EKS-ORC-00114

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ORC-00114

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/LRRK	369.9	7.5E-111	1882	2129	248

Status

Unreviewed

Ensembl Protein

ENSOCUP00000006801

UniProt Accession

G1STZ5;

Protein Name

Protein Synonyms/Alias

Gene Name

LRRK2

Gene Synonyms/Alias

LRRK2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSOCUG00000007857	ENSOCUP00000006801	ENSOCUT00000007867

Organism

Oryctolagus cuniculus

Functional Description

Protein Length

2527

Protein Sequence
(FASTA)

MASGGGSNQG SDEDEESLKK LLVKLNNVQE GKQVETLVQT LEDLLVFTYS ERASRLFRGK 60

SFHVPLLIVL DSYMRVASVQ QVGWSLLCKL IEVCPDTMQS LMGPQDVGSD WEVLGVHQLI 120

LRMLSVHSAS VNLLTVGLKA LDLLLTSGKI TLLILEEESD IFLLIFDAMR TFPANDEIQK 180

LGCKALHVLF ERVSEEQLTE FVENKDYMIL LSALKNFKDE EEIVLHVLHC LHSLAIPCNN 240

VEVLMSGNVR CYNIVVEAMK AFPVSEKIQE VSCCLLHRLT LGNFFNILVL NEVHAFVVRA 300

VRRYPENAAL QISALGCLAL LTETIFLNQD LEEKSEAQSD KLFWLEACYK ALTGHRKNRH 360

VQEAACWSLN NLLMYHSSLH ERIGDEDGQL PAHREVMLSM LMHSSSKEVF QASANALSTL 420

LEQNVNFRKI LLSKGIYLNV LELMQRHAHS PEVAESGCKM LNHLFEGSHI SLDTVAAVVP 480

KIITVMRSHE ASLSVQLEAL RAILHFMMPG MPEESREETE SQRNLNVVRK QCFRSDIHKL 540

VLAALNRFVG NPGIQKCGLK VMASITQVPD ALEVLSLEGA VDSVLHTLHM YPDDQEIQCL 600

GLSLVGRLIA KKNLCTGTGH LLAKILVSSL QRFKDAAEVQ LEGFRTVLAI LELSVSFSKL 660

LVHHSFDSVI FHQMSSSITE QKDQQFLSLC CKCFAKLAME DELKNAMLQR ACDQNNSIMV 720

ECLLLLGADA NQTKEATSLI CQQVCEKESS PKLVELLLDS GSREQDVRKA LAVSIGKGDS 780

QVISLLLKRL ALDLANNSIC LGGFGIGKIE PSWLGPLFPD KTSNLRKQTN IGSILARMVL 840

RHQMKSAVEE GAAPGSEENF PEGVLDKLDE WTFIPDSSMD SVFGQSDDLD SEGSEGSFLV 900

RKKSSSIGVG EFYRDPVLQR CSPNLPRHSN SLGPVFDQED LRRQKRKILS SDDSLRSTKL 960

QSHGRQSDSV SSLASEREYI TSLDLSANEL REVDALSRRG CLSGHLEHLE RLELQQNALV 1020

SFPQPLCENN TGLFKMNLTA NAFLFLLPLG FFLVLPCYSN LDVSRNDIGP SVILDPAVRC 1080

