EKS-ORC-00030

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ORC-00030

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Jak	346.4	1.4E-103	875	1147	273

Status

Unreviewed

Ensembl Protein

ENSOCUP00000005398

UniProt Accession

G1SQL4;

Protein Name

Tyrosine-protein kinase

Protein Synonyms/Alias

Gene Name

JAK1

Gene Synonyms/Alias

JAK1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSOCUG00000006227	ENSOCUP00000005398	ENSOCUT00000006236

Organism

Oryctolagus cuniculus

Functional Description

Protein Length

1157

Protein Sequence
(FASTA)

LQYLNIKEDC NAMAFCAKMR SSKKTEVDLE APEPGVEVVF YLSDREPLRL GSGEYTAEEV 60

CIRAAQECRI SPLCHNLFAL YDESTKLWYA PNRTITVDDK TSLRLHYRMR FYFTNWHGTN 120

DSEQSVWRHS PKKQKNGYEK KKVPDATPLL DANSLEYLFA QGQYDLVKCL APIRDPKTEQ 180

DGHDIENECL GMAVLAISHY AMMRKMQLPE LPKDISYKRY IPETLNKSIR QRNLLTRMRI 240

NNVFKDFLKE FNNKTICDSS VSTHDLKVKY LATLETLTKH YGAEIFETSM LLISSENEMN 300

WFHSSDSGIV LYYEVMVTGN LGIQWRQKPN VVPVEKEKSK LKRKKLENKL RKDEERNKTR 360

EEWNNFSYFP EITHIVIKES VVSINKQDNK KMELKLSSHE EALSFVSLVD GYFRLTADAH 420

HYLCTDVAPP LIVHNIQNGC HGPICTEYAI NKLRQEGNEE GMYVLRWSCT DFDNILMTVT 480

CFEKSETCAG WQRQFKNFQI EVRKGCYSLH GSDRSFPSLG ELMSHLKKQI LRTDNISFVL 540

KRCCQPKPRE ISNLLVATKK AQEWQPVYPM SQLSFDRILK KDIMQGEHLG RGTRTHIYAG 600

TLVDHKDDEG TSEEKRIKVI LKVLDPSHRD ISLAFFEAAS MMRQVSHKHI VYLYGVCVRD 660

VENIMVEEFV EGGPLDLFMH RKSDLLTTPW KFKVAKQLAS ALSYLEDKDM VHGNVCTKNL 720

LLAREGIDSE CGPFIKLSDP GIPITVLSRQ ECIERIPWIA PECVEDSKNL SVAADKWSFG 780

TTLWEICYNG EIPLKDKTLI EKERFYESRC RPVTPSCKEL ADLMTRCMNY DPNQRPFFRA 840

IMRDINKLEE QNPDIVSERK PATEVDPTHF EKRFLKRIRD LGEGHFGKVE LCRYDPEGDN 900

TGEQVAVKSL KPESGGNHIA DLKKEIEILR NLYHENIVKY KGICTEDGGN GIKLIMEFLP 960

SGSLKEYLPK NKNKINLKQQ LKYAVQICKG MDYLGSRQYV HRDLAARNVL VESEHQVKIG 1020

DFGLTKAIET DKEYYTVKDD RDSPVFWYAP ECLIQCKFYI ASDVWSFGVT LHELLTYCDS 1080

EYSPMALFLK MIGPTHGQMT VTRLVNTLKE GKRLPCPPNC PDQVYQLMRK CWEFQPSNRT 1140

TFQNLIEGFE AILKKHE 1157

Nucleotide Sequence
(FASTA)

