EKS-ORC-00247

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ORC-00247

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Other/PLK	425.5	8.6E-128	53	305	253

Status

Unreviewed

Ensembl Protein

ENSOCUP00000007325

UniProt Accession

G1SV90;

Protein Name

Protein Synonyms/Alias

Gene Name

PLK1

Gene Synonyms/Alias

PLK1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSOCUG00000008476	ENSOCUP00000007325	ENSOCUT00000008475

Organism

Oryctolagus cuniculus

Functional Description

Protein Length

604

Protein Sequence
(FASTA)

MSAALSAAKL ARAPADPGKA GGPGVAAPGA PAAAPPAKEI PEVLVDPRSR RRYVRGRFLG 60

KGGFAKCFEI SDADTKEVFA GKIVPKSLLL KPHQKEKMSM EISIHRSLAH QHVVGFHGFF 120

EDSDFVFVVL ELCRRRSLLE LHKRRKALTE PEARYYLRQI VLGCQYLHRN RVIHRDLKLG 180

NLFLNEDLEV KIGDFGLATK VEYDGERKKT LCGTPNYIAP EVLSKKGHSF EVDVWSIGCI 240

MYTLLVGKPP FETSCLKETY LRIKKNEYSI PKHINPVAAS LIQKMLQTDP SARPTINELL 300

SDEFFTSGYI PARLPITCLT IPPRFSIAPS SLDPSSRKPL TVLNKGLENP LPERPREKEE 360

PVVRETNEAV ECHLSDMLQQ LHSVNASKPS ERGLVRQEEA EDPACIPIFW VSKWVDYSDK 420

YGLGYQLCDN SVGVLFNDST RLILYNDGDS LQYIERDGTE SYLTVSSHPN SLMKKITLLK 480

YFRNYMSEHL LKAGANITPR EGDELARLPY LRTWFRTRSA IILHLSNGTV QINFFQDHTK 540

LILCPLMAAV TYIDEKRDFR TYRLSLLEEY GCCKELASRL RYARTMVDKL LSSRSASNRL 600

KASS 604

Nucleotide Sequence
(FASTA)

