EKS-ORC-00378
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-ORC-00378
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/PDGFR594.96.3E-179586918333
StatusUnreviewed
Ensembl ProteinENSOCUP00000006129
UniProt AccessionG1SSC3;
Protein Name
Protein Synonyms/Alias
Gene NameC-KIT
Gene Synonyms/Alias
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSOCUG00000007086ENSOCUP00000006129ENSOCUT00000007088
OrganismOryctolagus cuniculus
Functional Description
Protein Length969
Protein Sequence
(FASTA)
LEDARICWCS WLVVSMSKHY HAGSSQPSAS PGQPAPPVIQ PAQPELTVDA GSRFSLECID 60
PGSVRWTFES LGQLSDSEHS QWTREEAEAA NTGRYTCTNA GGLSSSIYVF VRDPRQLFLV 120
GLPLYGREDS DTLVRCPLTD PDVTNYTLKE CEGKPLPKDL TFVPDPKAGI TIKNVRRAYH 180
RLCLRCAADR EGTTVQSEKF ILKVRAAAAI KAVPVVSVSR TSCLLREGEE FSVTCTVRDV 240
STAVLSAWLK EDGQRTNGQV RRHSWHQGDF HYERQETLTI GAARVADSGV FMCYANNTFG 300
SANVTTTLKV VDKGFIRVFS VTNTTMFVND GENVDLVVQY EAYPRPTQQQ WLYMNRTSAS 360
KWEDHPESEN ESNIRYVSKL HLTRLKGSEA GTYTFLVSNA DVNASVAFNV YVNTKPKILT 420
SKRLVNGVLQ CEAAGFPEPT IDWYFCLGTE QRCSAPVWPV AVQVQNASEQ PFGKPVVQSA 480
IDSSAFKHNG TVECRASNDA GQSSAYFNFA LKGNSKGILL FNPISVIYSL TCVHACVCLY 540
VTVYLQLDSI KMGRGKKGNA ITFIFTSRPP PPTTDPVPIR PVPLAGKTLG AGAFGKVVEA 600
TAYGLIKSDA AMTVAVKMLK PSAHLTEREA LMSELKVLSY LGNHMNIVNL LGACTVGGPT 660
LVITEYCCYG DLLNFLRRKR DSFICSKQED HGEAALYKNL LQSKEPSCSD STNEYMDMKP 720
GVSYVVPTKA DRRRSARVGS YIERDVTPAV LEDDELALDL EDLLSFSYQV AKGMAFLASK 780
NCIHRDLAAR NILLTHGRIT KICDFGLARD IKSDSNYVVK GNARLPVKWM APESIFNCVY 840
TFESDVWSYG IFLWELFSLG SSPYPGMPVD SKFYKMIKEG FRMLSPEHAP AEMYDIMKTC 900
WDADPLKRPT FKQIVQLIET QISESTHHVY SNVCNSSPNP AHPAVDHSVR VNSVGSSASS 960
TQPLLVHED 969
Nucleotide Sequence
(FASTA)
TTGGAGGATG CGCGAATCTG CTGGTGTTCG TGGCTAGTTG TGTCAATGAG CAAGCACTAC 60
CATGCAGGCT CTTCGCAGCC ATCTGCGAGC CCAGGGCAGC CGGCTCCCCC CGTCATCCAG 120
CCAGCACAGC CGGAGCTGAC CGTGGATGCC GGCAGCAGGT TCTCGCTGGA GTGCATCGAC 180
CCGGGCTCCG TCAGGTGGAC TTTCGAGAGC CTGGGTCAGC TGAGTGACAG CGAGCACAGC 240
CAATGGACGC GCGAGGAGGC GGAGGCCGCC AACACGGGCA GGTACACCTG CACCAACGCG 300
GGCGGCCTGA GCAGCTCCAT CTACGTGTTC GTGAGAGATC CGCGGCAGCT GTTCCTCGTG 360
GGCCTGCCCC TGTACGGCCG AGAAGACAGT GACACGCTGG TCCGCTGTCC GCTGACCGAC 420
CCGGACGTGA CCAACTACAC CCTCAAGGAG TGCGAGGGGA AGCCTCTCCC CAAGGACTTG 480
ACCTTCGTCC CGGACCCCAA GGCCGGCATC ACCATCAAGA ACGTGAGGCG CGCCTACCAC 540
CGGCTGTGCC TGCGCTGCGC CGCCGACCGC GAGGGCACAA CCGTGCAGTC GGAAAAATTC 600
ATCCTGAAAG TGAGAGCAGC CGCAGCCATC AAGGCCGTCC CGGTGGTGTC CGTGTCTAGG 660
ACGAGCTGCC TGCTTAGAGA GGGGGAAGAG TTCTCAGTGA CCTGCACGGT CAGAGACGTG 720
TCCACCGCCG TGCTGTCCGC GTGGCTGAAG GAGGACGGCC AGCGGACAAA CGGCCAGGTG 780
