EKS-ORC-00138

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ORC-00138

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/FGFR	557.5	4.8E-168	465	741	277

Status

Unreviewed

Ensembl Protein

ENSOCUP00000015816

UniProt Accession

G1SSB0;

Protein Name

Fibroblast growth factor receptor

Protein Synonyms/Alias

Gene Name

FGFR2

Gene Synonyms/Alias

FGFR2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSOCUG00000007069	ENSOCUP00000015816	ENSOCUT00000024584
ENSOCUG00000007069	ENSOCUP00000006114	ENSOCUT00000007069
ENSOCUG00000007069	ENSOCUP00000019865	ENSOCUT00000026402

Organism

Oryctolagus cuniculus

Functional Description

Protein Length

766

Protein Sequence
(FASTA)

MATVSLARPS FNLVEDATVE PEEPPTKYQI SQPEVYVAAP GESLELRCLL KDASVISWTK 60

DGVHLGPNNR TVLIGEYLQI RGATPRDSGL YACTAARTVD SDTWYFMVNV TDAISSGDDE 120

DDTDGAEDFV SENSNSKRAP YWTNTEKMEK RLHAVPAANT VKFRCPAGGS PTPTMRWLKN 180

GKEFKQEHRI GGYKVRNQHW SLIMESVVPS DKGNYTCVVE NEYGSINHTY HLDVVERSPH 240

RPILQAGLPA NASTVVGGDV EFVCKVYSDA QPHIQWIKHV EKNGSKYGPD GLPYLKVLKA 300

AGVNTTDKEI EVLYIRNVTF EDAGEYTCLA GNSIGISFHS AWLTVLPAPV REKEITASPD 360

YLEIAIYCIG VFLIVCMVIT VIVCRMKTTS KKPDFSSQPA VHKLTKRIPL RRQVSAESSS 420

SMNSNTPLVR ITTRLSSAAD TPMLAGVSEY ELPEDPKWEF PRDKLTLGKP LGEGCFGQVV 480

MAEAVGIDKD KPKEAVTVAV KMLKDDATEK DLSDLVSEME MMKMIGKHKN IINLLGACTQ 540

DGPLYVLVEY ASKGNLREYL RARRPPGMEY SYDINRVPEE QMTFKDLVSC TYQLARGMEY 600

LASQKCIHRD LAARNVLVTE NNVMKIADFG LARDINNIDY YKKTTNGRLP VKWMAPEALF 660

DRVYTHQSDV WSFGVLMWEI FTLGGSPYPG IPVEELFKLL KEGHRMDKPA NCTNELYMMM 720

RDCWHAVPSQ RPTFKQLVED LDRILTLTTN EEYLDLSQPL EPYSPS 766

Nucleotide Sequence
(FASTA)

