EKS-ORC-00196
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-ORC-00196
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
Other/NKF2577.11.3E-173121476356
StatusUnreviewed
Ensembl ProteinENSOCUP00000005454
UniProt AccessionG1SQQ8;
Protein Name
Protein Synonyms/Alias
Gene NamePINK1
Gene Synonyms/Alias PINK1;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSOCUG00000006306ENSOCUP00000005454ENSOCUT00000006307
OrganismOryctolagus cuniculus
Functional Description
Protein Length546
Protein Sequence
(FASTA)
KPSPACSWGR NGPRRLGPRE RAGRDAVPGV QRRGGGLGLP ERYRFFRQSV TGLAARLQRQ 60
FAMRVFLAFG LGLGLIEEKQ AESRRAAAAC REIQAIFTQR SRLEADPLAA RRRQGFQLEE 120
YLIGQPIGKG CSAAVYEAAM PALPVRLEVA QGARRPGSGP DPAAAGAQEA HAPAAPAFPL 180
AIKMMWNISA GSSSEAIFRT MSQELVPASR VALAGEYGAV THRKSKGRPK WLAPHPNIIR 240
VFRAFTSSVP LLPGALVDYP DVLPPRLHPE GLGHGRTLFL VMKNYPCTLR QYLRVNTPSP 300
RLATVMTLQL LEGVAHLVQQ GIAHRDLKSD NILVELDADG CPWLVITDFG CCLADEHVGL 360
QLPFTSWYVD RGGNGCLMAP EVSTACPGPR TVIDYSKTDA WAVGAIAYEI FGLANPFYGQ 420
GRARLESRSY QEAQLPALPP SVPPDARQLV KSLLQREPAK RPSARVAANV LHLSLWGEQI 480
LALKNLQLDR VVGWLLQQSA AAMLAGRSCV ETKMKVLFLA SLECEALCQA ALLLRAWRAA 540
PGQLCA 546
Nucleotide Sequence
(FASTA)
AAGCCAAGTC CGGCCTGCAG CTGGGGGCGC AACGGCCCGA GGCGGCTGGG GCCGCGAGAG 60
CGCGCGGGAC GGGACGCGGT TCCTGGCGTT CAGCGGCGCG GGGGCGGCTT GGGGCTCCCC 120
GAGCGCTACC GCTTCTTCCG CCAGTCGGTG ACCGGGCTGG CGGCGCGGCT CCAGCGGCAG 180
TTCGCGATGC GGGTCTTTCT GGCCTTCGGG CTGGGCCTGG GCCTCATCGA GGAGAAGCAG 240
GCGGAGAGCC GACGGGCCGC CGCGGCCTGC CGGGAGATCC AGGCCATCTT CACCCAGAGA 300
AGCAGGCTGG AGGCCGACCC GCTGGCCGCC AGGCGCCGGC AGGGCTTCCA GCTGGAGGAG 360
TACCTGATCG GGCAGCCCAT CGGCAAGGGC TGCAGCGCCG CCGTCTACGA AGCCGCCATG 420
CCCGCCTTGC CTGTGCGCCT GGAGGTGGCA CAGGGTGCCC GGCGCCCGGG GAGCGGCCCG 480
GATCCCGCGG CAGCAGGAGC CCAGGAGGCG CACGCTCCCG CCGCCCCTGC CTTTCCCTTG 540
GCCATCAAGA TGATGTGGAA CATCTCGGCC GGCTCCTCCA GCGAGGCCAT CTTCAGGACC 600
ATGAGCCAGG AGCTCGTCCC AGCCAGCCGA GTGGCCCTGG CCGGGGAGTA CGGAGCGGTC 660
ACGCACAGAA AATCCAAGGG ACGTCCCAAG TGGCTGGCCC CTCACCCCAA CATCATCCGG 720
GTTTTCCGCG CCTTCACCTC GTCTGTGCCA CTGCTGCCGG GGGCCCTGGT CGACTACCCT 780
GACGTGCTGC CCCCACGCCT CCACCCTGAG GGCCTGGGCC ACGGACGGAC GCTGTTCCTC 840
GTCATGAAGA ACTACCCCTG CACCCTGCGC CAGTACCTTC GCGTGAACAC CCCGAGCCCC 900
CGCCTGGCCA CGGTGATGAC CCTGCAGTTG CTGGAGGGCG TGGCTCACCT GGTGCAGCAG 960
GGCATCGCAC ACAGAGACCT GAAGTCTGAC AACATCCTCG TGGAGCTGGA CGCAGACGGC 1020
