EKS-ORC-00294
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-ORC-00294
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
STE/STE20355.12.6E-10625289265
StatusUnreviewed
Ensembl ProteinENSOCUP00000007084
UniProt AccessionG1SUP1;
Protein Name
Protein Synonyms/Alias
Gene NameMAP4K4
Gene Synonyms/Alias MAP4K4;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSOCUG00000008180ENSOCUP00000007084ENSOCUT00000008192
ENSOCUG00000008180ENSOCUP00000026025ENSOCUT00000026055
OrganismOryctolagus cuniculus
Functional Description
Protein Length1323
Protein Sequence
(FASTA)
MANDSPAKSL VDIDLSSLRD PAGIFELVEV VGNGTYGQVY KGRHVKTGQL AAIKVMDVTE 60
DEEEEIKLEI NMLKKYSHHR NIATYYGAFI KKSPPGHDDQ LWLVMEFCGA GSITDLVKNT 120
KGNTLKEDWI AYISREILRG LAHLHIHHVI HRDIKGQNVL LTENAEVKLV DFGVSAQLDR 180
TVGRRNTFIG TPYWMAPEVI ACDENPDATY DYRSDLWSCG ITAIEMAEGA PPLCDMHPMR 240
ALFLIPRNPP PRLKSKKWSK KFFSFIEGCL VKNYMQRPST EQLLKHPFIR DQPNERQVRI 300
QLKDHIDRTR KKRGEKDETE YEYSGSEEEE EEVPEQEGEP SSIVNVPGES TLRRDFLRLQ 360
QENKERSEAL RRQQLLQEQQ LREQEEYKRQ LLAERQKRIE QQKEQRRRLE EQQRREREAR 420
RQQEREQRRR EQEEKRRLEE LERRRKEEEE RRRAEEEKRR VEREQEYIRR QLEEEQRHLE 480
ILQQQLLQEQ AMLLECRWRE MEEHRQAERL QRQLQQEQAY LLSLQHDHRR PPPQLPQLPQ 540
QPPVQQERSK PAYHAPEPKP HYEPADRARE VEDRFRKTNH SSPEAQSKQT GRVLEPPVPS 600
RSESFSNGNS ESVHPALQRP TEPQVQWSHL ASLKNNVSPV SRSHSFSDPS PPKFAHHHLR 660
SQDPCPTSRS EVLSQSSDSK SEVPDPTQKA WSRSDSDEVP PRVPVRTTSR SPVLSRRDSP 720
LQGSGQQNSQ AGQRNSTSSI EPRLLWERVE KLVPRPGSGS SSGSSNSGSQ PGSHPGSQSG 780
SGERFRVRSS SKSEGSPSQR LENATKKPED KKEVFRPLKP AVRMDLTALA KELRAVEDVR 840
PPHKVTDYSS SSEESGTTDE EEDDVEQEGA DESTSGPEDT RAASSLNLSN GETESVKTMI 900
VHDDVESEPA MTPSKEGTLI VRQTQSASST LQKHKSSSSF TPFIDPRLLQ ISPSSGTTVT 960
SVVGFSCDGM RPEAIRQDPT RKGSVVNVNP TNTRPQSDTP EIRKYKKRFN SEILCAALWG 1020
VNLLVGTESG LMLLDRSGQG KVYPLINRRR FQQMDVLEGL NVLVTISGKK DKLRVYYLSW 1080
LRNKILHNDP EVEKKQGWTT VGDLEGCVHY KVVKYERIKF LVIALKSSVE VYAWAPKPYH 1140
KFMAFKSFGE LAHKPLLVDL TVEEGQRLKV IYGSCAGFHA VDVDSGSVYD IYLPTHIQCS 1200
IKPHAIIILP NTDGMELLVC YEDEGVYVNT YGRITKDVVL QWGEMPTSVA YIRSNQTMGW 1260
GEKAIEIRSV ETGHLDGVFM HKRAQRLKFL CERNDKVFFA SVRSGGSSQV YFMTLGRTSL 1320
LSW 1323
Nucleotide Sequence
(FASTA)
ATGGCGAACG ACTCTCCTGC AAAAAGTCTG GTGGACATTG ACCTCTCCTC CCTGCGGGAC 60
CCTGCTGGGA TTTTTGAGCT GGTGGAAGTG GTTGGAAATG GCACCTACGG ACAAGTCTAT 120
AAGGGTCGAC ATGTTAAAAC GGGTCAGTTG GCGGCCATCA AGGTTATGGA TGTCACTGAG 180
GATGAAGAGG AAGAAATCAA ACTGGAGATA AATATGCTGA AGAAATACTC TCATCATAGA 240
