EPS-ORC-00008

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EPS-ORC-00008

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
DSP/aDSP	152.2	1.0E-44	133	278	146

Status

Unreviewed

Ensembl Protein

ENSOCUP00000005371

UniProt Accession

G1U257;

Protein Name

Protein Synonyms/Alias

Gene Name

DUSP27

Gene Synonyms/Alias

DUSP27;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSOCUG00000006203	ENSOCUP00000005371	ENSOCUT00000006201
ENSOCUG00000006203	ENSOCUP00000023452	ENSOCUT00000021014

Organism

Oryctolagus cuniculus

Functional Description

Protein Length

1142

Protein Sequence
(FASTA)

MATQGDPEDE QVVPSEEDEA DVRTVQARYL RSPSPSQRSM VSDAETESIF MEPIHLSSAV 60

AAKQIINEEF KPRGLRAEAE CPGMLESAEQ LLVEDLYNRV REKMDDTSLY NTPCVMDLQR 120

ALLQDRQEAP RNEVDEVWPN IFIAEKSVAV NKGRLKRLGI THILNAAHGT GVYTGPDFYT 180

GLEIQYLGVE VDDFPEVDIS QHFRKAAEFL DEALLTYRGK VLVSSEMGVS RSAVLVVAYL 240

MIFHNMAILE ALLTLRRKRP ICPNEGFLKQ LRELNEKLME ERDEDEADAD ADADSDGAAG 300

STLGARVQAL TVEEDDDITS LLSGSSLGKA SRASKPPTLI DEEEEEKLYE AWKRGQGLGT 360

GQGPQGGDGR CSASAGQGGA QPEDGDAEDE DVERLIQEWQ SRNERYQAQG HRRWGREAGS 420

SVGRRRRHTL SESSTFESLS SRDVRILKQQ LQRGRQSPGP RRRSDSVSTD STWDVWNERL 480

QEIEREASRS YHCRSKREQV EAGSRAREDD DEESVSSEAS SFYNFCSRNK DKLTALERWK 540

IKRIQFGFHK KDSEAGDSSS EQGAVDAEGA RKPADVSLSA YQAWKLKHQK QVGSENKEEV 600

LELSKGEDAV LAKKRQRRLE LLERSRQTLE ESQSLGGWEA ESSAASGSIP LSAFWSAAPS 660

VSADGDTASV LSSQSLRSHL SQASNPTTPL PTLPVGPGDT ISIASIQNWI ANVVSETLAQ 720

KQNEMLLLSR PPSVASFKAA APAASCLGDD QVSMLSGQSS SSLGACLPPQ SQARPSSDTQ 780

SVLSSSTALG SRAEGTGGRV RGTSKPIYSL FADNVDLKEL GRKEREMQAQ LSEKMSEYKV 840

EKLASDNKRS SLFKKKKVKA EEDDVLGDRD EDTDSAIGSF RYSSRSNSQK PETDASSSLA 900

VSNHYENSSR AGREMDSSIS RWLSGLGTEE KSPPQSDWSG SSRGKYTRSS LFRETESKSS 960

SYKFSKSQSQ EQDTTSYHEA NGSSVRSSSR FSASSTKEGR ETHKFSRSTF SETSSSREAS 1020

PEPYFFRRTP EPPEGAESPE LPRPSWARPR DWEDVEESSK SDFSEFGAKR KFTQSFMRSD 1080

EEGEKEKTEN REEGRFASGR RSQYRRSTDR EEEEEMDDEA IIAAWRRRQE ETRTKLQRRR 1140

ED 1142

Nucleotide Sequence
(FASTA)

