EKS-ORC-00318

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ORC-00318

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Other/PEK	367.9	4.0E-110	590	1003	414

Status

Unreviewed

Ensembl Protein

ENSOCUP00000005633

UniProt Accession

G1SR58;

Protein Name

Protein Synonyms/Alias

Gene Name

EIF2AK4

Gene Synonyms/Alias

EIF2AK4;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSOCUG00000006506	ENSOCUP00000005633	ENSOCUT00000006516
ENSOCUG00000006506	ENSOCUP00000023220	ENSOCUT00000025662

Organism

Oryctolagus cuniculus

Functional Description

Protein Length

1651

Protein Sequence
(FASTA)

MAGGRGAPGR GRDEPPESYP QRQDHELQAL EAIYGADFQD LRPDACRPVK EPPEINLVLY 60

PQGLTGEEVY VKVDLRVKCP PTYPDVVPEI ELKNAKGLSN ESVNLLKSRL EELAKKHCGE 120

VMIFELAYHV QSFLSEHNKP PPKSFHEEML ERRAQEEQQR LLEAKRKEEE EQREILHEIQ 180

RRKEEIKEEK KRKEIAKQER LEIASLSNQN HTSRKDPGGH RTAALLHGGS PDFVGNGKHR 240

ANSSGRSRRE RQYSVCSGED SPGSCEILYF CLGGPDQLMV HKGKCVGSDE QLGKLVYNAL 300

ETATGSFVLL YEWVLQWQKK MGPFLTSQER EKIDKCKKQI QGAETEFNSL VKLSHPNIVR 360

YFAMNLKEQD DSIVVDILVE HISGVSLATH LSRSGPVPVH QLRRYAAQLL SGLDYLHSNS 420

VVHKVLSASN VLVDAEGAVK ITDYSISKRL ADICKEDVFE QTRVRFSDNA LPYKTGKKGD 480

VWRLGLLLLS LSQGQECGEY PVTIPGDLPA DFQDFLKKCV CLDDKERWSP QQLLKHSFVN 540

PQPKTPLVEQ SPEDSGGQDY VETVIPSNQL PSAAFFSETQ RQFSRYFIEF EELQLLGKGA 600

FGAVIKVQNK LDGCCYAVKR IPINPASRHF RRIKGEVTLL SRLHHENIVR YYNAWIERHE 660

RPAGTGTPPQ DSGPLARDGR AARAQAAGDT GDTDGPDSVE ANAPPPITSS VEWSTSGERS 720

ASARFPAAGP GSSSDDEDDE DEHDGVFSQS FLPASDSESD IIFDNEDENS KSQNQDEDCR 780

EENGGCESEL SVTTEAVHYL YIQMEYCEKS TLRDTIDQGL YRDTIRLWRL FREILDGLAY 840

IHEKGMIHRD LKPVNIFLDS DDHVKIGDFG LATDHLAFSA DGKQEDQADS LIKSDPSGRL 900

TGMVGTALYV SPEVQGSTKS AYNQKVDLFS LGIIFFEMSY HPMVTASERI FVLNQLRDPA 960

SPKFPEDFDD GEHTKQKSVI SWLLNHDPAK RPTATELLKS ELLPPPQMEE SELHEVLHHT 1020

LANVDGKAYR TMMAQIFSQR ISPAIDYTYD SDILKGNFSI RAAKIQQHVC ETIIRIFKRH 1080

GAVQLCTPLL LPRNRQIYEH NEAALFMDHS GMLVMLPFDL RVPFARYVAR NNILNLKRYC 1140

IERVFRPRKL DRFHPKELLE CAFDIVTSTT NSSLPTAEII YTIYEIIQEF PALQERNYSI 1200

YLNHTMLLKA ILLHCGIPED KLSQVYVILC DAVTEKLTRR EVEAKFCNLS LSSNSLCRLY 1260

KFIEQKGDLQ DLMPTINSLI KQKTGVSQLV KYGLKELEEV VGLLKKLGVK LQVFINLGLV 1320

YKVQQHNGII FQFVAFIRRR QRAVPEILAA GGRYDLLIPQ FRGPQALGPV PTAIGASIAI 1380

DKISTAVLNM EEPATVSSCD LLVVSVGQMS MSRAIHLTQK LWTAGITAEI MYDWSQSQEE 1440

LQEYCRHHEI TCVALVSDKE GSHVKVKSFE KERQTEKRVL ESDLVDHVVH KLRTKVSDER 1500

NIREVSDNLA VQNLKGSFSN ASGLFEIHGA TVIPIVSVMA PEKLSASTRR RYETQVQTRL 1560

QTSLANLHQK SSEIEILAVD LPKETILQFL SLEWDADEQA FNTTVKQLLS RLPKQRYLKL 1620

VCDEIYNIKV EKKVSVLFLY SYRDDYYRIL F 1651

Nucleotide Sequence
(FASTA)