LTLRQLNLSY NQLSAVPESL AEVAEKLEQL LLEGNKISGT CSPLSLKELK ILNLSKNHIS 1140

CLPENFLEAC PKVESFSARM NLLADMPFLP SSMTSLKLSQ NKFTSVPEAI LNLPHLRSLD 1200

MSSNDIQCLP GPARWTSLNL RELLFSYNQI SVLDLSEKAH AWCRVEKLHL AHNKLKEIPP 1260

EIGYLENLTS LDVSYNSELR SFPNEMGKLS KIWDLPLDEL RLNFDFKHVG CKAKDIIRFL 1320

QQRLRKAVPY NRMKLMIVGN TGSGKTTLLQ QLMRAKKADV GMQGATVGID VRDWPVQIRS 1380

KGKRDLVLNV WDFAGREEFY STHPHFMTQR ALYLAVYDLS KGQAEVDAMK PWLFNIKARA 1440

SSSPVILVGT HLDVSDEKQR KACIGKITRE LLNKRGFPAI RDYHFVNATE ESDALAKLRK 1500

TIINESLNFK IRDQPVVGQL IPDCYVELEK IILSERKNVP TEFPVIDRKR LLQLVRDNQL 1560

QLDENELPHA IHFLNESGVL LHFQDPALQL SDLYFVEPKW LCKVMAQILT VKVEGYPKHP 1620

KGIISRRDVE KFLSKKRRFP KNYMTQYVKL LEKFQIALPI GEEYLLVPSS LSDHRPVIEL 1680

PHCENSEIII RLYEMPYFPM GFWSRLINRL LEISPYMLSG RERALRPNRM YWRQGIYLNW 1740

SPEAYCLVGS EVLDHHPESF LKITVPSCRK GCILLGQVVD HIDSLMEEWF PGLLEIDICG 1800

EGETLLKKWA LYSFNDGEEH QKILLDDLMK KAEEGDLLIN PDQPRLTIPI SQIAPDLVLA 1860

DLPRNIMLNN DELEFQQAPE FLLGDGSFGS VYRAVYEGEE VAVKIFNKHT SLRLLRQELV 1920

VLCHLHHPSL ISLLAAGIRP RMLVMELAPK GSLDRLLQQD KASLTRTLQH RIALHVADGL 1980

RYLHSAMIIY RDLKPHNVLL FTLYPNAAII AKIADYGISQ YCCRMGIKTS EGTPGFRAPE 2040

VARGNVIYNQ QADVYSFGLL LYDILTTGGR IVEGLKFPNE FDELAIQGKL PDPVKEYGCT 2100

PWPLVEKLIK KCLKENPQER PTSAQVFDIL NSAELICLMR HILIPKSVTV ECMVASSPGG 2160

KSTSIWLGCS HTDKGQLSFL NLNTEGHTTE EVSESRVLCL ALVSLPVEKE SWIVCGTQSG 2220

ALLAISTEDG KRRHSLEKMT DSVTCLYCNS FPKQSKQKNF LLVGTADGKL AIFEDKTVKC 2280

EGAAPVKTLN IGNVSTPLMC LSESVNSTEK NTMWGGCGTK IFSLSHDFTV QKLIETRTNQ 2340

LFSYAAFSDS NIIAVAVDTA LYVAKKNSPV VEVWDKKTEK LCELIDCVHF LKEAMAVGKQ 2400

ESKHSLFYSV RVKALCLQKN TALWIGTGGG HILLLDLSTR RVIRIIYNFC DSVRVMATAQ 2460

SGKGSLKNVM LVLGYNRKSA EGTLQSLEIQ SCLSIWDTNL PHEVQNLEKH IEVRKELAEK 2520

MRRTSVE 2527

Nucleotide Sequence
(FASTA)

