EKS-ORC-00100
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-ORC-00100
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Tec482.43.1E-145271521251
StatusUnreviewed
Ensembl ProteinENSOCUP00000006616
UniProt AccessionG1STH8;
Protein Name
Protein Synonyms/Alias
Gene NameTXK
Gene Synonyms/Alias TXK;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSOCUG00000007648ENSOCUP00000006616ENSOCUT00000007648
OrganismOryctolagus cuniculus
Functional Description
Protein Length527
Protein Sequence
(FASTA)
MICFSDNSIQ SIFCCCCCCS VQKRQVRTQI SLSKDEDLSE KYAPHRRPWL SEWSRKHQSS 60
RDRTQPSKRK PLPPLPPSEL AEERIRVKAL YDFLPREPCN LALKRAHEYL ILEKYDRHWW 120
KARDSLGNEG FIPSNYVTEN KPTNLEIYEW YHRNITRNQA ERLLRQESKE GTFIVRDSRH 180
LGSYTISVFI KARRSTEAMI KHYQIKRNDS GQWYVAERHL FPSIPELIRY HQHNAAGLMT 240
RLRSPVGLMD NCLPATAGFS YEKWEIDPSE LAFVKKIGSG QFGVVHLGKW RAHIQVAIKA 300
INEGSMSEED FIEEAKVMTK LSHSRLVQLY GVCTQQKPLY IVTEFMENGC LLNYLRERKG 360
KLRKEMLLSV CQDVCEGMEY LEKNCYIHRD LAARNCLVSS TCIVKISDFG MTRYVLDDEY 420
ISSSGAKFPI KWSPPEVFHF NKYSSKSDVW SFGVLMWEVF TEGKMPFENK SNLQVVEAIS 480
KGFRLYRPYL APVSVYEVMY SCWHEKPEGR PTFAELLQVL TEMAETW 527
Nucleotide Sequence
(FASTA)
ATGATCTGTT TTTCAGATAA TTCCATCCAG TCCATTTTCT GTTGCTGCTG TTGCTGTTCC 60
GTGCAGAAAC GTCAAGTGCG AACACAAATC AGCTTGAGCA AAGATGAAGA CCTTTCAGAA 120
AAGTACGCTC CGCACCGCAG GCCCTGGCTC AGCGAGTGGT CAAGGAAGCA TCAATCCAGC 180
AGGGACCGGA CCCAGCCATC CAAGCGCAAG CCGCTTCCTC CGCTGCCACC CTCTGAGCTT 240
GCTGAGGAGC GGATCCGAGT CAAGGCACTT TACGATTTTC TGCCCAGAGA GCCTTGTAAC 300
CTGGCATTGA AGAGAGCACA CGAATACCTG ATCCTGGAGA AGTACGACCG TCACTGGTGG 360
AAAGCGAGGG ACTCTTTAGG GAACGAAGGC TTTATCCCTA GCAACTACGT GACTGAAAAC 420
AAACCAACCA ACTTAGAAAT CTATGAGTGG TACCATAGAA ACATTACCAG AAACCAAGCA 480
GAGCGCCTGC TGAGACAAGA GTCTAAAGAA GGTACATTTA TTGTCAGAGA CTCAAGACAT 540
TTGGGATCCT ACACAATTTC CGTGTTTATA AAAGCCAGGA GAAGCACGGA GGCTATGATA 600
AAACATTATC AGATCAAAAG GAATGACTCG GGACAGTGGT ACGTGGCTGA AAGACACCTC 660
TTCCCATCCA TTCCCGAGTT GATCCGGTAC CACCAGCACA ACGCGGCGGG TCTCATGACC 720
CGTCTCCGCT CCCCAGTTGG TCTGATGGAC AACTGTTTAC CGGCCACAGC TGGCTTTAGC 780
TATGAAAAGT GGGAGATAGA TCCATCTGAA TTGGCTTTCG TCAAAAAGAT TGGAAGCGGT 840
CAGTTCGGGG TAGTCCATCT AGGTAAATGG CGAGCACACA TCCAGGTGGC CATCAAAGCT 900
ATCAACGAAG GCTCCATGTC TGAAGAGGAT TTCATCGAAG AGGCAAAAGT GATGACGAAA 960
TTATCACACT CAAGGCTCGT TCAGCTTTAT GGGGTGTGTA CACAGCAGAA GCCCCTCTAC 1020
ATTGTGACAG AGTTCATGGA AAATGGCTGC CTGCTTAACT ACCTGAGGGA GAGAAAAGGA 1080
AAACTTCGGA AGGAAATGCT ACTGAGCGTG TGCCAGGATG TATGTGAGGG GATGGAATAT 1140
CTGGAGAAAA ACTGCTATAT TCACAGGGAT TTAGCGGCAA GAAATTGTCT GGTCAGCTCT 1200
ACCTGTATTG TGAAGATCTC AGACTTTGGG ATGACAAGGT ACGTTTTGGA CGACGAATAT 1260
ATCAGTTCTT CTGGAGCCAA GTTCCCAATC AAGTGGTCCC CCCCTGAAGT TTTTCATTTC 1320
AACAAGTACA GCAGTAAATC TGACGTCTGG TCATTTGGAG TTTTAATGTG GGAAGTTTTC 1380
ACTGAAGGGA AGATGCCTTT TGAAAATAAA TCAAATTTGC AAGTCGTGGA AGCCATTTCT 1440
AAAGGCTTCA GGCTGTATCG CCCCTACTTG GCACCGGTGT CTGTATATGA AGTCATGTAC 1500
AGCTGTTGGC ATGAGAAACC CGAAGGCCGT CCTACGTTTG CTGAACTGCT GCAGGTCCTC 1560
ACAGAGATGG CCGAAACCTG GTGA 1584
Domain Profile
S: 1     ltllkelgsgqfgvvklgkwrakidvaikaikegamseedfieeakvmmklshpklvqly  60
         l+++k++gsgqfgvv+lgkwra+i+vaikai+eg+mseedfieeakvm+klsh++lvqly
