EKS-ORC-00358
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-ORC-00358
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TKL/MLK316.12.0E-94161396236
StatusUnreviewed
Ensembl ProteinENSOCUP00000004933
UniProt AccessionG1SPG5;
Protein Name
Protein Synonyms/Alias
Gene NameMAP3K12
Gene Synonyms/Alias MAP3K12;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSOCUG00000005689ENSOCUP00000004933ENSOCUT00000005693
OrganismOryctolagus cuniculus
Functional Description
Protein Length893
Protein Sequence
(FASTA)
MACLHETRTP SPSFGGFVST LSEASMRKLD PDTSDCTPEK DLTPTQCVLR DVVPLGGQGG 60
GGPSPSPGGE PPPEPFANSV LQLHEQDAGG PGGATGSPES RASRVRADEV RLQCQSGSGF 120
LEGLFGCLRP VWTMIGKAYS TEHKQQQEDP WEVPFEEILD LQWVGSGAQG AVFLGRFHGE 180
EVAVKKVRDL KETDIKHLRK LKHPNIITFK GVCTQAPCYC ILMEFCAQGQ LYEVLRAGRP 240
VTPSLLVDWS MGIAGGMNYL HLHKIIHRDL KSPNMLITYD DVVKISDFGT SKELSDKSTK 300
MSFAGTVAWM APEVIRNEPV SEKVDIWSFG VVLWELLTGE IPYKDVDSSA IIWGVGSNSL 360
HLPVPSSCPD GFKILLRQCW NSKPRNRPSF RQILLHLDIA SADVLSTPQE TYFKSQAEWR 420
EEVKLHFEKI KSEGTCLHRL EEELVMRRRE ELRHALDIRE HYERKLERAN NLYMELNALM 480
LQLELKEREL LRREQALERR CPGLLKSHPS RGILHGNTME KLIKKRNVPQ KLSPHSKRPD 540
ILKTESLLPK LDAALSGVGL PGCPKGPPSP GRNRRGKTRH RKASAKGSCG DLPGLRAAVP 600
AHEPGGPGSP GSLAGGPSAW EACPPALRGL HHDLLLRKMS SSSPDLLSAA LGARGRGTSG 660
AAGDPGSPPP ARGDTPPSEG SAPGSTSPDS PGGAKGEPPP AVGPGEGVGL LGTGKEGTAG 720
RGGSRAGSQH LTPAALLYRA AVTRSQKRGI SSEEEEGEVD SEVELTSSQR WPQGLNMRQS 780
LSTFSSENPS DGEEGTASEP SPSGTPEVGS TNTDERPDER SDDMCSQGSE LPSDPPASEV 840
VTDPEPSSLP IPQQDLLRGE QGPPNSEDSD CDSTELDNSN SIDALRPPAS LPP 893
Nucleotide Sequence
(FASTA)
ATGGCCTGCC TCCATGAGAC CCGCACGCCC TCCCCTTCCT TCGGGGGCTT CGTGTCCACG 60
CTCAGCGAGG CATCCATGCG CAAACTGGAC CCGGACACTT CCGACTGCAC CCCCGAGAAG 120
GACCTGACCC CTACGCAGTG CGTGCTTCGC GATGTAGTGC CCCTCGGTGG GCAGGGCGGG 180
GGCGGGCCCA GCCCCTCCCC GGGTGGGGAG CCGCCCCCCG AGCCTTTTGC CAACAGCGTT 240
CTGCAGCTCC ACGAGCAGGA CGCAGGAGGC CCCGGGGGAG CCACGGGGTC TCCTGAGAGC 300
CGGGCGTCCA GGGTTCGAGC TGACGAGGTG CGGCTACAGT GCCAGAGTGG CAGTGGCTTC 360
CTGGAAGGCC TCTTTGGCTG CCTGCGCCCC GTGTGGACCA TGATTGGCAA GGCCTACTCC 420
ACGGAGCACA AGCAGCAGCA GGAAGACCCT TGGGAGGTCC CCTTTGAGGA AATCCTGGAC 480
CTGCAGTGGG TAGGCTCGGG GGCCCAGGGC GCCGTCTTCC TGGGGCGCTT CCACGGGGAA 540
GAGGTGGCTG TGAAGAAGGT GCGAGACCTC AAGGAGACTG ACATCAAACA CCTGCGGAAG 600
CTGAAGCACC CCAACATCAT CACTTTCAAG GGTGTGTGCA CCCAGGCCCC CTGCTACTGC 660
ATCCTCATGG AGTTCTGCGC CCAGGGCCAG CTGTACGAGG TGCTGCGGGC TGGCCGCCCA 720
GTCACCCCCT CCTTGCTGGT TGACTGGTCC ATGGGCATCG CCGGGGGCAT GAACTACCTA 780
CACCTGCACA AGATCATCCA CCGAGACCTC AAGTCCCCTA ACATGCTAAT CACATACGAT 840