ATGGCTGGGG GCCGTGGGGC CCCCGGGCGC GGCCGGGACG AGCCGCCCGA GAGCTATCCA 60

CAGCGACAGG ACCACGAACT GCAGGCCCTG GAGGCCATCT ACGGCGCCGA CTTCCAAGAC 120

CTGCGGCCGG ACGCGTGCAG ACCGGTCAAA GAACCCCCTG AAATCAATTT AGTGTTGTAC 180

CCTCAGGGCC TAACTGGTGA AGAAGTATAT GTGAAAGTGG ATTTAAGGGT TAAATGCCCA 240

CCAACCTATC CAGATGTAGT TCCTGAAATA GAGTTAAAGA ATGCCAAAGG TCTTTCAAAT 300

GAAAGTGTTA ATTTGCTAAA ATCCCGCCTG GAAGAACTGG CAAAAAAACA CTGTGGTGAG 360

GTGATGATAT TTGAACTGGC CTACCATGTG CAGTCATTTC TGAGCGAGCA TAACAAGCCC 420

CCACCCAAGT CTTTCCATGA AGAAATGCTG GAGAGGCGGG CACAGGAGGA GCAACAGAGG 480

CTGCTGGAGG CTAAGCGGAA GGAGGAGGAG GAGCAACGTG AAATCCTTCA TGAGATTCAG 540

AGAAGGAAAG AAGAGATAAA AGAAGAGAAA AAAAGGAAGG AAATAGCTAA GCAGGAACGC 600

TTGGAAATTG CTAGTTTGTC AAACCAAAAT CACACCTCCA GGAAAGACCC AGGAGGACAC 660

AGAACAGCTG CCCTTCTACA TGGAGGTTCT CCAGACTTTG TAGGGAATGG TAAACATCGG 720

GCCAACTCCT CAGGGAGGTC CAGGCGAGAA CGTCAGTACT CTGTATGTAG TGGTGAAGAT 780

TCGCCTGGCT CTTGTGAAAT CCTGTATTTC TGCCTGGGTG GTCCTGATCA GCTCATGGTG 840

CACAAAGGGA AATGTGTTGG CAGTGATGAG CAGCTTGGAA AATTAGTGTA CAATGCTCTG 900

GAAACAGCCA CCGGCAGCTT TGTCTTGCTA TATGAGTGGG TCCTTCAGTG GCAGAAAAAA 960

ATGGGTCCGT TTCTTACCAG TCAAGAAAGA GAGAAGATTG ATAAGTGCAA AAAGCAGATT 1020

CAAGGGGCAG AAACAGAATT CAACTCACTG GTGAAACTGA GCCATCCAAA CATAGTTCGC 1080

TACTTTGCAA TGAACCTCAA AGAGCAAGAT GACTCCATTG TGGTAGACAT TTTAGTGGAA 1140

CACATTAGCG GTGTCTCTCT CGCCACACAC CTGAGTCGCT CAGGCCCCGT CCCTGTGCAT 1200

CAACTGCGGA GGTACGCAGC TCAGCTCCTG TCCGGTCTCG ATTATCTTCA CAGCAATTCC 1260

GTGGTTCACA AGGTCCTGAG TGCATCTAAT GTCTTGGTGG ATGCAGAGGG CGCCGTCAAG 1320

ATTACGGACT ACAGCATTTC TAAGCGCCTT GCAGACATTT GCAAGGAGGA TGTGTTTGAG 1380

CAAACGCGAG TTCGTTTTAG TGACAATGCG CTGCCTTATA AAACCGGGAA GAAAGGGGAT 1440

GTTTGGCGTC TGGGCCTTCT GCTGCTCTCC CTCAGCCAAG GACAGGAGTG TGGGGAGTAC 1500

CCTGTGACCA TCCCTGGTGA CTTGCCAGCT GACTTTCAAG ATTTCCTGAA GAAGTGCGTT 1560

TGCTTAGATG ACAAGGAGAG GTGGAGCCCT CAGCAGCTGT TGAAACACAG CTTTGTAAAT 1620

CCTCAGCCAA AGACGCCGTT AGTGGAACAG AGTCCTGAAG ATTCTGGGGG CCAGGATTAC 1680

GTTGAGACTG TCATTCCCAG CAACCAGCTA CCCAGCGCGG CATTCTTCAG TGAGACCCAG 1740

AGACAGTTTT CCCGGTATTT CATTGAATTT GAAGAATTGC AGCTTCTTGG CAAAGGGGCT 1800

TTCGGAGCTG TCATCAAGGT GCAGAATAAG CTGGATGGCT GCTGCTACGC GGTGAAGCGC 1860

ATCCCCATTA ATCCCGCCAG CAGGCACTTC CGCAGGATCA AGGGTGAAGT GACGCTGCTG 1920

TCGCGCCTGC ACCATGAGAA TATCGTGCGC TATTACAACG CCTGGATCGA GCGGCACGAG 1980