Q: 271   LAFVKKIGSGQFGVVHLGKWRAHIQVAIKAINEGSMSEEDFIEEAKVMTKLSHSRLVQLY  330
         68**********************************************************
S: 61    gvclkqkpiyivteylengcllnylrekkkklekelllemckdvcegmeylerksfihrd  120
         gvc++qkp+yivte++engcllnylre+k+kl+ke+ll++c+dvcegmeyle++++ihrd
Q: 331   GVCTQQKPLYIVTEFMENGCLLNYLRERKGKLRKEMLLSVCQDVCEGMEYLEKNCYIHRD  390
         ************************************************************
S: 121   laarnclvdeelvvkvsdfglaryvlddqyvssvgakfpvkwsppevlsyskyssksdvw  180
         laarnclv+++++vk+sdfg++ryvldd+y+ss+gakfp+kwsppev++++kyssksdvw
Q: 391   LAARNCLVSSTCIVKISDFGMTRYVLDDEYISSSGAKFPIKWSPPEVFHFNKYSSKSDVW  450
         ************************************************************
S: 181   afgvlmwevfsegklpyekksnsevvekvsrglrlyrpklaskkvyevmkscwkekpeer  240
         +fgvlmwevf+egk+p+e+ksn +vve++s+g+rlyrp la+ +vyevm+scw+ekpe+r
Q: 451   SFGVLMWEVFTEGKMPFENKSNLQVVEAISKGFRLYRPYLAPVSVYEVMYSCWHEKPEGR  510
         ************************************************************
S: 241   ptfkellsale  251
         ptf+ell+ l+
Q: 511   PTFAELLQVLT  521
         *******9986
Domain Sequence
(FASTA)
LAFVKKIGSG QFGVVHLGKW RAHIQVAIKA INEGSMSEED FIEEAKVMTK LSHSRLVQLY 60
GVCTQQKPLY IVTEFMENGC LLNYLRERKG KLRKEMLLSV CQDVCEGMEY LEKNCYIHRD 120
LAARNCLVSS TCIVKISDFG MTRYVLDDEY ISSSGAKFPI KWSPPEVFHF NKYSSKSDVW 180
SFGVLMWEVF TEGKMPFENK SNLQVVEAIS KGFRLYRPYL APVSVYEVMY SCWHEKPEGR 240
PTFAELLQVL T 251
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; SH3 domain; Transferase; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Tursiops truncatus"; ?>
EKS-AIM-00100
EKS-BOT-00109
EKS-CAJ-00110
EKS-CAF-00110
EKS-CAP-00106
EKS-EQC-00106
EKS-ERE-00053
EKS-FEC-00104
EKS-GAG-00089
EKS-GOG-00109
EKS-HOS-00111
EKS-LAC-00111
EKS-LOA-00104
EKS-MAM-00104
EKS-MEG-00084
EKS-MIM-00047
EKS-MOD-00108
EKS-MUM-00110
EKS-MUP-00112
EKS-MYL-00122
EKS-NOL-00101
EKS-OTG-00110
EKS-PAT-00099
EKS-PES-00091
EKS-POA-00101
EKS-RAN-00106
EKS-SAH-00103
EKS-SUS-00096
EKS-TUT-00096
Gene Ontology
GO:0005737; C:cytoplasm
GO:0005634; C:nucleus
GO:0005524; F:ATP binding
GO:0004713; F:protein tyrosine kinase activity
GO:0001012; F:RNA polymerase II regulatory region DNA binding
GO:0007202; P:activation of phospholipase C activity
GO:0002250; P:adaptive immune response
GO:0032609; P:interferon-gamma production
GO:0032633; P:interleukin-4 production
GO:0001865; P:NK T cell differentiation
GO:0032729; P:positive regulation of interferon-gamma production
GO:0060335; P:positive regulation of interferon-gamma-mediated signaling pathway
GO:0046777; P:protein autophosphorylation
GO:0006357; P:regulation of transcription from RNA polymerase II promoter
GO:0050852; P:T cell receptor signaling pathway
KEGG
InterPros
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980; SH2.
IPR001452; SH3_domain.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
Pfam
PF07714; Pkinase_Tyr; 1.
PF00017; SH2; 1.
PF00018; SH3_1; 1.
SMARTs
SM00252; SH2; 1.
SM00326; SH3; 1.
SM00219; TyrKc; 1.
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS50001; SH2; 1.
PS50002; SH3; 1.
Prints
PR00401; SH2DOMAIN.
PR00109; TYRKINASE.
Created Date20-Feb-2013