AATATTGCAA CATACTACGG TGCTTTCATT AAAAAGAGCC CTCCAGGACA CGATGACCAA 300
CTCTGGCTTG TTATGGAGTT CTGTGGGGCT GGGTCCATCA CAGACCTCGT GAAGAACACC 360
AAAGGGAACA CGCTCAAAGA AGACTGGATC GCGTACATCT CCAGAGAGAT CCTGAGGGGA 420
CTGGCACACC TTCATATTCA TCATGTGATT CACCGGGACA TCAAGGGCCA GAATGTTCTG 480
CTGACCGAGA ACGCTGAGGT GAAACTCGTT GATTTTGGTG TGAGTGCTCA GCTGGACAGG 540
ACGGTGGGGC GGAGGAATAC CTTCATTGGC ACCCCCTATT GGATGGCTCC TGAGGTCATC 600
GCCTGTGATG AGAACCCAGA TGCCACCTAC GACTACAGGA GTGACCTTTG GTCTTGTGGC 660
ATTACGGCCA TTGAGATGGC AGAAGGTGCT CCCCCTCTCT GTGACATGCA TCCAATGAGA 720
GCACTGTTTC TCATTCCCAG AAACCCTCCT CCCCGGCTGA AGTCAAAAAA ATGGTCAAAG 780
AAATTTTTTA GTTTCATAGA GGGATGCCTG GTGAAGAATT ACATGCAGCG GCCCTCCACA 840
GAACAGCTTT TGAAACATCC TTTCATAAGG GACCAGCCAA ATGAAAGGCA AGTTAGAATC 900
CAACTTAAGG ATCATATAGA CCGGACCCGA AAGAAGAGAG GAGAGAAAGA TGAAACTGAG 960
TACGAGTATA GTGGGAGTGA GGAAGAAGAA GAGGAAGTGC CTGAACAGGA AGGAGAGCCA 1020
AGTTCCATTG TGAATGTGCC TGGTGAGTCC ACTCTGCGGC GGGACTTCCT GAGACTGCAG 1080
CAGGAGAACA AGGAGCGCTC TGAGGCTCTT CGCAGGCAAC AGCTGCTGCA GGAGCAGCAG 1140
CTCCGCGAGC AGGAAGAGTA CAAAAGGCAG CTGCTGGCAG AGAGACAGAA GCGGATCGAG 1200
CAGCAGAAAG AACAGAGGCG GCGGCTGGAA GAGCAACAAA GGAGAGAGCG AGAAGCTAGA 1260
AGGCAGCAAG AACGTGAGCA GCGGAGGAGA GAACAAGAGG AGAAGAGGCG CCTGGAGGAA 1320
CTGGAGAGGA GACGCAAAGA GGAAGAAGAG AGGAGACGGG CAGAAGAGGA AAAGCGGAGG 1380
GTTGAAAGGG AACAGGAGTA TATCAGGCGG CAGCTGGAAG AGGAGCAGCG GCACCTGGAG 1440
ATCCTGCAGC AGCAGCTGCT CCAGGAGCAG GCCATGTTAC TGGAGTGCCG ATGGCGGGAG 1500
ATGGAGGAGC ACCGGCAGGC AGAGAGGCTC CAGAGGCAGT TGCAACAAGA ACAAGCCTAT 1560
CTCCTGTCTC TACAGCACGA CCACAGGAGG CCGCCCCCGC AGCTCCCGCA GCTCCCGCAG 1620
CAGCCACCCG TGCAGCAGGA ACGGAGCAAG CCGGCCTACC ACGCTCCCGA GCCCAAGCCC 1680
CACTACGAGC CCGCAGACCG CGCTCGAGAG GTGGAAGATA GATTTAGGAA AACTAACCAC 1740
AGCTCCCCCG AAGCCCAGTC TAAGCAGACA GGCAGAGTAT TGGAGCCGCC AGTGCCTTCC 1800
CGATCAGAGT CTTTTTCCAA TGGCAACTCC GAGTCTGTGC ATCCTGCCCT GCAGAGACCC 1860
ACGGAGCCAC AGGTACAGTG GTCCCACCTG GCATCTCTCA AGAACAATGT TTCCCCTGTC 1920
TCGCGATCCC ATTCCTTCAG TGACCCTTCT CCTCCCAAAT TTGCACACCA TCATCTTCGT 1980
TCTCAGGACC CATGTCCAAC TTCCCGCAGT GAGGTGCTCA GTCAGAGCTC TGACTCTAAG 2040
TCGGAGGTGC CTGACCCCAC CCAAAAGGCT TGGTCTAGAT CAGACAGTGA CGAGGTGCCT 2100
CCAAGGGTTC CTGTGAGAAC AACATCTCGT TCCCCTGTTC TGTCCCGTCG GGATTCCCCA 2160
CTGCAGGGAA GTGGACAGCA AAACAGCCAA GCAGGACAAA GAAACTCCAC CAGTAGTATC 2220
GAGCCCAGGC TCCTCTGGGA GAGAGTGGAG AAGCTGGTGC CCAGGCCTGG CAGTGGCAGC 2280
TCCTCAGGGT CCAGCAACTC GGGATCCCAG CCTGGGTCAC ACCCTGGGTC TCAGAGTGGC 2340
