EKS-ORC-00098

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ORC-00098

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Tec	489.6	1.8E-147	370	620	251

Status

Unreviewed

Ensembl Protein

ENSOCUP00000006624

UniProt Accession

G1STI6;

Protein Name

Protein Synonyms/Alias

Gene Name

TEC

Gene Synonyms/Alias

TEC;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSOCUG00000007656	ENSOCUP00000006624	ENSOCUT00000007657

Organism

Oryctolagus cuniculus

Functional Description

Protein Length

631

Protein Sequence
(FASTA)

MNFNTILEEI LIKRSQQKKK TSPLNYKERL FVLTKSMLTY YEGRAEKKYR KGFIDISKIK 60

CVEIVKNDDA VIPCQNKYPF QVVHDANTLY IFAPSAHSRD QWVKKLKEEI KNNNNIMIKY 120

HPKFWADGSY QCCRQTEKLA PGCEKYNLFE SSIRKALPPA PETKKRRPPP PVPPEEEDNG 180

EEIVVAMYDF YATEAHDLRL ERGQEYIILE KNDVHWWRAR DKYGSEGYIP SNYVTGKKSN 240

NLDQYEWYCR NMNRSKAEQL LRSEDKEGGF MVRDSSQPGL YTVSLYTKFG GESSSGFRHY 300

HIKETTTSPK KYYLAEKHAF ASIPEIIEYH KHNAAGLVTR LRYPVSTKGK NAPTTAGFSY 360

EKWEINPSEL TFMRELGSGL FGVVRLGKWR AQYKVAIKAI REGAMCEEDF IEEAKVMMKL 420

THPKLVQLYG VCTQQKPIYI VTEFMERGCL LNFLRQRQGH FSRDALLSMC QDVCEGMEYL 480

ERNSFIHRDL AARNCLVNDA GVVKVSDFGM ARYVLDDQYT SSSGAKFPVK WCPPEVFNYS 540

RFSSKSDVWS FGVLMWEVFT EGRMPFEKNT NYEVVTMVTR GHRLFRPKLA SKYIYDMMLR 600

CWQEKPEGRP SFEELLRAID ELVECEESFG R 631

Nucleotide Sequence
(FASTA)

