EKS-ORC-00155

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ORC-00155

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
AGC/PKC	479.8	2.6E-144	254	512	259

Status

Unreviewed

Ensembl Protein

ENSOCUP00000006368

UniProt Accession

G1U7J6;

Protein Name

Protein kinase C

Protein Synonyms/Alias

Gene Name

PRKCA

Gene Synonyms/Alias

PRKCA;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSOCUG00000007362	ENSOCUP00000006368	ENSOCUT00000007365
ENSOCUG00000007362	ENSOCUP00000025402	ENSOCUT00000029669

Organism

Oryctolagus cuniculus

Functional Description

Protein Length

596

Protein Sequence
(FASTA)

DPRSKHKFKI HTYGSPTFCD HCGSLLYGLI HQGMKCDTCD MNVHKQCVIN VPSLCGMDHT 60

EKRGRIYLKA EVTDEKLHVT VRDAKNLIPM DPNGLSDPYV KLKLIPDPKN ESKQKTKTIR 120

STLNPQWNES FTFKLKPSDK DRRLSVEIWD WDRTTRNDFM GSLSFGVSEL MKMPASGWYK 180

LLNQEEGEYY NVPIPEGDED GNVELRQKFE ACVYMTLKIV EKAKLGPAGN KVISPSEDRK 240

QPSNNLDRVK LTDFNFLMVL GKGSFGKVML ADRKGTEELY AIKILKKDVV IQDDDVECTM 300

VEKRVLALMD KPPFLTQLHS CFQTVDRLYF VMEYVNGGDL MYHIQQVGKF KEPQAVFYAA 360

EISIGLFFLH KRGIIYRDLK LDNVMLDSEG HIKIADFGMC KEHMMDGVTT RTFCGTPDYI 420

APEIIAYQPY GKSVDWWAYG VLLYEMLAGQ PPFDGEDEDE LFQSIMEHNV SYPKSLSKEA 480

VSICKGLMTK HPAKRLGCGP EGERDVREHA FFRRIDWEKL ENREIQPPFK PKVCGKGAEN 540

FDKFFTRGQP VLTPPDQLVI ANIDQSDFEG FSYVNPQFVH PILQSSPTPA PPPPVF 596

Nucleotide Sequence
(FASTA)

