKS-ICT-00047
EKS-LAC-00057
EKS-LOA-00051
EKS-MEG-00042
EKS-MOD-00052
EKS-MUM-00052
EKS-MUP-00052
EKS-MYL-00057
EKS-NOL-00048
EKS-ORA-00043
EKS-ORL-00064
EKS-OTG-00053
EKS-PAT-00046
EKS-PES-00045
EKS-PEM-00028
EKS-POA-00047
EKS-RAN-00051
EKS-SAH-00050
EKS-SUS-00042
EKS-TAG-00045
EKS-TAR-00070
EKS-TEN-00073
EKS-VIP-00024
EKS-XET-00051
EKS-XIM-00072
Gene Ontology
GO:0005737; C:cytoplasm
GO:0005634; C:nucleus
GO:0005886; C:plasma membrane
GO:0005524; F:ATP binding
GO:0005509; F:calcium ion binding
GO:0004674; F:protein serine/threonine kinase activity
GO:0005057; F:receptor signaling protein activity
GO:0071277; P:cellular response to calcium ion
GO:0035556; P:intracellular signal transduction
GO:0043066; P:negative regulation of apoptotic process
GO:0070374; P:positive regulation of ERK1 and ERK2 cascade
GO:0010628; P:positive regulation of gene expression
GO:0033138; P:positive regulation of peptidyl-serine phosphorylation
GO:0070849; P:response to epidermal growth factor stimulus
KEGG
InterPros
IPR020454; DAG/PE-bd.
IPR011009; Kinase-like_dom.
IPR002219; Prot_Kinase_C-like_PE/DAG-bd.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR003116; Raf-like_ras-bd.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF00130; C1_1; 1.
PF07714; Pkinase_Tyr; 1.
PF02196; RBD; 1.
SMARTs
SM00109; C1; 1.
SM00455; RBD; 1.
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
PS50898; RBD; 1.
PS00479; ZF_DAG_PE_1; 1.
PS50081; ZF_DAG_PE_2; 1.
Prints
PR00008; DAGPEDOMAIN.
Created Date20-Feb-2013