EKS-ORC-00154

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ORC-00154

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Other/TTK	484.3	1.1E-145	495	761	267

Status

Unreviewed

Ensembl Protein

ENSOCUP00000022113

UniProt Accession

G1SSE5;

Protein Name

Protein Synonyms/Alias

Gene Name

TTK

Gene Synonyms/Alias

TTK;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSOCUG00000007124	ENSOCUP00000022113	ENSOCUT00000023702
ENSOCUG00000007124	ENSOCUP00000006160	ENSOCUT00000007126

Organism

Oryctolagus cuniculus

Functional Description

Protein Length

827

Protein Sequence
(FASTA)

MEAEELSGKE LTIDSIMTKV RDLTDELSLN KISADTTGTV NQIMLMANNP EDWLNFLLKL 60

EKNSVPLNDA LLNKLIGRYS QAIEALPPDK YGQNESFARI QVRFAELKAI QEPDDARDYF 120

QMARANCKKF AFVHVSFAQF ELSQGNFKKS RQLLHKAVES GAVPLEMLEI AIQNLNLQKK 180

QLLSEEEKKS LSAPTVLSAQ ESLPSSQGHL QNRNTNCDTR GQAAKARVLY GENLPPQDAE 240

ISHRNPLKQA TKTKRSCPFG RVPVNLLNSP DCNEKIDGSV VPSFTKRQIS GSECRDLIVP 300

GFRSSGNDSC ELRNLKSVQN SHSKEPLVSD EKSCELTAES VTLKNKTDSS LLTQLEETKE 360

HQEPKIPESN QKPWQPKRKS ECVSQNPATF SSQWHIPERT PKVDAESPPL TAPKWIDPKS 420

ICKTPSNNTL DDYMSCFRTP VVKNDFAPAR QLSTPYSQVA YFQQQQQIPA TPLQNLQVSA 480

SSSTNECISV KGRIYSILKQ IGSGGSSKVF QVLNEKKQIH AIKYVSLEEA DNQTVESYRN 540

EIAYLNKLQQ HSDKIIRLYD YEITDQYIYM VMECGNIDLN SWLKKKKSIN PWERKSYWKN 600

MLEAVHTIHQ HGIVHSDLKP ANFLIVDGML KLIDFGIANQ MQPDTTSIVK DSQVGTINYM 660

PPEAIKDMSS SRENGKSKSK ISPKSDVWSL GCILYYMTYG KTPFQHIINQ ISKLHAIIDP 720

NHEIEFPDIP EKDLQDVLKR CLIRDPKLRI SIPELLAHPY VQIQAHPGNQ IAKGTSDEMK 780

NILGQLVGLN SPNSILKAAK TLYEHYSCGE SHDSSSSNAS ERKKSQK 827

Nucleotide Sequence
(FASTA)

