EKS-ORC-00361

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ORC-00361

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/MLK	263.9	1.8E-78	195	445	251

Status

Unreviewed

Ensembl Protein

ENSOCUP00000005697

UniProt Accession

G1SRA9;

Protein Name

Protein Synonyms/Alias

Gene Name

ILK

Gene Synonyms/Alias

ILK;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSOCUG00000006593	ENSOCUP00000005697	ENSOCUT00000006593

Organism

Oryctolagus cuniculus

Functional Description

Protein Length

452

Protein Sequence
(FASTA)

MDDIFTQCRE GNAVAVRLWL DNTENDLNQG DDHGFSPLHW ACREGRSAVV EMLIMRGARI 60

NVMNRGDDTP LHLAASHGHR DIVQKLLQYK ADINAVNEHG NVPLHYACFW GQDQVAEDLV 120

ANGALVSICN KYGEMPVDKA KAPLRELLRE RAEKMGQNLN RIPYKDTFWK GTTRTRPRNG 180

TLNKHSGIDF KQLNFLAKLN ENHSGELWKG RWQGNDIVVK VLKVRDWSTR KSRDFNEECP 240

RLRIFSHPNV LPVLGACQSP PAPHPTLITH WMPYGSLYNV LHEGTNFVVD QSQAVKFALD 300

MARGMAFLHT LEPLIPRHAL NSRSVMIDED MTARISMADV KFSFQCPGRM YAPAWVAPEA 360

LQKKPEDTNR RSADMWSFAV LLWELVTREV PFADLSNMEI GMKVALEGLR PTIPPGISPH 420

VCKLMKICMN EDPAKRPKFD MIVPILEKMQ DK 452

Nucleotide Sequence
(FASTA)