GATGTGGTCA AGATCTCAGA TTTCGGCACT TCCAAGGAGC TGAGTGACAA GAGCACCAAG 900
ATGTCCTTTG CAGGGACAGT GGCCTGGATG GCCCCAGAGG TGATCCGCAA TGAGCCCGTG 960
TCTGAGAAGG TGGACATCTG GTCCTTTGGT GTGGTGCTGT GGGAACTGCT GACGGGTGAG 1020
ATTCCCTACA AAGACGTGGA CTCCTCCGCC ATCATCTGGG GTGTGGGCAG CAACAGTCTG 1080
CATCTGCCTG TGCCCTCCAG CTGCCCAGAT GGCTTCAAAA TCCTACTCCG CCAGTGCTGG 1140
AACAGCAAAC CTCGAAACCG CCCATCATTC CGGCAGATCC TGCTGCACCT GGACATCGCC 1200
TCAGCCGACG TGCTCTCCAC ACCGCAGGAG ACCTACTTCA AGTCCCAGGC AGAGTGGCGG 1260
GAAGAAGTCA AGCTGCACTT TGAAAAGATT AAGTCCGAAG GGACCTGTCT GCACCGCCTG 1320
GAAGAGGAGC TGGTGATGCG GAGGAGAGAG GAGCTCAGAC ATGCCTTGGA CATCCGGGAA 1380
CACTATGAGA GGAAGCTGGA GCGCGCCAAC AATCTGTACA TGGAACTGAA TGCTCTCATG 1440
TTGCAGCTGG AACTCAAGGA GCGGGAGCTG CTCAGGCGGG AGCAAGCTCT AGAGCGCAGG 1500
TGCCCGGGCC TGCTGAAGTC CCACCCTTCC CGAGGCATCC TGCATGGCAA CACCATGGAG 1560
AAGCTCATCA AGAAGCGCAA TGTGCCGCAG AAGCTGTCTC CTCACAGCAA AAGGCCAGAT 1620
ATCCTCAAGA CCGAGTCTTT ACTACCTAAG CTAGATGCAG CCCTGAGTGG AGTGGGGCTT 1680
CCTGGGTGCC CCAAAGGACC CCCTTCACCG GGGCGGAATC GCCGTGGCAA GACGCGTCAC 1740
CGGAAGGCCA GCGCCAAGGG CAGCTGCGGG GACCTGCCTG GGCTTCGTGC AGCTGTGCCA 1800
GCCCATGAAC CCGGGGGACC GGGAAGCCCG GGGTCCCTAG CAGGGGGACC TTCAGCTTGG 1860
GAGGCCTGCC CCCCAGCCCT CCGTGGGCTC CACCATGACC TCCTGCTCCG CAAGATGTCT 1920
TCCTCGTCCC CAGACCTGCT GTCGGCAGCA CTAGGAGCCC GGGGCCGGGG CACCTCAGGG 1980
GCAGCTGGTG ATCCTGGCTC GCCACCACCT GCCAGGGGGG ACACACCCCC CAGCGAAGGC 2040
TCAGCCCCTG GCTCCACCAG CCCAGATTCA CCTGGGGGAG CCAAAGGAGA GCCCCCTCCA 2100
GCAGTAGGGC CTGGCGAAGG CGTGGGGCTG CTGGGAACTG GAAAGGAAGG GACAGCAGGC 2160
CGGGGAGGAA GCCGGGCTGG GTCCCAACAC TTGACCCCGG CTGCACTGCT GTACAGGGCT 2220
GCTGTCACCA GAAGTCAGAA ACGCGGCATC TCCTCAGAAG AGGAGGAAGG AGAGGTAGAC 2280
AGTGAAGTAG AGCTGACATC AAGCCAGAGG TGGCCTCAGG GCCTGAACAT GCGCCAGTCA 2340
CTATCTACCT TCAGCTCAGA GAATCCATCA GACGGGGAGG AAGGTACAGC TAGTGAGCCT 2400
TCCCCTAGTG GCACACCTGA GGTTGGCAGT ACCAACACCG ACGAGCGGCC GGATGAACGG 2460
TCTGATGACA TGTGCTCCCA GGGCTCGGAA CTTCCATCGG ACCCACCAGC TTCTGAGGTG 2520
GTCACTGATC CCGAACCCAG CTCCCTGCCT ATCCCACAGC AGGACCTACT CCGAGGTGAG 2580
CAGGGCCCTC CCAATTCTGA GGACTCAGAC TGTGACAGCA CTGAACTGGA CAACTCCAAC 2640
AGCATTGATG CCTTGCGGCC CCCAGCCTCC CTCCCTCCC 2679
Domain Profile
S: 4     eeligsgafgkvykakwrkkevavKklreeaeekekleklereakllsklshpniiellG  63
          +++gsga+g+v+ ++++++evavKk+r+ +e+         ++k+l+kl+hpnii+++G
Q: 161   LQWVGSGAQGAVFLGRFHGEEVAVKKVRDLKET---------DIKHLRKLKHPNIITFKG  211
         689**************************9999.........******************
S: 64    vcleepnlllvmeyveggsLsnvlhekskreidlevlvswalqiArGmaYLhseapkkii  123
