EKS-ORC-00246
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-ORC-00246
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
Other/PLK428.21.3E-12877329253
StatusUnreviewed
Ensembl ProteinENSOCUP00000006130
UniProt AccessionG1SSC4;
Protein Name
Protein Synonyms/Alias
Gene NamePLK2
Gene Synonyms/Alias PLK2;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSOCUG00000007089ENSOCUP00000006130ENSOCUT00000007089
OrganismOryctolagus cuniculus
Functional Description
Protein Length680
Protein Sequence
(FASTA)
MELLRTITYQ PAASTKICEQ ALGKASGGDS KKKRPQQVSE EPQAQVPPAA AHHQHHHSHS 60
GPEISRIIVD PTTGKRYCRG KVLGKGGFAK CYEMTDLTNN KVYAAKIIPH SRVAKPHQRE 120
KIDKEIELHR ILHHKHVVQF YHYFEDKENI YILLEYCSRR SMAHILKARK VLTEPEVRYY 180
LRQIVSGLKY LHEQEILHRD LKLGNFFINE AMELKVGDFG LAARLEPLEH RRRTICGTPN 240
YLSPEVLNKQ GHGCESDIWA LGCVMYTMLL GRPPFETTNL KETYRCIREA RYTMPSSLLA 300
PAKHLIASML SKNPEDRPSL DDIIRHDFFL QGFTPDKLSS SCCHTVPDFH LSSPAKNFFK 360
KAAAALFGGK KDKARYIDTH NRVSKEDEEI YKLRHDLKKT SITQQPSKHR TDEELQPPTT 420
MVARTGTPAV ENKQQIGDAI RMIVRGTLGS CSSSSECLED STMGSVADTV ARVLRGCLEN 480
MPAADCIPKE QLSTSFQWVT KWVDYSNKYG FGYQLSDHTV GVLFNNGAHM SLLPDKKTVH 540
YYAELGQCSV FPATDAPEQF ISQVTVLKYF SHYMEENLMD GGDLPSVTDI RRPRLYLLQW 600
LKSDKALMML FNDGTFQVNF YHDHTKIIIC SQNEEYLLTY INEDRISTTF RLTTLLMSGC 660
SLELKHRMEY ALNMLLQRCN 680
Nucleotide Sequence
(FASTA)
ATGGAGCTCT TGAGGACTAT CACCTACCAG CCGGCCGCCA GCACCAAGAT CTGCGAGCAG 60
GCGCTGGGCA AGGCCAGCGG CGGGGACTCG AAGAAGAAGC GGCCGCAGCA GGTCTCCGAG 120
GAGCCGCAGG CGCAGGTGCC GCCGGCGGCC GCGCACCACC AGCACCACCA TTCGCACTCG 180
GGGCCCGAGA TCTCGCGGAT TATCGTGGAT CCTACGACGG GGAAGCGCTA CTGCCGGGGC 240
AAAGTGCTGG GGAAGGGTGG CTTTGCAAAA TGTTACGAGA TGACAGATTT GACAAACAAC 300
AAAGTCTACG CTGCAAAAAT CATCCCGCAC AGCAGAGTAG CTAAACCTCA TCAAAGGGAA 360
AAGATTGACA AAGAAATCGA GCTTCACAGG ATTCTTCACC ATAAGCACGT CGTGCAGTTT 420
TACCACTACT TTGAAGACAA AGAAAACATT TACATTCTCT TGGAATACTG CAGTAGAAGG 480
TCGATGGCTC ACATCTTGAA AGCAAGAAAG GTGTTGACAG AGCCAGAAGT CCGATACTAC 540
CTCAGGCAGA TTGTGTCTGG ACTCAAGTAC CTTCACGAGC AAGAAATCTT ACACAGAGAT 600
CTCAAACTAG GGAACTTTTT TATTAATGAA GCCATGGAGC TGAAAGTCGG GGACTTCGGA 660
TTGGCAGCCA GGCTGGAACC TTTGGAACAC AGAAGGAGAA CAATATGCGG TACCCCGAAT 720
TATCTCTCTC CTGAAGTCCT CAACAAACAA GGGCATGGCT GTGAATCAGA CATTTGGGCA 780
TTAGGCTGTG TAATGTATAC AATGTTACTA GGAAGGCCCC CATTTGAAAC CACAAATCTG 840
AAAGAAACCT ACAGGTGCAT AAGAGAAGCT AGGTATACAA TGCCATCTTC ACTGCTGGCT 900