ATGGCCAGTG GCGGTGGCAG CAACCAGGGC AGCGACGAGG ACGAGGAAAG TCTGAAGAAG 60

TTGCTGGTCA AGCTGAACAA CGTCCAGGAG GGCAAGCAGG TCGAGACGCT GGTGCAGACC 120

CTGGAGGACC TGCTCGTGTT CACGTACTCG GAGCGCGCCT CAAGGCTGTT TCGGGGCAAA 180

AGCTTCCACG TGCCTCTGCT GATCGTGTTG GATTCGTATA TGAGGGTCGC GAGTGTGCAG 240

CAGGTGGGCT GGTCGCTTCT GTGCAAACTG ATAGAAGTCT GTCCAGACAC TATGCAAAGC 300

TTGATGGGGC CCCAAGACGT TGGCAGTGAT TGGGAGGTCC TTGGAGTCCA CCAGCTGATT 360

CTTCGAATGC TCTCAGTCCA CAGTGCCAGT GTGAACCTGT TGACAGTGGG ACTGAAGGCC 420

TTGGACCTCC TTCTGACTTC AGGTAAAATC ACTTTGCTGA TACTGGAGGA AGAAAGCGAT 480

ATTTTCCTGT TGATTTTTGA TGCCATGCGC ACCTTCCCAG CCAATGATGA GATCCAGAAG 540

CTTGGGTGCA AAGCTCTGCA TGTGCTGTTT GAGAGAGTCT CTGAGGAACA ACTGACTGAA 600

TTTGTTGAGA ACAAAGATTA TATGATATTG CTGAGTGCAT TAAAAAATTT TAAAGATGAA 660

GAGGAGATAG TCCTCCATGT CCTACACTGT TTGCATTCCT TGGCAATTCC GTGCAACAAC 720

GTGGAAGTGC TCATGAGCGG CAATGTCAGG TGCTACAATA TTGTGGTGGA AGCCATGAAA 780

GCCTTCCCTG TTAGTGAGAA GATTCAAGAA GTGAGTTGCT GCTTGCTGCA CAGGCTGACC 840

CTGGGCAATT TTTTCAACAT CCTGGTGCTG AACGAGGTGC ACGCGTTTGT GGTGAGAGCT 900

GTGCGGCGGT ATCCCGAGAA CGCAGCGCTG CAGATCTCGG CGCTGGGCTG CCTGGCGCTC 960

CTCACTGAGA CCATTTTTTT AAATCAAGAC TTAGAGGAAA AGAGTGAGGC TCAGAGTGAC 1020

AAGCTGTTCT GGCTGGAAGC CTGCTACAAG GCGCTCACGG GGCACCGGAA GAACAGGCAT 1080

GTGCAGGAGG CGGCGTGCTG GTCCCTGAAC AACCTGCTCA TGTACCACAG CAGCCTGCAC 1140

GAGAGGATCG GCGACGAGGA CGGCCAGCTC CCTGCGCACA GGGAGGTGAT GCTGTCCATG 1200

CTGATGCACT CCTCGTCGAA GGAAGTCTTC CAGGCATCGG CAAACGCGCT GTCGACCCTC 1260

CTGGAGCAAA ATGTTAATTT CAGAAAGATC CTGTTGTCTA AAGGGATATA CCTGAATGTT 1320

CTGGAGTTAA TGCAGCGGCA CGCACATTCC CCTGAAGTGG CCGAGAGTGG CTGTAAGATG 1380

CTGAACCACC TGTTTGAAGG CAGTCACATT TCCCTGGATA CAGTGGCGGC AGTGGTCCCC 1440

AAAATAATAA CAGTTATGAG AAGTCACGAG GCGTCACTGT CAGTGCAGCT GGAGGCACTC 1500

CGAGCTATTC TACATTTTAT GATGCCAGGC ATGCCGGAAG AGTCCAGAGA GGAAACAGAA 1560

TCTCAGCGGA ACCTAAACGT GGTTAGAAAG CAGTGTTTCA GGAGTGACAT CCACAAACTG 1620

GTCCTCGCCG CTTTGAACAG GTTCGTTGGA AATCCTGGGA TTCAGAAATG TGGATTGAAA 1680

GTCATGGCTT CGATAACGCA GGTGCCGGAT GCGCTAGAGG TGCTATCGCT GGAGGGTGCT 1740

