EKS-ORC-00443

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ORC-00443

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/MAPK	374.8	2.9E-112	141	427	287

Status

Unreviewed

Ensembl Protein

ENSOCUP00000006705

UniProt Accession

G1STQ5;

Protein Name

Protein Synonyms/Alias

Gene Name

NLK

Gene Synonyms/Alias

NLK;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSOCUG00000007764	ENSOCUP00000006705	ENSOCUT00000007762

Organism

Oryctolagus cuniculus

Functional Description

Protein Length

527

Protein Sequence
(FASTA)

MSLCGARANA KMMAAYNGGT SAAAAGHHHH HHHHLPHLPP PHLHHHHHPQ HHLHPGSAAA 60

VHPVQQHTSS AAAAAAAAAA AAAMLNPGQQ QPYFPSPAPG QAPGPAAAAP AQVQAAAAAT 120

VKAHHHQHSH HPQQQLDIEP DRPIGYGAFG VVWSVTDPRD GKRVALKKMP NVFQNLVSCK 180

RVFRELKMLC FFKHDNVLSA LDILQPPHID YFEEIYVVTE LMQSDLHKII VSPQPLSSDH 240

VKVFLYQILR GLKYLHSAGI LHRDIKPGNL LVNSNCVLKI CDFGLARVEE LDESRHMTQE 300

VVTQYYRAPE ILMGSRHYSN AIDIWSVGCI FAELLGRRIL FQAQSPIQQL DLITDLLGTP 360

SLEAMRTACE GAKAHILRGP HKQPSLPVLY TLSSQATHEA VHLLCRMLVF DPSKRISAKD 420

ALAHPYLDEG RLRYHTCMCK CCFSTSTGRV YTSDFEPITN PKFDDTFEKN LSSVRQVKEI 480

IHQFILEQQK GNRVPLCINP QSAAFKSFIS STVAQPSEMP PSPLVWE 527

Nucleotide Sequence
(FASTA)