         vc++ p+++++me++++g+L++vl++   r ++++ lv+w++ iA Gm+YLh +   kii
Q: 212   VCTQAPCYCILMEFCAQGQLYEVLRA--GRPVTPSLLVDWSMGIAGGMNYLHLH---KII  266
         **************************..99************************...9**
S: 124   hrdLksknvLlseekktlkicdFGtarelsk.stkmsaagtlawmaPEvlkeekvseksD  182
         hrdLks+n+L+ + ++++ki+dFGt++els+ stkms+agt+awmaPEv+++e+vsek+D
Q: 267   HRDLKSPNMLI-TYDDVVKISDFGTSKELSDkSTKMSFAGTVAWMAPEVIRNEPVSEKVD  325
         ***********.99****************99****************************
S: 183   vwSygvvLWelltrevPykdlselaiaykvalkglrlpipsscpeklkkLmkecwnedpe  242
         +wS+gvvLWellt+e+Pykd+++ ai+++v++++l+lp+psscp+ +k L+++cwn++p+
Q: 326   IWSFGVVLWELLTGEIPYKDVDSSAIIWGVGSNSLHLPVPSSCPDGFKILLRQCWNSKPR  385
         ************************************************************
S: 243   kRpsfseivks  253
         +Rpsf++i+ +
Q: 386   NRPSFRQILLH  396
         ********876
Domain Sequence
(FASTA)
LQWVGSGAQG AVFLGRFHGE EVAVKKVRDL KETDIKHLRK LKHPNIITFK GVCTQAPCYC 60
ILMEFCAQGQ LYEVLRAGRP VTPSLLVDWS MGIAGGMNYL HLHKIIHRDL KSPNMLITYD 120
DVVKISDFGT SKELSDKSTK MSFAGTVAWM APEVIRNEPV SEKVDIWSFG VVLWELLTGE 180
IPYKDVDSSA IIWGVGSNSL HLPVPSSCPD GFKILLRQCW NSKPRNRPSF RQILLH 236
KeywordComplete proteome; Reference proteome.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00355
EKS-ANC-00369
EKS-BOT-00381
EKS-CAE-00303
EKS-CAJ-00386
EKS-CAF-00381
EKS-CAP-00413
EKS-DAR-00760
EKS-DIO-00060
EKS-DRM-00177
EKS-EQC-00370
EKS-FEC-00368
EKS-GAA-00464
EKS-GOG-00371
EKS-HOS-00388
EKS-ICT-00359
EKS-LAC-00398
EKS-LOA-00389
EKS-MAM-00380
EKS-MUM-00414
EKS-MUP-00373
EKS-MYL-00378
EKS-NOL-00348
EKS-OCP-00078
EKS-ORN-00489
EKS-ORL-00451
EKS-OTG-00383
EKS-PAT-00361
EKS-PEM-00201
EKS-POA-00371
EKS-PRC-00080
EKS-PTV-00100
EKS-RAN-00396
EKS-SAH-00348
EKS-SUS-00332
EKS-TAR-00485
EKS-TEN-00482
EKS-XET-00494
EKS-XIM-00478
Gene Ontology
GO:0033267; C:axon part
GO:0005829; C:cytosol
GO:0030426; C:growth cone
GO:0005886; C:plasma membrane
GO:0005524; F:ATP binding
GO:0000287; F:magnesium ion binding
GO:0004709; F:MAP kinase kinase kinase activity
GO:0000186; P:activation of MAPKK activity
GO:0016572; P:histone phosphorylation
GO:0000165; P:MAPK cascade
GO:0018105; P:peptidyl-serine phosphorylation
GO:0018107; P:peptidyl-threonine phosphorylation
GO:0046777; P:protein autophosphorylation
KEGG
InterPros
IPR011009; Kinase-like_dom.
IPR017419; MAP3K12_MAP3K13.
IPR000719; Prot_kinase_cat_dom.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF07714; Pkinase_Tyr; 1.
SMARTs
Prosites
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
Prints
PR00109; TYRKINASE.
Created Date20-Feb-2013