EKS-ORC-00151
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-ORC-00151
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
CAMK/RSKb441.61.0E-132427687261
StatusUnreviewed
Ensembl ProteinENSOCUP00000007699
UniProt AccessionG1SW53;
Protein NameRibosomal protein S6 kinase
Protein Synonyms/Alias
Gene NameRPS6KA5
Gene Synonyms/Alias RPS6KA5;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSOCUG00000008913ENSOCUP00000007699ENSOCUT00000008917
ENSOCUG00000008913ENSOCUP00000021919ENSOCUT00000025707
OrganismOryctolagus cuniculus
Functional Description
Protein Length798
Protein Sequence
(FASTA)
MEEKGGSGDG AVGTSGDGGD TGEQLLTVKH ELRTANLTGH AEKVGIENFE LLKVLGTGAY 60
GKVFLVRKIS GHDTGKLYAM KVLKKATIVQ KAKSREHTRT ERQVLEHIRQ SPFLVTLHYA 120
FQTETKLHLI LDYINGGELF THLSQRERFT EHEVQIYVGE IVLALEHLHK LGIIYRDIKL 180
ENILLDSNGH VVLTDFGLSK EFVADETERA YSFCGTIEYM APDIVRGGDS GHDKAVDWWS 240
LGVLMYELLT GASPFTVDGE KNSQAEISRR ILKSEPPYPQ EMSALAKDLL QRLLMKDPEK 300
RLGCGPRDAD EIKEHLFFQK INWDDLAAKK VPAPFKPVIR DELDVSNFAE EFTEMDPTYS 360
PAALPQSSER LFQGYSFVAP SILFKRNAAV IDPLQFHVGV ERPGATNVAR SAMMKDSPFY 420
QHYDLDLKDK PLGEGSFSIC RKCVHKKSSQ AFAVKIISKR MEANTQKEIT ALKLCEGHPN 480
IVKLHEVFHD QLHTFLVMEL LSGGELFERI KKKQHFSETE ASYIMRKLVS AVSHMHDVGV 540
VHRDLKPENL LFTDENDNLE IKVIDFGFAR LKPPDNQPLK TPCFTLHYAA PELLNHNGYD 600
ESCDLWSLGV ILYTMLSGQV PFQSHDRSLT CTSAVEIMKK IKKGDFSFEG EAWKNVSQEA 660
KDLIQGLLTV DPNKRLKMSG LRYNEWLQDG SQLSSNPLMT PDILGSSGAA VHTCVKATFH 720
AFNKYKREGF CLQTVDKAPL AKRRKMKKTS TSTETRSSSS ESSHSSSSHS HGKTTPTAAL 780
PPSQPDGGPS DGLFQFSD 798
Nucleotide Sequence
(FASTA)
ATGGAGGAGA AGGGCGGCAG CGGCGACGGC GCCGTGGGGA CCAGCGGGGA CGGCGGCGAC 60
ACGGGGGAGC AGCTCCTCAC GGTCAAGCAC GAGCTGCGGA CGGCTAATTT AACAGGACAT 120
GCAGAGAAGG TGGGGATTGA AAATTTTGAG CTCCTGAAGG TCCTGGGAAC TGGAGCGTAC 180
GGGAAAGTAT TTCTGGTTCG TAAAATAAGT GGTCACGACA CTGGAAAGCT GTACGCCATG 240
AAGGTTTTGA AGAAGGCGAC CATCGTTCAG AAGGCCAAAA GCAGGGAGCA CACGAGGACG 300
GAGCGGCAGG TCCTGGAGCA CATCAGGCAG TCGCCGTTCC TGGTGACGCT GCACTATGCT 360
TTCCAGACAG AGACCAAGCT CCATCTCATC TTAGATTATA TAAATGGTGG AGAACTTTTT 420
ACTCACCTTT CTCAGAGAGA GCGGTTCACA GAGCACGAGG TGCAGATCTA CGTGGGAGAG 480
ATCGTACTCG CCCTGGAACA CCTCCACAAG TTGGGCATTA TATACCGTGA CATTAAGCTT 540
GAGAATATTC TACTTGATTC TAACGGCCAT GTGGTGCTGA CAGATTTTGG TCTGAGTAAG 600
GAGTTTGTGG CTGATGAAAC TGAAAGAGCA TATTCCTTCT GTGGAACTAT CGAGTACATG 660
GCGCCAGACA TCGTCCGAGG GGGAGACTCG GGACATGACA AGGCCGTTGA CTGGTGGAGC 720
TTAGGGGTCC TGATGTACGA GTTACTGACG GGAGCGTCTC CTTTCACTGT GGACGGGGAG 780
AAGAACTCCC AAGCTGAGAT ATCCAGGAGA ATATTAAAAA GTGAGCCTCC ATATCCCCAA 840
GAAATGAGTG CGTTAGCCAA AGACCTACTT CAGCGCCTTC TGATGAAGGA TCCCGAGAAG 900
AGACTGGGCT GCGGCCCGCG GGATGCAGAT GAAATCAAGG AGCATCTCTT CTTCCAGAAA 960
ATCAACTGGG ACGATTTAGC TGCCAAAAAA GTGCCCGCGC CATTCAAGCC GGTGATTCGA 1020
GACGAACTGG ACGTGAGCAA CTTCGCCGAG GAGTTCACAG AAATGGACCC CACCTATTCC 1080
CCCGCAGCCC TGCCCCAGAG CTCCGAGAGG CTGTTCCAGG GCTATTCTTT CGTGGCTCCT 1140
