EKS-ORC-00050

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ORC-00050

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/RAF	388.3	2.4E-116	538	802	265

Status

Unreviewed

Ensembl Protein

ENSOCUP00000006098

UniProt Accession

G1SS96;

Protein Name

Protein Synonyms/Alias

Gene Name

KSR1

Gene Synonyms/Alias

KSR1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSOCUG00000007048	ENSOCUP00000006098	ENSOCUT00000007051

Organism

Oryctolagus cuniculus

Functional Description

Protein Length

848

Protein Sequence
(FASTA)

LQAKLVRYIC KQRQCKLSVA PSERTLELNS YPRFSDWLYI FSVRPELVQE IPRELTLDAL 60

LEMNEAKVKE TLRRCGASPE ECGRLQHALA CLRKVTGLGG EHKEDSGWSS VDARRESGSG 120

PPTDTLPPAS LPWTPGSSQL GRGGSSTQGP RSVSVSALPA SDSAAPGLSE GLSDTCLPLH 180

ASGRLTPRAL HSFITPPATP QLRRHAKLKP PRTPPPPSRK VFQLLPSFPT LTRSKSHESQ 240

LGNRIDDVTP MRFDLPHGSP QMVRRDIGLS VTHRFSTKSW LSQVCHVCQK SMMFGVKCKH 300

CRLKCHNKCT KEAPACRISF LPPVTLRRTE SVPSDINNPV DRAAEPHFGT LPKALTKKEH 360

PPAMNHLDSS SNPSSTTSST PSSPAPFPTS NPSSATTPPN PSPGQRDSRF NFPAAYFIHH 420

RQQFIFPVPS AGHHWKCLLM AELKTVGFNI SAFPQTAPPP DTADGDRPDE QPGADVDTLE 480

APGAEAEEPE AGRSEAEDDE DEVDDLPSSR RPWRGPISRK ASQTSVYLQE WDIPFEQVEL 540

GEPIGQGRWG RVHRGRWHGE VAIRLLEMDG HNQDHLKLFK KEVMNYRQTR HENVVLFMGA 600

CMNPPHLAII TSFCKGRTLH SFVRDPKTSL DINKTRQIAQ EIIKGMGYLH AKGIVHKDLK 660

SKNVFYDNGK VVITDFGLFG ISGVFREERR ENQLKLSHDW LCYLAPEIVR EMTPGKDEDQ 720

LPFSKAADVY AFGTIWYELQ ARDWPFKTQA AEALIWQIGS GEGMKRILAS INLGKEVSEI 780

LSACWAFDLQ GRPSFSLLMD MLEKLPKLNR RLSHPGHFWK SADINGSKVV PRFERFGLGV 840

LESSNPKM 848

Nucleotide Sequence
(FASTA)