TCCGGAGAAC GCTTCAGAGT CAGATCATCA TCCAAGTCTG AAGGCTCTCC ATCTCAGCGC 2400
CTTGAAAATG CAACTAAAAA GCCAGAAGAT AAAAAAGAAG TGTTTAGACC TCTCAAGCCT 2460
GCTGTAAGGA TGGATTTGAC AGCACTGGCC AAAGAGCTTC GAGCTGTGGA AGACGTGCGG 2520
CCTCCTCACA AAGTGACCGA CTACTCCTCT TCCAGTGAGG AGTCCGGGAC GACGGACGAG 2580
GAGGAGGACG ACGTGGAGCA GGAAGGGGCC GACGAGTCCA CCTCGGGACC GGAGGACACC 2640
AGAGCCGCGT CGTCTCTGAA CTTGAGCAAT GGGGAAACGG AATCCGTGAA AACCATGATT 2700
GTCCACGACG ACGTTGAAAG TGAGCCGGCC ATGACCCCAT CCAAGGAGGG CACGCTGATT 2760
GTCCGCCAGA CTCAGTCCGC TAGTAGCACA CTCCAGAAAC ACAAATCTTC CTCCTCCTTT 2820
ACACCTTTTA TAGACCCCAG ATTACTACAG ATTTCTCCAT CTAGTGGGAC GACAGTGACT 2880
TCTGTGGTGG GATTTTCCTG TGATGGAATG AGGCCAGAAG CCATAAGGCA AGATCCTACC 2940
CGGAAGGGCT CAGTGGTCAA TGTGAATCCG ACCAACACAA GACCACAGAG TGACACCCCT 3000
GAGATTCGTA AATACAAGAA GAGGTTTAAC TCTGAGATTC TGTGTGCAGC CTTATGGGGA 3060
GTGAATTTGC TGGTGGGGAC AGAGAGTGGC CTGATGCTGC TGGACAGAAG TGGCCAAGGG 3120
AAGGTTTATC CTCTGATCAA CCGAAGACGC TTCCAACAAA TGGATGTGCT TGAAGGCTTG 3180
AACGTCCTGG TGACCATATC TGGCAAAAAG GATAAGTTAC GTGTCTACTA TTTGTCTTGG 3240
TTAAGAAATA AAATACTTCA CAATGATCCA GAAGTTGAGA AGAAACAGGG ATGGACAACT 3300
GTAGGGGATC TGGAAGGGTG TGTGCACTAT AAAGTTGTAA AATATGAAAG AATCAAATTT 3360
CTAGTAATTG CTTTGAAGAG TTCTGTGGAA GTCTATGCGT GGGCACCTAA GCCATATCAC 3420
AAATTTATGG CCTTTAAGTC GTTCGGCGAG CTGGCACATA AGCCACTGTT GGTGGATCTC 3480
ACTGTGGAAG AAGGCCAGAG GCTCAAAGTG ATCTACGGGT CCTGTGCAGG GTTCCATGCC 3540
GTGGATGTGG ATTCGGGATC AGTCTACGAC ATTTATCTAC CAACACACAT CCAATGTAGC 3600
ATCAAACCCC ACGCTATCAT CATCCTCCCC AACACAGATG GGATGGAGCT TCTGGTGTGC 3660
TATGAAGACG AGGGAGTTTA TGTGAACACG TATGGGAGGA TCACCAAGGA TGTGGTTCTG 3720
CAGTGGGGAG AGATGCCCAC ATCTGTAGCA TATATTCGAT CTAATCAGAC AATGGGCTGG 3780
GGAGAGAAAG CCATTGAGAT CCGGTCTGTG GAAACTGGCC ATTTGGATGG TGTGTTTATG 3840
CACAAAAGGG CTCAAAGACT AAAATTCTTA TGTGAACGCA ATGACAAGGT GTTCTTTGCC 3900
TCTGTTCGGT CTGGTGGCAG CAGTCAGGTG TATTTCATGA CCTTAGGCAG GACTTCCCTT 3960
CTGAGCTGG 3969
Domain Profile
S: 1     yelleeigkGalgkvylarekktgelvaikkinlekqekleelqkeisvlkklkh.pniv  59
         +el+e++g+G++g+vy++r++ktg+l+aik++++++ +++ee++ ei++lkk++h +ni 
Q: 25    FELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE-DEEEEIKLEINMLKKYSHhRNIA  83
         899********************************8.999*************998****
S: 60    eylesflk......eeelwlvmeylagGslsdlvkeelkselkEeqiayilrevlkaLey  113
         +y+++f+k      +++lwlvme++ +Gs++dlvk+++ ++lkE++iayi re+l++L++
Q: 84    TYYGAFIKksppghDDQLWLVMEFCGAGSITDLVKNTKGNTLKEDWIAYISREILRGLAH  143