ATGGACGACA TTTTCACTCA GTGCCGGGAG GGCAACGCGG TTGCCGTGCG CCTGTGGCTG 60

GACAACACCG AGAACGACCT CAACCAGGGG GATGATCATG GCTTCTCCCC TTTGCACTGG 120

GCCTGCCGAG AGGGTCGCTC TGCTGTGGTT GAGATGCTCA TCATGCGGGG CGCACGGATC 180

AATGTGATGA ACCGTGGAGA TGATACCCCC CTGCACCTGG CTGCCAGCCA TGGACACCGT 240

GATATTGTAC AGAAGCTGTT GCAGTACAAA GCTGACATCA ATGCAGTGAA TGAGCATGGG 300

AATGTGCCCC TGCACTATGC CTGCTTTTGG GGCCAAGACC AAGTGGCAGA GGATCTGGTT 360

GCTAACGGGG CCCTTGTCAG CATCTGTAAC AAGTATGGAG AGATGCCTGT GGACAAAGCG 420

AAGGCACCCC TAAGAGAGCT TCTCCGAGAG CGGGCAGAGA AGATGGGCCA GAATCTGAAC 480

CGTATTCCAT ACAAGGACAC ATTTTGGAAG GGGACCACCC GCACTCGGCC CCGAAATGGG 540

ACTCTGAACA AGCACTCTGG CATTGACTTC AAACAGCTCA ACTTTCTGGC GAAGCTCAAC 600

GAGAATCATT CAGGAGAGTT GTGGAAGGGC CGCTGGCAGG GCAATGACAT CGTGGTGAAG 660

GTGCTGAAGG TTCGAGACTG GAGTACAAGG AAGAGCAGAG ACTTCAATGA GGAGTGTCCT 720

CGGCTCAGGA TTTTCTCGCA TCCAAATGTT CTCCCAGTGC TAGGAGCCTG CCAGTCTCCA 780

CCTGCTCCTC ACCCAACCCT CATTACGCAC TGGATGCCAT ATGGATCCCT CTACAATGTA 840

CTACATGAAG GCACCAATTT TGTCGTGGAC CAGAGCCAAG CTGTGAAGTT TGCTTTGGAC 900

ATGGCAAGGG GCATGGCATT CCTACACACA CTAGAGCCCC TCATCCCACG ACATGCACTC 960

AATAGCCGTA GTGTAATGAT TGATGAGGAC ATGACTGCCC GGATCAGCAT GGCCGATGTC 1020

AAGTTCTCTT TCCAATGCCC TGGACGCATG TATGCACCTG CCTGGGTAGC CCCTGAAGCT 1080

TTGCAGAAGA AGCCTGAAGA CACAAACAGA CGCTCAGCAG ACATGTGGAG TTTTGCAGTG 1140

CTTCTGTGGG AACTGGTGAC AAGAGAGGTA CCTTTTGCTG ACCTCTCCAA TATGGAGATT 1200

GGAATGAAGG TGGCACTGGA AGGCCTTCGG CCCACCATCC CACCAGGTAT TTCCCCCCAT 1260

GTGTGCAAGC TCATGAAGAT CTGCATGAAT GAAGACCCTG CTAAGCGACC CAAATTTGAC 1320

ATGATTGTGC CTATCCTGGA GAAGATGCAG GACAAATAG 1359

Domain Profile

S: 3     leeligsgafgkvykakwrkkevavKklreeaeekekleklereakllsklshpniiell  62

         +  +++++++g+++k++w++++++vK l++++++++k++++++e+ +l+ +shpn++ +l

Q: 195   FLAKLNENHSGELWKGRWQGNDIVVKVLKVRDWSTRKSRDFNEECPRLRIFSHPNVLPVL  254

         667899******************************************************

S: 63    Gvcleepn..lllvmeyveggsLsnvlhekskreidlevlvswalqiArGmaYLhseapk  120

         G+c+++p+   +l+++++++gsL+nvlhe ++ ++d++++v++al++ArGma+Lh+ +p

Q: 255   GACQSPPAphPTLITHWMPYGSLYNVLHEGTNFVVDQSQAVKFALDMARGMAFLHTLEPL  314

         ******99745**********************************************997

S: 121   kiihrdLksknvLlseekktlkicdFGtarelskstkmsaa.gtlawmaPEvlkeekvs.  178

          i ++ L+s++v++ +e++t++i++ +++++   s+++  + +++aw+aPE+l++++ +

Q: 315   -IPRHALNSRSVMI-DEDMTARISM-ADVKF---SFQCPGRmYAPAWVAPEALQKKPEDt  368

         .*************.**********.88888...78999998**************9998

S: 179   ..eksDvwSygvvLWelltrevPykdlselaiaykvalkglrlpipsscpeklkkLmkec  236

           +++D+wS++v+LWel+trevP++dls+++i +kval+glr++ip+ ++++++kLmk c

Q: 369   nrRSADMWSFAVLLWELVTREVPFADLSNMEIGMKVALEGLRPTIPPGISPHVCKLMKIC  428

         8899********************************************************

S: 237   wnedpekRpsfseivks  253

         +nedp+kRp+f++iv +

Q: 429   MNEDPAKRPKFDMIVPI  445

         **************986

Domain Sequence
(FASTA)

FLAKLNENHS GELWKGRWQG NDIVVKVLKV RDWSTRKSRD FNEECPRLRI FSHPNVLPVL 60

GACQSPPAPH PTLITHWMPY GSLYNVLHEG TNFVVDQSQA VKFALDMARG MAFLHTLEPL 120

IPRHALNSRS VMIDEDMTAR ISMADVKFSF QCPGRMYAPA WVAPEALQKK PEDTNRRSAD 180

MWSFAVLLWE LVTREVPFAD LSNMEIGMKV ALEGLRPTIP PGISPHVCKL MKICMNEDPA 240

KRPKFDMIVP I 251

Keyword

ANK repeat; Complete proteome; Reference proteome; Repeat.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tupaia belangeri"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0001658	; P:branching involved in ureteric bud morphogenesis
GO:0045197	; P:establishment or maintenance of epithelial cell apical/basal polarity
GO:0030513	; P:positive regulation of BMP signaling pathway
GO:0090263	; P:positive regulation of canonical Wnt receptor signaling pathway
GO:0008284	; P:positive regulation of cell proliferation
GO:0045669	; P:positive regulation of osteoblast differentiation
GO:0042327	; P:positive regulation of phosphorylation
GO:0045893	; P:positive regulation of transcription, DNA-dependent

KEGG

InterPros

IPR002110	; Ankyrin_rpt.
IPR020683	; Ankyrin_rpt-contain_dom.
IPR016253	; Integrin-linked_kinase.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.

Pfam

PF12796	; Ank_2; 1.
PF07714	; Pkinase_Tyr; 1.

SMARTs

SM00248

; ANK; 3.

Prosites

PS50297	; ANK_REP_REGION; 1.
PS50088	; ANK_REPEAT; 3.
PS50011	; PROTEIN_KINASE_DOM; 1.

Prints

Created Date

20-Feb-2013