GTTGACTCGG TGCTGCACAC GCTGCACATG TACCCGGATG ACCAAGAAAT TCAGTGTCTG 1800

GGTTTAAGTC TTGTAGGACG CTTGATTGCA AAGAAAAATT TATGCACAGG AACCGGGCAT 1860

CTGCTGGCGA AAATTCTCGT GTCCAGCTTG CAGCGGTTCA AGGACGCTGC TGAAGTGCAG 1920

TTGGAAGGTT TTCGGACCGT CTTAGCAATA CTTGAATTGT CAGTGTCTTT TTCCAAGCTG 1980

CTTGTCCACC ATTCATTTGA TTCAGTAATA TTCCATCAGA TGTCTTCCAG TATTACGGAA 2040

CAGAAGGATC AGCAGTTTCT AAGCCTCTGT TGCAAGTGCT TTGCAAAGTT GGCCATGGAG 2100

GATGAGCTTA AGAATGCGAT GCTGCAGCGG GCCTGTGACC AGAACAACAG CATCATGGTG 2160

GAGTGCTTGC TGCTCTTGGG AGCTGACGCC AACCAGACCA AGGAGGCCAC TTCTTTAATT 2220

TGTCAGCAGG TCTGTGAGAA GGAGAGCAGC CCCAAGCTGG TGGAGCTGCT GCTGGACAGC 2280

GGGTCCCGGG AGCAGGACGT GCGCAAGGCA CTGGCCGTCA GCATCGGGAA GGGCGACAGC 2340

CAGGTCATCA GCCTGCTCTT GAAGAGGCTG GCCCTGGATC TGGCCAACAA CAGCATCTGC 2400

CTCGGAGGAT TTGGTATTGG AAAAATTGAG CCTTCCTGGC TCGGTCCTTT ATTTCCAGAT 2460

AAGACATCCA ATTTAAGGAA ACAAACAAAT ATTGGCTCTA TACTAGCCAG AATGGTGCTG 2520

AGGCATCAGA TGAAAAGCGC CGTGGAGGAG GGGGCCGCCC CAGGCAGCGA GGAGAACTTC 2580

CCCGAGGGCG TGCTGGACAA GTTGGATGAG TGGACCTTCA TTCCCGACTC TTCGATGGAC 2640

AGTGTGTTTG GTCAGAGCGA TGATCTGGAC AGTGAAGGAA GTGAAGGCTC ATTTCTTGTG 2700

AGAAAGAAAT CAAGTTCAAT TGGTGTAGGA GAGTTTTACC GGGATCCTGT ATTGCAGCGC 2760

TGCTCCCCAA ATTTGCCAAG GCATTCCAAT TCACTGGGAC CCGTTTTTGA TCAGGAAGAT 2820

TTACGGAGGC AAAAAAGGAA AATCCTGTCA TCAGATGACT CACTGAGGTC GACCAAGCTG 2880

CAGTCCCACG GGAGGCAGTC AGACAGCGTG TCCTCCCTGG CTTCGGAGAG GGAGTACATC 2940

ACCTCCTTAG ACCTTTCAGC GAATGAACTC AGGGAGGTCG ATGCCCTGAG CCGCAGGGGC 3000

TGCCTGAGTG GCCACTTGGA GCACCTGGAG AGGCTAGAGC TGCAGCAGAA TGCACTGGTC 3060

AGCTTCCCAC AGCCACTCTG CGAGAATAAT ACCGGTCTTT TTAAAATGAA TCTTACTGCA 3120

AATGCATTTC TCTTTCTGCT ACCTCTTGGG TTTTTCTTGG TCTTACCATG TTACAGCAAC 3180

CTCGATGTCT CCCGCAATGA CATTGGGCCC TCTGTCATCC TGGATCCCGC GGTGAGGTGT 3240

CTGACCCTGC GGCAGCTGAA TCTGTCCTAT AACCAGCTGT CTGCTGTCCC TGAGAGCCTC 3300

GCAGAGGTGG CTGAGAAACT GGAGCAGCTG CTTCTAGAAG GAAATAAAAT ATCAGGCACA 3360

TGCTCCCCCT TGAGCCTGAA GGAACTGAAG ATCTTAAACC TTAGTAAAAA CCACATTTCA 3420

TGCCTACCAG AGAACTTTCT GGAAGCTTGT CCTAAAGTGG AGAGTTTCAG CGCCAGGATG 3480

