EKS-ORC-00461

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ORC-00461

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Other/TBCK	429.2	4.8E-129	18	273	256

Status

Unreviewed

Ensembl Protein

ENSOCUP00000007363

UniProt Accession

G1SVB8;

Protein Name

Protein Synonyms/Alias

Gene Name

TBCK

Gene Synonyms/Alias

TBCK;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSOCUG00000008514	ENSOCUP00000007363	ENSOCUT00000008521
ENSOCUG00000008514	ENSOCUP00000025582	ENSOCUT00000023514

Organism

Oryctolagus cuniculus

Functional Description

Protein Length

893

Protein Sequence
(FASTA)

MFPLKDAEIG AFTFFASALP HDVCGSNGLP LTPNSIKILG RFQILKTITH PRLCQYVDIS 60

RGKHERLVVV AEHCERSLED LLRERKPVSY SKVLCIAFEV LQGLQYMNKH GIVHRALSPH 120

NILLDQKGHI KLAKFGLYHM TAHGDDVDFP IGYPSYLAPE VIAQGISRTT DHVPSEKPLP 180

SGPKSDVWSL GIILFELCVG RKLFQSLDIS ERLKFLLTLD CVDDTITVLA EEHGCLDIIK 240

ELPENVIDLL KKCLTFHPSK RPTPDELMKD KLFSEVSPLY TPFIKPASLF SSSLRCADLT 300

LPEDISQLCK DTNSDYLAER SIEEVYYLWC LAGGDLEKEL VNKEIIRSKP PICTLPNFLF 360

EDGESFGQGR DRSSLLDDTT VTLSLCQLRN RLKDVGGEAF YPLLEDDQSN LPHSNSNNEL 420

SAAATLPLII RERDTEYQLN RIILFDRLLK AYPYKKNQIW KEARVDIPPL MRGLTWAALL 480

GVEGAIHAKY DAIDKDTPIP TDRQIEVDIP RCHQYDELLS SPEGHAKFRR VLKAWVVSHP 540

DLVYWQGLDS LCAPFLYLNF NNEALAYACM SAFIPKYLYN FFLKDNSHVI QEYLTVFSQM 600

IAFHDPELSN HLNEIGFIPD LYAIPWFLTM FTHVFPLHKI FHLWDTLLLG NSSFPFCIGV 660

AILQQLRDRL LANGFNECIL LFSDLPEIDI ERCVRESINL FCWTPKSATY RQHAQPPKPT 720

SDSSGVRSSA PYFSAECPDP PKSDLSRESI PLNDLKSEVS PRISAEDLID LCELTMTGHF 780

KTPAKKTKSG KPKLLVVDIR NTEDFIRGHI SGSINIPFSS AFTAEGELTQ GPHTAVLQNF 840

KGKVIVIVGN VAKHTAEFAA HLVKMKYPRI CILDGGINKI KPTGLLTVPS PQI 893

Nucleotide Sequence
(FASTA)

