EKS-ORC-00177

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ORC-00177

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/LISK	412.4	8.9E-124	61	309	249

Status

Unreviewed

Ensembl Protein

ENSOCUP00000006456

UniProt Accession

G1ST43;

Protein Name

Protein Synonyms/Alias

Gene Name

TESK2

Gene Synonyms/Alias

TESK2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSOCUG00000007464	ENSOCUP00000006456	ENSOCUT00000007464

Organism

Oryctolagus cuniculus

Functional Description

Protein Length

572

Protein Sequence
(FASTA)

MDRSKRNSIA GFPPRVERLE EFEGGGGGDG NMTQVGRVWP SSYRALIGAF SRLTRLDDFT 60

CEKIGSGFFS EVFKVCHRAS GQVMALKMNT LSSNRANMLK EVQLMNRLSH PNILRFMGVC 120

VHQGQLHALT EYINSGNLEQ LLDSNLHLPW TVRVKLAYDI AVGLSYLHLK GIFHRDLTSK 180

NCLIKRDENG YSAVVADFGL AEKIPDVSMG SEKLAVVGSP FWMAPEVLRD EPYNEKADVF 240

SYGIILCEII ARIQADPDYL PRTENFGLDY DAFQHMVGDC PPDFLQLTFN CCNMDPKLRP 300

SFVEIGKTLE EILRHLQEEE PEDRKLQPTA KGLLEKVPGV KRLSSLDDKI PHKSPRPSPR 360

RTVCLSRSRS DIFSHKPPHT VSVLDPYYQP QRDGASRIPK VNPFSARQDL KGGKIKLFDL 420

PSKSVISLVF DLDAPGPGTM PLADWQEPLA LPARRSCSLP GSPEFLHREA CPFVGREESL 480

SDGPPPRLSS LKYRVREIPP FQASALPAAL AHEAMDCSDP QEENGFGPRP QGTRPCHGGA 540

SEEMEVEQRP RGLAPGPLSV SSMGLKSQGE QD 572

Nucleotide Sequence
(FASTA)