AATTTGCTTG CCGACATGCC TTTCTTGCCT TCCTCCATGA CAAGCTTAAA ACTATCTCAA 3540

AACAAATTTA CAAGTGTTCC AGAAGCAATT TTAAATCTTC CACACCTGCG GTCCCTGGAC 3600

ATGAGCAGCA ATGACATCCA GTGTCTGCCA GGCCCCGCAC GCTGGACGTC CTTGAACTTA 3660

CGGGAACTAC TGTTCAGCTA CAATCAGATC AGCGTGTTGG ACTTGAGCGA AAAGGCGCAT 3720

GCGTGGTGTC GAGTGGAGAA ACTGCACCTT GCTCACAATA AACTGAAGGA GATTCCTCCT 3780

GAGATCGGCT ATCTGGAGAA TCTGACATCT CTTGATGTGA GTTACAACTC CGAACTGAGG 3840

TCCTTTCCCA ACGAAATGGG GAAACTAAGC AAAATCTGGG ATCTGCCTCT GGATGAACTG 3900

CGTCTTAACT TTGATTTTAA ACACGTAGGA TGCAAAGCCA AAGACATCAT AAGGTTTCTT 3960

CAGCAGCGGC TCAGAAAGGC CGTGCCGTAC AACCGAATGA AACTCATGAT CGTGGGCAAT 4020

ACCGGGAGTG GCAAGACCAC CTTGCTGCAG CAGTTAATGA GAGCCAAGAA GGCCGACGTC 4080

GGCATGCAGG GCGCCACGGT CGGCATCGAC GTGAGGGACT GGCCCGTGCA GATCAGAAGC 4140

AAAGGGAAGA GAGACCTCGT GCTGAACGTG TGGGACTTCG CAGGGCGCGA GGAGTTCTAC 4200

AGCACACACC CCCATTTCAT GACCCAGCGT GCTCTGTACC TGGCCGTGTA TGATCTCAGC 4260

AAGGGACAGG CTGAAGTTGA TGCCATGAAG CCCTGGCTCT TCAACATAAA GGCACGGGCG 4320

TCATCCTCCC CCGTGATCCT CGTGGGCACG CACCTGGACG TTTCTGACGA GAAGCAGCGC 4380

AAGGCCTGCA TCGGCAAGAT CACACGGGAG CTCCTGAACA AGCGTGGCTT CCCCGCCATC 4440

CGGGACTACC ACTTCGTCAA CGCCACCGAG GAGTCCGATG CCTTGGCCAA GCTCCGGAAG 4500

ACCATCATCA ACGAGAGCCT GAATTTCAAG ATCCGAGATC AGCCTGTTGT CGGGCAGCTG 4560

ATTCCAGACT GCTATGTAGA ACTTGAGAAA ATCATTTTGT CCGAACGTAA AAATGTGCCA 4620

ACTGAATTTC CCGTAATTGA CCGGAAACGA TTGTTACAAC TGGTGAGAGA CAATCAGCTG 4680

CAGCTGGATG AGAATGAGCT TCCTCACGCC ATTCATTTCC TAAACGAATC AGGGGTTCTT 4740

CTTCATTTTC AAGACCCAGC GCTGCAGCTG AGTGACTTGT ACTTTGTGGA ACCCAAGTGG 4800

CTCTGCAAAG TCATGGCCCA GATTTTGACA GTGAAAGTGG AAGGCTATCC GAAACATCCT 4860

AAGGGAATTA TTTCACGTAG AGATGTGGAA AAATTCCTGT CGAAGAAAAG GAGATTTCCA 4920

AAGAATTACA TGACACAGTA CGTTAAACTC CTGGAAAAAT TCCAGATCGC CTTGCCAATA 4980

GGAGAAGAGT ACTTACTGGT TCCAAGCAGT CTCTCTGACC ACCGGCCCGT AATAGAGCTT 5040

CCACACTGTG AGAACTCGGA AATCATCATC CGGCTCTATG AAATGCCTTA TTTCCCCATG 5100

GGGTTTTGGT CAAGATTAAT TAACCGGTTA CTTGAGATCT CACCTTACAT GCTTTCGGGA 5160

AGAGAACGAG CGCTTCGCCC CAACAGAATG TACTGGCGCC AGGGCATCTA CCTGAACTGG 5220

