EPS-ORC-00012

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EPS-ORC-00012

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
DSP/aDSP	118.8	1.9E-34	29	169	141

Status

Unreviewed

Ensembl Protein

ENSOCUP00000006845

UniProt Accession

G1SU32;

Protein Name

Protein Synonyms/Alias

Gene Name

DUSP12

Gene Synonyms/Alias

DUSP12;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSOCUG00000007924	ENSOCUP00000006845	ENSOCUT00000007921

Organism

Oryctolagus cuniculus

Functional Description

Protein Length

341

Protein Sequence
(FASTA)

MLESQSPSHG FQDRNPSESP TASAVPMLEV RPGLYLGGAA AVAEPDHLRE AGITAILTVD 60

SEEPGFKAGA GVEGLRSLFV PALDKPETDL LSHLDRCVAF IGQARTEGRA VLVHCHAGVS 120

RSVAIVTAFV MKNDKLSFEE AYENLQTIKP EAKMNEGFEW QLKLYQAMGY EVDTSSAIYK 180

QYRLQKVTEK YPELQSLPQE LFAVDPTTVS QGLKDEVLYK CRKCRNCRRS LFRSSSILGH 240

SEGSGPLAFA HKRMAPSFML ATGTQCTSYF IEPVQWMESA LLGVMDGQLL CPKCSAKLGS 300

FNWYGEQCSC GRWITPAFQI HKNRVDEKKM LPVLGSQTRK I 341

Nucleotide Sequence
(FASTA)

ATGTTGGAAT CTCAGAGTCC CAGCCATGGC TTCCAGGATC GGAATCCGAG CGAGAGCCCG 60

ACCGCCTCCG CCGTGCCCAT GTTGGAAGTG CGGCCAGGGC TGTACCTGGG TGGAGCCGCG 120

GCCGTGGCGG AGCCGGACCA CCTCAGAGAG GCGGGGATCA CGGCCATCCT GACGGTGGAC 180

TCGGAGGAGC CCGGGTTCAA GGCGGGGGCT GGGGTCGAGG GTCTGCGGAG CCTCTTCGTG 240

CCGGCGCTAG ATAAACCCGA GACTGACTTG CTCAGCCACC TGGATCGGTG CGTGGCCTTC 300

ATCGGCCAGG CCCGCACTGA GGGCCGTGCA GTGTTGGTGC ACTGTCATGC AGGAGTCAGT 360

CGAAGTGTGG CGATAGTGAC AGCTTTTGTG ATGAAGAATG ACAAGCTTAG CTTTGAAGAA 420

GCCTACGAGA ACCTCCAGAC CATCAAACCA GAGGCTAAGA TGAACGAAGG GTTTGAGTGG 480

CAACTGAAAT TATACCAGGC AATGGGATAT GAAGTGGATA CCTCTAGTGC GATTTATAAG 540

CAATATCGTT TACAAAAGGT TACAGAGAAG TATCCAGAAT TGCAGAGTTT ACCTCAAGAA 600

CTCTTTGCTG TTGACCCAAC CACTGTTTCA CAAGGACTGA AAGATGAAGT TCTCTACAAG 660

TGTAGAAAGT GCAGGAATTG CAGGCGATCC TTATTTCGAA GTTCAAGTAT TTTGGGTCAC 720

AGTGAAGGAA GTGGACCATT AGCTTTTGCC CACAAGAGAA TGGCACCATC ATTCATGCTT 780

GCTACAGGGA CTCAATGTAC ATCTTATTTC ATTGAACCTG TACAGTGGAT GGAATCTGCT 840

TTGTTGGGAG TGATGGATGG GCAGCTGCTT TGTCCAAAAT GCAGTGCCAA ATTGGGTTCC 900

TTCAATTGGT ATGGTGAACA GTGCTCATGT GGAAGATGGA TAACACCTGC TTTCCAAATA 960

CATAAGAACA GAGTGGATGA AAAGAAAATG CTGCCAGTTT TGGGATCACA AACAAGAAAA 1020

ATATGA 1026

Domain Profile

S: 4     eilpglylgdqataldrreLsklgitvvinaslsvikvqviPeylikkgityknipvdDs  63

         e+ pglylg++a + +  +L+++git ++++  +   ++++  +   +g + + +p+ D+

Q: 29    EVRPGLYLGGAAAVAEPDHLREAGITAILTVDSEEPGFKAGAGV---EGLRSLFVPALDK  85

         799**********************************9998776...5999999******

S: 64    dvtdllqyfdeaaefideakekggkvlvHCaaGvsRSatlvlaYLmkveglslsdAieav  123

         ++tdll+++d++++fi +a+++g++vlvHC+aGvsRS+++v+a++mk  +ls+++A+e++

Q: 86    PETDLLSHLDRCVAFIGQARTEGRAVLVHCHAGVSRSVAIVTAFVMKNDKLSFEEAYENL  145

         ************************************************************

S: 124   krkrpsiepnegfleQLlelekkl  147

         ++ +p++++negf +QL +++ ++

Q: 146   QTIKPEAKMNEGFEWQLKLYQAMG  169

         ********************9886

Domain Sequence
(FASTA)

EVRPGLYLGG AAAVAEPDHL REAGITAILT VDSEEPGFKA GAGVEGLRSL FVPALDKPET 60

DLLSHLDRCV AFIGQARTEG RAVLVHCHAG VSRSVAIVTA FVMKNDKLSF EEAYENLQTI 120

KPEAKMNEGF EWQLKLYQAM G 141

Keyword

Complete proteome; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Danio rerio"; ?>Dasypus novemcinctus"; ?>Drosophila melanogaster"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005634	; C:nucleus
GO:0008138	; F:protein tyrosine/serine/threonine phosphatase activity
GO:0006470	; P:protein dephosphorylation

KEGG

InterPros

IPR000340	; Dual-sp_phosphatase_cat-dom.
IPR020422	; Dual-sp_phosphatase_subgr_cat.
IPR024950	; DUSP.
IPR016278	; DUSP12.
IPR000387	; Tyr/Dual-specificity_Pase.

Pfam

PF00782

; DSPc; 1.

SMARTs

SM00195

; DSPc; 1.

Prosites

PS50056	; TYR_PHOSPHATASE_2; 1.
PS50054	; TYR_PHOSPHATASE_DUAL; 1.

Prints

Created Date

20-Feb-2013