TGTCCCTGGC TGGTGATCAC CGACTTCGGC TGCTGTCTGG CTGACGAGCA CGTCGGCCTG 1080
CAGCTGCCGT TCACCAGCTG GTACGTGGAT CGGGGTGGCA ACGGCTGCCT GATGGCTCCA 1140
GAGGTGTCCA CGGCCTGTCC TGGCCCCAGG ACGGTGATTG ACTACAGCAA GACCGACGCC 1200
TGGGCAGTGG GCGCGATTGC CTACGAGATC TTCGGGCTCG CCAACCCCTT TTACGGCCAG 1260
GGCAGGGCCC GCCTCGAGAG CCGCAGTTAC CAGGAGGCCC AGCTGCCTGC CCTCCCTCCG 1320
TCAGTGCCCC CGGACGCCAG GCAGCTGGTG AAGTCCCTGC TCCAGCGAGA GCCGGCCAAG 1380
AGGCCGTCCG CCCGAGTTGC CGCCAACGTG CTGCACCTAA GCCTGTGGGG GGAGCAGATT 1440
CTGGCGCTGA AGAACCTGCA GCTGGACCGG GTGGTGGGCT GGCTCCTCCA GCAGTCAGCC 1500
GCCGCCATGC TGGCCGGGAG GAGCTGTGTG GAGACGAAGA TGAAGGTGCT CTTTCTGGCC 1560
AGCCTGGAGT GTGAGGCGCT CTGCCAAGCG GCCCTGCTGC TCCGCGCGTG GAGGGCGGCC 1620
CCGGGGCAGC TCTGCGCGTA G 1641
Domain Profile
S: 1     yligealgkgcnaavyeatlatldqelekakhlgllgkevtvvlaeidqesavaakkfpl  60
         ylig+ +gkgc+aavyea +++l+ +le+a+     g +++  +a++++ +a+aa++fpl
Q: 121   YLIGQPIGKGCSAAVYEAAMPALPVRLEVAQGARRPGSGPDPAAAGAQEAHAPAAPAFPL  180
         99*****************************99999************************
S: 61    aiklmfnieadssseallksmsqelvpasrvaldgeygav........pkllakhPnivr  112
         aik+m+ni+a+sssea++++msqelvpasrval+geygav        pk la+hPni+r
Q: 181   AIKMMWNISAGSSSEAIFRTMSQELVPASRVALAGEYGAVthrkskgrPKWLAPHPNIIR  240
         ************************************************************
S: 113   vlrafidsvkllPdalldyPdalparlypeglgegktlylvmkrydqtlreylesqdrst  172
         v+raf++sv+llP+al+dyPd+lp+rl+peglg+g+tl+lvmk+y++tlr+yl ++++s+
Q: 241   VFRAFTSSVPLLPGALVDYPDVLPPRLHPEGLGHGRTLFLVMKNYPCTLRQYLRVNTPSP  300
         ************************************************************
S: 173   rlaalllaqlleavdhlvkhgvahrdlksdnilveldddeiPvlviadfGCcladkvdgl  232
         rla+++++qlle+v hlv++g+ahrdlksdnilveld d++P+lvi+dfGCclad+++gl
Q: 301   RLATVMTLQLLEGVAHLVQQGIAHRDLKSDNILVELDADGCPWLVITDFGCCLADEHVGL  360
         ************************************************************
S: 233   rlpyessevdkGGnaalmaPeistavpGpsavinyekadtWavGalayeifglsnPfyge  292
         +lp++s++vd+GGn++lmaPe+sta pGp++vi+y+k d+WavGa+ayeifgl+nPfyg+
Q: 361   QLPFTSWYVDRGGNGCLMAPEVSTACPGPRTVIDYSKTDAWAVGAIAYEIFGLANPFYGQ  420
         ************************************************************
S: 293   gkaslesasyqeaqlPalpesvppelrqlvydllkreaskrvsadiaanvlqlslf  348
         g+a les+syqeaqlPalp svpp++rqlv +ll+re++kr+sa++aanvl+lsl+
