EKS-ORC-00374
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-ORC-00374
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Axl545.13.0E-164489754266
StatusUnreviewed
Ensembl ProteinENSOCUP00000005395
UniProt AccessionG1TI58;
Protein Name
Protein Synonyms/Alias
Gene NameTYRO3
Gene Synonyms/Alias TYRO3;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSOCUG00000006229ENSOCUP00000005395ENSOCUT00000006232
ENSOCUG00000006229ENSOCUP00000016626ENSOCUT00000022596
OrganismOryctolagus cuniculus
Functional Description
Protein Length859
Protein Sequence
(FASTA)
LLSLLVPESL PSDLKLWGAP VKMTVSQGLP VRLNCTVEGL DSPDIHWMKD GAVIETLDEV 60
FIQLDDRHWV SFLSLKSVER SDAGHYWCQA YDGGETEMSQ QVWLTVEGVP FFTVEPKDLA 120
VPPNASFQLF CEAVGPPEPV TIFWWREHTK VGGPVPSPSI LNVTGVTQST EFSCEARNIK 180
GLAFSRPATI FIQALPAAPF NVTVTKLSSS NASVAWMPGA DGRALIQSCT VQVTQAPGNW 240
EVLAVVVPVP PFTCLLRDLA PATNYSLRVR CANALGPSPY ADWVPFQTRG LAPSSAPQNL 300
HAIRTDSGLI LEWEEVILKG PSEAPLGPYK LFWVQDNGTQ EELMVEGTRV NLTGWDPQKD 360
LIARVCASNA IGYGPWSRSL VVSSRDHAGR QGPPHSRTSW VPVVLGVLTA LVTAAALALI 420
LLRKRRKETR FGQAFDSVVA GGEPAIHFRA ARSFNRERPE RIEATLDSLG ISDELKDRLE 480
DVLIPEQQFT LGRMLGKGEF GSVREAQLKQ EDGSFVKVAV KMLKADIIAS SDIEEFLKEA 540
ACMKEFDHPH VAKLVGVSLR SRAKGRLPIP MVILPFMKHG DLHAFLLASR VGENPFNLPL 600
QTLIRFMVDI ACGMEYLSSR NFIHRDLAAR NCMLAEDMTV CVADFGLSRK IYSGDYYRQG 660
CASKLPVKWL ALESLADNLY TVYSDVWAFG VTMWEIMTRG QTPYAGIENA EIYNYLIGGN 720
RLKQPPECME DVYELMYQCW SADPKQRPSF TCLRMELETI LGHLSVLSTS QDPLYINIGR 780
TQEPAEGCSG ELPGGDEPSG GAGDGSSIRA AEGTPSDYRY ILSPGGLAEP SGQAEQQPES 840
PVNEAQRLLQ QGLLPHSSC 859
Nucleotide Sequence
(FASTA)
CTGCTCAGCC TCCTGGTCCC TGAGTCCCTT CCCAGTGACC TGAAGCTCTG GGGAGCCCCG 60
GTGAAGATGA CCGTGTCTCA GGGGCTGCCC GTGAGGCTCA ACTGCACCGT GGAGGGGCTG 120
GACAGCCCTG ACATCCACTG GATGAAGGAC GGGGCTGTCA TCGAGACCCT GGACGAGGTG 180
TTCATCCAGC TGGACGATCG GCACTGGGTC AGCTTCCTCA GCCTGAAGTC AGTGGAGCGC 240
TCGGATGCGG GCCACTACTG GTGCCAAGCG TATGATGGGG GAGAAACGGA GATGTCCCAG 300
CAGGTGTGGC TCACGGTCGA AGGTGTGCCG TTTTTCACGG TGGAGCCCAA AGATCTGGCA 360
GTGCCGCCCA ATGCCTCTTT CCAACTGTTC TGTGAGGCCG TGGGTCCCCC TGAACCCGTC 420
ACCATTTTCT GGTGGAGAGA ACACACGAAA GTTGGGGGCC CCGTTCCCTC TCCCTCCATT 480
TTAAATGTGA CAGGGGTGAC CCAGAGCACC GAGTTTTCCT GCGAAGCCCG CAACATAAAG 540
GGCCTGGCCT TTTCTCGCCC TGCCACTATT TTCATTCAAG CACTGCCTGC AGCTCCTTTC 600
AACGTCACAG TGACAAAGCT CTCCAGCAGC AATGCCAGCG TGGCCTGGAT GCCGGGGGCT 660
GACGGCCGAG CCCTCATCCA GTCCTGTACA GTCCAGGTGA CACAGGCCCC AGGGAACTGG 720
GAGGTCCTGG CTGTCGTGGT GCCCGTGCCA CCCTTTACCT GCCTGCTCCG GGACCTGGCG 780
CCTGCCACTA ACTACAGCCT CAGGGTGCGC TGTGCCAACG CCTTGGGACC CTCTCCCTAT 840
GCCGACTGGG TGCCCTTTCA GACAAGAGGG CTAGCCCCAT CCAGCGCCCC CCAGAACCTC 900
CATGCCATTC GCACGGACTC GGGCCTCATC CTGGAGTGGG AAGAAGTGAT TCTCAAGGGG 960
CCTTCCGAAG CCCCCCTGGG ACCCTATAAA CTGTTCTGGG TCCAAGACAA TGGGACCCAG 1020