CGGCCGGCGG GGACCGGGAC ACCGCCCCAG GACTCGGGGC CCCTGGCCCG GGACGGGCGA 2040

GCCGCACGCG CGCAGGCGGC GGGCGACACT GGCGACACTG ACGGCCCGGA CAGTGTGGAG 2100

GCCAACGCCC CGCCGCCCAT CACCAGCTCG GTGGAGTGGA GCACATCGGG CGAGCGCTCA 2160

GCCAGCGCCC GCTTCCCGGC TGCGGGCCCG GGCTCCAGCA GCGACGATGA AGACGACGAG 2220

GACGAACACG ACGGTGTCTT CTCTCAGTCC TTCCTACCAG CTTCAGATTC TGAAAGTGAT 2280

ATCATCTTTG ATAATGAAGA TGAGAACAGT AAGAGTCAGA ATCAGGATGA AGACTGCAGA 2340

GAGGAGAATG GTGGCTGTGA AAGTGAGCTG TCAGTGACGA CTGAGGCTGT GCACTACCTG 2400

TATATCCAGA TGGAGTATTG CGAAAAGAGC ACTTTACGTG ACACCATCGA CCAGGGACTA 2460

TACCGAGACA CCATCAGACT CTGGAGGCTT TTCCGAGAGA TTCTCGATGG ACTGGCTTAT 2520

ATCCATGAGA AAGGAATGAT TCACCGGGAT TTGAAGCCTG TCAACATTTT TTTGGATTCT 2580

GATGACCATG TGAAAATAGG TGATTTTGGT TTGGCGACAG ACCACCTAGC ATTTTCTGCT 2640

GACGGCAAAC AGGAGGATCA GGCAGACTCC TTGATTAAAT CAGACCCTTC AGGCCGCTTG 2700

ACCGGGATGG TTGGCACTGC TCTATATGTA AGCCCAGAGG TCCAGGGGAG CACCAAGTCT 2760

GCATACAACC AGAAAGTGGA TCTCTTCAGC CTGGGAATTA TCTTCTTTGA GATGTCCTAT 2820

CACCCCATGG TCACAGCCTC AGAAAGGATC TTTGTCCTCA ACCAACTCAG AGATCCCGCT 2880

TCGCCTAAGT TTCCAGAAGA CTTCGATGAT GGAGAACATA CAAAGCAGAA ATCTGTCATC 2940

TCCTGGCTGC TGAACCACGA TCCGGCCAAG CGGCCCACGG CCACAGAACT GCTCAAGAGC 3000

GAGCTGCTGC CCCCGCCCCA GATGGAGGAG TCGGAGCTGC ATGAGGTGCT GCACCACACG 3060

CTGGCCAACG TGGATGGGAA GGCCTATCGC ACCATGATGG CCCAGATCTT CTCCCAGCGC 3120

ATCTCCCCCG CCATCGACTA CACCTACGAC AGCGACATCC TCAAGGGCAA CTTCTCAATC 3180

CGTGCGGCCA AGATCCAGCA ACATGTGTGT GAAACCATCA TCCGCATCTT TAAACGACAC 3240

GGAGCTGTCC AGTTGTGTAC CCCACTGCTG CTTCCCCGAA ACAGGCAAAT ATATGAGCAC 3300

AATGAAGCTG CCTTATTCAT GGACCACAGC GGGATGCTGG TGATGCTGCC CTTCGACCTA 3360

CGGGTCCCTT TTGCAAGATA TGTGGCAAGA AATAACATAC TGAATTTGAA ACGATACTGC 3420

ATAGAACGCG TATTCAGACC TCGCAAGTTA GATCGATTTC ATCCCAAAGA ACTTCTGGAA 3480

TGTGCATTTG ACATCGTCAC TTCTACCACC AACAGCTCCC TGCCCACTGC TGAAATCATC 3540

TACACCATCT ATGAAATCAT CCAGGAGTTC CCGGCCCTTC AGGAAAGAAA CTACAGTATT 3600

TATTTGAATC ATACCATGTT ATTGAAAGCA ATACTATTAC ACTGTGGGAT CCCAGAAGAT 3660

AAACTCAGTC AAGTCTATGT TATTCTGTGT GATGCCGTGA CAGAGAAGCT GACGAGGAGA 3720

GAAGTGGAAG CTAAATTTTG TAATCTGTCT TTGTCTTCTA ACAGTCTGTG TCGACTCTAC 3780

AAGTTTATTG AGCAGAAGGG AGACTTGCAA GACCTAATGC CGACAATCAA CTCATTAATA 3840

AAACAGAAGA CAGGTGTCTC CCAGTTGGTG AAATACGGCT TGAAAGAGCT GGAAGAGGTC 3900