CTGCAGGCCA AGCTGGTCCG GTACATCTGC AAGCAGCGGC AGTGCAAGCT CAGCGTGGCT 60

CCCAGCGAGA GGACCTTGGA GCTCAACAGC TACCCCCGCT TCAGTGACTG GCTCTACATC 120

TTCAGTGTGA GGCCCGAGTT GGTGCAGGAG ATCCCCCGCG AACTCACGCT GGACGCCCTG 180

CTGGAGATGA ACGAGGCCAA GGTGAAGGAG ACGCTGCGGC GCTGTGGAGC CAGCCCCGAG 240

GAGTGCGGCC GCCTGCAGCA CGCCCTCGCC TGCCTGCGGA AGGTCACGGG CCTGGGAGGA 300

GAGCACAAAG AGGACTCAGG CTGGAGTTCA GTGGATGCTC GGCGGGAAAG TGGCTCTGGG 360

CCTCCCACGG ACACCCTCCC TCCAGCCAGC CTGCCCTGGA CACCAGGCAG CTCCCAGCTG 420

GGCAGAGGGG GCAGCAGTAC CCAGGGCCCA CGCTCCGTCT CCGTGTCAGC CCTGCCCGCC 480

TCGGACTCCG CAGCCCCTGG CCTGAGCGAG GGCCTCTCGG ACACCTGCCT CCCGCTGCAC 540

GCCAGCGGGC GGCTCACCCC CCGCGCCCTG CACAGCTTCA TCACGCCACC CGCCACGCCC 600

CAGCTGCGCC GGCATGCCAA GCTGAAGCCG CCACGGACGC CCCCGCCGCC CAGCCGCAAG 660

GTCTTCCAGC TGCTGCCCAG CTTCCCCACG CTCACCCGGA GCAAGTCCCA CGAGTCGCAG 720

CTCGGGAACC GCATCGACGA CGTCACCCCC ATGCGGTTTG ATCTCCCGCA CGGATCCCCA 780

CAGATGGTAC GAAGGGACAT CGGACTCTCT GTGACGCACA GGTTCTCCAC CAAGTCCTGG 840

CTGTCGCAGG TGTGCCACGT GTGCCAGAAG AGCATGATGT TTGGAGTGAA GTGCAAGCAT 900

TGCAGGTTGA AGTGTCACAA CAAGTGCACA AAGGAAGCCC CCGCCTGTAG GATCTCCTTC 960

CTGCCACCAG TAACCCTTCG GAGGACGGAA TCTGTGCCCT CGGACATCAA CAACCCGGTG 1020

GACAGAGCAG CCGAACCCCA CTTCGGGACC CTCCCCAAAG CACTGACAAA GAAGGAGCAT 1080

CCTCCGGCCA TGAACCACCT GGACTCCAGC AGTAACCCGT CGTCCACCAC CTCCTCCACG 1140

CCCTCCTCGC CGGCGCCCTT CCCGACGTCC AACCCCTCCA GCGCCACCAC ACCACCCAAC 1200

CCCTCACCTG GCCAGCGGGA CAGCAGGTTC AACTTCCCAG CTGCCTACTT CATTCATCAT 1260

AGACAGCAGT TCATCTTCCC AGTGCCATCT GCTGGTCATC ATTGGAAATG CCTCCTTATG 1320

GCAGAGTTGA AAACTGTTGG GTTCAACATC TCGGCCTTCC CGCAGACAGC GCCGCCCCCC 1380

GACACAGCCG ACGGTGACCG GCCCGACGAG CAGCCTGGAG CCGACGTGGA CACACTGGAG 1440

GCTCCTGGAG CGGAGGCTGA GGAGCCGGAG GCGGGGAGGT CAGAGGCCGA AGATGACGAG 1500

GACGAGGTGG ACGACCTGCC CAGCTCCCGG CGGCCCTGGC GCGGCCCCAT CTCCCGCAAG 1560

GCCAGCCAGA CCAGCGTGTA CCTGCAGGAG TGGGACATCC CCTTCGAGCA GGTGGAGCTG 1620

GGCGAGCCCA TCGGGCAGGG CCGCTGGGGC CGCGTGCACC GGGGCCGCTG GCACGGCGAG 1680

GTGGCCATCC GCCTGCTGGA GATGGACGGC CACAACCAGG ACCACCTGAA GCTGTTCAAG 1740

AAGGAGGTGA TGAACTACCG GCAGACGCGG CACGAGAACG TGGTGCTGTT CATGGGCGCC 1800

TGCATGAACC CGCCCCACCT GGCCATCATC ACCAGCTTCT GCAAGGGGCG GACGTTGCAC 1860

TCGTTTGTGA GAGACCCCAA GACGTCCCTG GACATCAACA AGACGAGGCA GATTGCGCAG 1920

GAGATCATCA AGGGCATGGG CTATCTCCAC GCCAAGGGCA TTGTGCACAA GGATCTCAAG 1980

TCCAAGAACG TCTTCTACGA CAACGGCAAA GTGGTCATCA CGGACTTCGG GCTCTTTGGG 2040

ATCTCGGGCG TGTTCCGAGA GGAGCGGCGT GAGAACCAGC TGAAGCTGTC CCATGACTGG 2100

CTGTGCTACC TGGCGCCTGA GATCGTGCGT GAGATGACGC CCGGGAAGGA CGAGGACCAG 2160

CTGCCGTTCT CCAAAGCTGC TGACGTCTAT GCGTTCGGGA CCATCTGGTA TGAGCTCCAA 2220

GCACGGGACT GGCCCTTCAA GACCCAGGCC GCCGAGGCCC TGATCTGGCA GATTGGAAGC 2280

GGGGAAGGAA TGAAGCGCAT CCTGGCCTCC ATCAACCTGG GGAAGGAAGT CAGCGAGATC 2340

