EKS-ORC-00001
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-ORC-00001
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Eph520.47.1E-157621878258
StatusUnreviewed
Ensembl ProteinENSOCUP00000005814
UniProt AccessionG1SRK6;
Protein Name
Protein Synonyms/Alias
Gene NameEPHA4
Gene Synonyms/Alias EPHA4;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSOCUG00000006723ENSOCUP00000005814ENSOCUT00000006726
OrganismOryctolagus cuniculus
Functional Description
Protein Length986
Protein Sequence
(FASTA)
MAGIFYFVFF SFLFGVCDAV TGSRVYPANE VTLLDSRSVQ GELGWIASPL EGGWEEVSIM 60
DEKNTPIRTY QVCNVMEPSQ NNWLRTDWIT REGAQRVYIE IKFTLRDCNS LPGVMGTCKE 120
TFNLYYYESD NDKERFIRES QFAKIDTIAA DESFTQVDIG DRIMKLNTEI RDVGPLSRKG 180
FYLAFQDVGA CIALVSVRVF YKKCPLTVRN LAQFPDTITG ADTSSLVEVR GSCVNNSEEK 240
DVPKMYCGAD GEWLVPIGNC LCNAGHEEQS GECQACKIGY YKALSTDATC AKCPPHSYSV 300
WEGATSCTCD RGFFRADNDA ASMPCTRPPS APLNLISNVN ETSVNLEWSS PQNTGGRQDI 360
SYNVVCKKCG AGDPSKCRPC GSGVHYTPQQ NGLKSTKVSI TDLLAHTNYT FEIWAVNGVS 420
KYNPSPDQSV SVTVTTNQAA PSSIALVQAK EVTRYSVALA WLEPDRPNGV ILEYEVKYYE 480
KDQNERSYRI VRTAARNTDI KGLNPLTSYV FHVRARTAAG YGDFSEPLEV TTNTVPSRII 540
GDGANSTVLL VSVSGSVVLV VILIAAFVIS RRRSKYSKAK QEADEEKHLN QGVRTYVDPF 600
TYEDPNQAVR EFAKEIDASC IKIEKVIGVG EFGEVCSGRL KVPGKREICV AIKTLKAGYT 660
DKQRRDFLSE ASIMGQFDHP NIIHLEGVVT KCKPVMIITE YMENGSLDAF LRKNDGRFTV 720
IQLVGMLRGI GSGMKYLSDM SYVHRDLAAR NILVNSNLVC KVSDFGMSRV LEDDPEAAYT 780
TRGGKIPIRW TAPEAIAYRK FTSASDVWSY GIVMWEVMSY GERPYWDMSN QDVIKAIEEG 840
YRLPPPMDCP IALHQLMLDC WQKERSDRPK FGQIVNMLDK LIRNPNSLKR TGTESSRPNT 900
ALLDPSSPEF SAVVSVGDWL QAIKMDRYKD NFTAAGYTTL EAVVHMNQDD LSRIGITAIT 960
HQNKILSSVQ AMRTQMQQMH GRMVPV 986
Nucleotide Sequence
(FASTA)
ATGGCTGGGA TTTTCTATTT CGTCTTCTTT TCGTTTCTCT TTGGGGTCTG CGACGCTGTC 60
ACCGGTTCCA GGGTGTACCC CGCGAATGAA GTTACTCTAT TGGATTCCAG ATCCGTTCAG 120
GGAGAACTTG GGTGGATAGC AAGTCCTTTG GAAGGAGGGT GGGAGGAAGT GAGTATTATG 180
GATGAAAAAA ATACGCCAAT CCGAACCTAC CAAGTGTGCA ACGTGATGGA ACCGAGCCAG 240
AACAACTGGC TACGAACTGA TTGGATCACC CGAGAAGGGG CTCAGAGGGT GTATATTGAG 300
ATCAAGTTCA CCTTGAGGGA CTGCAATAGT CTTCCGGGCG TCATGGGGAC TTGCAAGGAG 360
ACCTTTAACC TGTACTACTA CGAATCAGAC AATGACAAAG AGCGCTTCAT TAGAGAGAGC 420
CAGTTTGCCA AGATCGACAC CATTGCTGCT GACGAGAGCT TCACCCAAGT GGACATTGGT 480
GATCGAATCA TGAAGCTGAA TACGGAGATC CGGGATGTAG GGCCGCTGAG CAGAAAAGGA 540