GTCGGGCTGC TGAAGAAACT TGGCGTGAAG TTACAGGTCT TCATCAACCT GGGCCTGGTT 3960

TACAAGGTGC AGCAGCACAA CGGGATCATC TTCCAATTTG TGGCATTCAT CAGACGAAGA 4020

CAGAGGGCTG TACCCGAAAT CCTTGCTGCT GGCGGCAGAT ACGACCTGCT GATCCCCCAG 4080

TTTAGAGGAC CACAAGCTCT GGGGCCAGTG CCCACTGCCA TCGGGGCCAG CATAGCTATT 4140

GACAAGATAT CCACTGCTGT CCTCAACATG GAGGAGCCTG CTACCGTAAG CTCTTGTGAC 4200

CTCCTGGTTG TCAGTGTTGG CCAGATGTCC ATGTCCAGGG CCATCCACCT AACTCAGAAA 4260

CTCTGGACAG CAGGAATCAC AGCAGAAATC ATGTACGACT GGTCACAGTC CCAGGAGGAA 4320

TTACAGGAGT ACTGCAGACA TCATGAAATC ACCTGTGTGG CCCTTGTCTC GGATAAAGAA 4380

GGCAGCCACG TCAAGGTTAA GTCTTTTGAG AAGGAAAGGC AAACAGAGAA GCGCGTGCTG 4440

GAATCTGATC TTGTGGACCA TGTTGTGCAC AAACTGAGGA CTAAAGTCAG TGATGAAAGG 4500

AATATCAGAG AAGTTTCCGA TAATCTTGCA GTGCAAAATC TGAAGGGGTC ATTTTCTAAT 4560

GCTTCAGGTT TGTTTGAAAT CCATGGAGCA ACAGTTATTC CCATTGTGAG CGTGATGGCC 4620

CCGGAGAAGC TGTCGGCCAG CACCAGGAGG CGGTATGAGA CTCAGGTGCA AACCCGACTT 4680

CAGACCTCCC TTGCCAATTT ACATCAGAAG AGCAGTGAAA TCGAGATTCT GGCCGTGGAT 4740

CTACCCAAAG AAACGATTTT ACAGTTTTTA TCATTAGAGT GGGATGCTGA TGAACAGGCA 4800

TTTAACACAA CTGTGAAGCA GCTGCTATCA CGCCTACCGA AGCAAAGATA CCTTAAATTG 4860

GTTTGTGATG AAATTTATAA CATCAAAGTA GAGAAAAAGG TGTCTGTGCT ATTTCTGTAT 4920

AGCTATAGAG ATGACTACTA CAGAATCTTA TTT 4953

Domain Profile

S: 1     feeikvlGkGgfgvVlkaknkldkkeyaikriklnkakkelekverevkaLaklehpniv  60

         fee+++lGkG+fg+V+k++nkld+++ya+kri++n a++++++++ ev++L++l+h+niv

Q: 590   FEELQLLGKGAFGAVIKVQNKLDGCCYAVKRIPINPASRHFRRIKGEVTLLSRLHHENIV  649

         89**********************************************************

S: 61    rYfaawleekeesl..............................................  74

         rY++aw+e++e+++

Q: 650   RYYNAWIERHERPAgtgtppqdsgplardgraaraqaagdtgdtdgpdsveanapppits  709

         *******************************************99999999999999999

S: 75    ..............................................tdsseveaeaelee  88

                                                       +++s++  + e e+

Q: 710   svewstsgersasarfpaagpgsssddeddedehdgvfsqsflpasDSESDIIFDNEDEN  769

         999999988888888888888888888888888888888888888522344433333333

S: 89    sesseesdtk...................llyiqmelceketLkdwiderkllesrselv  129

         s+s+++++                     +lyiqme+cek+tL+d+id+  l++++ +l+

Q: 770   SKSQNQDEDCreenggceselsvtteavhYLYIQMEYCEKSTLRDTIDQG-LYRDTIRLW  828