ATGAATTTTA ACACTATTCT AGAAGAGATT CTTATTAAAA GATCACAGCA GAAAAAGAAG 60

ACGTCACCCC TAAACTACAA AGAGAGGCTT TTCGTACTGA CAAAGTCCAT GTTAACCTAC 120

TACGAAGGTC GAGCAGAGAA AAAATACAGA AAAGGATTTA TTGATATTTC CAAAATCAAA 180

TGTGTGGAAA TAGTGAAGAA TGATGACGCT GTCATTCCCT GTCAAAATAA GTATCCATTT 240

CAGGTTGTCC ACGATGCAAA TACACTTTAC ATTTTTGCAC CTAGTGCCCA TAGCAGGGAC 300

CAGTGGGTGA AGAAATTAAA AGAAGAAATA AAGAACAACA ATAATATTAT GATTAAATAT 360

CATCCTAAAT TCTGGGCAGA CGGAAGCTAT CAGTGTTGCA GACAAACTGA AAAACTAGCT 420

CCTGGATGTG AAAAATACAA CCTTTTTGAA AGTAGTATAA GAAAAGCACT ACCTCCAGCA 480

CCAGAAACAA AGAAGCGGAG GCCTCCCCCA CCAGTTCCGC CTGAAGAAGA AGATAACGGA 540

GAGGAAATCG TTGTGGCGAT GTATGATTTC TATGCGACGG AAGCACATGA TCTGCGCCTA 600

GAGAGAGGCC AGGAGTACAT CATCCTAGAG AAGAACGATG TTCATTGGTG GAGAGCGAGA 660

GATAAATACG GGAGTGAAGG ATATATCCCA AGTAATTATG TAACAGGAAA GAAATCAAAC 720

AATTTAGATC AATATGAATG GTACTGCAGA AATATGAACA GGAGCAAGGC AGAGCAACTC 780

CTCAGAAGTG AAGATAAAGA AGGTGGTTTT ATGGTAAGGG ACTCCAGTCA ACCAGGCTTA 840

TACACAGTGT CCCTTTATAC GAAGTTTGGC GGAGAAAGTT CATCAGGTTT CAGGCATTAT 900

CATATAAAGG AAACAACAAC GTCTCCAAAG AAGTATTACC TAGCAGAAAA GCATGCTTTT 960

GCTTCAATTC CTGAGATTAT TGAATATCAT AAGCACAATG CAGCAGGACT CGTCACCAGG 1020

CTGCGATACC CAGTTAGTAC CAAGGGGAAG AATGCACCAA CCACTGCAGG ATTCAGCTAC 1080

GAGAAGTGGG AGATTAACCC TTCAGAGCTG ACCTTCATGC GGGAGCTGGG CAGCGGGCTC 1140

TTCGGAGTGG TGAGGCTTGG CAAGTGGCGA GCCCAGTACA AAGTAGCCAT CAAAGCTATT 1200

AGGGAGGGCG CCATGTGTGA GGAGGACTTC ATAGAAGAAG CTAAAGTGAT GATGAAACTG 1260

ACACACCCGA AGTTAGTCCA GCTTTACGGC GTTTGCACCC AGCAGAAACC CATCTACATC 1320

GTCACCGAGT TCATGGAGCG CGGCTGCCTT CTGAATTTCC TCCGGCAGAG ACAAGGTCAC 1380

TTCAGCAGAG ATGCGCTGCT GAGCATGTGT CAGGACGTGT GTGAAGGCAT GGAGTACCTG 1440

GAGAGAAACA GCTTCATCCA CCGAGACCTG GCTGCCAGGA ATTGTCTAGT GAATGATGCG 1500

GGAGTTGTGA AAGTATCGGA TTTTGGAATG GCCAGGTATG TTCTGGACGA TCAGTACACA 1560

AGTTCTTCCG GTGCCAAGTT TCCTGTGAAG TGGTGTCCAC CTGAAGTGTT TAATTATAGC 1620

CGCTTCAGCA GCAAATCGGA CGTTTGGTCC TTTGGTGTGT TAATGTGGGA AGTGTTCACC 1680

GAAGGCAGGA TGCCCTTTGA AAAAAACACC AATTATGAAG TGGTAACCAT GGTTACCCGC 1740

GGCCACCGAC TCTTCCGGCC AAAGCTGGCA TCCAAATACA TCTATGACAT GATGCTAAGA 1800

TGTTGGCAGG AGAAACCAGA AGGAAGGCCT TCCTTTGAAG AGCTGCTGCG TGCCATAGAC 1860

GAACTAGTTG AATGTGAAGA AAGCTTTGGA AGA 1893

Domain Profile

S: 1     ltllkelgsgqfgvvklgkwrakidvaikaikegamseedfieeakvmmklshpklvqly  60

         lt+++elgsg fgvv+lgkwra+++vaikai+egam+eedfieeakvmmkl+hpklvqly

Q: 370   LTFMRELGSGLFGVVRLGKWRAQYKVAIKAIREGAMCEEDFIEEAKVMMKLTHPKLVQLY  429

         79**********************************************************

S: 61    gvclkqkpiyivteylengcllnylrekkkklekelllemckdvcegmeylerksfihrd  120

         gvc++qkpiyivte++e+gclln+lr+++++++++ ll+mc+dvcegmeyler+sfihrd

Q: 430   GVCTQQKPIYIVTEFMERGCLLNFLRQRQGHFSRDALLSMCQDVCEGMEYLERNSFIHRD  489

         ************************************************************

S: 121   laarnclvdeelvvkvsdfglaryvlddqyvssvgakfpvkwsppevlsyskyssksdvw  180

         laarnclv+++ vvkvsdfg+aryvlddqy+ss+gakfpvkw+ppev++ys++ssksdvw

Q: 490   LAARNCLVNDAGVVKVSDFGMARYVLDDQYTSSSGAKFPVKWCPPEVFNYSRFSSKSDVW  549

         ************************************************************

S: 181   afgvlmwevfsegklpyekksnsevvekvsrglrlyrpklaskkvyevmkscwkekpeer  240

         +fgvlmwevf+eg++p+ek++n+evv++v+rg+rl+rpklask++y++m +cw+ekpe+r

Q: 550   SFGVLMWEVFTEGRMPFEKNTNYEVVTMVTRGHRLFRPKLASKYIYDMMLRCWQEKPEGR  609

         ************************************************************

S: 241   ptfkellsale  251

         p+f+ell+a+

Q: 610   PSFEELLRAID  620

         ********985

Domain Sequence
(FASTA)

LTFMRELGSG LFGVVRLGKW RAQYKVAIKA IREGAMCEED FIEEAKVMMK LTHPKLVQLY 60

GVCTQQKPIY IVTEFMERGC LLNFLRQRQG HFSRDALLSM CQDVCEGMEY LERNSFIHRD 120

LAARNCLVND AGVVKVSDFG MARYVLDDQY TSSSGAKFPV KWCPPEVFNY SRFSSKSDVW 180

SFGVLMWEVF TEGRMPFEKN TNYEVVTMVT RGHRLFRPKL ASKYIYDMML RCWQEKPEGR 240

PSFEELLRAI D 251

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; SH3 domain; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dasypus novemcinctus"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005737	; C:cytoplasm
GO:0005856	; C:cytoskeleton
GO:0005524	; F:ATP binding
GO:0004715	; F:non-membrane spanning protein tyrosine kinase activity
GO:0005543	; F:phospholipid binding
GO:0050853	; P:B cell receptor signaling pathway
GO:0007229	; P:integrin-mediated signaling pathway
GO:0035556	; P:intracellular signal transduction
GO:0010543	; P:regulation of platelet activation

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR011993	; PH_like_dom.
IPR001849	; Pleckstrin_homology.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980	; SH2.
IPR001452	; SH3_domain.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.
IPR001562	; Znf_Btk_motif.

Pfam

PF00779	; BTK; 1.
PF00169	; PH; 1.
PF07714	; Pkinase_Tyr; 1.
PF00017	; SH2; 1.
PF00018	; SH3_1; 1.

SMARTs

SM00107	; BTK; 1.
SM00233	; PH; 1.
SM00252	; SH2; 1.
SM00326	; SH3; 1.
SM00219	; TyrKc; 1.

Prosites

PS50003	; PH_DOMAIN; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS50001	; SH2; 1.
PS50002	; SH3; 1.
PS51113	; ZF_BTK; 1.

Prints

PR00401	; SH2DOMAIN.
PR00452	; SH3DOMAIN.
PR00402	; TECBTKDOMAIN.
PR00109	; TYRKINASE.

Created Date

20-Feb-2013