CTACAGTATC TAAATATAAA AGAGGACTGC AATGCCATGG CTTTCTGTGC TAAAATGAGG 60

AGCTCCAAGA AGACCGAGGT GGATCTGGAG GCCCCTGAGC CTGGGGTGGA AGTGGTCTTC 120

TATCTGTCGG ACAGGGAACC CCTCCGGCTG GGCAGTGGAG AGTACACGGC GGAGGAGGTG 180

TGCATCAGGG CCGCACAGGA ATGCCGTATC TCTCCTCTGT GTCACAACCT CTTTGCCTTG 240

TATGATGAGA GCACCAAGCT CTGGTATGCT CCGAATCGCA CCATCACTGT TGATGACAAG 300

ACGTCCCTCC GGCTGCACTA CCGGATGAGG TTCTATTTCA CCAACTGGCA TGGGACCAAT 360

GACAGCGAGC AGTCTGTGTG GCGACATTCT CCAAAGAAGC AGAAAAATGG CTATGAGAAA 420

AAGAAGGTTC CAGATGCAAC CCCTCTCCTT GACGCCAACT CCCTGGAGTA TCTGTTTGCT 480

CAGGGACAAT ATGATTTGGT CAAATGCCTG GCTCCTATTC GAGACCCCAA GACGGAACAG 540

GATGGGCATG ACATCGAGAA TGAGTGTCTA GGGATGGCCG TCCTGGCCAT CTCACACTAT 600

GCCATGATGA GGAAAATGCA ATTGCCTGAA CTCCCCAAGG ACATCAGCTA TAAGCGATAT 660

ATCCCAGAAA CGTTGAATAA GTCCATCAGA CAGAGGAACC TTCTCACCAG GATGCGGATT 720

AATAATGTTT TCAAGGATTT CCTAAAGGAG TTTAACAACA AGACCATTTG TGACAGCAGC 780

GTGTCAACAC ATGACCTGAA AGTGAAATAC CTTGCTACTT TGGAGACTTT GACAAAACAT 840

TATGGTGCTG AAATATTTGA GACTTCCATG TTACTGATCT CATCAGAAAA TGAGATGAAT 900

TGGTTTCATT CCAGTGACAG TGGAATTGTT CTCTACTATG AAGTGATGGT GACTGGAAAT 960

CTTGGAATCC AGTGGAGGCA GAAACCAAAT GTTGTGCCTG TTGAAAAAGA AAAAAGTAAA 1020

CTGAAGCGGA AGAAACTGGA AAATAAACTC AGGAAAGATG AGGAGAGAAA CAAAACGCGA 1080

GAAGAGTGGA ACAATTTTTC CTACTTCCCT GAAATCACTC ACATTGTAAT AAAGGAGTCT 1140

GTGGTCAGCA TTAACAAGCA GGATAACAAA AAAATGGAAC TGAAGCTCTC TTCCCATGAG 1200

GAGGCCTTGT CCTTCGTGTC CCTGGTGGAT GGCTACTTCC GGCTCACAGC AGATGCCCAT 1260

CATTACCTCT GCACTGACGT GGCTCCACCA CTGATCGTCC ACAACATACA GAATGGCTGT 1320

CATGGTCCAA TCTGCACAGA GTATGCCATC AATAAACTGC GGCAAGAAGG GAATGAGGAG 1380

GGGATGTACG TGCTGAGGTG GAGCTGCACC GACTTTGACA ACATCCTCAT GACTGTCACC 1440

TGCTTTGAGA AGTCTGAGAC ATGTGCTGGG TGGCAGAGAC AGTTCAAGAA CTTTCAGATC 1500

GAGGTGCGGA AGGGCTGCTA CAGCCTGCAC GGCTCAGACC GCAGCTTCCC CAGCCTGGGA 1560

GAACTCATGA GCCACCTCAA GAAGCAGATC CTGCGTACAG ACAACATCAG CTTCGTGCTG 1620

AAACGCTGCT GCCAGCCCAA GCCCAGAGAG ATCTCTAACC TGCTGGTGGC TACTAAGAAA 1680

GCCCAGGAGT GGCAGCCTGT CTATCCCATG AGCCAGCTGA GTTTTGACCG GATCCTCAAG 1740

AAAGATATCA TGCAGGGCGA GCACCTGGGG AGAGGCACCA GAACCCATAT CTACGCCGGG 1800

ACCCTGGTGG ATCACAAGGA TGACGAAGGG ACTTCAGAAG AGAAGAGAAT AAAAGTGATC 1860

CTCAAAGTCT TAGACCCCAG CCACAGGGAC ATCTCTCTGG CCTTCTTTGA GGCAGCCAGC 1920

ATGATGAGAC AGGTCTCCCA CAAGCACATC GTGTACCTCT ATGGTGTCTG TGTCCGCGAC 1980

GTGGAGAATA TCATGGTGGA AGAGTTTGTG GAAGGAGGGC CCCTCGATCT CTTCATGCAC 2040