ATGTTTCCCT TAAAGGATGC TGAAATAGGT GCCTTTACCT TCTTTGCCTC GGCTTTGCCA 60

CATGATGTTT GTGGAAGCAA TGGGCTTCCT CTCACACCAA ATTCTATAAA AATTTTAGGG 120

CGCTTTCAAA TTCTTAAGAC CATCACCCAT CCCCGACTTT GTCAGTATGT GGATATATCT 180

AGAGGAAAAC ATGAAAGACT CGTTGTGGTG GCTGAACACT GTGAACGGAG TCTGGAAGAC 240

TTGCTTCGAG AAAGGAAACC TGTGAGCTAT TCAAAGGTTT TGTGCATAGC ATTTGAAGTA 300

CTTCAGGGCT TACAGTATAT GAACAAACAT GGTATAGTAC ACCGAGCACT GTCTCCTCAT 360

AATATCCTGT TGGACCAAAA GGGACATATT AAATTGGCTA AATTTGGACT TTATCACATG 420

ACAGCTCACG GTGATGATGT TGATTTTCCA ATTGGGTATC CATCATACTT GGCACCGGAG 480

GTAATTGCAC AAGGAATTTC TAGAACAACT GATCATGTGC CCAGTGAAAA ACCATTGCCT 540

TCTGGCCCCA AATCAGATGT GTGGTCTCTT GGAATCATTT TGTTTGAGCT TTGTGTGGGA 600

AGAAAATTAT TTCAGAGCTT GGATATTTCT GAAAGACTAA AATTTTTGCT TACTCTGGAC 660

TGTGTAGATG ACACTATTAC AGTTCTGGCT GAAGAGCATG GGTGTCTGGA CATTATAAAG 720

GAGCTTCCTG AAAATGTGAT AGATCTTTTG AAGAAGTGTC TCACCTTCCA CCCTTCAAAG 780

AGGCCAACTC CAGATGAATT GATGAAGGAC AAATTGTTCA GTGAAGTGTC ACCTTTATAT 840

ACCCCCTTTA TCAAACCTGC CAGTCTGTTT TCATCTTCTT TGAGATGTGC TGACTTAACT 900

TTGCCTGAGG ATATCAGTCA GTTGTGCAAA GATACAAACA GTGATTACCT GGCAGAAAGA 960

TCTATTGAAG AAGTTTATTA CCTTTGGTGT TTGGCTGGAG GTGACTTGGA GAAAGAGCTT 1020

GTCAACAAGG AAATCATTCG ATCCAAGCCA CCTATCTGCA CACTCCCCAA TTTTCTCTTT 1080

GAAGATGGTG AAAGTTTTGG ACAAGGCCGT GATAGAAGTT CACTTTTAGA TGATACCACT 1140

GTGACATTGT CATTGTGCCA GCTAAGAAAT AGATTGAAAG ACGTTGGTGG AGAGGCATTT 1200

TATCCATTAC TTGAAGATGA TCAGTCGAAT TTACCTCATT CAAACAGCAA TAATGAGTTG 1260

TCTGCAGCTG CCACTCTTCC TTTAATCATC CGAGAGAGGG ACACAGAGTA CCAGCTAAAC 1320

AGAATCATTC TCTTTGACAG GCTGCTAAAG GCTTATCCCT ATAAAAAAAA TCAAATTTGG 1380

AAAGAAGCAA GAGTTGACAT TCCTCCTCTG ATGAGAGGAT TAACCTGGGC TGCTCTTCTG 1440

GGAGTTGAGG GGGCTATTCA TGCCAAATAT GATGCGATTG ATAAAGACAC ACCAATTCCT 1500

ACAGATAGAC AGATTGAAGT GGATATTCCT CGCTGTCATC AGTATGATGA ACTGTTATCA 1560

TCACCAGAAG GTCATGCAAA ATTTAGGCGT GTATTAAAAG CCTGGGTGGT ATCACATCCT 1620

GATCTTGTAT ACTGGCAAGG TCTTGACTCA CTTTGTGCTC CATTCCTGTA TCTAAATTTC 1680

AATAATGAGG CCTTGGCTTA TGCATGTATG TCTGCTTTTA TTCCCAAATA CCTGTATAAC 1740

TTCTTCTTGA AAGACAACTC TCATGTAATC CAAGAGTATT TGACTGTGTT TTCTCAGATG 1800

ATTGCATTCC ATGATCCAGA GCTAAGTAAT CATCTCAATG AGATTGGCTT CATTCCTGAT 1860

CTCTATGCCA TCCCTTGGTT TCTCACCATG TTTACTCATG TTTTTCCACT GCACAAAATT 1920

TTTCACCTCT GGGATACCTT ACTACTTGGG AATTCCTCTT TCCCCTTCTG TATCGGAGTA 1980

GCTATTCTTC AGCAGCTGCG AGACCGGCTT TTGGCTAACG GCTTTAATGA ATGCATTCTT 2040

CTCTTCTCTG ACTTACCAGA AATCGACATT GAACGCTGTG TTCGAGAATC AATCAACTTG 2100

TTTTGTTGGA CTCCTAAAAG TGCTACTTAT AGACAGCATG CTCAGCCTCC AAAACCAACT 2160

TCTGACAGTA GTGGAGTCAG AAGTTCAGCA CCTTATTTCT CTGCTGAGTG TCCAGACCCA 2220

CCGAAGTCAG ATCTGTCAAG AGAATCCATC CCATTAAATG ACCTGAAATC AGAAGTATCA 2280

