EKS-ORC-00436

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ORC-00436

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/MAPK	429.4	7.0E-129	26	310	285

Status

Unreviewed

Ensembl Protein

ENSOCUP00000006524

UniProt Accession

G1U3R3;

Protein Name

Protein Synonyms/Alias

Gene Name

MAPK12

Gene Synonyms/Alias

MAPK12;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSOCUG00000007543	ENSOCUP00000024028	ENSOCUT00000024886
ENSOCUG00000007543	ENSOCUP00000006524	ENSOCUT00000007544

Organism

Oryctolagus cuniculus

Functional Description

Protein Length

366

Protein Sequence
(FASTA)

LAATGPARAF TGQEVTKTAW EVRAVYHDLQ PVGSGAYGAV CSAVDSRTGA KVAIKKLYRP 60

FQSELFAKRA YRELRLLQHM RHENVIGLLD VFTPDETLDD FTDFYLVMPF MGTDLGKLMK 120

HEKLSEDRIQ FLVYQMLKGL KYIHAAGVIH RDLKPGNLAV NEDCELKILD FGLARQADSE 180

MTGYVVTRWY RAPEVILNWM HYTQTVDIWS VGCIMAEMIT GKTLFKGSDH LDQLKEIMKV 240

TGTPPADFVQ KLRSADAKQY MQGLPECERK DFASVVTNAS PLAVNLLEKM LVLDGDQRVT 300

AAEALAHPYF ESLHDTEDEP TAQKYDDSFD DVDRTLDEWK RVTYKEVLSF KPPRQLGARV 360

SKETAL 366

Nucleotide Sequence
(FASTA)

CTCGCCGCCA CCGGCCCCGC AAGGGCTTTT ACCGGCCAGG AGGTGACCAA GACCGCCTGG 60

GAGGTGCGCG CTGTGTATCA TGACCTGCAG CCCGTGGGCT CCGGCGCCTA CGGCGCCGTG 120

TGCTCGGCAG TGGACAGCCG CACGGGCGCC AAGGTGGCCA TCAAGAAGCT GTACCGTCCC 180

TTCCAGTCGG AGCTGTTCGC CAAGCGTGCC TACCGCGAGC TGCGCCTGCT CCAGCACATG 240

CGCCACGAGA ACGTGATCGG CCTGCTGGAC GTGTTCACTC CAGACGAGAC CCTGGACGAC 300

TTCACAGACT TTTACCTGGT GATGCCGTTC ATGGGCACCG ACCTGGGCAA GCTCATGAAG 360

CACGAGAAGC TGAGTGAGGA CCGCATCCAG TTCCTGGTGT ACCAGATGCT GAAGGGGCTG 420

AAGTACATCC ACGCTGCTGG CGTCATCCAC AGGGACTTGA AGCCCGGCAA CCTGGCAGTG 480

AATGAGGACT GTGAGCTGAA GATCCTGGAC TTTGGCCTGG CCAGGCAGGC TGACAGTGAG 540

ATGACTGGCT ATGTGGTGAC CCGGTGGTAC CGGGCCCCCG AGGTCATCCT GAACTGGATG 600

CACTACACAC AGACAGTGGA CATCTGGTCG GTGGGCTGCA TCATGGCGGA GATGATTACG 660

GGGAAGACGC TGTTCAAGGG CAGTGACCAC CTGGACCAGC TGAAGGAGAT CATGAAGGTG 720

ACAGGGACGC CTCCGGCCGA CTTCGTGCAA AAGCTGCGGA GCGCTGATGC CAAGCAGTAC 780

ATGCAGGGCC TCCCCGAGTG TGAGAGGAAG GACTTTGCCT CCGTGGTGAC CAACGCAAGC 840

CCTCTGGCCG TGAACCTCCT GGAGAAGATG TTGGTGCTGG ACGGGGACCA GCGGGTGACA 900

GCGGCCGAGG CGCTGGCCCA CCCCTACTTC GAGTCCCTGC ACGACACGGA GGACGAGCCC 960

ACAGCCCAGA AGTACGACGA CTCCTTTGAT GACGTGGACC GCACCCTGGA CGAGTGGAAG 1020

CGTGTCACTT ACAAAGAGGT GCTCAGCTTC AAGCCTCCCA GGCAGCTGGG GGCCAGGGTC 1080

TCCAAGGAGA CGGCCCTGTG A 1101

Domain Profile

S: 1     yeslkplgeGaygvvvsavdkrteervaikklsrpfqketsakrtlRElkllkelkheNi  60

         y++l+p+g+Gayg v+savd+rt+ +vaikkl rpfq+e  akr++REl+ll++++heN+

Q: 26    YHDLQPVGSGAYGAVCSAVDSRTGAKVAIKKLYRPFQSELFAKRAYRELRLLQHMRHENV  85

         7899********************************************************

S: 61    iklldvftpeeeleelkdvYlvtelmetdLkkviksqklsdehiklllyqilrglkylHs  120

         i lldvftp+e+l++++d+Ylv+ +m+tdL k++k++kls+++i++l+yq+l+glky+H+

Q: 86    IGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLSEDRIQFLVYQMLKGLKYIHA  145

         ************************************************************

S: 121   anviHrDlKPsNllvnedcelkildFGlarsadkekekklteyvatrwYraPeillslke  180

         a+viHrDlKP+Nl+vnedcelkildFGlar+ad+e    +t+yv+trwYraPe++l++++

Q: 146   AGVIHRDLKPGNLAVNEDCELKILDFGLARQADSE----MTGYVVTRWYRAPEVILNWMH  201

         **********************************9....*********************

S: 181   ytkavDiWsvGCIlaElltgkplfpgkdeidqlekilevlgtpseeflkkieseearnyi  240

         yt++vDiWsvGCI+aE++tgk+lf+g+d++dql++i++v+gtp ++f++k++s  a++y+

Q: 202   YTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPADFVQKLRSADAKQYM  261

         ************************************************************

S: 241   kslpkkkkkdfeelfpkaseealdLleklLvldpdkRisveeaLehpYl  289

         + lp+ ++kdf++++++as+ a++Llek+Lvld d+R++++eaL+hpY+

Q: 262   QGLPECERKDFASVVTNASPLAVNLLEKMLVLDGDQRVTAAEALAHPYF  310

         ************************************************6

Domain Sequence
(FASTA)

YHDLQPVGSG AYGAVCSAVD SRTGAKVAIK KLYRPFQSEL FAKRAYRELR LLQHMRHENV 60

IGLLDVFTPD ETLDDFTDFY LVMPFMGTDL GKLMKHEKLS EDRIQFLVYQ MLKGLKYIHA 120

AGVIHRDLKP GNLAVNEDCE LKILDFGLAR QADSEMTGYV VTRWYRAPEV ILNWMHYTQT 180

VDIWSVGCIM AEMITGKTLF KGSDHLDQLK EIMKVTGTPP ADFVQKLRSA DAKQYMQGLP 240

ECERKDFASV VTNASPLAVN LLEKMLVLDG DQRVTAAEAL AHPYF 285

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Phosphoprotein; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0000287	; F:magnesium ion binding
GO:0004707	; F:MAP kinase activity
GO:0000165	; P:MAPK cascade
GO:0045445	; P:myoblast differentiation
GO:0018105	; P:peptidyl-serine phosphorylation

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR003527	; MAP_kinase_CS.
IPR008352	; MAPK_p38.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS01351	; MAPK; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.

Prints

PR01773

; P38MAPKINASE.

Created Date

20-Feb-2013