ATGGCGACCC AGGGGGACCC AGAGGACGAG CAGGTAGTCC CAAGCGAGGA GGATGAAGCG 60

GACGTGAGGA CGGTGCAGGC CCGGTACCTT CGGAGCCCCT CCCCCAGCCA GCGCTCGATG 120

GTCTCCGACG CAGAGACAGA GAGCATTTTC ATGGAGCCCA TTCACCTCTC CTCTGCTGTG 180

GCTGCCAAAC AGATCATCAA CGAAGAATTC AAGCCTCGGG GGCTGAGAGC AGAGGCGGAA 240

TGCCCGGGCA TGCTGGAGTC GGCAGAGCAG CTGCTGGTGG AGGACCTGTA CAACCGCGTC 300

AGGGAGAAGA TGGACGACAC CAGCCTGTAC AACACCCCCT GCGTCATGGA CCTGCAGCGG 360

GCCCTGCTCC AGGACCGCCA AGAGGCCCCC CGGAATGAGG TGGATGAGGT CTGGCCCAAT 420

ATCTTCATTG CTGAGAAGAG CGTGGCTGTG AACAAGGGGA GGCTGAAACG CCTGGGAATT 480

ACCCACATCC TGAATGCCGC GCATGGCACA GGCGTCTACA CTGGCCCTGA CTTCTACACT 540

GGCCTGGAGA TCCAGTACCT GGGGGTGGAG GTGGATGACT TCCCGGAGGT GGACATCTCC 600

CAGCACTTCC GGAAGGCGGC CGAGTTCCTG GATGAAGCAC TGCTGACCTA TAGAGGGAAG 660

GTCCTGGTCA GCAGTGAGAT GGGCGTCAGC CGCTCGGCGG TGCTGGTGGT GGCCTACCTG 720

ATGATCTTCC ACAACATGGC CATCCTGGAG GCCCTGCTCA CCCTGCGCCG GAAGCGGCCC 780

ATCTGCCCCA ACGAAGGCTT CCTGAAGCAG CTGCGCGAGC TCAACGAGAA GCTCATGGAG 840

GAGCGGGACG AGGACGAGGC GGACGCGGAC GCGGACGCGG ACTCGGACGG GGCCGCAGGG 900

AGCACGCTGG GGGCCAGAGT GCAGGCCCTG ACCGTGGAGG AGGACGACGA CATCACCAGC 960

CTCTTGAGCG GTTCCTCCCT GGGCAAGGCC AGCCGGGCCT CCAAGCCCCC GACGCTCATC 1020

GACGAAGAGG AAGAGGAGAA GCTCTATGAG GCCTGGAAGA GGGGGCAGGG CCTAGGCACG 1080

GGCCAAGGCC CCCAGGGCGG GGACGGCAGG TGCTCAGCCT CGGCCGGCCA GGGTGGGGCG 1140

CAGCCGGAGG ACGGGGATGC GGAGGACGAA GACGTGGAGA GGCTCATCCA GGAGTGGCAG 1200

AGCCGGAATG AGAGGTACCA AGCCCAGGGG CACCGGCGGT GGGGGCGCGA GGCCGGCTCC 1260

TCGGTGGGCA GAAGGCGGAG GCACACGCTG AGCGAGAGCA GCACTTTCGA GAGCCTGAGC 1320

AGCCGCGACG TGCGGATCTT GAAGCAGCAG CTGCAGAGGG GCCGCCAGAG CCCAGGCCCC 1380

CGACGCCGCT CGGACTCGGT GTCCACCGAC AGCACCTGGG ACGTGTGGAA CGAGCGACTG 1440

CAGGAGATCG AGCGGGAAGC TTCACGCAGC TACCACTGCC GGAGCAAGAG GGAGCAGGTG 1500

GAGGCAGGCA GCAGGGCGCG AGAGGATGAC GACGAGGAGA GCGTGTCCTC GGAGGCCAGC 1560

TCCTTCTATA ACTTCTGCAG CAGGAACAAG GACAAGCTCA CTGCCCTGGA AAGGTGGAAG 1620

ATCAAGAGAA TCCAGTTTGG ATTTCACAAG AAAGACTCAG AGGCAGGAGA CAGCAGCAGC 1680

GAGCAGGGAG CCGTGGACGC AGAGGGCGCG AGGAAGCCTG CGGATGTGAG CCTGTCGGCC 1740

TACCAGGCCT GGAAGCTGAA ACATCAGAAG CAGGTGGGCA GCGAGAACAA GGAGGAGGTG 1800

CTAGAGCTCA GCAAGGGCGA GGACGCCGTC CTGGCTAAGA AGAGACAAAG GAGGCTGGAG 1860

CTGCTGGAGA GAAGCAGGCA GACGCTGGAG GAGAGCCAGT CCCTGGGAGG CTGGGAGGCA 1920

GAGAGCTCAG CTGCCAGTGG GAGCATCCCC CTGTCTGCCT TCTGGTCGGC AGCCCCCTCT 1980

GTCAGCGCTG ACGGGGACAC AGCGTCAGTC CTCAGCTCCC AGAGCCTCCG CTCCCACCTG 2040

TCTCAGGCCT CCAACCCCAC CACACCCCTG CCTACCCTGC CCGTGGGCCC CGGAGACACC 2100

ATTTCCATTG CCAGTATCCA GAACTGGATC GCCAACGTGG TCAGCGAGAC CCTCGCCCAG 2160

AAGCAAAATG AGATGCTGCT GTTGTCCCGC CCACCATCCG TGGCAAGCTT CAAGGCGGCA 2220

GCACCAGCGG CCAGCTGCCT GGGGGATGAC CAAGTGTCCA TGCTCAGCGG CCAGAGCAGC 2280

TCCTCCCTGG GGGCCTGCCT GCCGCCCCAG AGCCAGGCCA GACCCAGCTC CGACACACAG 2340

TCAGTGCTGT CTTCCAGCAC TGCGCTGGGC TCCAGGGCTG AAGGCACTGG GGGCAGAGTG 2400