         33333222224788888888999999999*********************.9********

S: 130   mrlfkqllegleylHskgliHrdLkpsniFldsddqvKigDFgLatalaealkedvkqda  189

          rlf+++l+gl+y+H+kg+iHrdLkp+niFldsdd+vKigDFgLat+ + a+++d kq++

Q: 829   -RLFREILDGLAYIHEKGMIHRDLKPVNIFLDSDDHVKIGDFGLATD-HLAFSADGKQED  886

         .*********************************************9.888899999999

S: 190   qske.......akhtgqvgtklymsPeql..eksqYnkkvDifsLGlilfeLly.pfste  239

         q+ +       ++ tg+vgt+ly+sPe++  +ks+Yn+kvD+fsLG+i+fe++y p+ t+

Q: 887   QADSliksdpsGRLTGMVGTALYVSPEVQgsTKSAYNQKVDLFSLGIIFFEMSYhPMVTA  946

         999888888877*****************999****************************

S: 240   mervetltelrd...gkipedfdd.kvpkekkllqkllsrdpkeRpsasellksell  292

         +er+ +l++lrd    k+pedfdd +++k+k+++++ll++dp++Rp+a+ellksell

Q: 947   SERIFVLNQLRDpasPKFPEDFDDgEHTKQKSVISWLLNHDPAKRPTATELLKSELL  1003

         ************9999**************************************986

Domain Sequence
(FASTA)

FEELQLLGKG AFGAVIKVQN KLDGCCYAVK RIPINPASRH FRRIKGEVTL LSRLHHENIV 60

RYYNAWIERH ERPAGTGTPP QDSGPLARDG RAARAQAAGD TGDTDGPDSV EANAPPPITS 120

SVEWSTSGER SASARFPAAG PGSSSDDEDD EDEHDGVFSQ SFLPASDSES DIIFDNEDEN 180

SKSQNQDEDC REENGGCESE LSVTTEAVHY LYIQMEYCEK STLRDTIDQG LYRDTIRLWR 240

LFREILDGLA YIHEKGMIHR DLKPVNIFLD SDDHVKIGDF GLATDHLAFS ADGKQEDQAD 300

SLIKSDPSGR LTGMVGTALY VSPEVQGSTK SAYNQKVDLF SLGIIFFEMS YHPMVTASER 360

IFVLNQLRDP ASPKFPEDFD DGEHTKQKSV ISWLLNHDPA KRPTATELLK SELL 414

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004694	; F:eukaryotic translation initiation factor 2alpha kinase activity
GO:0000049	; F:tRNA binding
GO:0009267	; P:cellular response to starvation
GO:0030968	; P:endoplasmic reticulum unfolded protein response
GO:0017148	; P:negative regulation of translation
GO:0043558	; P:regulation of translational initiation in response to stress

KEGG

InterPros

IPR004154	; Anticodon-bd.
IPR026920	; EIF2AK4.
IPR024435	; GCN2_anticodon-bd_dom.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR006575	; RWD-domain.
IPR008271	; Ser/Thr_kinase_AS.
IPR016255	; Ser/Thr_kinase_GCN2.
IPR016135	; UBQ-conjugating_enzyme/RWD.

Pfam

PF12745	; HGTP_anticodon2; 1.
PF00069	; Pkinase; 3.
PF05773	; RWD; 1.

SMARTs

SM00591

; RWD; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 2.
PS00108	; PROTEIN_KINASE_ST; 1.
PS50908	; RWD; 1.

Prints

Created Date

20-Feb-2013