TTTTACCTGG CTTTTCAGGA TGTGGGGGCC TGCATAGCCC TAGTGTCTGT CCGTGTGTTC 600
TATAAGAAGT GTCCACTCAC CGTTCGCAAT CTGGCCCAGT TTCCAGATAC CATCACAGGG 660
GCTGATACCT CATCTCTGGT GGAAGTTCGA GGCTCCTGCG TCAACAACTC AGAAGAGAAG 720
GATGTGCCAA AAATGTACTG TGGGGCAGAT GGTGAGTGGC TGGTACCCAT TGGCAACTGT 780
TTGTGCAACG CTGGGCATGA AGAGCAGAGT GGAGAATGCC AAGCTTGCAA AATCGGATAC 840
TACAAGGCTC TCTCCACGGA TGCCACCTGT GCCAAGTGTC CACCCCACAG CTACTCTGTC 900
TGGGAAGGCG CCACCTCGTG CACCTGTGAT CGAGGCTTTT TCAGAGCCGA CAATGATGCT 960
GCCTCCATGC CCTGCACCCG CCCACCATCC GCTCCCCTCA ACCTCATTTC AAACGTGAAC 1020
GAGACATCAG TGAACTTGGA ATGGAGCAGT CCTCAGAATA CAGGTGGTCG TCAGGATATC 1080
TCCTACAATG TGGTTTGCAA GAAATGTGGA GCTGGTGACC CCAGCAAGTG CCGCCCCTGT 1140
GGAAGTGGGG TCCACTATAC ACCACAGCAG AACGGCCTGA AGAGCACCAA GGTCTCCATC 1200
ACTGACCTTC TAGCTCACAC CAATTACACG TTTGAGATCT GGGCTGTGAA TGGAGTTTCC 1260
AAGTATAACC CTAGCCCTGA CCAGTCCGTT TCTGTCACTG TGACAACCAA TCAAGCAGCT 1320
CCATCATCCA TTGCCTTGGT CCAGGCTAAA GAAGTCACAA GATATAGTGT GGCATTGGCT 1380
TGGTTGGAAC CAGATCGACC CAATGGGGTT ATCTTGGAAT ATGAAGTCAA ATACTATGAG 1440
AAGGATCAAA ATGAGCGAAG CTATCGTATA GTTCGGACAG CTGCCAGGAA CACGGATATC 1500
AAAGGCCTGA ACCCTCTCAC TTCCTATGTT TTCCATGTGA GAGCCAGGAC AGCAGCTGGC 1560
TATGGAGACT TCAGTGAGCC CTTGGAGGTG ACGACCAACA CAGTGCCTTC CCGGATCATC 1620
GGCGATGGGG CCAACTCCAC AGTCCTTCTG GTCTCTGTCT CAGGCAGTGT GGTGCTGGTG 1680
GTCATCCTCA TTGCAGCTTT TGTCATCAGC AGGAGACGGA GTAAATACAG TAAAGCAAAA 1740
CAAGAAGCAG ATGAAGAGAA ACATTTAAAT CAAGGTGTTA GAACTTATGT GGATCCCTTT 1800
ACATATGAAG ATCCCAACCA AGCAGTTCGA GAATTCGCCA AAGAAATCGA TGCATCCTGT 1860
ATTAAGATTG AAAAAGTCAT AGGTGTTGGT GAATTTGGCG AAGTGTGCAG TGGGCGTCTC 1920
AAAGTGCCTG GCAAGAGAGA GATCTGTGTG GCCATCAAGA CTCTGAAAGC GGGTTATACA 1980
GACAAACAGA GGAGAGACTT CCTCAGTGAG GCCAGCATCA TGGGACAGTT TGACCACCCG 2040
AACATAATTC ACTTGGAAGG TGTCGTCACC AAATGTAAAC CAGTAATGAT CATAACAGAA 2100
TATATGGAGA ATGGCTCTTT GGATGCATTC CTCAGGAAGA ATGATGGTAG ATTTACAGTC 2160
ATTCAGCTGG TGGGCATGCT TCGTGGCATC GGGTCCGGGA TGAAGTACTT ATCTGACATG 2220
AGCTATGTGC ATCGTGATCT GGCCGCCCGG AACATCCTGG TAAATAGCAA CTTAGTCTGC 2280
AAAGTGTCTG ATTTCGGCAT GTCACGCGTG CTTGAGGATG ATCCGGAAGC AGCGTACACC 2340
ACCAGGGGTG GCAAGATTCC TATCCGGTGG ACCGCGCCAG AGGCAATTGC CTATCGTAAA 2400
TTCACATCAG CCAGTGATGT ATGGAGCTAT GGAATCGTTA TGTGGGAAGT GATGTCGTAT 2460