ATGGCAACCG TGTCCCTGGC CAGGCCCTCC TTCAATTTGG TTGAGGACGC CACGGTGGAG 60

CCGGAAGAGC CACCAACCAA ATACCAAATC TCTCAACCGG AAGTGTACGT GGCCGCGCCA 120

GGGGAGTCGC TAGAGTTGCG CTGCCTGTTG AAAGATGCCT CCGTGATCAG TTGGACTAAG 180

GATGGGGTGC ACTTGGGGCC CAACAATAGG ACAGTGCTTA TTGGGGAGTA CTTGCAGATA 240

AGAGGCGCCA CGCCTAGGGA CTCCGGCCTC TATGCTTGTA CTGCTGCTAG GACTGTAGAC 300

AGTGACACTT GGTACTTCAT GGTGAATGTC ACAGATGCCA TCTCTTCTGG AGATGACGAG 360

GACGACACGG ACGGCGCCGA AGACTTTGTC AGTGAGAACA GTAACAGCAA GAGAGCGCCC 420

TACTGGACCA ACACGGAGAA GATGGAGAAA CGCCTGCACG CCGTCCCGGC CGCCAACACC 480

GTTAAGTTCC GCTGCCCGGC GGGGGGGAGC CCGACCCCCA CCATGCGGTG GCTCAAGAAC 540

GGGAAGGAGT TTAAGCAGGA GCATCGCATC GGAGGCTATA AGGTGCGAAA CCAGCACTGG 600

AGCCTTATCA TGGAGAGCGT GGTCCCTTCC GACAAAGGCA ATTATACGTG CGTGGTGGAG 660

AACGAGTACG GGTCCATCAA CCACACCTAC CACCTCGACG TCGTGGAGCG GTCTCCGCAC 720

CGGCCCATCC TCCAGGCGGG GCTGCCGGCC AATGCCTCCA CGGTGGTGGG AGGTGACGTG 780

GAGTTTGTGT GCAAGGTGTA CAGTGACGCA CAGCCCCACA TCCAGTGGAT CAAGCACGTG 840

GAAAAGAACG GCAGTAAATA CGGGCCCGAC GGGCTGCCCT ACCTCAAGGT ACTCAAGGCT 900

GCCGGTGTTA ACACCACGGA CAAAGAAATT GAGGTTCTCT ATATTCGGAA TGTAACTTTT 960

GAGGATGCTG GGGAGTATAC GTGCTTGGCG GGTAATTCTA TTGGGATATC CTTTCACTCT 1020

GCATGGTTGA CAGTTCTGCC AGCTCCCGTA AGAGAAAAGG AGATTACAGC CTCCCCAGAC 1080

TACCTGGAGA TAGCCATTTA CTGCATAGGG GTCTTCCTGA TCGTGTGCAT GGTGATCACC 1140

GTCATCGTGT GCCGCATGAA GACCACCAGC AAGAAGCCGG ACTTCAGCAG CCAGCCGGCG 1200

GTGCACAAGC TAACCAAGCG CATCCCCCTG CGGAGACAGG TCTCGGCCGA GTCCAGCTCC 1260

TCCATGAACT CCAACACCCC GCTGGTGAGG ATTACGACGC GCCTGTCCTC CGCCGCGGAC 1320

ACCCCCATGC TGGCGGGCGT CTCTGAGTAC GAGCTGCCGG AGGACCCCAA ATGGGAGTTC 1380

CCCAGAGACA AGCTGACGCT GGGCAAACCC CTGGGAGAAG GTTGCTTTGG GCAAGTGGTC 1440

ATGGCCGAAG CTGTGGGAAT TGACAAAGAC AAGCCCAAGG AGGCAGTCAC TGTGGCGGTG 1500

AAAATGTTGA AAGATGACGC CACGGAAAAG GACCTTTCGG ATCTGGTCTC GGAGATGGAG 1560

ATGATGAAGA TGATCGGAAA ACACAAGAAC ATCATCAATC TTCTTGGCGC CTGTACGCAG 1620

GATGGGCCGC TGTACGTCCT GGTTGAGTAC GCCTCCAAGG GCAACCTGCG CGAGTACCTG 1680

CGAGCCCGCA GGCCGCCCGG CATGGAGTAC TCCTACGACA TTAACCGGGT GCCCGAAGAA 1740

CAGATGACCT TCAAGGACCT GGTGTCGTGC ACCTACCAGC TGGCCAGGGG CATGGAGTAC 1800

TTGGCTTCCC AGAAGTGTAT TCACCGGGAT TTAGCAGCCA GAAACGTTTT GGTCACGGAG 1860

AACAATGTGA TGAAAATAGC AGACTTCGGA CTGGCCAGAG ATATCAACAA CATCGACTAT 1920

TACAAGAAAA CCACCAATGG TCGACTTCCA GTCAAGTGGA TGGCTCCGGA AGCCCTGTTC 1980

GATCGGGTGT ACACTCACCA GAGTGATGTC TGGTCTTTCG GGGTGTTGAT GTGGGAGATC 2040

TTCACGTTAG GGGGCTCGCC CTACCCAGGC ATTCCCGTGG AGGAACTCTT CAAGCTGCTC 2100

AAGGAAGGAC ATAGGATGGA CAAGCCGGCC AACTGCACCA ACGAGCTGTA TATGATGATG 2160

AGAGACTGCT GGCACGCGGT GCCCTCACAG AGACCCACGT TCAAGCAGTT GGTGGAAGAC 2220

TTGGATCGCA TTCTCACTCT GACAACCAAC GAGGAGTACT TGGACCTCAG CCAGCCTCTC 2280

GAGCCATACT CACCTAGTTA G 2301

Domain Profile

S: 1     lvlgkllGeGafGqvvkaeaigldkdkekkevtvavkmlkedatdkdladlvsemevlkl  60

         l+lgk+lGeG+fGqvv+aea+g+dkdk+k++vtvavkmlk+dat+kdl+dlvseme++k+

Q: 465   LTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKM  524

         79**********************************************************

S: 61    iGkhkniinllGactqeGplyviveyaakGnlreflrarrpkgeeaskdkskaseeqlte  120

         iGkhkniinllGactq+Gplyv+veya+kGnlre+lrarrp+g+e+s+d ++++eeq+t+

Q: 525   IGKHKNIINLLGACTQDGPLYVLVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTF  584

         ************************************************************

S: 121   kdlvsfayqvarGmeylaskkcihrdlaarnvlvtednvlkiadfGlardvheidyykkt  180

         kdlvs++yq+arGmeylas+kcihrdlaarnvlvte+nv+kiadfGlard+++idyykkt

Q: 585   KDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKT  644

         ************************************************************

S: 181   tnGrlpvkwmapealfdrvytsqsdvwsfGvllweiltlGgspypgiaveelfkllkeGh  240

         tnGrlpvkwmapealfdrvyt+qsdvwsfGvl+wei+tlGgspypgi+veelfkllkeGh

Q: 645   TNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGH  704

         ************************************************************

S: 241   rmekpakctkelyvlmrecwhakaserptfkqlvedl  277

         rm+kpa+ct+ely++mr+cwha++s+rptfkqlvedl

Q: 705   RMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDL  741

         ***********************************97

Domain Sequence
(FASTA)