GAGGAGCTGA TGGTGGAGGG GACCAGGGTC AATTTGACCG GCTGGGATCC CCAGAAGGAC 1080
CTGATCGCTC GCGTGTGCGC ATCCAACGCA ATAGGCTACG GGCCCTGGAG TCGGTCACTG 1140
GTGGTCTCCT CCCGCGACCA TGCAGGCCGC CAGGGCCCTC CCCACAGCCG CACATCCTGG 1200
GTGCCTGTAG TCTTGGGTGT GCTCACGGCT CTGGTGACGG CTGCTGCCCT GGCTCTCATC 1260
CTGCTTCGGA AGAGGCGGAA GGAGACACGG TTCGGGCAAG CCTTTGACAG CGTCGTAGCT 1320
GGAGGGGAAC CCGCCATTCA CTTCCGGGCA GCCCGGTCCT TCAATCGAGA AAGGCCAGAG 1380
CGCATTGAGG CCACACTGGA CAGCTTGGGC ATCAGCGATG AACTGAAGGA CAGACTGGAG 1440
GACGTGCTCA TCCCTGAGCA GCAGTTCACC CTGGGCCGCA TGCTGGGCAA AGGAGAGTTT 1500
GGTTCGGTGC GGGAGGCCCA GCTGAAGCAG GAAGACGGCT CCTTCGTGAA AGTGGCTGTG 1560
AAGATGCTGA AAGCTGACAT CATTGCCTCA AGTGACATTG AAGAATTCCT CAAAGAAGCA 1620
GCTTGCATGA AGGAGTTTGA CCATCCACAC GTGGCCAAGC TTGTTGGGGT GAGCCTCCGG 1680
AGCAGGGCTA AAGGCCGCCT CCCCATCCCC ATGGTCATCC TGCCCTTCAT GAAGCACGGG 1740
GACCTGCACG CCTTCCTGCT CGCCTCCCGG GTTGGGGAGA ACCCCTTTAA CCTGCCCCTC 1800
CAGACCCTGA TCCGGTTCAT GGTGGACATT GCCTGTGGCA TGGAATACCT GAGCTCCCGG 1860
AACTTCATCC ACCGAGACCT GGCCGCTCGG AATTGCATGC TGGCCGAGGA CATGACCGTG 1920
TGCGTGGCTG ACTTTGGACT CTCCCGGAAG ATCTATAGCG GGGACTACTA TCGTCAGGGC 1980
TGCGCCTCCA AGTTGCCTGT CAAGTGGCTG GCCCTGGAGA GCCTGGCTGA CAACCTGTAT 2040
ACTGTGTACA GCGACGTGTG GGCCTTTGGA GTGACCATGT GGGAGATTAT GACTCGTGGG 2100
CAGACGCCTT ATGCTGGCAT CGAAAACGCT GAGATCTACA ACTACCTCAT CGGCGGGAAC 2160
CGCCTGAAGC AGCCTCCGGA GTGCATGGAG GATGTGTATG AGCTCATGTA CCAGTGCTGG 2220
AGCGCCGACC CCAAGCAGCG CCCAAGCTTC ACATGCCTGC GAATGGAACT GGAGACCATC 2280
CTGGGCCACC TCTCCGTGCT GTCCACCAGC CAGGACCCCT TGTATATCAA CATTGGGAGA 2340
ACCCAGGAGC CTGCCGAGGG GTGCAGCGGG GAGCTGCCTG GCGGGGATGA GCCCAGTGGC 2400
GGGGCTGGGG ATGGCAGTAG CATAAGGGCA GCAGAGGGCA CCCCCAGTGA CTATCGGTAC 2460
ATCCTCAGCC CCGGAGGGCT CGCCGAGCCA TCTGGGCAGG CGGAGCAGCA GCCGGAGAGC 2520
CCCGTCAATG AGGCCCAGAG GCTTCTGCAG CAAGGGCTGC TGCCCCACAG TAGCTGT 2577
Domain Profile
S: 1     lvlgkvlgegefgsvmegqlkqedgsilkvavktlkldiiarseieeflseaacmkefdh  60
         ++lg++lg+gefgsv+e+qlkqedgs++kvavk+lk+diia+s+ieefl+eaacmkefdh
Q: 489   FTLGRMLGKGEFGSVREAQLKQEDGSFVKVAVKMLKADIIASSDIEEFLKEAACMKEFDH  548
         68**********************************************************
S: 61    pnvirlvgvslessekgrlpkpvvilpfmkygdlhafllysrlgenpvylplqtlvkfmv  120
         p+v++lvgvsl+s++kgrlp+p+vilpfmk+gdlhafll+sr+genp++lplqtl++fmv
Q: 549   PHVAKLVGVSLRSRAKGRLPIPMVILPFMKHGDLHAFLLASRVGENPFNLPLQTLIRFMV  608
         ************************************************************
S: 121   diasgmeylssrnfihrdlaarncmlaedmtvcvadfglskkiysgdyyrqgriaklpvk  180
         dia+gmeylssrnfihrdlaarncmlaedmtvcvadfgls+kiysgdyyrqg+++klpvk
Q: 609   DIACGMEYLSSRNFIHRDLAARNCMLAEDMTVCVADFGLSRKIYSGDYYRQGCASKLPVK  668
         ************************************************************
S: 181   wiaiesladrvytsksdvwafgvtmweiatrgqtpyagvenaeiydyllqgnrlkqpedc  240
         w+a+eslad++yt+ sdvwafgvtmwei+trgqtpyag+enaeiy+yl++gnrlkqp++c