AGGGGGACCA GTAAGCCCAT CTACAGCCTC TTCGCTGACA ACGTGGACCT GAAGGAGCTC 2460

GGCCGGAAGG AGAGGGAGAT GCAGGCGCAG CTCAGTGAGA AGATGTCCGA GTACAAAGTG 2520

GAAAAGCTGG CCTCAGACAA CAAGCGCAGC TCCCTTTTCA AGAAGAAGAA GGTCAAGGCC 2580

GAAGAGGACG ACGTCCTGGG GGACAGGGAT GAGGACACTG ACAGTGCCAT CGGGAGCTTC 2640

CGATACTCTT CCCGCAGCAA CTCCCAAAAA CCCGAGACAG ACGCCTCCTC CTCGCTGGCT 2700

GTCTCTAACC ACTATGAAAA CAGCAGCAGA GCTGGCAGAG AGATGGACAG CAGCATCAGC 2760

AGGTGGCTCA GTGGCCTTGG GACAGAGGAG AAGTCCCCTC CCCAGAGCGA CTGGTCTGGG 2820

AGCTCCCGGG GGAAGTACAC CCGATCGTCC CTGTTCCGGG AGACGGAGTC CAAATCGTCC 2880

AGTTACAAGT TCTCCAAGTC CCAGTCCCAG GAGCAGGACA CCACCTCCTA CCACGAGGCG 2940

AACGGCAGCT CTGTGAGAAG CTCCTCGCGC TTCTCTGCCT CCTCCACCAA GGAGGGCAGA 3000

GAGACGCACA AGTTCTCCAG ATCCACCTTC AGCGAGACCT CAAGCTCCCG AGAGGCGAGC 3060

CCAGAGCCCT ACTTCTTCCG CAGAACCCCC GAGCCCCCTG AAGGGGCCGA GTCCCCGGAG 3120

CTGCCGCGCC CCAGCTGGGC CAGGCCCAGG GACTGGGAAG ACGTGGAAGA GTCCTCCAAG 3180

TCGGATTTCT CCGAATTTGG GGCTAAGCGG AAATTCACCC AGAGCTTCAT GAGGTCTGAC 3240

GAGGAGGGAG AGAAGGAGAA GACAGAAAAC AGAGAAGAAG GGAGGTTTGC CTCCGGGCGG 3300

CGGTCCCAGT ATCGGAGAAG CACGGACAGG GAGGAAGAGG AGGAAATGGA CGATGAGGCC 3360

ATCATTGCTG CCTGGAGGCG GCGGCAGGAA GAAACCAGGA CGAAGCTGCA GAGGAGGAGA 3420

GAGGACTGA 3429

Domain Profile

S: 1     evteilpglylgdqataldrreLsklgitvvinaslsvikvqviPeylikkgityknipv  60

         ev+e++p+++++++ +a+++  L++lgit+++na++++    ++P++++  +i+y++++v

Q: 133   EVDEVWPNIFIAEKSVAVNKGRLKRLGITHILNAAHGTGV-YTGPDFYTGLEIQYLGVEV  191

         69**********************************8765.79*****************

S: 61    dDsdvtdllqyfdeaaefidea.kekggkvlvHCaaGvsRSatlvlaYLmkveglslsdA  119

         dD ++ d++q+f++aaef+dea  + +gkvlv +++GvsRSa+lv+aYLm+++++++ +A

Q: 192   DDFPEVDISQHFRKAAEFLDEAlLTYRGKVLVSSEMGVSRSAVLVVAYLMIFHNMAILEA  251

         **********************8999**********************************

S: 120   ieavkrkrpsiepnegfleQLlelekkl  147

         + +++rkr  i+pnegfl+QL+el++kl

Q: 252   LLTLRRKR-PICPNEGFLKQLRELNEKL  278

         ********.689************9987

Domain Sequence
(FASTA)

EVDEVWPNIF IAEKSVAVNK GRLKRLGITH ILNAAHGTGV YTGPDFYTGL EIQYLGVEVD 60

DFPEVDISQH FRKAAEFLDE ALLTYRGKVL VSSEMGVSRS AVLVVAYLMI FHNMAILEAL 120

LTLRRKRPIC PNEGFLKQLR ELNEKL 146

Keyword

Complete proteome; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0008138	; F:protein tyrosine/serine/threonine phosphatase activity
GO:0006470	; P:protein dephosphorylation

KEGG

InterPros

IPR020417	; Atypical_DUSP.
IPR020405	; Atypical_DUSP_famA.
IPR000340	; Dual-sp_phosphatase_cat-dom.
IPR020422	; Dual-sp_phosphatase_subgr_cat.
IPR024950	; DUSP.
IPR000387	; Tyr/Dual-specificity_Pase.

Pfam

PF00782

; DSPc; 1.

SMARTs

SM00195

; DSPc; 1.

Prosites

PS50056	; TYR_PHOSPHATASE_2; 1.
PS50054	; TYR_PHOSPHATASE_DUAL; 1.

Prints

PR01908	; ADSPHPHTASE.
PR01909	; ADSPHPHTASEA.

Created Date

20-Feb-2013