CCTGCGAAGC ACTTAATAGC TAGCATGTTG TCCAAAAACC CAGAGGATCG TCCCAGTTTG 960
GATGACATCA TACGGCATGA CTTTTTTTTG CAGGGCTTCA CTCCGGACAA GCTTTCTTCT 1020
AGCTGTTGTC ATACAGTTCC AGATTTCCAC TTATCAAGCC CAGCTAAGAA TTTCTTTAAG 1080
AAAGCGGCTG CTGCTCTTTT TGGTGGCAAA AAAGATAAAG CAAGATATAT TGACACACAC 1140
AATAGAGTGT CTAAAGAAGA TGAAGAAATT TACAAGCTTA GGCATGACTT GAAAAAGACT 1200
TCAATAACTC AGCAACCCAG CAAACATAGG ACAGATGAGG AGCTGCAGCC ACCTACCACC 1260
ATGGTTGCGA GAACTGGAAC ACCGGCGGTG GAGAACAAAC AGCAGATAGG AGATGCTATC 1320
CGCATGATAG TCAGAGGGAC TCTGGGCAGC TGCAGCAGCA GTAGTGAATG CCTTGAAGAC 1380
AGTACCATGG GAAGTGTTGC AGACACTGTG GCAAGAGTGC TTCGAGGATG TCTAGAAAAC 1440
ATGCCAGCAG CTGACTGCAT TCCCAAAGAG CAGCTGAGCA CATCCTTTCA GTGGGTCACC 1500
AAATGGGTCG ATTACTCTAA CAAGTATGGC TTTGGGTACC AGCTCTCAGA CCACACAGTT 1560
GGAGTCCTCT TCAACAACGG TGCTCACATG AGCCTCCTTC CGGACAAAAA AACAGTTCAC 1620
TATTATGCAG AGCTTGGCCA GTGTTCTGTT TTCCCAGCAA CAGATGCCCC TGAACAGTTC 1680
ATTAGTCAAG TGACGGTGCT GAAATACTTT TCTCATTACA TGGAGGAGAA TCTCATGGAT 1740
GGTGGCGATC TCCCTAGTGT GACAGATATT CGAAGACCTC GGCTCTACCT CCTTCAGTGG 1800
CTAAAATCTG ATAAGGCCTT AATGATGCTC TTCAATGATG GCACCTTTCA GGTGAATTTC 1860
TACCATGATC ATACAAAAAT AATCATCTGT AGTCAAAATG AAGAATACCT TCTTACTTAC 1920
ATCAACGAGG ATAGGATATC TACAACTTTC AGACTCACGA CTCTGCTGAT GTCTGGCTGT 1980
TCGTTAGAAC TGAAGCATCG AATGGAATAT GCCCTGAACA TGCTCTTACA GAGATGTAAC 2040
TAG 2043
Domain Profile
S: 1     yergkllGkGgfakcyelkdletkevfavkvvpksllakekqrekvekeieihrslkhkn  60
         y+rgk+lGkGgfakcye++dl++++v+a+k++p+s++ak++qrek++keie+hr l+hk+
Q: 77    YCRGKVLGKGGFAKCYEMTDLTNNKVYAAKIIPHSRVAKPHQREKIDKEIELHRILHHKH  136
         99**********************************************************
S: 61    ivklyeffedkenvylvlelcsrrslaellkrrkaltepevryylrqivsglkylhekri  120
         +v++y++fedken+y++le+csrrs+a++lk+rk+ltepevryylrqivsglkylhe++i
Q: 137   VVQFYHYFEDKENIYILLEYCSRRSMAHILKARKVLTEPEVRYYLRQIVSGLKYLHEQEI  196
         ************************************************************
S: 121   lhrdlklgnlflneelevkigdfGlatrlekeeerkktlcGtPnyiaPevlskkghslev  180
         lhrdlklgn+f+ne++e+k+gdfGla+rle+ e+r++t+cGtPny++Pevl+k+gh++e+
Q: 197   LHRDLKLGNFFINEAMELKVGDFGLAARLEPLEHRRRTICGTPNYLSPEVLNKQGHGCES  256
         ************************************************************
S: 181   diWslGcilytllvGkPPfetkelketyekikkaeyslPsslskeaksliakllkkePee  240
         diW+lGc++yt+l+G+PPfet++lkety++i++a+y++Pssl ++ak+lia++l+k+Pe+