Q: 669   WLALESLADNLYTVYSDVWAFGVTMWEIMTRGQTPYAGIENAEIYNYLIGGNRLKQPPEC  728
         ************************************************************
S: 241   ldelydlmyrcweadpkdrpsfsvlr  266
         ++++y+lmy+cw+adpk+rpsf+ lr
Q: 729   MEDVYELMYQCWSADPKQRPSFTCLR  754
         ***********************998
Domain Sequence
(FASTA)
FTLGRMLGKG EFGSVREAQL KQEDGSFVKV AVKMLKADII ASSDIEEFLK EAACMKEFDH 60
PHVAKLVGVS LRSRAKGRLP IPMVILPFMK HGDLHAFLLA SRVGENPFNL PLQTLIRFMV 120
DIACGMEYLS SRNFIHRDLA ARNCMLAEDM TVCVADFGLS RKIYSGDYYR QGCASKLPVK 180
WLALESLADN LYTVYSDVWA FGVTMWEIMT RGQTPYAGIE NAEIYNYLIG GNRLKQPPEC 240
MEDVYELMYQ CWSADPKQRP SFTCLR 266
KeywordATP-binding; Complete proteome; Disulfide bond; Immunoglobulin domain; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Repeat; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00372
EKS-ANC-00384
EKS-BOT-00399
EKS-CAJ-00404
EKS-CAF-00400
EKS-CAP-00424
EKS-CIS-00152
EKS-DAR-00777
EKS-EQC-00387
EKS-FEC-00382
EKS-GAG-00338
EKS-GAA-00488
EKS-GOG-00387
EKS-HOS-00403
EKS-ICT-00375
EKS-LAC-00416
EKS-LOA-00403
EKS-MAM-00399
EKS-MEG-00329
EKS-MOD-00385
EKS-MUM-00432
EKS-MUP-00390
EKS-MYL-00393
EKS-NOL-00364
EKS-ORN-00511
EKS-ORA-00344
EKS-ORL-00465
EKS-OTG-00402
EKS-PAT-00374
EKS-PES-00355
EKS-POA-00391
EKS-PTV-00110
EKS-RAN-00411
EKS-SAH-00365
EKS-SUS-00346
EKS-TAG-00471
EKS-TAR-00502
EKS-TAS-00046
EKS-XET-00511
EKS-XIM-00503
Gene Ontology
GO:0016021; C:integral to membrane
GO:0005524; F:ATP binding
GO:0004713; F:protein tyrosine kinase activity
GO:0043277; P:apoptotic cell clearance
GO:0021885; P:forebrain cell migration
GO:0001779; P:natural killer cell differentiation
GO:0050728; P:negative regulation of inflammatory response
GO:0045824; P:negative regulation of innate immune response
GO:0051250; P:negative regulation of lymphocyte activation
GO:0043524; P:negative regulation of neuron apoptotic process
GO:0034122; P:negative regulation of toll-like receptor signaling pathway
GO:0070050; P:neuron homeostasis
GO:0042698; P:ovulation cycle
GO:0070527; P:platelet aggregation
GO:0046777; P:protein autophosphorylation
GO:0043491; P:protein kinase B signaling cascade
GO:0032940; P:secretion by cell
GO:0007283; P:spermatogenesis
GO:0034446; P:substrate adhesion-dependent cell spreading
GO:0060068; P:vagina development
KEGG
InterPros
IPR003961; Fibronectin_type3.
IPR007110; Ig-like.
IPR013783; Ig-like_fold.
IPR013098; Ig_I-set.
IPR003599; Ig_sub.
IPR003598; Ig_sub2.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
Pfam
PF00041; fn3; 1.
PF07679; I-set; 1.
PF07714; Pkinase_Tyr; 1.
SMARTs
SM00060; FN3; 2.
SM00409; IG; 1.
SM00408; IGc2; 1.
SM00219; TyrKc; 1.
Prosites
PS50853; FN3; 2.
PS50835; IG_LIKE; 2.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
Prints
PR00109; TYRKINASE.
Created Date20-Feb-2013