ATGTCTCTTT GTGGCGCAAG AGCCAACGCA AAAATGATGG CGGCTTACAA TGGCGGTACA 60

TCTGCAGCAG CAGCAGGTCA CCACCACCAC CATCACCACC ACCTTCCACA CCTTCCTCCT 120

CCTCACCTTC ACCACCACCA CCACCCTCAG CACCATCTTC ATCCGGGGTC GGCCGCTGCT 180

GTCCACCCTG TGCAGCAGCA TACCTCTTCG GCAGCTGCGG CAGCCGCAGC AGCGGCCGCA 240

GCCGCAGCCA TGTTAAACCC TGGGCAACAA CAGCCATATT TCCCATCACC GGCACCGGGA 300

CAGGCTCCTG GACCGGCCGC AGCAGCCCCA GCTCAGGTAC AGGCTGCTGC AGCTGCCACC 360

GTGAAGGCGC ACCATCATCA GCACTCGCAT CACCCGCAAC AGCAGCTGGA CATTGAGCCG 420

GATAGACCCA TTGGATATGG AGCCTTTGGC GTTGTCTGGT CAGTAACAGA TCCAAGAGAT 480

GGAAAGAGAG TAGCACTCAA GAAGATGCCC AACGTCTTCC AGAATCTGGT CTCTTGCAAA 540

AGAGTCTTCC GGGAATTGAA GATGTTGTGT TTTTTTAAAC ATGATAATGT ACTCTCTGCC 600

CTTGACATAC TCCAACCTCC ACACATTGAC TATTTTGAAG AAATATACGT TGTCACAGAA 660

TTGATGCAGA GTGACCTACA TAAAATTATT GTGTCTCCTC AACCACTCAG CTCAGATCAT 720

GTCAAAGTTT TTCTTTATCA GATTTTGCGA GGTTTGAAAT ATCTCCATTC AGCTGGCATT 780

TTACATCGAG ACATTAAGCC AGGGAATCTG CTTGTGAACA GCAACTGTGT TCTAAAGATT 840

TGTGATTTTG GATTGGCCAG AGTTGAAGAA TTGGATGAAT CCCGTCATAT GACTCAGGAA 900

GTTGTTACTC AGTATTATCG GGCTCCGGAA ATCCTGATGG GCAGCCGTCA TTACAGCAAT 960

GCTATTGACA TCTGGTCTGT CGGATGTATC TTTGCAGAAC TACTAGGACG AAGAATATTG 1020

TTTCAGGCAC AGAGTCCCAT TCAGCAGTTG GATTTGATCA CAGATCTGTT GGGCACACCA 1080

TCACTGGAAG CAATGAGGAC GGCTTGTGAA GGCGCTAAGG CACACATACT CAGGGGTCCT 1140

CATAAACAGC CATCTCTTCC TGTACTCTAT ACCCTGTCTA GCCAGGCTAC ACATGAAGCT 1200

GTTCATCTCC TTTGCAGGAT GTTGGTCTTT GATCCATCTA AAAGAATATC CGCTAAGGAT 1260

GCCTTAGCCC ACCCCTACTT AGATGAAGGG CGACTACGAT ACCACACGTG TATGTGTAAA 1320

TGTTGCTTTT CCACCTCCAC TGGAAGAGTT TATACCAGTG ACTTTGAGCC CATCACCAAT 1380

CCCAAATTTG ATGACACTTT TGAGAAGAAC CTCAGTTCTG TCAGACAGGT TAAAGAAATT 1440

ATCCACCAGT TTATTTTGGA ACAGCAGAAA GGAAACAGAG TGCCTCTCTG CATCAACCCT 1500

CAGTCTGCTG CTTTTAAGAG CTTTATTAGT TCCACTGTTG CTCAGCCGTC TGAGATGCCC 1560

CCATCTCCTC TGGTGTGGGA G 1581

Domain Profile

S: 4     lkplgeGaygvvvsavdkrteervaikklsrpfqketsakrtlRElkllkelkheNiikl  63

          +p+g Ga+gvv+s++d r+++rva+kk+ ++fq+ +s+kr++RElk+l  +kh+N+++

Q: 141   DRPIGYGAFGVVWSVTDPRDGKRVALKKMPNVFQNLVSCKRVFRELKMLCFFKHDNVLSA  200

         689*********************************************************

S: 64    ldvftpeeeleelkdvYlvtelmetdLkkviksq.klsdehiklllyqilrglkylHsan  122

         ld+++p + ++ ++++Y+vtelm++dL+k+i s   ls++h+k++lyqilrglkylHsa+

Q: 201   LDILQPPH-IDYFEEIYVVTELMQSDLHKIIVSPqPLSSDHVKVFLYQILRGLKYLHSAG  259

         *******9.**********************99879************************

S: 123   viHrDlKPsNllvnedcelkildFGlarsadkekekklteyvatrwYraPeillslkeyt  182

         ++HrD+KP+Nllvn++c lki+dFGlar+++ ++++++t++v+t++YraPeil+ +++y+

Q: 260   ILHRDIKPGNLLVNSNCVLKICDFGLARVEELDESRHMTQEVVTQYYRAPEILMGSRHYS  319

         *********************************999************************

S: 183   kavDiWsvGCIlaElltgkplfpgkdeidqlekilevlgtpseeflkkieseearnyiks  242

         +a+DiWsvGCI+aEll +++lf++++ i+ql++i+++lgtps e +++ ++  a+++i +

Q: 320   NAIDIWSVGCIFAELLGRRILFQAQSPIQQLDLITDLLGTPSLEAMRTACEG-AKAHILR  378

         ************************************************9996.7777777

S: 243   lpkkkkk..dfeelfpkaseealdLleklLvldpdkRisveeaLehpYl  289

          p+k+     + +l ++a++ea++Ll ++Lv+dp+kRis+++aL+hpYl

Q: 379   GPHKQPSlpVLYTLSSQATHEAVHLLCRMLVFDPSKRISAKDALAHPYL  427

         77666644457788888*******************************7

Domain Sequence
(FASTA)

DRPIGYGAFG VVWSVTDPRD GKRVALKKMP NVFQNLVSCK RVFRELKMLC FFKHDNVLSA 60

LDILQPPHID YFEEIYVVTE LMQSDLHKII VSPQPLSSDH VKVFLYQILR GLKYLHSAGI 120

LHRDIKPGNL LVNSNCVLKI CDFGLARVEE LDESRHMTQE VVTQYYRAPE ILMGSRHYSN 180

AIDIWSVGCI FAELLGRRIL FQAQSPIQQL DLITDLLGTP SLEAMRTACE GAKAHILRGP 240

HKQPSLPVLY TLSSQATHEA VHLLCRMLVF DPSKRISAKD ALAHPYL 287

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005634	; C:nucleus
GO:0005524	; F:ATP binding
GO:0000287	; F:magnesium ion binding
GO:0004707	; F:MAP kinase activity
GO:0030178	; P:negative regulation of Wnt receptor signaling pathway
GO:0018107	; P:peptidyl-threonine phosphorylation
GO:0046777	; P:protein autophosphorylation
GO:0006355	; P:regulation of transcription, DNA-dependent
GO:0033136	; P:serine phosphorylation of STAT3 protein
GO:0007179	; P:transforming growth factor beta receptor signaling pathway

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR003527	; MAP_kinase_CS.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS01351	; MAPK; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013