ATGGAGGCTG AGGAGTTAAG TGGCAAAGAA TTGACAATTG ATTCCATAAT GACCAAAGTA 60

AGAGACTTAA CGGATGAGCT AAGCTTGAAT AAAATCTCTG CTGATACTAC AGGAACTGTT 120

AACCAAATTA TGTTGATGGC AAATAATCCA GAGGACTGGT TGAATTTCTT GCTCAAACTA 180

GAGAAAAATA GTGTCCCCCT AAATGATGCT CTTTTAAATA AATTGATTGG TCGTTATAGT 240

CAAGCAATTG AAGCACTTCC TCCAGATAAA TATGGCCAAA ATGAGAGTTT TGCTCGAATT 300

CAAGTGAGAT TTGCTGAATT AAAAGCTATT CAAGAGCCAG ATGATGCCCG CGACTACTTT 360

CAAATGGCCA GAGCAAACTG CAAGAAATTC GCTTTTGTAC ATGTATCTTT TGCACAGTTT 420

GAATTGTCAC AAGGTAATTT CAAAAAAAGT AGACAGCTTC TTCATAAAGC TGTAGAAAGT 480

GGAGCAGTAC CATTAGAAAT GCTGGAAATT GCCATCCAAA ATTTAAACCT TCAGAAAAAG 540

CAGCTGCTTT CAGAGGAAGA AAAGAAAAGT TTATCAGCAC CTACAGTATT ATCTGCCCAA 600

GAATCATTGC CCAGCTCACA GGGACATTTA CAGAATAGGA ACACCAATTG TGACACCAGA 660

GGACAGGCTG CTAAAGCCAG GGTTTTGTAT GGAGAGAATT TGCCCCCACA AGATGCAGAA 720

ATAAGCCATC GAAATCCCTT GAAACAAGCT ACCAAAACTA AACGGTCATG CCCATTTGGA 780

AGAGTCCCAG TTAACCTTCT GAATAGCCCA GATTGTAATG AGAAAATAGA TGGTTCAGTT 840

GTGCCAAGTT TTACAAAAAG ACAGATCTCT GGATCAGAAT GCAGAGATTT AATTGTGCCT 900

GGATTTAGAT CAAGTGGAAA TGATTCCTGT GAATTGAGAA ATTTAAAGAG TGTTCAAAAC 960

AGCCATTCCA AGGAACCTTT GGTATCAGAT GAAAAGAGTT GTGAACTTAC TGCTGAATCA 1020

GTAACCCTGA AGAATAAAAC TGACTCAAGT CTTCTAACTC AATTAGAAGA AACTAAAGAA 1080

CATCAAGAAC CAAAAATTCC AGAAAGTAAC CAGAAGCCTT GGCAACCTAA GAGAAAGTCA 1140

GAATGTGTGA GTCAAAATCC TGCTACATTT TCAAGTCAGT GGCACATTCC AGAGCGAACC 1200

CCAAAAGTAG ATGCAGAGTC ACCACCACTA ACAGCACCTA AATGGATTGA TCCAAAATCT 1260

ATTTGTAAGA CGCCAAGCAA CAATACCCTG GATGATTACA TGAGCTGTTT TAGAACTCCA 1320

GTTGTAAAGA ACGACTTTGC ACCTGCTCGT CAGTTGTCAA CACCGTATAG CCAAGTTGCC 1380

TACTTCCAGC AGCAGCAGCA AATACCCGCT ACTCCACTTC AGAATTTACA GGTTTCAGCA 1440

TCCTCTTCAA CAAATGAATG TATTTCAGTT AAAGGAAGAA TTTATTCCAT ATTAAAGCAG 1500

ATAGGAAGTG GAGGTTCAAG TAAGGTATTT CAGGTACTGA ATGAAAAGAA ACAGATACAT 1560

GCTATAAAAT ATGTAAGCTT AGAAGAAGCA GATAACCAAA CTGTGGAGAG TTACCGGAAC 1620

GAAATAGCTT ATTTGAATAA GCTACAGCAA CACAGTGATA AGATCATCCG ACTTTATGAT 1680

TATGAAATCA CAGACCAGTA CATCTACATG GTAATGGAAT GTGGAAATAT TGATCTTAAT 1740

AGTTGGCTTA AAAAGAAAAA ATCCATTAAT CCATGGGAAC GCAAAAGCTA CTGGAAAAAT 1800

ATGTTGGAGG CAGTACACAC AATCCATCAA CATGGCATTG TTCACAGTGA TCTGAAACCT 1860

GCTAACTTTC TGATAGTTGA CGGAATGCTA AAGCTAATTG ATTTTGGAAT TGCAAACCAA 1920

ATGCAACCAG ATACAACAAG TATTGTTAAA GATTCTCAGG TTGGCACAAT TAATTATATG 1980

CCACCAGAAG CCATCAAAGA TATGTCTTCC TCAAGAGAGA ATGGGAAATC CAAATCAAAG 2040