TCTCCTGAAG CTTACTGCCT GGTGGGATCT GAAGTCTTAG ACCATCACCC AGAGAGTTTC 5280

TTAAAGATTA CAGTTCCTTC TTGTAGAAAA GGCTGCATTC TACTGGGCCA AGTCGTGGAC 5340

CACATTGACT CTCTCATGGA GGAGTGGTTT CCTGGGCTGC TGGAGATTGA CATCTGCGGC 5400

GAAGGAGAAA CCCTTTTAAA GAAGTGGGCA TTGTATAGTT TTAATGACGG TGAAGAACAT 5460

CAAAAAATCT TACTGGATGA CTTGATGAAG AAAGCAGAAG AAGGAGACCT CCTGATAAAT 5520

CCCGATCAAC CGAGACTCAC CATCCCCATA TCTCAGATTG CTCCGGACCT GGTTTTGGCT 5580

GACCTGCCTA GAAACATTAT GCTGAACAAC GATGAGCTGG AGTTTCAGCA GGCTCCGGAG 5640

TTTCTCTTAG GGGACGGCAG TTTTGGATCC GTGTACCGGG CCGTGTACGA AGGAGAAGAG 5700

GTGGCGGTGA AGATTTTCAA CAAGCACACG TCTCTCCGGC TGCTGAGACA GGAGCTGGTG 5760

GTGCTCTGCC ACCTGCACCA CCCCAGCCTG ATCTCGCTGC TGGCGGCTGG GATCCGCCCG 5820

CGGATGCTCG TGATGGAGCT GGCCCCCAAG GGCTCCTTGG ACCGGCTGCT GCAGCAAGAC 5880

AAAGCCAGCC TCACCAGGAC CCTGCAGCAC AGGATCGCGC TGCACGTGGC CGACGGCTTG 5940

AGATACCTGC ACTCAGCCAT GATCATCTAC CGGGACCTGA AGCCCCACAA CGTGCTGCTG 6000

TTCACCCTGT ACCCCAACGC CGCCATCATC GCGAAGATCG CCGACTACGG GATTTCTCAG 6060

TACTGCTGCA GGATGGGCAT CAAAACCTCA GAGGGCACGC CAGGGTTTCG TGCGCCTGAA 6120

GTTGCCAGAG GAAATGTCAT TTATAACCAG CAGGCCGATG TGTATTCGTT TGGCTTGCTG 6180

CTCTATGACA TTTTGACAAC GGGAGGTAGG ATCGTAGAGG GTTTGAAGTT CCCCAATGAA 6240

TTTGATGAAT TAGCAATACA AGGAAAATTA CCTGATCCAG TTAAAGAATA TGGCTGTACT 6300

CCCTGGCCAT TGGTGGAGAA GTTAATTAAA AAGTGTTTGA AAGAAAATCC TCAAGAAAGG 6360

CCTACTTCTG CGCAGGTGTT TGACATTTTG AATTCCGCTG AGCTGATCTG TCTGATGAGA 6420

CACATTCTAA TCCCTAAGAG TGTCACCGTC GAGTGCATGG TGGCTTCGAG CCCCGGAGGC 6480

AAGAGCACGA GCATTTGGCT GGGCTGCAGC CACACCGACA AGGGGCAGCT GTCGTTTCTT 6540

AACCTCAACA CGGAAGGACA CACTACTGAG GAAGTTAGTG AGAGCAGAGT CCTGTGCCTG 6600

GCCTTGGTGT CCCTTCCTGT TGAGAAGGAA AGCTGGATTG TGTGTGGGAC TCAGTCTGGT 6660

GCCCTCCTGG CCATCAGCAC GGAGGATGGG AAGAGGAGAC ACAGCCTGGA AAAGATGACC 6720

GATTCTGTCA CTTGCTTATA CTGCAATTCC TTTCCTAAGC AAAGCAAGCA AAAAAATTTT 6780

CTTTTGGTGG GAACTGCTGA TGGCAAGTTA GCGATTTTTG AAGATAAGAC TGTGAAGTGT 6840

GAAGGAGCCG CTCCTGTGAA GACCCTCAAC ATCGGAAACG TGAGCACCCC ACTGATGTGC 6900

CTGAGTGAAT CCGTGAATTC AACAGAGAAA AACACGATGT GGGGAGGGTG TGGAACCAAG 6960