CTGTCTGCCT GCTGGGCTTT CGACCTGCAG GGGAGACCCA GCTTCAGCCT GCTGATGGAC 2400

ATGCTGGAGA AACTGCCCAA GCTGAACCGG CGGCTCTCTC ACCCTGGCCA CTTCTGGAAG 2460

TCAGCTGACA TTAACGGCAG CAAAGTTGTG CCCCGCTTTG AAAGGTTTGG CCTGGGGGTC 2520

CTGGAGTCCA GTAATCCAAA GATGTAG 2547

Domain Profile

S: 1     velaekiGsGrfGtvyrgkwhGdvavkllnveelseeqleaFkkevaaykktRhenivLF  60

         vel+e iG+Gr+G+v+rg+whG+va++ll+++ +++++l+ Fkkev++y++tRhen+vLF

Q: 538   VELGEPIGQGRWGRVHRGRWHGEVAIRLLEMDGHNQDHLKLFKKEVMNYRQTRHENVVLF  597

         67899*******************************************************

S: 61    mG.yvskpelaivtslckgssLykllheqetkldlaklidiarqiaqgmdYLhakkilhk  119

         mG ++++p+lai+ts+ckg++L++++++ +t+ld++k+++ia++i++gm+YLhak+i+hk

Q: 598   MGaCMNPPHLAIITSFCKGRTLHSFVRDPKTSLDINKTRQIAQEIIKGMGYLHAKGIVHK  657

         ************************************************************

S: 120   DlksknilleeglkvvitDFgllsvkrllsg.rrekqleipkgwilylapeviralsidl  178

         Dlkskn+++++g kvvitDFgl+ ++ + ++ rre+ql+++++w++ylape++r++++++

Q: 658   DLKSKNVFYDNG-KVVITDFGLFGISGVFREeRRENQLKLSHDWLCYLAPEIVREMTPGK  716

         ************.***************9977****************************

S: 179   eqdelpfskesDvyafGivlyellarelpykeesadqilfavgrG..lkpdlskvksklp  236

         ++d+lpfsk++DvyafG+++yel+ar++p+k+++a++ ++++g+G  +k+ l+++  +l+

Q: 717   DEDQLPFSKAADVYAFGTIWYELQARDWPFKTQAAEALIWQIGSGegMKRILASI--NLG  774

         ******************************************99988********..***

S: 237   kelkellleClkfekeeRPlftqilkkl  264

         ke++e+l++C++f+ + RP+f+ ++++l

Q: 775   KEVSEILSACWAFDLQGRPSFSLLMDML  802

         ************************9985

Domain Sequence
(FASTA)

VELGEPIGQG RWGRVHRGRW HGEVAIRLLE MDGHNQDHLK LFKKEVMNYR QTRHENVVLF 60

MGACMNPPHL AIITSFCKGR TLHSFVRDPK TSLDINKTRQ IAQEIIKGMG YLHAKGIVHK 120

DLKSKNVFYD NGKVVITDFG LFGISGVFRE ERRENQLKLS HDWLCYLAPE IVREMTPGKD 180

EDQLPFSKAA DVYAFGTIWY ELQARDWPFK TQAAEALIWQ IGSGEGMKRI LASINLGKEV 240

SEILSACWAF DLQGRPSFSL LMDML 265

Keyword

Complete proteome; Metal-binding; Reference proteome; Zinc.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ornithorhynchus anatinus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>

Gene Ontology

GO:0005622	; C:intracellular
GO:0005524	; F:ATP binding
GO:0046872	; F:metal ion binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0035556	; P:intracellular signal transduction
GO:0043410	; P:positive regulation of MAPK cascade

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR025561	; KSR_SAM-like_dom.
IPR002219	; Prot_Kinase_C-like_PE/DAG-bd.
IPR000719	; Prot_kinase_cat_dom.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF13543	; KSR1-SAM; 1.
PF07714	; Pkinase_Tyr; 1.

SMARTs

SM00109

; C1; 1.

Prosites

PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.
PS00479	; ZF_DAG_PE_1; 1.
PS50081	; ZF_DAG_PE_2; 1.

Prints

Created Date

20-Feb-2013