LTLGKPLGEG CFGQVVMAEA VGIDKDKPKE AVTVAVKMLK DDATEKDLSD LVSEMEMMKM 60

IGKHKNIINL LGACTQDGPL YVLVEYASKG NLREYLRARR PPGMEYSYDI NRVPEEQMTF 120

KDLVSCTYQL ARGMEYLASQ KCIHRDLAAR NVLVTENNVM KIADFGLARD INNIDYYKKT 180

TNGRLPVKWM APEALFDRVY THQSDVWSFG VLMWEIFTLG GSPYPGIPVE ELFKLLKEGH 240

RMDKPANCTN ELYMMMRDCW HAVPSQRPTF KQLVEDL 277

Keyword

ATP-binding; Complete proteome; Immunoglobulin domain; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Repeat; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005938	; C:cell cortex
GO:0009986	; C:cell surface
GO:0031012	; C:extracellular matrix
GO:0005887	; C:integral to plasma membrane
GO:0005634	; C:nucleus
GO:0005524	; F:ATP binding
GO:0005007	; F:fibroblast growth factor-activated receptor activity
GO:0001525	; P:angiogenesis
GO:0007409	; P:axonogenesis
GO:0030282	; P:bone mineralization
GO:0060349	; P:bone morphogenesis
GO:0060667	; P:branch elongation involved in salivary gland morphogenesis
GO:0060670	; P:branching involved in labyrinthine layer morphogenesis
GO:0048755	; P:branching morphogenesis of a nerve
GO:0060449	; P:bud elongation involved in lung branching
GO:0045165	; P:cell fate commitment
GO:0048557	; P:embryonic digestive tract morphogenesis
GO:0009880	; P:embryonic pattern specification
GO:0061031	; P:endodermal digestive tract morphogenesis
GO:0060664	; P:epithelial cell proliferation involved in salivary gland morphogenesis
GO:0060595	; P:fibroblast growth factor receptor signaling pathway involved in mammary gland specification
GO:0031069	; P:hair follicle morphogenesis
GO:0032808	; P:lacrimal gland development
GO:0060601	; P:lateral sprouting from an epithelium
GO:0070307	; P:lens fiber cell development
GO:0060174	; P:limb bud formation
GO:0048286	; P:lung alveolus development
GO:0060463	; P:lung lobe morphogenesis
GO:0060484	; P:lung-associated mesenchyme development
GO:0060615	; P:mammary gland bud formation
GO:0003149	; P:membranous septum morphogenesis
GO:0060915	; P:mesenchymal cell differentiation involved in lung development
GO:0060916	; P:mesenchymal cell proliferation involved in lung development
GO:0030901	; P:midbrain development
GO:0035264	; P:multicellular organism growth
GO:0008285	; P:negative regulation of cell proliferation
GO:0045839	; P:negative regulation of mitosis
GO:0000122	; P:negative regulation of transcription from RNA polymerase II promoter
GO:0007528	; P:neuromuscular junction development
GO:0042476	; P:odontogenesis
GO:0035265	; P:organ growth
GO:0030916	; P:otic vesicle formation
GO:0003148	; P:outflow tract septum morphogenesis
GO:0018108	; P:peptidyl-tyrosine phosphorylation
GO:0090263	; P:positive regulation of canonical Wnt receptor signaling pathway
GO:0060045	; P:positive regulation of cardiac muscle cell proliferation
GO:0051781	; P:positive regulation of cell division
GO:0060501	; P:positive regulation of epithelial cell proliferation involved in lung morphogenesis
GO:0070374	; P:positive regulation of ERK1 and ERK2 cascade
GO:0002053	; P:positive regulation of mesenchymal cell proliferation
GO:0010518	; P:positive regulation of phospholipase activity
GO:0045944	; P:positive regulation of transcription from RNA polymerase II promoter
GO:0009791	; P:post-embryonic development
GO:0060527	; P:prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis
GO:0060523	; P:prostate epithelial cord elongation
GO:0046777	; P:protein autophosphorylation
GO:0060687	; P:regulation of branching involved in prostate gland morphogenesis
GO:0010453	; P:regulation of cell fate commitment
GO:0040036	; P:regulation of fibroblast growth factor receptor signaling pathway
GO:0040014	; P:regulation of multicellular organism growth
GO:0051150	; P:regulation of smooth muscle cell differentiation
GO:0008589	; P:regulation of smoothened signaling pathway
GO:0060529	; P:squamous basal epithelial stem cell differentiation involved in prostate gland acinus development
GO:0048489	; P:synaptic vesicle transport
GO:0001657	; P:ureteric bud development
GO:0055010	; P:ventricular cardiac muscle tissue morphogenesis

KEGG

InterPros

IPR007110	; Ig-like.
IPR013783	; Ig-like_fold.
IPR013098	; Ig_I-set.
IPR003598	; Ig_sub2.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.
IPR016248	; Tyr_kinase_fibroblast_GF_rcpt.

Pfam

PF07679	; I-set; 3.
PF07714	; Pkinase_Tyr; 1.

SMARTs

SM00408	; IGc2; 3.
SM00219	; TyrKc; 1.

Prosites

PS50835	; IG_LIKE; 3.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013