ATAAGCCCAA AAAGTGATGT TTGGTCCTTA GGATGCATCT TGTACTATAT GACTTATGGC 2100

AAAACACCAT TTCAGCATAT AATTAATCAG ATTTCCAAAT TACATGCCAT AATTGATCCC 2160

AATCATGAAA TTGAATTTCC TGATATTCCA GAGAAAGATC TTCAAGATGT GTTAAAGCGT 2220

TGCTTAATAA GGGACCCTAA ACTGAGGATA TCGATTCCTG AGCTCCTGGC ACATCCATAT 2280

GTTCAAATTC AAGCTCATCC AGGTAACCAA ATTGCTAAGG GAACATCTGA TGAAATGAAA 2340

AATATTCTGG GCCAACTTGT TGGTCTGAAT TCTCCTAACT CCATTTTGAA AGCTGCTAAA 2400

ACTTTATACG AGCACTATAG TTGTGGTGAA AGTCATGATT CTTCATCATC CAACGCTTCT 2460

GAAAGAAAAA AATCCCAAAA G 2481

Domain Profile

S: 1     yeilkklGsGGsskvfkvksekkrvyalkvvdleaaddqtidgykneielleklqdqs.k  59

         y+ilk++GsGGsskvf+v++ekk+++a+k+v+le+ad+qt+++y+nei++l+klq++s k

Q: 495   YSILKQIGSGGSSKVFQVLNEKKQIHAIKYVSLEEADNQTVESYRNEIAYLNKLQQHSdK  554

         99********************************************************9*

S: 60    virlydyeledsllylvmecGdidlnkilkkkksiepdyelvsyykemleavkvihqhGi  119

         +irlydye++d+++y+vmecG+idln++lkkkksi+p +e++sy+k+mleav++ihqhGi

Q: 555   IIRLYDYEITDQYIYMVMECGNIDLNSWLKKKKSINP-WERKSYWKNMLEAVHTIHQHGI  613

         *************************************.**********************

S: 120   vhsdlkPanfllvdGilklidfGianavaedttsivkesqvGtvnylaPealkdmsssqs  179

         vhsdlkPanfl+vdG+lklidfGian++++dttsivk+sqvGt+ny++Pea+kdmsss

Q: 614   VHSDLKPANFLIVDGMLKLIDFGIANQMQPDTTSIVKDSQVGTINYMPPEAIKDMSSS--  671

         **********************************************************..

S: 180   sereaekskikvsrksdvwslGcilylllygktPfgsirnqvskllaiinPdveiefPei  239

           re++ksk+k+s+ksdvwslGcily+++ygktPf++i+nq+skl+aii+P++eiefP+i

Q: 672   --RENGKSKSKISPKSDVWSLGCILYYMTYGKTPFQHIINQISKLHAIIDPNHEIEFPDI  729

         ..**********************************************************

S: 240   tsniekslvellkaclkrnPkkrisvdellsspfv  274

         +   ek+l+++lk cl r+Pk ris++ell++p+v

Q: 730   P---EKDLQDVLKRCLIRDPKLRISIPELLAHPYV  761

         *...*****************************96

Domain Sequence
(FASTA)

YSILKQIGSG GSSKVFQVLN EKKQIHAIKY VSLEEADNQT VESYRNEIAY LNKLQQHSDK 60

IIRLYDYEIT DQYIYMVMEC GNIDLNSWLK KKKSINPWER KSYWKNMLEA VHTIHQHGIV 120

HSDLKPANFL IVDGMLKLID FGIANQMQPD TTSIVKDSQV GTINYMPPEA IKDMSSSREN 180

GKSKSKISPK SDVWSLGCIL YYMTYGKTPF QHIINQISKL HAIIDPNHEI EFPDIPEKDL 240

QDVLKRCLIR DPKLRISIPE LLAHPYV 267

Keyword

Complete proteome; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.
IPR011990	; TPR-like_helical.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013