GGAGAAAGAC CTTACTGGGA TATGTCCAAT CAAGATGTGA TTAAAGCCAT TGAGGAAGGC 2520
TATCGGCTAC CCCCTCCGAT GGACTGCCCC ATTGCACTGC ACCAGCTGAT GCTGGACTGC 2580
TGGCAGAAGG AGAGAAGCGA CAGGCCTAAA TTTGGGCAGA TTGTCAACAT GTTGGACAAA 2640
CTCATCCGCA ATCCCAACAG CTTGAAGAGG ACAGGGACGG AGAGTTCCAG ACCAAACACT 2700
GCCTTGTTGG ATCCAAGCTC CCCTGAATTC TCTGCCGTGG TATCAGTGGG CGATTGGCTG 2760
CAGGCCATTA AAATGGACCG GTATAAGGAT AACTTCACAG CTGCTGGTTA TACCACACTA 2820
GAGGCTGTGG TGCACATGAA CCAGGATGAC CTGTCAAGAA TTGGCATCAC AGCTATCACC 2880
CACCAGAATA AGATCTTGAG CAGTGTCCAG GCGATGCGGA CCCAAATGCA GCAGATGCAT 2940
GGCAGAATGG TTCCTGTC 2958
Domain Profile
S: 1     vkiekviGaGefGevcsGrlklpgkreiavaiktlkagstekqrrdflseasilGqfdhp  60
         +kiekviG GefGevcsGrlk+pgkrei+vaiktlkag+t+kqrrdflseasi+Gqfdhp
Q: 621   IKIEKVIGVGEFGEVCSGRLKVPGKREICVAIKTLKAGYTDKQRRDFLSEASIMGQFDHP  680
         79**********************************************************
S: 61    niirleGvvtkskpvmivteymengaldsflrkkdgqftviqlvgmlrGiasgmkylsdm  120
         nii+leGvvtk+kpvmi+teymeng+ld+flrk+dg+ftviqlvgmlrGi+sgmkylsdm
Q: 681   NIIHLEGVVTKCKPVMIITEYMENGSLDAFLRKNDGRFTVIQLVGMLRGIGSGMKYLSDM  740
         ************************************************************
S: 121   gyvhrdlaarnilvnsnlvckvsdfGlsrvleddseaayttsggkipirwtapeaiayrk  180
         +yvhrdlaarnilvnsnlvckvsdfG+srvledd+eaaytt+ggkipirwtapeaiayrk
Q: 741   SYVHRDLAARNILVNSNLVCKVSDFGMSRVLEDDPEAAYTTRGGKIPIRWTAPEAIAYRK  800
         ************************************************************
S: 181   ftsasdvwsyGivlwevlsyGerpywdmsnqdvikaieegyrlpppmdcpaalyqlmldc  240
         ftsasdvwsyGiv+wev+syGerpywdmsnqdvikaieegyrlpppmdcp al+qlmldc
Q: 801   FTSASDVWSYGIVMWEVMSYGERPYWDMSNQDVIKAIEEGYRLPPPMDCPIALHQLMLDC  860
         ************************************************************
S: 241   wqkdraerpkfeqivsil  258
         wqk+r++rpkf qiv++l
Q: 861   WQKERSDRPKFGQIVNML  878
         ***************985
Domain Sequence
(FASTA)
IKIEKVIGVG EFGEVCSGRL KVPGKREICV AIKTLKAGYT DKQRRDFLSE ASIMGQFDHP 60
NIIHLEGVVT KCKPVMIITE YMENGSLDAF LRKNDGRFTV IQLVGMLRGI GSGMKYLSDM 120
SYVHRDLAAR NILVNSNLVC KVSDFGMSRV LEDDPEAAYT TRGGKIPIRW TAPEAIAYRK 180
FTSASDVWSY GIVMWEVMSY GERPYWDMSN QDVIKAIEEG YRLPPPMDCP IALHQLMLDC 240
WQKERSDRPK FGQIVNML 258
KeywordATP-binding; Complete proteome; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00001
EKS-ANC-00001