Q: 257   DIWALGCVMYTMLLGRPPFETTNLKETYRCIREARYTMPSSLLAPAKHLIASMLSKNPED  316
         ************************************************************
S: 241   rpsleevlkdefl  253
         rpsl+++++++f+
Q: 317   RPSLDDIIRHDFF  329
         ************8
Domain Sequence
(FASTA)
YCRGKVLGKG GFAKCYEMTD LTNNKVYAAK IIPHSRVAKP HQREKIDKEI ELHRILHHKH 60
VVQFYHYFED KENIYILLEY CSRRSMAHIL KARKVLTEPE VRYYLRQIVS GLKYLHEQEI 120
LHRDLKLGNF FINEAMELKV GDFGLAARLE PLEHRRRTIC GTPNYLSPEV LNKQGHGCES 180
DIWALGCVMY TMLLGRPPFE TTNLKETYRC IREARYTMPS SLLAPAKHLI ASMLSKNPED 240
RPSLDDIIRH DFF 253
KeywordATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Danio rerio"; ?>Dasypus novemcinctus"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Rattus norvegicus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>
EKS-AIM-00243
EKS-ANC-00250
EKS-BOT-00260
EKS-CAJ-00266
EKS-CAF-00267
EKS-CAP-00295
EKS-CHH-00011
EKS-DAR-00595
EKS-DAN-00009
EKS-ECT-00011
EKS-EQC-00252
EKS-FEC-00246
EKS-GAG-00218
EKS-GOG-00258
EKS-HOS-00267
EKS-ICT-00245
EKS-LAC-00272
EKS-LOA-00270
EKS-MAM-00262
EKS-MEG-00208
EKS-MIM-00016
EKS-MOD-00259
EKS-MUM-00292
EKS-MYL-00263
EKS-NOL-00241
EKS-ORN-00338
EKS-ORA-00229
EKS-OTG-00266
EKS-PAT-00247
EKS-PES-00232
EKS-PEM-00136
EKS-POA-00253
EKS-PRC-00018
EKS-RAN-00275
EKS-SUS-00226
EKS-TAG-00276
EKS-TAR-00334
EKS-TEN-00329
EKS-VIP-00009
EKS-XET-00335
EKS-XIM-00330
EKS-SAC-00030
EKS-SCP-00027
Gene Ontology
GO:0005814; C:centriole
GO:0005524; F:ATP binding
GO:0004674; F:protein serine/threonine kinase activity
GO:0004871; F:signal transducer activity
GO:0000082; P:G1/S transition of mitotic cell cycle
GO:0007613; P:memory
GO:0007093; P:mitotic cell cycle checkpoint
GO:0007052; P:mitotic spindle organization
GO:0043066; P:negative regulation of apoptotic process
GO:0043123; P:positive regulation of I-kappaB kinase/NF-kappaB cascade
GO:0046599; P:regulation of centriole replication
GO:0048167; P:regulation of synaptic plasticity
KEGG
InterPros
IPR011009; Kinase-like_dom.
IPR000959; POLO_box_duplicated_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR002290; Ser/Thr_dual-sp_kinase_dom.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF00069; Pkinase; 1.
PF00659; POLO_box; 2.
SMARTs
SM00220; S_TKc; 1.
Prosites
PS50078; POLO_BOX; 2.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
Prints
Created Date20-Feb-2013