AGGCGCCACA GCTGGCATCA GGGCGACTTC CACTACGAGC GCCAGGAGAC GCTGACGATC 840
GGCGCGGCGA GAGTGGCGGA CTCCGGGGTG TTCATGTGCT ACGCCAACAA CACCTTCGGG 900
TCGGCGAATG TCACCACGAC CTTGAAAGTC GTAGATAAAG GCTTCATCCG GGTCTTCTCG 960
GTGACCAACA CCACCATGTT TGTCAACGAC GGAGAAAACG TGGACTTGGT GGTGCAGTAC 1020
GAGGCGTACC CGCGGCCCAC GCAGCAGCAG TGGCTGTACA TGAACAGGAC CTCCGCCAGC 1080
AAGTGGGAGG ACCACCCAGA GTCAGAGAAT GAGAGCAACA TCAGATACGT GAGCAAGCTG 1140
CACCTGACCA GACTGAAGGG GAGCGAGGCC GGCACCTACA CGTTTCTCGT GTCCAATGCT 1200
GATGTCAACG CTTCCGTGGC CTTTAACGTT TACGTGAACA CGAAACCAAA GATCCTGACT 1260
TCCAAAAGAC TGGTGAACGG CGTGCTGCAG TGTGAGGCAG CAGGATTCCC GGAGCCCACC 1320
ATAGACTGGT ATTTCTGTCT GGGAACCGAG CAGAGGTGCT CGGCGCCGGT GTGGCCGGTG 1380
GCCGTGCAGG TCCAGAATGC GTCGGAGCAG CCCTTCGGGA AGCCGGTGGT CCAGAGCGCC 1440
ATCGACTCGA GCGCCTTCAA GCACAATGGC ACGGTGGAGT GCAGGGCGTC CAACGACGCG 1500
GGCCAGAGCT CCGCCTACTT CAACTTTGCC CTTAAAGGTA ACAGCAAAGG TATACTCCTC 1560
TTTAATCCAA TTTCAGTCAT ATACTCACTC ACGTGTGTGC ATGCGTGTGT GTGTCTTTAT 1620
GTAACTGTAT ATTTACAGCT TGACTCCATT AAGATGGGCA GAGGAAAAAA GGGGAATGCA 1680
ATCACTTTTA TCTTTACTTC CCGCCCCCCG CCCCCCACCA CTGACCCTGT CCCCATCCGT 1740
CCTGTTCCTC TCGCAGGGAA GACCCTGGGC GCCGGCGCCT TCGGGAAGGT GGTGGAGGCC 1800
ACGGCCTACG GGCTGATCAA GTCGGATGCG GCCATGACCG TCGCTGTGAA GATGCTGAAA 1860
CCGAGCGCCC ACCTGACGGA GCGGGAAGCC CTCATGTCCG AGCTCAAGGT GCTGAGCTAC 1920
CTGGGGAATC ACATGAACAT CGTGAACCTC CTGGGAGCCT GCACCGTCGG AGGGCCCACC 1980
CTGGTCATTA CAGAGTACTG CTGCTACGGG GACCTCCTGA ACTTCCTGCG GAGAAAGCGG 2040
GATTCGTTCA TCTGCTCCAA GCAGGAGGAC CACGGGGAAG CCGCCCTCTA CAAGAACCTC 2100
CTGCAGTCCA AGGAGCCGTC CTGCAGCGAC AGCACCAACG AGTACATGGA CATGAAGCCC 2160
GGTGTCTCCT ACGTCGTCCC CACCAAGGCA GACAGAAGAC GATCCGCCAG AGTCGGCTCC 2220
TACATAGAGC GAGACGTGAC GCCCGCCGTC CTGGAGGACG ACGAGCTGGC CCTGGACCTG 2280
GAGGACTTGT TGAGCTTTTC CTACCAGGTG GCCAAGGGCA TGGCTTTCCT CGCCTCCAAG 2340
AACTGTATCC ACAGAGACCT GGCCGCCAGG AACATCCTCC TTACCCACGG GCGCATCACC 2400
AAGATCTGCG ACTTCGGCCT CGCCCGAGAC ATCAAGAGCG ACTCCAACTA TGTGGTTAAA 2460
GGAAACGCCC GGCTCCCCGT GAAGTGGATG GCCCCGGAGA GCATCTTCAA CTGCGTGTAC 2520
ACGTTTGAGA GCGACGTCTG GTCCTACGGC ATCTTCCTGT GGGAGCTGTT CTCCTTAGGC 2580
AGCAGCCCCT ACCCCGGGAT GCCGGTGGAC TCCAAGTTCT ACAAGATGAT CAAGGAGGGC 2640
TTCCGGATGC TGAGCCCCGA GCATGCACCT GCTGAGATGT ATGACATCAT GAAGACTTGC 2700
TGGGACGCTG ACCCGCTGAA AAGGCCCACC TTCAAGCAGA TCGTGCAGCT CATCGAGACG 2760
CAGATCTCAG AGAGCACCCA CCACGTTTAC TCCAACGTGT GCAACAGCAG CCCCAACCCC 2820
GCGCACCCCG CCGTGGACCA CTCGGTGCGC GTCAATTCCG TGGGCAGCAG TGCCTCCTCC 2880
ACGCAGCCCC TGCTCGTGCA TGAAGACTGA 2910
Domain Profile
S: 4     GkvlGsGafGkvveatayGlsksdavlkvavkmlkstarssekealmselkilshlGehe  63
