EKS-ORC-00203

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ORC-00203

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
STE/STE7	387.1	4.8E-116	53	314	262

Status

Unreviewed

Ensembl Protein

ENSOCUP00000006577

UniProt Accession

G1STE8;

Protein Name

Protein Synonyms/Alias

Gene Name

MAP2K6

Gene Synonyms/Alias

MAP2K6;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSOCUG00000007606	ENSOCUP00000006577	ENSOCUT00000007607

Organism

Oryctolagus cuniculus

Functional Description

Protein Length

334

Protein Sequence
(FASTA)

MSQSKGKKRN PGLKIPKEAF EQPQTSSTPP RDLDSKACIS IGNQNFEVKA DDLEPIMELG 60

RGAYGVVEKM RHVPSGQIMA VKRIRATVNS QEQKRLLMDL DISMRTVDCP FTVTFYGALF 120

REGDVWICME LMDTSLDKFY KQVIDKGQTI PEDILGKIAV SIVKALEHLH SKLSVIHRDV 180

KPSNVLINTL GQVKMCDFGI SGYLVDSVAK TIDAGCKPYM APERINPELN QKGYSVKSDI 240

WSLGITMIEL AILRFPYDSW GTPFQQLKQV VEEPSPQLPA DKFSAEFVDF TSQCLKKNSK 300

ERPTYPELMQ HPFFTVHESK ATDVASFVKL ILGD 334

Nucleotide Sequence
(FASTA)

ATGTCTCAGT CGAAAGGCAA AAAACGAAAC CCTGGCCTTA AAATTCCAAA AGAAGCATTT 60

GAACAACCTC AGACCAGTTC CACGCCACCT CGAGATTTAG ACTCCAAGGC TTGCATTTCT 120

ATTGGAAATC AGAACTTTGA GGTTAAGGCA GATGACCTGG AACCTATAAT GGAACTGGGA 180

CGAGGTGCGT ACGGGGTGGT GGAGAAGATG CGGCACGTGC CCAGCGGGCA GATCATGGCG 240

GTGAAGCGGA TCCGGGCCAC AGTAAATAGC CAGGAGCAGA AAAGGCTATT GATGGATTTG 300

GATATTTCCA TGAGGACAGT GGACTGTCCC TTTACTGTCA CCTTTTATGG CGCCCTCTTC 360

CGGGAGGGTG ATGTCTGGAT CTGCATGGAG CTCATGGATA CATCACTAGA TAAATTCTAC 420

AAACAAGTCA TTGATAAAGG CCAAACAATT CCAGAGGACA TCTTAGGGAA AATAGCTGTT 480

TCTATTGTAA AAGCATTAGA ACATTTACAC AGTAAGCTCT CTGTCATTCA TCGAGACGTC 540

AAGCCTTCTA ATGTGCTGAT TAATACCCTG GGCCAAGTGA AGATGTGTGA CTTTGGAATC 600

AGTGGCTACC TGGTGGATTC AGTTGCTAAA ACAATTGATG CGGGTTGCAA ACCATACATG 660

GCCCCTGAAA GAATAAACCC AGAGCTCAAC CAGAAGGGAT ACAGTGTGAA GTCTGACATT 720

TGGAGTCTGG GCATCACCAT GATTGAGTTG GCCATCCTCC GGTTTCCCTA TGATTCTTGG 780

GGCACTCCCT TCCAGCAACT CAAACAGGTG GTAGAAGAGC CATCGCCACA ACTCCCAGCA 840

GACAAGTTCT CTGCAGAATT TGTTGACTTT ACCTCACAGT GCTTGAAGAA GAATTCCAAA 900

GAAAGGCCTA CATATCCAGA GCTTATGCAA CATCCATTCT TCACTGTACA TGAATCCAAA 960

GCAACAGATG TGGCATCTTT TGTAAAATTG ATTCTTGGAG AC 1002

Domain Profile

S: 1     lekleelGaGnggvVekvlhkksgkilavKtirleikkeeqkqilrelevlkkssnspyi  60

         le + elG+G++gvVek++h +sg+i+avK+ir++++++eqk++l++l++ +++ ++p++

Q: 53    LEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRTVDCPFT  112

         57789*******************************************************

S: 61    vkfyGafvsegdvsicmelmdgtsldkvlkkvlekkkripekvlgkiavavvkaleylke  120

         v+fyGa+++egdv+icmelmd tsldk++k+v++k ++ipe++lgkiav++vkale+l++

Q: 113   VTFYGALFREGDVWICMELMD-TSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHS  171

         *********************.**************************************

S: 121   klkiiHRDvKPsNiLvnskGevKlCDFGvsgqlvdsiAksa.vGtksYmaPErieg...k  176

         kl++iHRDvKPsN+L+n+ G+vK+CDFG+sg+lvds+Ak++ +G+k+YmaPEri++   +

Q: 172   KLSVIHRDVKPSNVLINTLGQVKMCDFGISGYLVDSVAKTIdAGCKPYMAPERINPelnQ  231

         ********************************************************9999

S: 177   kkYsvksdvWslGltlvelatgrypyeklkeilellkaivneeppklpeeefseefqefv  236

         k Ysvksd+WslG+t++ela+ r+py+++ +++++lk++v+e++p+lp+++fs ef++f

Q: 232   KGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQLPADKFSAEFVDFT  291

         9***********************************************************

S: 237   skClkkdekeRpklkellkhafi  259

         s+Clkk++keRp++ el++h+f+

Q: 292   SQCLKKNSKERPTYPELMQHPFF  314

         *********************96

Domain Sequence
(FASTA)

LEPIMELGRG AYGVVEKMRH VPSGQIMAVK RIRATVNSQE QKRLLMDLDI SMRTVDCPFT 60

VTFYGALFRE GDVWICMELM DTSLDKFYKQ VIDKGQTIPE DILGKIAVSI VKALEHLHSK 120

LSVIHRDVKP SNVLINTLGQ VKMCDFGISG YLVDSVAKTI DAGCKPYMAP ERINPELNQK 180

GYSVKSDIWS LGITMIELAI LRFPYDSWGT PFQQLKQVVE EPSPQLPADK FSAEFVDFTS 240

QCLKKNSKER PTYPELMQHP FF 262

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0000187	; P:activation of MAPK activity
GO:0060048	; P:cardiac muscle contraction
GO:0000165	; P:MAPK cascade

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013