EKS-BOT-00001
EKS-CAF-00001
EKS-CAP-00001
EKS-DAR-00001
EKS-EQC-00001
EKS-FEC-00001
EKS-GAG-00001
EKS-GAA-00001
EKS-GOG-00001
EKS-HOS-00002
EKS-ICT-00001
EKS-LAC-00002
EKS-LOA-00001
EKS-MAM-00001
EKS-MEG-00001
EKS-MOD-00001
EKS-MUM-00001
EKS-MUP-00001
EKS-MYL-00001
EKS-NOL-00001
EKS-ORN-00001
EKS-ORA-00001
EKS-ORL-00001
EKS-OTG-00005
EKS-PAT-00001
EKS-PES-00001
EKS-PEM-00004
EKS-POA-00001
EKS-PRC-00001
EKS-PTV-00001
EKS-RAN-00001
EKS-SAH-00001
EKS-SUS-00001
EKS-TAG-00001
EKS-TAR-00001
EKS-TAS-00001
EKS-TEN-00006
EKS-XET-00002
EKS-XIM-00001
Gene Ontology
GO:0030424; C:axon
GO:0030425; C:dendrite
GO:0031901; C:early endosome membrane
GO:0005887; C:integral to plasma membrane
GO:0005524; F:ATP binding
GO:0005004; F:GPI-linked ephrin receptor activity
GO:0005005; F:transmembrane-ephrin receptor activity
GO:0007628; P:adult walking behavior
GO:0021957; P:corticospinal tract morphogenesis
GO:0097156; P:fasciculation of motor neuron axon
GO:0097155; P:fasciculation of sensory neuron axon
GO:0008045; P:motor neuron axon guidance
GO:0048681; P:negative regulation of axon regeneration
GO:0018108; P:peptidyl-tyrosine phosphorylation
GO:0043507; P:positive regulation of JUN kinase activity
GO:2001108; P:positive regulation of Rho guanyl-nucleotide exchange factor activity
GO:0046777; P:protein autophosphorylation
GO:0048710; P:regulation of astrocyte differentiation
GO:0061001; P:regulation of dendritic spine morphogenesis
GO:0032314; P:regulation of Rac GTPase activity
GO:0032317; P:regulation of Rap GTPase activity
KEGG
InterPros
IPR001090; Ephrin_rcpt_lig-bd_dom.
IPR003961; Fibronectin_type3.
IPR008979; Galactose-bd-like.
IPR013783; Ig-like_fold.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001660; SAM.
IPR013761; SAM/pointed.
IPR011510; SAM_2.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR016257; Tyr_kinase_ephrin_rcpt.
IPR001426; Tyr_kinase_rcpt_V_CS.
Pfam
PF01404; Ephrin_lbd; 1.
PF00041; fn3; 2.
PF07714; Pkinase_Tyr; 1.
PF07647; SAM_2; 1.
SMARTs
SM00615; EPH_lbd; 1.
SM00060; FN3; 2.
SM00454; SAM; 1.
SM00219; TyrKc; 1.
Prosites
PS51550; EPH_LBD; 1.
PS50853; FN3; 2.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS00790; RECEPTOR_TYR_KIN_V_1; 1.
PS00791; RECEPTOR_TYR_KIN_V_2; 1.
PS50105; SAM_DOMAIN; 1.
Prints
PR00109; TYRKINASE.
Created Date20-Feb-2013