ATTTTCTCAT TGTCTCATGA TTTCACTGTT CAGAAACTCA TTGAAACAAG GACAAATCAG 7020

CTGTTTTCTT ACGCAGCTTT CAGTGATTCC AACATCATCG CGGTGGCAGT GGACACGGCT 7080

CTCTACGTTG CTAAGAAAAA TAGCCCTGTG GTGGAAGTGT GGGATAAGAA GACAGAAAAA 7140

CTCTGCGAGC TCATAGACTG CGTGCACTTT CTAAAGGAAG CGATGGCAGT AGGAAAGCAG 7200

GAGTCAAAGC ACAGCCTGTT CTACTCCGTG CGCGTGAAGG CGCTTTGCCT TCAGAAGAAC 7260

ACGGCGCTCT GGATCGGGAC CGGAGGAGGC CACATCCTGC TCCTGGACCT CTCCACGCGG 7320

CGCGTGATCC GCATCATCTA CAACTTCTGT GATTCCGTGC GCGTCATGGC GACAGCACAG 7380

TCAGGTAAAG GAAGCCTTAA AAATGTCATG CTGGTCCTGG GCTACAACCG GAAGAGTGCC 7440

GAAGGTACTT TACAAAGTTT AGAGATACAA TCTTGCTTGT CTATTTGGGA CACAAATCTT 7500

CCGCATGAAG TACAAAATTT AGAAAAACAC ATTGAAGTGA GAAAAGAATT AGCTGAGAAA 7560

ATGAGAAGAA CGTCTGTTGA GTAA 7584

Domain Profile

S: 6     llGrGafGsvyraavkGeevavkafkiaadklkrdslelalkayselrqelsvLlalkhP  65

         llG+G+fGsvyra ++Geevavk+f+      k++sl+l       lrqel+vL++l+hP

Q: 1882  LLGDGSFGSVYRAVYEGEEVAVKIFN------KHTSLRL-------LRQELVVLCHLHHP  1928

         79************************......*******.......**************

S: 66    sivsLvgisikPlalvleLaplgsLdrlLsedkksssklgrtltkkialqvargleyLhk  125

         s++sL++++i+P++lv+eLap+gsLdrlL++dk+s   l+rtl+++ial+va+gl+yLh+

Q: 1929  SLISLLAAGIRPRMLVMELAPKGSLDRLLQQDKAS---LTRTLQHRIALHVADGLRYLHS  1985

         *********************************99...**********************

S: 126   kkiiyrdLksenvLvwslspkeailikladyGisrqslrsGakgveGteGfraPeivrge  185

         ++iiyrdLk++nvL+++l+p++ai++k+adyGis++++r+G+k++eGt+GfraPe++rg+

Q: 1986  AMIIYRDLKPHNVLLFTLYPNAAIIAKIADYGISQYCCRMGIKTSEGTPGFRAPEVARGN  2045

         ************************************************************

S: 186   vvydekvdvfsfGlllyell.sgkrpvegeeqlkivekl.lkGkrPvlvkeeevlptpll  243

         v+y++++dv+sfGllly++l +g r+veg ++++++++l ++Gk+P++vke++++p+pl+

Q: 2046  VIYNQQADVYSFGLLLYDILtTGGRIVEGLKFPNEFDELaIQGKLPDPVKEYGCTPWPLV  2105

         ********************999*************************************

S: 244   d.LlveCwkekPekrPtasqvvsi  266

         + L+++C+ke+P++rPt++qv++i

Q: 2106  EkLIKKCLKENPQERPTSAQVFDI  2129

         99********************96

Domain Sequence
(FASTA)