ATGGATCGGA GCAAACGGAA TTCAATTGCA GGATTTCCTC CACGTGTGGA ACGTCTTGAA 60

GAGTTTGAAG GAGGTGGAGG AGGGGATGGA AACATGACCC AGGTGGGAAG AGTTTGGCCA 120

TCTTCATACC GAGCTCTTAT AGGTGCCTTC TCCAGACTGA CGCGTTTGGA TGATTTTACC 180

TGTGAAAAAA TAGGATCTGG CTTCTTCTCT GAAGTTTTCA AGGTGTGCCA CCGAGCTTCG 240

GGTCAGGTGA TGGCTCTTAA GATGAATACC TTGAGCAGTA ACCGAGCAAA TATGCTGAAA 300

GAAGTACAGC TCATGAATAG ACTCTCTCAT CCCAACATCC TTAGGTTCAT GGGTGTATGT 360

GTTCATCAAG GACAGTTGCA TGCACTTACA GAGTATATCA ACTCCGGGAA CCTGGAACAG 420

TTGCTAGACA GTAACCTGCA TTTGCCCTGG ACTGTGAGGG TGAAACTAGC CTATGACATA 480

GCAGTGGGTC TCAGCTACCT TCACCTCAAA GGCATTTTTC ATCGGGACCT CACATCCAAG 540

AACTGCTTGA TAAAAAGAGA TGAGAATGGT TACTCTGCAG TGGTGGCTGA CTTTGGCCTG 600

GCTGAGAAGA TCCCTGATGT CAGCATGGGG AGTGAGAAGC TGGCTGTGGT GGGATCTCCT 660

TTCTGGATGG CACCGGAGGT TCTGAGAGAT GAGCCCTATA ACGAAAAGGC GGACGTGTTC 720

TCTTATGGTA TCATCCTCTG CGAGATCATC GCCCGCATCC AGGCTGATCC GGACTATCTT 780

CCCCGCACAG AGAATTTCGG GCTGGACTAT GACGCTTTCC AGCACATGGT GGGAGACTGT 840

CCCCCAGACT TTCTGCAGCT CACCTTCAAC TGCTGTAATA TGGACCCCAA ACTGCGGCCA 900

TCCTTTGTGG AGATTGGGAA GACCCTCGAG GAAATTCTGA GGCACCTACA GGAGGAAGAA 960

CCAGAGGACA GAAAGCTGCA GCCCACAGCC AAGGGACTCC TAGAGAAAGT ACCTGGGGTA 1020

AAGCGACTAA GCTCACTGGA TGACAAGATC CCTCACAAGT CACCACGCCC AAGCCCAAGA 1080

CGTACTGTCT GTCTATCTCG AAGCCGTTCA GACATCTTCT CTCATAAACC CCCACATACA 1140

GTGAGCGTCT TGGACCCTTA TTACCAGCCA CAACGAGATG GTGCTTCCCG CATCCCCAAA 1200

GTCAACCCCT TCAGTGCACG CCAGGACCTC AAGGGTGGCA AGATCAAGTT ATTTGACCTG 1260

CCAAGCAAGT CTGTCATCTC CCTGGTATTT GACCTGGATG CACCAGGGCC TGGAACCATG 1320

CCCCTGGCTG ACTGGCAGGA ACCTTTGGCT CTACCAGCTC GTCGGTCATG TTCTTTGCCT 1380

GGTTCGCCTG AGTTCTTGCA TCGCGAGGCC TGTCCATTTG TGGGCCGAGA AGAATCGCTA 1440

TCTGATGGGC CCCCACCACG CCTCAGTAGT CTGAAGTACA GAGTAAGAGA GATCCCACCA 1500

TTCCAGGCAT CTGCTCTACC AGCTGCTCTG GCCCATGAAG CCATGGACTG CTCCGATCCC 1560

CAGGAAGAAA ATGGTTTTGG GCCCAGGCCC CAAGGGACCA GACCATGCCA TGGAGGTGCC 1620

TCTGAAGAGA TGGAGGTAGA ACAACGGCCA AGAGGCTTGG CTCCAGGCCC CCTCTCTGTC 1680

TCAAGCATGG GCCTGAAAAG CCAGGGAGAG CAGGAT 1716

Domain Profile

S: 4     geklGkGffsevfkvthrasGevmvlkeliradeenrknllkevkllrklehpnvlkfiG  63

          ek+G+Gffsevfkv hrasG+vm+lk  ++++++nr+n+lkev+l+++l+hpn+l+f+G

Q: 61    CEKIGSGFFSEVFKVCHRASGQVMALK--MNTLSSNRANMLKEVQLMNRLSHPNILRFMG  118

         59*************************..*******************************

S: 64    vlvkdkklhllteyiegGtlkellkskeslpwtqrvrlakdiasGlsylhskgiihrdln  123

         v+v++++lh+lteyi++G+l++ll+s+ +lpwt+rv+la+dia+Glsylh kgi+hrdl+

Q: 119   VCVHQGQLHALTEYINSGNLEQLLDSNLHLPWTVRVKLAYDIAVGLSYLHLKGIFHRDLT  178

         ************************************************************

S: 124   sknclvre...dksvvvadfGlarlvveerkkseklrslkkkdrkkrltvvGsPywmaPe  180

         skncl+++   ++s+vvadfGla          ek+++++++  +++l+vvGsP+wmaPe

Q: 179   SKNCLIKRdenGYSAVVADFGLA----------EKIPDVSMG--SEKLAVVGSPFWMAPE  226

         *******9887899*********..........9****9999..899*************

S: 181   vlkgksydekvdvfsfGivlceiiarveadPdylPrtedfgldvkafreklvaedcPeaf  240

         vl+++ y+ek+dvfs+Gi+lceiiar++adPdylPrte+fgld++af++ +v+ dcP++f

Q: 227   VLRDEPYNEKADVFSYGIILCEIIARIQADPDYLPRTENFGLDYDAFQH-MVG-DCPPDF  284

         *************************************************.999.******

S: 241   lklavvccdldpesrpsfeelekkl  265

         l+l+++cc++dp+ rpsf+e+ k+l

Q: 285   LQLTFNCCNMDPKLRPSFVEIGKTL  309

         *********************9876

Domain Sequence
(FASTA)

CEKIGSGFFS EVFKVCHRAS GQVMALKMNT LSSNRANMLK EVQLMNRLSH PNILRFMGVC 60

VHQGQLHALT EYINSGNLEQ LLDSNLHLPW TVRVKLAYDI AVGLSYLHLK GIFHRDLTSK 120

NCLIKRDENG YSAVVADFGL AEKIPDVSMG SEKLAVVGSP FWMAPEVLRD EPYNEKADVF 180

SYGIILCEII ARIQADPDYL PRTENFGLDY DAFQHMVGDC PPDFLQLTFN CCNMDPKLRP 240

SFVEIGKTL 249

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005634	; C:nucleus
GO:0005524	; F:ATP binding
GO:0004713	; F:protein tyrosine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266	; Tyr_kinase_AS.

Pfam

PF07714

; Pkinase_Tyr; 1.

SMARTs

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013