EKS-ORC-00153

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ORC-00153

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
AGC/PKG	496.2	2.0E-149	453	711	259

Status

Unreviewed

Ensembl Protein

ENSOCUP00000007323

UniProt Accession

G1SV88;

Protein Name

cGMP-dependent protein kinase

Protein Synonyms/Alias

Gene Name

PRKG2

Gene Synonyms/Alias

PRKG2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSOCUG00000008464	ENSOCUP00000007323	ENSOCUT00000008473

Organism

Oryctolagus cuniculus

Functional Description

Protein Length

762

Protein Sequence
(FASTA)

MGNGSVKPKH SKHPDGHSGN LTTDALRNKV AELERELRRR DAEIQEREYH LKELREQLSK 60

QTVAIAELTE ELQNKCIQLN KLQDVVHVQG GSLPQASPDK VLLEVHRKTS GLVSLHSRRG 120

AKAGVSAEPT TRTYDLNKPP EFSFEKARVR KDSSEKKLIT DALNKNQFLK RLDPQQIKDM 180

VECMYGRNYQ QGSYIIKQGE PGNHIFVLAE GRLEVFQGEK LLSSIPMWTT FGELAILYNC 240

TRTASVKAIT NVKTWALDRE VFQNIMRRTA QARDEQYRNF LRSVSLLKNL PEDKLTKIID 300

CLEVEYYDKG DYIIREGEEG STFFILAKGK VKVTQSTEGH DQPQLIKTLQ KGEYFGEKAL 360

ISDDVRSANI IAEENDVACL VIDRETFNQT VGTFEDLQKY LEGYVANLNR DDEKRHAKRS 420

MSSWKLSKAL SLEMIQLKEK VARFSSSSPF QNLEIIATLG VGGFGRVELV KVKNENVAFA 480

MKCIRKKHIV DTKQQEHVYS EKRILEELCS PFIVKLYRTF KDNKYVYMLL EACLGGELWS 540

ILRDRGSFDE PTSKFCVACV TEAFDYLHRL GIIYRDLKPE NLILDADGYL KLVDFGFAKK 600

IGSGQKTWTF CGTPEYVAPE VILNKGHDFS VDFWSLGILV YELLTGNPPF SGIDQMMTYN 660

LILKGIEKMD FPRKITRRPE DLIRRLCRQN PTERLGNLKN GINDIKKHRW LNGFNWEGLK 720

ARNLPSPLRR ELSGPIDHSY FDKYPPEKGV PPDELSGWDK DF 762

Nucleotide Sequence
(FASTA)