LLGDGSFGSV YRAVYEGEEV AVKIFNKHTS LRLLRQELVV LCHLHHPSLI SLLAAGIRPR 60

MLVMELAPKG SLDRLLQQDK ASLTRTLQHR IALHVADGLR YLHSAMIIYR DLKPHNVLLF 120

TLYPNAAIIA KIADYGISQY CCRMGIKTSE GTPGFRAPEV ARGNVIYNQQ ADVYSFGLLL 180

YDILTTGGRI VEGLKFPNEF DELAIQGKLP DPVKEYGCTP WPLVEKLIKK CLKENPQERP 240

TSAQVFDI 248

Keyword

ATP-binding; Complete proteome; GTP-binding; Leucine-rich repeat; Nucleotide-binding; Reference proteome; Repeat.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0032839	; C:dendrite cytoplasm
GO:0032473	; C:external side of mitochondrial outer membrane
GO:0045121	; C:membrane raft
GO:0043025	; C:neuronal cell body
GO:0005886	; C:plasma membrane
GO:0008021	; C:synaptic vesicle
GO:0005802	; C:trans-Golgi network
GO:0005524	; F:ATP binding
GO:0005525	; F:GTP binding
GO:0034211	; F:GTP-dependent protein kinase activity
GO:0005096	; F:GTPase activator activity
GO:0003924	; F:GTPase activity
GO:0004708	; F:MAP kinase kinase activity
GO:0000186	; P:activation of MAPKK activity
GO:0008340	; P:determination of adult lifespan
GO:0035640	; P:exploration behavior
GO:0048312	; P:intracellular distribution of mitochondria
GO:2000173	; P:negative regulation of branching morphogenesis of a nerve
GO:0061002	; P:negative regulation of dendritic spine morphogenesis
GO:0034260	; P:negative regulation of GTPase activity
GO:0007406	; P:negative regulation of neuroblast proliferation
GO:0014043	; P:negative regulation of neuron maturation
GO:0007528	; P:neuromuscular junction development
GO:0070997	; P:neuron death
GO:0018105	; P:peptidyl-serine phosphorylation
GO:0018107	; P:peptidyl-threonine phosphorylation
GO:0010508	; P:positive regulation of autophagy
GO:0060161	; P:positive regulation of dopamine receptor signaling pathway
GO:0043068	; P:positive regulation of programmed cell death
GO:0032436	; P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0031398	; P:positive regulation of protein ubiquitination
GO:0046777	; P:protein autophosphorylation
GO:0035564	; P:regulation of kidney size
GO:0040012	; P:regulation of locomotion
GO:0042391	; P:regulation of membrane potential
GO:0006979	; P:response to oxidative stress
GO:0007264	; P:small GTPase mediated signal transduction
GO:0022028	; P:tangential migration from the subventricular zone to the olfactory bulb

KEGG

InterPros

IPR020683	; Ankyrin_rpt-contain_dom.
IPR011989	; ARM-like.
IPR016024	; ARM-type_fold.
IPR011009	; Kinase-like_dom.
IPR001611	; Leu-rich_rpt.
IPR025875	; Leu-rich_rpt_4.
IPR003591	; Leu-rich_rpt_typical-subtyp.
IPR013684	; MIRO-like.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR020859	; ROC_GTPase.
IPR008271	; Ser/Thr_kinase_AS.
IPR005225	; Small_GTP-bd_dom.
IPR001806	; Small_GTPase.
IPR015943	; WD40/YVTN_repeat-like_dom.
IPR017986	; WD40_repeat_dom.

Pfam

PF00560	; LRR_1; 1.
PF12799	; LRR_4; 1.
PF08477	; Miro; 1.
PF00069	; Pkinase; 1.

SMARTs

SM00369

; LRR_TYP; 1.

Prosites

PS51450	; LRR; 10.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.
PS51424	; ROC; 1.

Prints

PR00449

; RASTRNSFRMNG.

Created Date

20-Feb-2013