CGGAAAAGCG ACCTGCTCAC GACGCCGTGG AAGTTCAAAG TTGCCAAGCA GCTGGCCAGC 2100

GCCCTGAGTT ACCTGGAGGA CAAGGACATG GTCCACGGGA ACGTGTGCAC CAAGAACCTA 2160

CTGCTAGCGC GCGAGGGCAT CGACAGCGAG TGCGGGCCGT TCATCAAGCT CAGCGACCCC 2220

GGCATCCCCA TCACCGTGCT GTCCCGGCAG GAGTGCATAG AACGCATCCC GTGGATTGCT 2280

CCCGAGTGTG TGGAAGACTC CAAGAACCTG AGCGTGGCTG CTGACAAGTG GAGCTTCGGA 2340

ACCACGCTCT GGGAGATCTG CTACAATGGC GAGATCCCCC TCAAAGACAA GACACTCATC 2400

GAGAAAGAGA GATTCTACGA GAGCCGCTGC CGGCCAGTGA CCCCGTCCTG TAAGGAGCTG 2460

GCGGACCTTA TGACCCGCTG CATGAACTAC GACCCCAACC AGAGACCCTT CTTCCGCGCC 2520

ATCATGAGAG ACATCAACAA GCTGGAAGAG CAGAATCCAG ACATCGTGTC GGAGAGGAAG 2580

CCAGCCACTG AGGTGGACCC CACGCATTTT GAAAAGCGCT TCCTCAAGAG GATCCGGGAC 2640

TTGGGCGAGG GCCACTTTGG GAAGGTTGAG CTCTGCAGGT ATGACCCCGA GGGGGACAAC 2700

ACGGGGGAGC AGGTGGCTGT GAAGTCCCTA AAGCCAGAGA GCGGCGGTAA CCACATAGCT 2760

GACCTCAAGA AGGAAATAGA AATCTTGCGG AACCTCTATC ACGAGAACAT CGTGAAGTAC 2820

AAAGGGATCT GCACCGAGGA CGGAGGAAAC GGTATTAAGC TCATCATGGA ATTTCTGCCT 2880

TCGGGAAGCC TTAAGGAGTA TCTTCCAAAG AATAAAAACA AAATTAATCT CAAGCAACAG 2940

CTAAAATATG CCGTGCAGAT TTGTAAGGGG ATGGACTATT TGGGTTCTCG GCAGTACGTC 3000

CACCGGGACT TAGCAGCAAG AAATGTCCTT GTTGAGAGTG AACACCAAGT GAAAATTGGA 3060

GACTTCGGCT TAACCAAAGC GATCGAGACA GACAAGGAGT ACTACACCGT CAAGGACGAC 3120

CGGGACAGCC CTGTGTTTTG GTATGCCCCA GAATGTTTAA TTCAGTGTAA ATTCTATATT 3180

GCCTCCGACG TCTGGTCCTT TGGAGTGACT CTGCACGAGC TACTCACTTA CTGTGATTCA 3240

GAATATAGTC CCATGGCCTT GTTCCTGAAA ATGATAGGCC CAACTCATGG CCAGATGACA 3300

GTAACAAGAC TTGTGAATAC ACTGAAGGAA GGAAAACGTT TGCCGTGTCC ACCCAACTGT 3360

CCAGATCAGG TTTATCAACT TATGAGGAAA TGCTGGGAAT TCCAACCTTC CAATCGGACA 3420

ACCTTTCAGA ACCTTATTGA AGGATTCGAA GCAATTTTAA AAAAGCATGA ATAA 3474

Domain Profile

S: 1     lkqiesLgkgtftkvfevredaegdsteeevalkvLk.esgedisrdfkreaeilsqlsh  59

         lk+i++Lg+g+f+kv+++r+d+egd+t+e+va+k Lk esg ++++d+k+e+eil++l+h

Q: 875   LKRIRDLGEGHFGKVELCRYDPEGDNTGEQVAVKSLKpESGGNHIADLKKEIEILRNLYH  934

         6899********************************************************

S: 60    ehivklkgvcvaegen..rlVmeyvesGsLdiyLrkkkealslsslldvakqlakameYL  117

         e+ivk+kg+c+++g n  +l+me+++sGsL++yL+k+k++++l+++l++a q++k+m+YL

Q: 935   ENIVKYKGICTEDGGNgiKLIMEFLPSGSLKEYLPKNKNKINLKQQLKYAVQICKGMDYL  994

         ************************************************************

S: 118   edkklvhrdvaarnvLveresnegtppfvklsdpglakavnqd.eYylvreerdsripwl  176