ATGGGAAATG GTTCAGTGAA ACCCAAGCAT TCCAAGCATC CAGATGGCCA CTCGGGGAAC 60

CTCACCACGG ATGCCCTGCG GAACAAGGTG GCAGAGCTGG AGAGGGAGCT GAGGAGGAGG 120

GATGCTGAGA TCCAGGAGCG GGAGTACCAC TTGAAGGAGC TGCGAGAGCA GCTGTCCAAG 180

CAGACTGTGG CCATCGCCGA GCTCACGGAG GAGCTGCAGA ATAAGTGCAT CCAGCTGAAC 240

AAGCTTCAGG ACGTGGTGCA CGTGCAGGGA GGAAGCCTGC CTCAGGCCTC TCCAGATAAG 300

GTGCTTCTTG AGGTGCACCG GAAGACCTCG GGGTTGGTCT CCCTGCATAG CAGGAGGGGA 360

GCAAAGGCTG GAGTGTCTGC CGAGCCAACA ACCCGAACCT ATGACCTCAA CAAACCCCCC 420

GAGTTTTCCT TTGAGAAAGC AAGAGTCAGA AAGGACTCCA GTGAGAAGAA GCTCATTACA 480

GATGCCCTTA ATAAAAACCA GTTTCTGAAG AGACTGGACC CTCAGCAGAT CAAAGACATG 540

GTGGAATGCA TGTACGGCAG GAACTACCAG CAAGGGAGTT ACATTATTAA ACAAGGAGAA 600

CCAGGGAATC ATATCTTTGT GCTAGCAGAG GGTCGACTAG AGGTATTTCA AGGGGAGAAA 660

TTGCTATCAT CTATCCCTAT GTGGACTACA TTTGGGGAAC TAGCCATTTT ATACAACTGT 720

ACAAGGACTG CCTCTGTGAA AGCTATCACC AATGTGAAAA CATGGGCTCT AGATCGAGAA 780

GTTTTCCAGA ATATAATGAG GAGGACAGCC CAAGCCAGAG ACGAGCAGTA CAGAAACTTC 840

CTCAGAAGTG TATCCTTGCT GAAGAACTTA CCTGAAGATA AATTAACCAA GATCATCGAC 900

TGCTTGGAAG TGGAATACTA CGACAAAGGA GATTACATCA TTAGAGAGGG TGAGGAGGGA 960

AGTACCTTTT TCATTTTGGC AAAAGGAAAG GTAAAAGTTA CACAGAGTAC AGAGGGCCAT 1020

GATCAGCCAC AGCTGATTAA AACGCTGCAG AAAGGAGAAT ACTTTGGAGA GAAAGCTCTT 1080

ATCAGTGATG ATGTCCGATC AGCTAACATT ATTGCTGAAG AAAATGATGT CGCCTGTCTG 1140

GTTATTGACC GAGAAACGTT CAATCAAACT GTTGGCACGT TCGAAGATCT CCAGAAATAC 1200

CTTGAAGGGT ATGTGGCAAA CCTGAACCGT GATGATGAAA AAAGACATGC AAAGAGGTCC 1260

ATGTCTAGCT GGAAGCTGTC CAAAGCGCTC TCTCTGGAGA TGATTCAGCT GAAGGAGAAG 1320

GTGGCCCGAT TTTCCTCATC ATCCCCATTC CAGAACCTTG AGATTATCGC AACACTGGGC 1380

GTTGGTGGGT TCGGAAGAGT TGAGCTTGTT AAAGTGAAAA ATGAGAATGT TGCGTTTGCA 1440

ATGAAGTGTA TAAGGAAGAA GCACATAGTG GACACTAAGC AACAGGAGCA TGTCTACTCA 1500

GAAAAGAGGA TCTTGGAAGA GTTGTGTTCT CCATTCATTG TGAAACTGTA TCGAACTTTC 1560

AAGGATAACA AGTACGTCTA CATGCTTCTG GAGGCATGCT TAGGTGGCGA GCTGTGGAGC 1620

ATATTAAGGG ACAGAGGCAG CTTTGATGAG CCCACCTCCA AATTCTGCGT AGCTTGTGTA 1680

ACAGAAGCAT TTGATTACCT ACATCGACTT GGTATTATCT ACAGAGACCT GAAGCCAGAA 1740

AACTTAATTC TAGATGCTGA TGGTTACCTT AAACTGGTTG ACTTTGGATT TGCTAAAAAA 1800

ATTGGATCTG GACAGAAGAC ATGGACGTTC TGTGGGACTC CAGAGTATGT GGCTCCTGAG 1860

GTCATTCTTA ACAAAGGGCA TGACTTCAGT GTGGACTTTT GGTCACTGGG AATCCTCGTG 1920

TATGAGCTAC TAACGGGCAA CCCACCCTTT TCTGGGATTG ACCAAATGAT GACCTATAAC 1980

CTGATTCTCA AAGGAATTGA AAAAATGGAT TTTCCTAGAA AGATAACCAG ACGACCTGAG 2040

GATTTGATCC GGAGGCTTTG CAGGCAAAAC CCAACAGAAA GACTGGGAAA TCTGAAGAAT 2100

GGAATCAATG ACATTAAGAA ACACAGGTGG TTAAATGGCT TTAATTGGGA GGGATTGAAA 2160

GCGCGGAATC TTCCATCACC CTTACGAAGA GAGCTCAGTG GACCTATCGA TCACAGCTAC 2220