ATGAGTGCAG CGCTGAGTGC AGCGAAGCTG GCGCGGGCGC CGGCCGACCC AGGGAAGGCT 60

GGCGGCCCCG GAGTGGCAGC TCCCGGAGCA CCGGCAGCTG CTCCGCCGGC CAAAGAGATC 120

CCCGAGGTCC TGGTGGACCC ACGCAGCCGG CGGCGCTATG TGCGGGGCCG CTTTCTGGGC 180

AAGGGCGGCT TCGCCAAATG CTTCGAGATC TCCGATGCGG ACACCAAGGA GGTGTTCGCC 240

GGCAAGATCG TGCCCAAGTC TCTGCTGCTC AAGCCGCACC AGAAGGAGAA AATGTCCATG 300

GAGATCTCCA TTCACCGCAG CCTGGCCCAC CAGCACGTCG TCGGCTTCCA CGGCTTTTTC 360

GAGGACAGCG ATTTCGTGTT CGTGGTGTTG GAGCTCTGCC GCCGCAGGTC TCTCCTGGAG 420

CTGCACAAGA GGAGGAAAGC GCTGACGGAG CCCGAGGCCC GCTACTACCT GCGGCAGATC 480

GTCCTTGGCT GCCAGTACCT GCACCGAAAC CGGGTCATCC ACCGGGACCT CAAGCTGGGG 540

AACCTCTTCC TGAATGAGGA CCTGGAGGTG AAAATAGGGG ATTTTGGGCT GGCAACCAAA 600

GTTGAATATG ACGGAGAACG GAAGAAGACC CTGTGTGGGA CTCCCAACTA CATAGCTCCC 660

GAGGTGCTGA GCAAGAAAGG GCACAGTTTC GAGGTGGACG TGTGGTCCAT CGGCTGCATC 720

ATGTATACCT TGTTAGTGGG CAAACCACCT TTTGAGACTT CTTGCCTAAA AGAGACCTAC 780

CTCCGGATTA AGAAGAATGA ATACAGCATT CCTAAGCACA TCAACCCTGT GGCTGCGTCC 840

CTCATCCAGA AGATGCTGCA GACAGACCCC TCTGCCCGCC CGACCATTAA CGAGCTGCTC 900

AGTGACGAGT TCTTCACTTC CGGCTACATC CCTGCCCGGC TGCCCATCAC CTGCCTCACC 960

ATTCCACCCA GGTTCTCAAT CGCTCCCAGC AGCCTGGACC CCAGCAGCCG GAAGCCTCTC 1020

ACCGTCCTTA ATAAAGGCTT GGAGAACCCC TTGCCGGAAC GTCCCCGGGA GAAAGAGGAA 1080

CCTGTGGTCC GGGAGACGAA TGAGGCGGTG GAGTGCCACC TCAGTGACAT GCTGCAGCAG 1140

CTGCACAGTG TGAACGCCTC CAAGCCCTCC GAGCGCGGGC TGGTGCGGCA AGAGGAGGCC 1200

GAGGATCCCG CCTGCATCCC CATCTTCTGG GTCAGCAAGT GGGTGGACTA CTCGGACAAG 1260

TATGGCCTCG GCTACCAGCT GTGCGACAAC AGCGTGGGGG TGCTCTTCAA CGACTCCACC 1320

CGCCTGATCC TCTACAACGA CGGCGACAGC CTGCAGTACA TAGAGCGAGA CGGCACCGAG 1380

TCCTACCTCA CCGTGAGTTC CCACCCCAAC TCCCTGATGA AGAAGATCAC CCTCCTGAAG 1440

TACTTCCGCA ATTACATGAG CGAGCACTTG CTGAAGGCAG GCGCCAACAT CACGCCGCGG 1500

GAAGGCGACG AGCTGGCCCG GCTGCCCTAC CTGCGGACCT GGTTCCGCAC CCGCAGCGCC 1560

ATCATCCTGC ACCTCAGCAA TGGCACCGTG CAGATCAACT TCTTCCAGGA TCACACCAAG 1620

CTCATCCTGT GCCCCCTGAT GGCTGCTGTG ACCTACATCG ATGAGAAGCG GGACTTCCGC 1680

ACGTACCGCC TGAGCCTCCT GGAGGAGTAC GGCTGCTGCA AGGAGCTGGC CAGCCGTCTG 1740

CGCTACGCCC GCACCATGGT GGACAAGCTG CTGAGCTCAC GCTCCGCCAG CAACCGCCTC 1800

AAGGCCTCCT CCTAG 1815

Domain Profile

S: 1     yergkllGkGgfakcyelkdletkevfavkvvpksllakekqrekvekeieihrslkhkn  60

         y rg++lGkGgfakc+e++d++tkevfa k+vpksll k++q+ek+++ei+ihrsl+h++

Q: 53    YVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQKEKMSMEISIHRSLAHQH  112

         89**********************************************************

S: 61    ivklyeffedkenvylvlelcsrrslaellkrrkaltepevryylrqivsglkylhekri  120

         +v ++ ffed+++v++vlelc+rrsl el+krrkaltepe+ryylrqiv g++ylh++r+

Q: 113   VVGFHGFFEDSDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRV  172

         ************************************************************

S: 121   lhrdlklgnlflneelevkigdfGlatrlekeeerkktlcGtPnyiaPevlskkghslev  180

         +hrdlklgnlflne+levkigdfGlat++e+++erkktlcGtPnyiaPevlskkghs+ev

Q: 173   IHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEV  232

         ************************************************************

S: 181   diWslGcilytllvGkPPfetkelketyekikkaeyslPsslskeaksliakllkkePee  240

         d+Ws+Gci+ytllvGkPPfet++lkety +ikk+eys+P+++++ a+sli+k+l+++P++

Q: 233   DVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPSA  292

         ************************************************************

S: 241   rpsleevlkdefl  253

         rp+++e+l+def+

Q: 293   RPTINELLSDEFF  305

         ************8

Domain Sequence
(FASTA)

YVRGRFLGKG GFAKCFEISD ADTKEVFAGK IVPKSLLLKP HQKEKMSMEI SIHRSLAHQH 60

VVGFHGFFED SDFVFVVLEL CRRRSLLELH KRRKALTEPE ARYYLRQIVL GCQYLHRNRV 120

IHRDLKLGNL FLNEDLEVKI GDFGLATKVE YDGERKKTLC GTPNYIAPEV LSKKGHSFEV 180

DVWSIGCIMY TLLVGKPPFE TSCLKETYLR IKKNEYSIPK HINPVAASLI QKMLQTDPSA 240

RPTINELLSD EFF 253

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tupaia belangeri"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005813	; C:centrosome
GO:0000942	; C:condensed nuclear chromosome outer kinetochore
GO:0030496	; C:midbody
GO:0005876	; C:spindle microtubule
GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0007092	; P:activation of mitotic anaphase-promoting complex activity
GO:0051297	; P:centrosome organization
GO:0000910	; P:cytokinesis
GO:0031572	; P:G2/M transition DNA damage checkpoint
GO:0000086	; P:G2/M transition of mitotic cell cycle
GO:0001578	; P:microtubule bundle formation
GO:0043066	; P:negative regulation of apoptotic process
GO:0045736	; P:negative regulation of cyclin-dependent protein kinase activity
GO:0000122	; P:negative regulation of transcription from RNA polymerase II promoter
GO:0018105	; P:peptidyl-serine phosphorylation
GO:0010800	; P:positive regulation of peptidyl-threonine phosphorylation
GO:0031648	; P:protein destabilization
GO:0071168	; P:protein localization to chromatin
GO:0016567	; P:protein ubiquitination
GO:0090007	; P:regulation of mitotic anaphase
GO:0043393	; P:regulation of protein binding

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000959	; POLO_box_duplicated_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069	; Pkinase; 1.
PF00659	; POLO_box; 2.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS50078	; POLO_BOX; 2.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013