         Gk+lG+GafGkvveatayGl+ksda+++vavkmlk++a+ +e+ealmselk+ls+lG+h+
Q: 586   GKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHM  645
         9***********************************************************
S: 64    nivnllGactkgGpiyviteyccyGdllnylrrkresflkkslekkkekeeeldskalla  123
         nivnllGact+gGp++viteyccyGdlln+lrrkr+sf+   ++k++++ e++ +k+l  
Q: 646   NIVNLLGACTVGGPTLVITEYCCYGDLLNFLRRKRDSFI---CSKQEDHGEAALYKNL--  700
         ***************************************...99999*********99..
S: 124   dkslrsksslssesseeyvdlkkdvsdvssskadklasekkksalerevkaaleeedsev  183
            l+sk+ ++s+s++ey+d+k++vs+v ++kad+++s+++ s++er+v++a+ e+d+ +
Q: 701   ---LQSKEPSCSDSTNEYMDMKPGVSYVVPTKADRRRSARVGSYIERDVTPAVLEDDELA  757
         ...9********************************************************
S: 184   leledllsfsyqvakGmeflaskncvhrdlaarnvllteGkvvkicdfGlardimkdsny  243
         l+ledllsfsyqvakGm+flasknc+hrdlaarn+llt+G+++kicdfGlardi++dsny
Q: 758   LDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKSDSNY  817
         ************************************************************
S: 244   vvkGnarlpvkwmapesifdslytvksdvwsyGillweifslGstpypgllvdskfykli  303
         vvkGnarlpvkwmapesif+++yt++sdvwsyGi+lwe+fslGs+pypg++vdskfyk+i
Q: 818   VVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMI  877
         ************************************************************
S: 304   keGyrmaqpayateeiyeimqkcweaepekrpsfkqlvell  344
         keG+rm +p++a++e+y+im++cw+a+p krp+fkq+v+l+
Q: 878   KEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLI  918
         **************************************996
Domain Sequence
(FASTA)
GKTLGAGAFG KVVEATAYGL IKSDAAMTVA VKMLKPSAHL TEREALMSEL KVLSYLGNHM 60
NIVNLLGACT VGGPTLVITE YCCYGDLLNF LRRKRDSFIC SKQEDHGEAA LYKNLLQSKE 120
PSCSDSTNEY MDMKPGVSYV VPTKADRRRS ARVGSYIERD VTPAVLEDDE LALDLEDLLS 180
FSYQVAKGMA FLASKNCIHR DLAARNILLT HGRITKICDF GLARDIKSDS NYVVKGNARL 240
PVKWMAPESI FNCVYTFESD VWSYGIFLWE LFSLGSSPYP GMPVDSKFYK MIKEGFRMLS 300
PEHAPAEMYD IMKTCWDADP LKRPTFKQIV QLI 333
KeywordATP-binding; Complete proteome; Disulfide bond; Immunoglobulin domain; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Repeat; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00374
EKS-ANC-00389
EKS-BOT-00402
EKS-CAJ-00407
EKS-CAF-00402
EKS-CAP-00432
EKS-DAR-00787
EKS-EQC-00394
EKS-FEC-00386
EKS-GAG-00341
EKS-GAA-00515
EKS-GOG-00394
EKS-HOS-00409
EKS-ICT-00381
EKS-LAC-00419
EKS-LOA-00412
EKS-MAM-00402
EKS-MEG-00335
EKS-MOD-00391
EKS-MUM-00435
EKS-MUP-00399
EKS-MYL-00397
EKS-NOL-00368
EKS-ORN-00514
EKS-ORA-00347
EKS-ORL-00472
EKS-OTG-00405
EKS-PAT-00381
EKS-PES-00357