TTTGACAAGT ATCCCCCTGA AAAGGGAGTG CCTCCAGATG AACTTTCAGG CTGGGATAAA 2280

GACTTC 2286

Domain Profile

S: 1     lkviatlgvggfgrvelvkvksdeskafalkilkkkhivdtkqqehvlsekrileeaksd  60

         l++iatlgvggfgrvelvkvk+ e+ afa+k+++kkhivdtkqqehv+sekrilee++s+

Q: 453   LEIIATLGVGGFGRVELVKVKN-ENVAFAMKCIRKKHIVDTKQQEHVYSEKRILEELCSP  511

         689******************9.999**********************************

S: 61    fivklyrtfkdekyvyllleaclggelwtilrdrgsfddktakfivacvvealeylhskn  120

         fivklyrtfkd+kyvy+lleaclggelw+ilrdrgsfd+ t+kf+vacv+ea++ylh+ +

Q: 512   FIVKLYRTFKDNKYVYMLLEACLGGELWSILRDRGSFDEPTSKFCVACVTEAFDYLHRLG  571

         ************************************************************

S: 121   iiyrdlkpenllldeegylklvdfgfakklksgkktwtfcgtpeyvapeiilnkghdlsv  180

         iiyrdlkpenl+ld++gylklvdfgfakk++sg+ktwtfcgtpeyvape+ilnkghd+sv

Q: 572   IIYRDLKPENLILDADGYLKLVDFGFAKKIGSGQKTWTFCGTPEYVAPEVILNKGHDFSV  631

         ************************************************************

S: 181   dywalgilvyelltgkppfsgvdplktynlilkgidklelprkitkeaedlikklcrdnp  240

         d+w+lgilvyelltg+ppfsg+d+++tynlilkgi+k+++prkit+++edli++lcr+np

Q: 632   DFWSLGILVYELLTGNPPFSGIDQMMTYNLILKGIEKMDFPRKITRRPEDLIRRLCRQNP  691

         ************************************************************

S: 241   aerlgylkggikdikkhkwf  260

         +erlg+lk+gi+dikkh+w+

Q: 692   TERLGNLKNGINDIKKHRWL  711

         *******************7

Domain Sequence
(FASTA)

LEIIATLGVG GFGRVELVKV KNENVAFAMK CIRKKHIVDT KQQEHVYSEK RILEELCSPF 60

IVKLYRTFKD NKYVYMLLEA CLGGELWSIL RDRGSFDEPT SKFCVACVTE AFDYLHRLGI 120

IYRDLKPENL ILDADGYLKL VDFGFAKKIG SGQKTWTFCG TPEYVAPEVI LNKGHDFSVD 180

FWSLGILVYE LLTGNPPFSG IDQMMTYNLI LKGIEKMDFP RKITRRPEDL IRRLCRQNPT 240

ERLGNLKNGI NDIKKHRWL 259

Keyword

ATP-binding; cGMP; cGMP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0030553	; F:cGMP binding
GO:0004692	; F:cGMP-dependent protein kinase activity

KEGG

InterPros

IPR000961	; AGC-kinase_C.
IPR016232	; cGMP-dependent_protein_kinase.
IPR002374	; cGMP_dep_kinase.
IPR018490	; cNMP-bd-like.
IPR018488	; cNMP-bd_CS.
IPR000595	; cNMP-bd_dom.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR014710	; RmlC-like_jellyroll.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00027	; cNMP_binding; 2.
PF00069	; Pkinase; 1.

SMARTs

SM00100	; cNMP; 2.
SM00133	; S_TK_X; 1.
SM00220	; S_TKc; 1.

Prosites

PS51285	; AGC_KINASE_CTER; 1.
PS00888	; CNMP_BINDING_1; 2.
PS00889	; CNMP_BINDING_2; 2.
PS50042	; CNMP_BINDING_3; 2.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

PR00104

; CGMPKINASE.

Created Date

20-Feb-2013