         *************9**********************************************
S: 114   lHskkviHrdikakniLlteegeVkLsdfgvaaqlektrkkrktvvgtpywmAPEviaqe  173
         lH ++viHrdik++n+Llte++eVkL+dfgv+aql++t+ +r+t++gtpywmAPEvia++
Q: 144   LHIHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACD  203
         ************************************************************
S: 174   ...ekgYdekaDiwslGItaielaegepPfkdleplkallkilkneppklkskkkfskef  230
            + +Yd+++D+ws+GItaie+aeg+pP++d++p++al++i++n+pp+lksk k+sk+f
Q: 204   enpDATYDYRSDLWSCGITAIEMAEGAPPLCDMHPMRALFLIPRNPPPRLKSK-KWSKKF  262
         999999********************************************888.******
S: 231   kefvekclqknpekRpsasellkhkFl  257
          +f+e cl kn+ +Rps+++llkh+F+
Q: 263   FSFIEGCLVKNYMQRPSTEQLLKHPFI  289
         **************************7
Domain Sequence
(FASTA)
FELVEVVGNG TYGQVYKGRH VKTGQLAAIK VMDVTEDEEE EIKLEINMLK KYSHHRNIAT 60
YYGAFIKKSP PGHDDQLWLV MEFCGAGSIT DLVKNTKGNT LKEDWIAYIS REILRGLAHL 120
HIHHVIHRDI KGQNVLLTEN AEVKLVDFGV SAQLDRTVGR RNTFIGTPYW MAPEVIACDE 180
NPDATYDYRS DLWSCGITAI EMAEGAPPLC DMHPMRALFL IPRNPPPRLK SKKWSKKFFS 240
FIEGCLVKNY MQRPSTEQLL KHPFI 265
KeywordATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.
Sequence SourceEnsembl
Orthology
Ortholog group
Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-ANC-00322
EKS-BOT-00336
EKS-CAE-00258
EKS-CAJ-00317
EKS-CAF-00339
EKS-CAP-00367
EKS-DAR-00697
EKS-DRM-00154
EKS-EQC-00318
EKS-GAG-00280
EKS-GAA-00383
EKS-GOG-00307
EKS-HOS-00318
EKS-LOA-00339
EKS-MAM-00315
EKS-MEG-00264
EKS-MOD-00311
EKS-MUM-00343
EKS-MUP-00324
EKS-MYL-00330
EKS-OCP-00056
EKS-ORN-00402
EKS-OTG-00318
EKS-PAT-00294
EKS-RAN-00346
EKS-SAH-00303
EKS-SUS-00288
EKS-TAG-00340
EKS-TAR-00407
EKS-TEN-00431
EKS-TUT-00074
EKS-XET-00401
EKS-XIM-00396
Gene Ontology
GO:0005737; C:cytoplasm
GO:0005524; F:ATP binding
GO:0004674; F:protein serine/threonine kinase activity
GO:0005083; F:small GTPase regulator activity
GO:0007243; P:intracellular protein kinase cascade
GO:0046328; P:regulation of JNK cascade
GO:0006950; P:response to stress
KEGG
InterPros
IPR001180; Citron.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR002290; Ser/Thr_dual-sp_kinase_dom.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF00780; CNH; 1.
PF00069; Pkinase; 1.
SMARTs
SM00036; CNH; 1.
SM00220; S_TKc; 1.
Prosites
PS50219; CNH; 1.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
Prints
Created Date20-Feb-2013