CCCAGGATTT CAGCAGAGGA CCTGATTGAC TTGTGTGAGC TGACGATGAC CGGCCACTTC 2340

AAAACACCTG CCAAGAAAAC AAAGTCTGGT AAACCAAAGC TCCTGGTGGT TGACATCCGG 2400

AACACTGAAG ATTTCATTCG GGGTCACATT TCAGGCAGTA TCAACATTCC ATTCAGCTCT 2460

GCGTTCACTG CAGAAGGGGA GCTCACCCAA GGTCCTCACA CAGCTGTGCT CCAGAACTTC 2520

AAAGGGAAAG TCATTGTCAT CGTGGGGAAT GTAGCAAAGC ACACAGCTGA GTTTGCAGCT 2580

CATCTTGTGA AGATGAAATA TCCAAGAATC TGTATTCTAG ATGGTGGCAT TAATAAGATC 2640

AAGCCAACAG GCCTGCTCAC CGTCCCATCT CCTCAAATC 2679

Domain Profile

S: 1     llaqdkdGsnGlplasnakkilGrfqiLkelqhdrLcqYldisrgkhervivvaehlels  60

         +l++d++GsnGlpl++n++kilGrfqiLk+++h+rLcqY+disrgkher++vvaeh+e+s

Q: 18    ALPHDVCGSNGLPLTPNSIKILGRFQILKTITHPRLCQYVDISRGKHERLVVVAEHCERS  77

         589*********************************************************

S: 61    LeDllkerkpvseslvlriayevlsgldylnkhnivhralepksilldrkgqkvkLakyG  120

         LeDll+erkpvs s+vl+ia+evl+gl+y+nkh+ivhral+p++illd+kg+ +kLak+G

Q: 78    LEDLLRERKPVSYSKVLCIAFEVLQGLQYMNKHGIVHRALSPHNILLDQKGH-IKLAKFG  136

         ****************************************************.*******

S: 121   LyhltayGkdvdfpigygsylaPerilqd.........edkllaatvksDvWsLglille  171

         Lyh+ta+G+dvdfpigy+sylaPe+i+q+         ++k+l++++ksDvWsLg+il+e

Q: 137   LYHMTAHGDDVDFPIGYPSYLAPEVIAQGisrttdhvpSEKPLPSGPKSDVWSLGIILFE  196

         ************************************************************

S: 172   lilgikLfaeldlserlkillklstvdetliklaeekkcldiikklderleallkkCLtl  231

         l++g+kLf++ld+serlk+ll+l++vd+t+ +laee++cldiik+l+e++++llkkCLt+

Q: 197   LCVGRKLFQSLDISERLKFLLTLDCVDDTITVLAEEHGCLDIIKELPENVIDLLKKCLTF  256

         ************************************************************

S: 232   lpskRpspdellkekvf  248

         +pskRp+pdel+k+k f

Q: 257   HPSKRPTPDELMKDKLF  273

         **************986

Domain Sequence
(FASTA)

ALPHDVCGSN GLPLTPNSIK ILGRFQILKT ITHPRLCQYV DISRGKHERL VVVAEHCERS 60

LEDLLRERKP VSYSKVLCIA FEVLQGLQYM NKHGIVHRAL SPHNILLDQK GHIKLAKFGL 120

YHMTAHGDDV DFPIGYPSYL APEVIAQGIS RTTDHVPSEK PLPSGPKSDV WSLGIILFEL 180

CVGRKLFQSL DISERLKFLL TLDCVDDTIT VLAEEHGCLD IIKELPENVI DLLKKCLTFH 240

PSKRPTPDEL MKDKLF 256

Keyword

Complete proteome; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005622	; C:intracellular
GO:0005524	; F:ATP binding
GO:0004672	; F:protein kinase activity
GO:0005097	; F:Rab GTPase activator activity
GO:0032851	; P:positive regulation of Rab GTPase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR000195	; Rab-GTPase-TBC_dom.
IPR001763	; Rhodanese-like_dom.

Pfam

PF00069	; Pkinase; 1.
PF00566	; RabGAP-TBC; 1.
PF00581	; Rhodanese; 1.

SMARTs

SM00450	; RHOD; 1.
SM00164	; TBC; 1.

Prosites

PS50011	; PROTEIN_KINASE_DOM; 1.
PS50206	; RHODANESE_3; 1.
PS50086	; TBC_RABGAP; 1.

Prints

Created Date

20-Feb-2013