GACCCCAGGA GCAAGCACAA GTTTAAAATC CACACCTACG GGAGCCCCAC CTTCTGCGAT 60

CACTGTGGGT CACTGCTGTA CGGACTCATC CACCAGGGGA TGAAATGTGA CACCTGCGAC 120

ATGAACGTTC ACAAGCAGTG TGTGATCAAT GTCCCCAGCC TGTGTGGGAT GGATCATACG 180

GAGAAGAGGG GACGGATCTA CCTGAAGGCC GAGGTCACCG ATGAAAAGCT CCACGTCACG 240

GTACGAGATG CAAAAAACCT GATCCCCATG GATCCCAACG GGCTTTCAGA TCCCTACGTG 300

AAGCTGAAAC TCATTCCTGA TCCCAAGAAT GAAAGCAAAC AAAAAACCAA AACCATCCGC 360

TCCACGCTGA ACCCGCAGTG GAACGAATCC TTTACCTTCA AATTAAAACC CTCCGACAAA 420

GACCGACGAC TGTCTGTAGA AATCTGGGAC TGGGACCGAA CAACAAGGAA TGACTTCATG 480

GGGTCGCTCT CCTTTGGCGT CTCGGAGCTC ATGAAGATGC CAGCCAGTGG ATGGTACAAG 540

TTGCTGAACC AAGAAGAAGG TGAATACTAC AATGTGCCCA TTCCGGAAGG GGACGAAGAT 600

GGGAACGTGG AGCTCAGGCA GAAATTCGAG GCATGTGTTT ACATGACGTT GAAGATTGTA 660

GAAAAAGCCA AGCTGGGGCC CGCTGGCAAC AAGGTGATCA GTCCCTCGGA AGACAGGAAG 720

CAGCCGTCCA ACAACCTGGA CCGAGTGAAG CTCACCGACT TCAACTTCCT CATGGTCCTG 780

GGAAAAGGCA GTTTTGGGAA GGTGATGCTG GCGGACAGGA AGGGCACGGA AGAGCTGTAC 840

GCCATCAAGA TCCTGAAGAA GGACGTGGTG ATTCAGGATG ACGACGTGGA GTGCACCATG 900

GTGGAGAAGC GGGTTCTGGC CCTGATGGAC AAGCCGCCCT TCCTGACACA GCTGCACTCC 960

TGCTTCCAGA CCGTGGACCG GCTGTACTTT GTCATGGAAT ACGTCAACGG CGGAGACCTC 1020

ATGTACCACA TCCAGCAAGT GGGAAAGTTC AAGGAGCCAC AAGCAGTATT CTATGCAGCA 1080

GAGATTTCCA TTGGGCTGTT CTTCCTTCAC AAAAGAGGGA TCATCTATAG GGACCTGAAG 1140

CTAGATAACG TCATGCTGGA CTCGGAAGGA CACATCAAAA TCGCTGACTT TGGGATGTGC 1200

AAGGAACACA TGATGGACGG GGTCACCACC AGGACCTTCT GTGGGACTCC AGATTACATC 1260

GCCCCGGAGA TCATCGCTTA TCAGCCGTAC GGCAAATCCG TGGACTGGTG GGCCTACGGC 1320

GTCCTGCTGT ATGAGATGCT GGCTGGGCAG CCTCCATTTG ATGGCGAGGA CGAAGACGAG 1380

CTGTTTCAGT CCATCATGGA GCACAACGTT TCCTACCCCA AATCCTTGTC CAAGGAGGCC 1440

GTCTCCATCT GCAAGGGGCT GATGACCAAA CACCCGGCCA AGCGGCTGGG CTGCGGGCCC 1500

GAGGGAGAGC GGGACGTGAG GGAACACGCC TTCTTCCGGA GGATCGACTG GGAGAAACTG 1560

GAGAACAGGG AGATCCAGCC GCCGTTCAAG CCCAAAGTGT GTGGCAAAGG AGCAGAAAAC 1620

TTCGACAAGT TCTTCACGCG AGGGCAGCCC GTGCTCACGC CGCCGGATCA ACTGGTCATC 1680

GCTAACATAG ACCAGTCTGA TTTCGAAGGG TTCTCGTATG TCAACCCCCA GTTCGTGCAC 1740

CCCATCCTAC AGAGCTCACC AACCCCTGCC CCACCCCCAC CGGTATTT 1788

Domain Profile

S: 1     fellkvlGkGsfgkvllaelkktdelyaikvlkkdvvlqdddveltlvekrvlalaskkp  60

         f++l+vlGkGsfgkv+la++k+t+elyaik+lkkdvv+qdddve+t+vekrvlal +k+p

Q: 254   FNFLMVLGKGSFGKVMLADRKGTEELYAIKILKKDVVIQDDDVECTMVEKRVLALMDKPP  313

         99**********************************************************

S: 61    flvqlfscfqtedrlffvleyvnGGdlmfhiqkarklkeerarfyaaeiilalkflhekg  120

         fl+ql+scfqt drl+fv+eyvnGGdlm+hiq+++k+ke++a+fyaaei+++l+flh++g

Q: 314   FLTQLHSCFQTVDRLYFVMEYVNGGDLMYHIQQVGKFKEPQAVFYAAEISIGLFFLHKRG  373

         ************************************************************

S: 121   iiyrdlkldnvlldaeGhikladfGlckeeilegkttstfcGtPdyiaPeilkeeeygks  180

         iiyrdlkldnv+ld+eGhik+adfG+cke++++g tt+tfcGtPdyiaPei+++++ygks

Q: 374   IIYRDLKLDNVMLDSEGHIKIADFGMCKEHMMDGVTTRTFCGTPDYIAPEIIAYQPYGKS  433

         ************************************************************

S: 181   vdwwalGvllyemlagqsPfegededelfesilekevlyPkslskeaveilkglltkdpe  240

         vdwwa+Gvllyemlagq+Pf+gededelf+si+e++v+yPkslskeav+i+kgl+tk+p+

Q: 434   VDWWAYGVLLYEMLAGQPPFDGEDEDELFQSIMEHNVSYPKSLSKEAVSICKGLMTKHPA  493

         ************************************************************

S: 241   krlGvkeegeedikehaff  259

         krlG+ +ege+d++ehaff

Q: 494   KRLGCGPEGERDVREHAFF  512

         ******************9

Domain Sequence
(FASTA)

FNFLMVLGKG SFGKVMLADR KGTEELYAIK ILKKDVVIQD DDVECTMVEK RVLALMDKPP 60

FLTQLHSCFQ TVDRLYFVME YVNGGDLMYH IQQVGKFKEP QAVFYAAEIS IGLFFLHKRG 120

IIYRDLKLDN VMLDSEGHIK IADFGMCKEH MMDGVTTRTF CGTPDYIAPE IIAYQPYGKS 180

VDWWAYGVLL YEMLAGQPPF DGEDEDELFQ SIMEHNVSYP KSLSKEAVSI CKGLMTKHPA 240

KRLGCGPEGE RDVREHAFF 259

Keyword

ATP-binding; Complete proteome; Kinase; Metal-binding; Nucleotide-binding; Reference proteome; Repeat; Serine/threonine-protein kinase; Transferase; Zinc; Zinc-finger.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005622	; C:intracellular
GO:0005524	; F:ATP binding
GO:0004697	; F:protein kinase C activity
GO:0008270	; F:zinc ion binding
GO:0035556	; P:intracellular signal transduction

KEGG

InterPros

IPR000961	; AGC-kinase_C.
IPR000008	; C2_Ca-dep.
IPR008973	; C2_Ca/lipid-bd_dom_CaLB.
IPR020477	; C2_dom.
IPR018029	; C2_membr_targeting.
IPR020454	; DAG/PE-bd.
IPR011009	; Kinase-like_dom.
IPR017892	; Pkinase_C.
IPR002219	; Prot_Kinase_C-like_PE/DAG-bd.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR014375	; Protein_kinase_C_a/b/g.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00130	; C1_1; 2.
PF00168	; C2; 1.
PF00069	; Pkinase; 1.
PF00433	; Pkinase_C; 1.

SMARTs

SM00109	; C1; 2.
SM00239	; C2; 1.
SM00133	; S_TK_X; 1.
SM00220	; S_TKc; 1.

Prosites

PS51285	; AGC_KINASE_CTER; 1.
PS50004	; C2; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.
PS00479	; ZF_DAG_PE_1; 1.
PS50081	; ZF_DAG_PE_2; 2.

Prints

PR00360	; C2DOMAIN.
PR00008	; DAGPEDOMAIN.

Created Date

20-Feb-2013