Q: 421   GRARLESRSYQEAQLPALPPSVPPDARQLVKSLLQREPAKRPSARVAANVLHLSLW  476
         *******************************************************9
Domain Sequence
(FASTA)
YLIGQPIGKG CSAAVYEAAM PALPVRLEVA QGARRPGSGP DPAAAGAQEA HAPAAPAFPL 60
AIKMMWNISA GSSSEAIFRT MSQELVPASR VALAGEYGAV THRKSKGRPK WLAPHPNIIR 120
VFRAFTSSVP LLPGALVDYP DVLPPRLHPE GLGHGRTLFL VMKNYPCTLR QYLRVNTPSP 180
RLATVMTLQL LEGVAHLVQQ GIAHRDLKSD NILVELDADG CPWLVITDFG CCLADEHVGL 240
QLPFTSWYVD RGGNGCLMAP EVSTACPGPR TVIDYSKTDA WAVGAIAYEI FGLANPFYGQ 300
GRARLESRSY QEAQLPALPP SVPPDARQLV KSLLQREPAK RPSARVAANV LHLSLW 356
KeywordComplete proteome; Reference proteome.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tupaia belangeri"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00200
EKS-BOT-00215
EKS-CAE-00184
EKS-CAJ-00221
EKS-CAF-00221
EKS-CAP-00240
EKS-CHH-00045
EKS-CIS-00247
EKS-DAR-00520
EKS-DIO-00111
EKS-DRM-00108
EKS-ECT-00082
EKS-EQC-00209
EKS-FEC-00202
EKS-GAG-00181
EKS-GAA-00264
EKS-GOG-00211
EKS-HOS-00221
EKS-ICT-00205
EKS-LAC-00227
EKS-LOA-00212
EKS-MAM-00217
EKS-MOD-00214
EKS-MUM-00218
EKS-MUP-00216
EKS-MYL-00218
EKS-NOL-00201
EKS-OCP-00140
EKS-ORN-00275
EKS-ORA-00189
EKS-ORL-00255
EKS-OTG-00221
EKS-PAT-00204
EKS-PES-00192
EKS-POA-00209
EKS-RAN-00210
EKS-SAH-00204
EKS-SOA-00066
EKS-SUS-00188
EKS-TAG-00234
EKS-TAR-00275
EKS-TEN-00271
EKS-TUB-00057
EKS-XIM-00267
Gene Ontology
GO:0005829; C:cytosol
GO:0005739; C:mitochondrion
GO:0005524; F:ATP binding
GO:0010857; F:calcium-dependent protein kinase activity
GO:0000287; F:magnesium ion binding
GO:0004674; F:protein serine/threonine kinase activity
GO:0007243; P:intracellular protein kinase cascade
GO:0000422; P:mitochondrion degradation
GO:0018105; P:peptidyl-serine phosphorylation
GO:0033603; P:positive regulation of dopamine secretion
GO:0043123; P:positive regulation of I-kappaB kinase/NF-kappaB cascade
GO:0090200; P:positive regulation of release of cytochrome c from mitochondria
GO:0032226; P:positive regulation of synaptic transmission, dopaminergic
GO:0043254; P:regulation of protein complex assembly
GO:0031396; P:regulation of protein ubiquitination
GO:0006950; P:response to stress
KEGG
InterPros
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF00069; Pkinase; 1.
SMARTs
Prosites
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
Prints
Created Date20-Feb-2013