EKS-ORC-00254

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ORC-00254

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/DYRK	448.7	1.4E-134	159	479	321

Status

Unreviewed

Ensembl Protein

ENSOCUP00000022093

UniProt Accession

G1SPQ6;

Protein Name

Protein Synonyms/Alias

Dual-specificity tyrosine-phosphorylation-regulated kinase 1A;

Gene Name

DYRK1A

Gene Synonyms/Alias

DYRK1A;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSOCUG00000005814	ENSOCUP00000005040	ENSOCUT00000005815
ENSOCUG00000005814	ENSOCUP00000022093	ENSOCUT00000021971

Organism

Oryctolagus cuniculus

Functional Description

Protein Length

750

Protein Sequence
(FASTA)

LLVGGETSAC KPSSVRLAPS FSFHAAGLQM AGQMPHSHQY SDRRQPNISD QQVSALSYSD 60

QIQQPLTNQV MPDIVMLQRR MPQTFRDPAT APLRKLSVDL IKTYKHINEV YYAKKKRRHQ 120

QGQGDDSSHK KERKVYNDGY DDDNYDYIVK NGEKWMDRYE IDSLIGKGSF GQVVKAYDRV 180

EQEWVAIKII KNKKAFLNQA QIEVRLLELM NKHDTEMKYY IVHLKRHFMF RNHLCLVFEM 240

LSYNLYDLLR NTNFRGVSLN LTRKFAQQMC TALLFLATPE LSIIHCDLKP ENILLCNPKR 300

SAIKIVDFGS SCQLGQRIYQ YIQSRFYRSP EVLLGMPYDL AIDMWSLGCI LVEMHTGEPL 360

FSGANEVDQM NKIVEVLGIP PAHILDQAPK ARKFFEKLPD GTWNLKKTKD GKREYKPPGT 420

RKLHNILGVE TGGPGGRRAG ESGHTVADYL KFKDLILRML DYDPKTRIQP YYALQHSFFK 480

KTADEGTNTS NSVSTSPAME QSQSSGTTSS TSSSSGGSSG TSNSGRARSD PTHQHRHSGG 540

HFTAAVQAMD CETHSPQVRQ QFPAPLGWSG TEAPTQVTVE THPVQETTFH VAPPQNALHH 600

HHGNSYGQQA LGNRTRPRVY NSPTNSSSTQ DSMEVGHSHH SMTSLSSSTT SSSTSSSSTG 660

NQGNQAYQNR PVAASTLDFG QNGAMDVNLT VYSNPRQETG IAGHPAYQFS ANTGPAHYMT 720

EGHLTMRQGA DREESPMTGV CVQQSPVASS 750

Nucleotide Sequence
(FASTA)