         +++++vhrd+aarnvLve+e++      vk++d+gl+ka+++d eYy+v+++rds+++w+

Q: 995   GSRQYVHRDLAARNVLVESEHQ------VKIGDFGLTKAIETDkEYYTVKDDRDSPVFWY  1048

         **********************......********************************

S: 177   apeclseaknlstasdvWsFgvtlyellt.cskgesp....lrsesle.......rklel  224

         apecl+++k +++asdvWsFgvtl+ellt c+++ sp    l++++++       r++++

Q: 1049  APECLIQCK-FYIASDVWSFGVTLHELLTyCDSEYSPmalfLKMIGPThgqmtvtRLVNT  1107

         *********.*******************************9****999***********

S: 225   leekerlpkpk.cpaelaelmtnclsyepsqrpsFraile  263

         l+e++rlp+p+ cp+++++lm++c++ +ps+r++F++++e

Q: 1108  LKEGKRLPCPPnCPDQVYQLMRKCWEFQPSNRTTFQNLIE  1147

         *************************************987

Domain Sequence
(FASTA)

LKRIRDLGEG HFGKVELCRY DPEGDNTGEQ VAVKSLKPES GGNHIADLKK EIEILRNLYH 60

ENIVKYKGIC TEDGGNGIKL IMEFLPSGSL KEYLPKNKNK INLKQQLKYA VQICKGMDYL 120

GSRQYVHRDL AARNVLVESE HQVKIGDFGL TKAIETDKEY YTVKDDRDSP VFWYAPECLI 180

QCKFYIASDV WSFGVTLHEL LTYCDSEYSP MALFLKMIGP THGQMTVTRL VNTLKEGKRL 240

PCPPNCPDQV YQLMRKCWEF QPSNRTTFQN LIE 273

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Phosphoprotein; Reference proteome; SH2 domain; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Oreochromis niloticus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005737	; C:cytoplasm
GO:0005856	; C:cytoskeleton
GO:0016020	; C:membrane
GO:0005634	; C:nucleus
GO:0005524	; F:ATP binding
GO:0004715	; F:non-membrane spanning protein tyrosine kinase activity
GO:0019221	; P:cytokine-mediated signaling pathway
GO:0007167	; P:enzyme linked receptor protein signaling pathway
GO:0007243	; P:intracellular protein kinase cascade
GO:0018108	; P:peptidyl-tyrosine phosphorylation
GO:0046677	; P:response to antibiotic

KEGG

InterPros

IPR019749	; Band_41_domain.
IPR019748	; FERM_central.
IPR000299	; FERM_domain.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980	; SH2.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.
IPR016251	; Tyr_kinase_non-rcpt_Jak/Tyk2.
IPR020776	; Tyr_kinase_non-rcpt_Jak1.

Pfam

PF07714

; Pkinase_Tyr; 2.

SMARTs

SM00295	; B41; 1.
SM00252	; SH2; 1.
SM00219	; TyrKc; 2.

Prosites

PS50057	; FERM_3; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 2.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS50001	; SH2; 1.

Prints

PR01823	; JANUSKINASE.
PR01824	; JANUSKINASE1.
PR00109	; TYRKINASE.

Created Date

20-Feb-2013