EKS-POA-00394
EKS-PTV-00114
EKS-RAN-00418
EKS-SAH-00372
EKS-SUS-00353
EKS-TAG-00473
EKS-TAR-00510
EKS-TEN-00511
EKS-XET-00515
EKS-XIM-00530
Gene Ontology
GO:0005737; C:cytoplasm
GO:0009897; C:external side of plasma membrane
GO:0005615; C:extracellular space
GO:0005887; C:integral to plasma membrane
GO:0005634; C:nucleus
GO:0005524; F:ATP binding
GO:0005020; F:stem cell factor receptor activity
GO:0005021; F:vascular endothelial growth factor-activated receptor activity
GO:0031532; P:actin cytoskeleton reorganization
GO:0000187; P:activation of MAPK activity
GO:0097067; P:cellular response to thyroid hormone stimulus
GO:0048066; P:developmental pigmentation
GO:0038093; P:Fc receptor signaling pathway
GO:0035234; P:germ cell programmed cell death
GO:0006687; P:glycosphingolipid metabolic process
GO:0007243; P:intracellular protein kinase cascade
GO:0002320; P:lymphoid progenitor cell differentiation
GO:0008584; P:male gonad development
GO:0002551; P:mast cell chemotaxis
GO:0032762; P:mast cell cytokine production
GO:0043303; P:mast cell degranulation
GO:0002573; P:myeloid leukocyte differentiation
GO:0002318; P:myeloid progenitor cell differentiation
GO:0043069; P:negative regulation of programmed cell death
GO:0018108; P:peptidyl-tyrosine phosphorylation
GO:0008284; P:positive regulation of cell proliferation
GO:0010628; P:positive regulation of gene expression
GO:0043410; P:positive regulation of MAPK cascade
GO:0051091; P:positive regulation of sequence-specific DNA binding transcription factor activity
GO:0042511; P:positive regulation of tyrosine phosphorylation of Stat1 protein
GO:0042517; P:positive regulation of tyrosine phosphorylation of Stat3 protein
GO:0042523; P:positive regulation of tyrosine phosphorylation of Stat5 protein
GO:0046777; P:protein autophosphorylation
GO:0048070; P:regulation of developmental pigmentation
GO:0009314; P:response to radiation
GO:0007286; P:spermatid development
GO:0048010; P:vascular endothelial growth factor receptor signaling pathway
GO:0038084; P:vascular endothelial growth factor signaling pathway
KEGG
InterPros
IPR007110; Ig-like.
IPR013783; Ig-like_fold.
IPR013098; Ig_I-set.
IPR003599; Ig_sub.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR016243; Tyr_kinase_CSF1/PDGF_rcpt.
IPR001824; Tyr_kinase_rcpt_3_CS.
IPR009134; Tyr_kinase_VEGFR_rcpt_N.
Pfam
PF07679; I-set; 1.
PF07714; Pkinase_Tyr; 1.
SMARTs
SM00409; IG; 3.
SM00219; TyrKc; 1.
Prosites
PS50835; IG_LIKE; 1.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS00240; RECEPTOR_TYR_KIN_III; 1.
Prints
PR01832; VEGFRECEPTOR.
Created Date20-Feb-2013