CTTCTTGTAG GAGGAGAGAC TTCAGCATGC AAACCTTCAT CTGTTCGGCT TGCACCGTCA 60

TTTTCATTCC ATGCTGCTGG CCTTCAGATG GCTGGACAGA TGCCCCATTC ACATCAGTAC 120

AGTGACCGTC GCCAGCCAAA CATAAGTGAC CAACAGGTTT CTGCCTTATC GTATTCTGAC 180

CAGATTCAGC AACCTCTAAC TAACCAGGTG ATGCCTGATA TTGTCATGTT ACAGAGGCGG 240

ATGCCCCAAA CCTTCCGTGA TCCAGCAACT GCTCCCCTGA GAAAACTTTC TGTTGACTTG 300

ATCAAAACAT ACAAGCATAT TAATGAGGTT TACTATGCAA AAAAGAAGCG AAGACACCAG 360

CAAGGCCAGG GAGACGATTC TAGTCACAAG AAGGAGCGGA AGGTTTACAA CGATGGTTAT 420

GATGACGACA ACTACGATTA TATTGTAAAA AACGGAGAAA AGTGGATGGA CCGTTATGAA 480

ATTGACTCCT TGATAGGCAA AGGTTCTTTT GGACAGGTGG TAAAGGCCTA TGATCGTGTG 540

GAGCAGGAAT GGGTTGCCAT TAAAATAATC AAGAACAAGA AGGCTTTTCT CAATCAAGCC 600

CAGATAGAAG TGCGACTTCT TGAGCTCATG AACAAACATG ACACTGAAAT GAAATATTAT 660

ATAGTGCATT TGAAACGCCA TTTTATGTTT CGAAACCATC TCTGTTTAGT TTTTGAAATG 720

CTGTCCTACA ACCTCTATGA TTTGTTGAGG AATACCAATT TCCGAGGGGT CTCCTTGAAC 780

CTTACGCGCA AGTTTGCACA ACAGATGTGC ACGGCACTGC TTTTCCTGGC AACTCCAGAA 840

CTTAGTATCA TTCACTGTGA TCTAAAACCT GAGAACATCC TTCTTTGTAA CCCCAAACGC 900

AGTGCAATCA AGATCGTCGA CTTTGGCAGT TCTTGTCAAT TGGGGCAGAG GATATACCAG 960

TATATTCAGA GTCGCTTCTA CCGGTCTCCG GAGGTGCTGC TGGGGATGCC GTACGACCTC 1020

GCTATTGACA TGTGGTCCCT CGGGTGTATC CTGGTCGAGA TGCACACCGG AGAGCCCCTG 1080

TTCAGTGGCG CCAACGAGGT AGATCAGATG AATAAAATAG TGGAAGTTCT GGGTATTCCA 1140

CCTGCTCATA TTCTTGATCA AGCACCAAAA GCAAGAAAGT TCTTTGAGAA GTTGCCAGAT 1200

GGCACTTGGA ACTTAAAGAA GACCAAAGAT GGAAAACGGG AGTACAAGCC ACCAGGAACC 1260

CGTAAACTTC ATAATATTCT TGGAGTGGAA ACAGGAGGGC CTGGTGGGCG ACGAGCTGGG 1320

GAGTCGGGTC ACACGGTAGC TGACTACTTG AAGTTCAAAG ACCTCATTTT AAGGATGCTT 1380

GATTATGACC CCAAAACTCG AATTCAACCT TATTATGCCC TGCAGCACAG TTTTTTCAAG 1440

AAAACAGCTG ATGAAGGTAC AAATACAAGT AACAGTGTGT CCACAAGCCC TGCGATGGAG 1500

CAGTCCCAGT CCTCAGGCAC CACCTCCAGC ACGTCGTCCA GCTCAGGTGG ATCATCGGGG 1560

ACGAGCAACA GTGGGCGAGC CAGGTCGGAT CCAACACATC AGCACCGGCA CAGCGGAGGC 1620

CACTTCACGG CCGCCGTCCA GGCCATGGAC TGTGAGACAC ACAGTCCCCA GGTGCGTCAG 1680

CAGTTCCCTG CTCCTCTTGG TTGGTCAGGC ACTGAAGCTC CTACACAAGT CACTGTTGAA 1740

ACTCACCCCG TTCAGGAAAC AACCTTCCAC GTAGCCCCTC CGCAGAACGC ACTGCATCAT 1800

CACCATGGAA ACAGTTATGG ACAGCAAGCC TTGGGCAACC GGACCAGGCC GAGGGTCTAC 1860

AATTCTCCAA CGAATAGCTC CTCTACCCAG GATTCCATGG AGGTTGGCCA CAGTCACCAC 1920

TCCATGACAT CCCTGTCTTC CTCAACGACT TCTTCCTCGA CATCGTCCTC CTCTACTGGT 1980

AACCAAGGCA ACCAGGCCTA CCAGAACCGC CCAGTGGCTG CTAGCACCTT GGACTTCGGA 2040

CAGAATGGAG CTATGGACGT CAATCTGACC GTCTACTCCA ATCCCCGCCA GGAGACTGGC 2100

ATCGCTGGAC ATCCAGCATA CCAGTTTTCT GCTAACACAG GTCCTGCACA TTACATGACT 2160

GAAGGACATC TGACGATGCG GCAAGGGGCC GACAGAGAGG AGTCCCCCAT GACAGGAGTG 2220

TGTGTGCAGC AGAGTCCTGT AGCTAGCTCG TGA 2253

Domain Profile

S: 1     yevlevigkGsfgqVvkaldkktkeivaikiiknkkrfarqaqeEveiLeklnkkdkeek  60

         ye++++igkGsfgqVvka+d+ ++e+vaikiiknkk+f++qaq+Ev++Le +nk+d+e+k

Q: 159   YEIDSLIGKGSFGQVVKAYDRVEQEWVAIKIIKNKKAFLNQAQIEVRLLELMNKHDTEMK  218

         9***********************************************************

S: 61    ynvvrllelfvfrnhlclvfellsqnLyellkknkfsglslklvrklaqqilkaLklLk.  119

         y++v+l+++f+frnhlclvfe+ls+nLy+ll++++f+g+sl+l+rk+aqq+++aL +L+

Q: 219   YYIVHLKRHFMFRNHLCLVFEMLSYNLYDLLRNTNFRGVSLNLTRKFAQQMCTALLFLAt  278

         **********************************************************99

S: 120   .elkiiHaDlKPeNillvekkrsevkviDFGsssavsqkeiytyiqsrfYraPEiilglk  178

          el+iiH+DlKPeNill+++krs++k++DFGss++  q+ iy+yiqsrfYr+PE++lg++

Q: 279   pELSIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLGQR-IYQYIQSRFYRSPEVLLGMP  337

         99*************************************.********************

S: 179   ydeaiDmWSlGcvlaElftGkpLfpGenevdqlalivevlglppekllekakkakkfftk  238

         yd aiDmWSlGc+l+E++tG+pLf+G+nevdq+++ivevlg+pp+++l++a ka+kff+k

Q: 338   YDLAIDMWSLGCILVEMHTGEPLFSGANEVDQMNKIVEVLGIPPAHILDQAPKARKFFEK  397

         ************************************************************

S: 239   keapkyilktk.........ksdrkkklvlnvkkaakkrkaplskelgealkekedkl.f  288

           + ++ lk++          ++rk +++l+v++ +     p+ +++ge+ ++++d+l f

Q: 398   LPDGTWNLKKTkdgkreykpPGTRKLHNILGVETGG-----PGGRRAGESGHTVADYLkF  452

         ********9997777777777777777777777776.....99*****************

S: 289   kdllkrmleldpakRitpkealkhpfv  315

         kdl+ rml++dp++Ri+p++al+h+f+

Q: 453   KDLILRMLDYDPKTRIQPYYALQHSFF  479

         **************************7

Domain Sequence
(FASTA)

YEIDSLIGKG SFGQVVKAYD RVEQEWVAIK IIKNKKAFLN QAQIEVRLLE LMNKHDTEMK 60

YYIVHLKRHF MFRNHLCLVF EMLSYNLYDL LRNTNFRGVS LNLTRKFAQQ MCTALLFLAT 120

PELSIIHCDL KPENILLCNP KRSAIKIVDF GSSCQLGQRI YQYIQSRFYR SPEVLLGMPY 180

DLAIDMWSLG CILVEMHTGE PLFSGANEVD QMNKIVEVLG IPPAHILDQA PKARKFFEKL 240

PDGTWNLKKT KDGKREYKPP GTRKLHNILG VETGGPGGRR AGESGHTVAD YLKFKDLILR 300

MLDYDPKTRI QPYYALQHSF F 321

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0030529	; C:ribonucleoprotein complex
GO:0005524	; F:ATP binding
GO:0004715	; F:non-membrane spanning protein tyrosine kinase activity
GO:0004674	; F:protein serine/threonine kinase activity
GO:0043518	; P:negative regulation of DNA damage response, signal transduction by p53 class mediator
GO:0018107	; P:peptidyl-threonine phosphorylation
GO:0090312	; P:positive regulation of protein deacetylation

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013