TCTATCCTCT TCAAGCGGAA TGCAGCCGTC ATCGATCCGC TGCAGTTCCA CGTGGGAGTC 1200
GAGCGCCCTG GAGCGACCAA CGTTGCCCGG AGTGCGATGA TGAAGGACTC TCCATTCTAC 1260
CAACACTATG ACCTAGATCT CAAAGACAAA CCACTGGGAG AAGGAAGTTT TTCTATTTGT 1320
CGAAAGTGTG TGCACAAAAA AAGTAGCCAA GCATTCGCCG TCAAAATAAT CAGCAAGAGG 1380
ATGGAAGCCA ATACTCAGAA AGAAATAACA GCTCTGAAAC TCTGTGAAGG ACACCCCAAT 1440
ATCGTGAAGC TGCATGAAGT GTTTCACGAT CAGCTTCACA CGTTCCTCGT CATGGAGCTG 1500
CTGAGCGGGG GAGAGCTGTT TGAGCGCATC AAGAAGAAGC AGCACTTCAG CGAGACCGAG 1560
GCCAGCTACA TCATGCGGAA GCTGGTGTCC GCCGTCAGCC ACATGCACGA CGTCGGAGTG 1620
GTGCACAGAG ACCTAAAGCC CGAGAATCTC TTGTTCACGG ACGAAAACGA CAACTTGGAA 1680
ATTAAAGTGA TTGACTTCGG GTTCGCCCGG CTGAAGCCGC CTGACAATCA GCCCCTGAAG 1740
ACCCCGTGCT TCACGCTGCA CTACGCCGCC CCCGAGCTCC TGAACCACAA CGGCTACGAC 1800
GAGTCGTGCG ACCTGTGGAG CCTGGGCGTC ATCCTGTATA CGATGCTGTC AGGGCAGGTT 1860
CCATTCCAGT CCCATGACAG AAGTCTGACG TGTACCAGTG CCGTGGAGAT TATGAAGAAA 1920
ATTAAAAAGG GAGATTTCTC CTTTGAAGGA GAAGCCTGGA AGAACGTATC CCAAGAGGCT 1980
AAAGATTTGA TCCAAGGACT TCTCACAGTT GATCCAAATA AAAGGCTTAA AATGTCTGGC 2040
TTGAGATACA ACGAATGGCT TCAAGATGGC AGTCAGCTGT CTTCCAACCC CCTGATGACG 2100
CCCGACATCC TGGGGTCTTC CGGAGCTGCC GTGCACACCT GTGTCAAAGC AACCTTCCAC 2160
GCCTTCAACA AGTACAAGCG AGAGGGCTTC TGCCTGCAGA CGGTGGATAA GGCCCCGCTG 2220
GCCAAGAGGC GCAAGATGAA GAAGACCAGC ACCAGCACCG AGACGCGCAG CAGCTCCAGC 2280
GAGAGCTCCC ACTCGTCGTC CTCGCACTCG CACGGCAAGA CCACGCCCAC GGCGGCGCTG 2340
CCGCCCAGCC AGCCCGACGG CGGCCCCAGC GACGGCCTCT TCCAGTTCTC CGAC 2394
Domain Profile
S: 2     evkedlGvGsysvckrcvhkatnqefavkiidks.krdtseeieillryeqhpnivtlkd  60
         +++++lG+Gs+s+c++cvhk++ q+favkii+k+ +++t++ei++l+++e+hpniv+l++
Q: 427   LKDKPLGEGSFSICRKCVHKKSSQAFAVKIISKRmEANTQKEITALKLCEGHPNIVKLHE  486
         5789******************************9*************************
S: 61    vyddgkyvylvlellkGGelldrikkkkffsereasailrtlvkaveylheqGvvhrdlk  120
         v++d+++++lv+ell GGel++rikkk++fse+eas+i+r+lv+av+++h++Gvvhrdlk
Q: 487   VFHDQLHTFLVMELLSGGELFERIKKKQHFSETEASYIMRKLVSAVSHMHDVGVVHRDLK  546
         ************************************************************
S: 121   penilyvdesdnaesikiidfGfaklkraengllktpcytlnfvapevlkrqGydeacdl  180
         pen+l++de+dn+e ik+idfGfa+lk+++n++lktpc+tl+++ape+l+++Gyde+cdl
Q: 547   PENLLFTDENDNLE-IKVIDFGFARLKPPDNQPLKTPCFTLHYAAPELLNHNGYDESCDL  605
         **************.*********************************************
S: 181   wslGvllytmlaGyvpf....angpedtaeeilakikeGkfslsGeawdsvseeakdlvs  236
         wslGv+lytml+G+vpf    +++++++a+ei++kik+G+fs++Geaw++vs+eakdl++
Q: 606   WSLGVILYTMLSGQVPFqshdRSLTCTSAVEIMKKIKKGDFSFEGEAWKNVSQEAKDLIQ  665
         *****************9998899************************************
S: 237   klltvdpakrlkleqllkhswl  258
         +lltvdp+krlk+++l++++wl
Q: 666   GLLTVDPNKRLKMSGLRYNEWL  687
         *********************7
Domain Sequence
(FASTA)
LKDKPLGEGS FSICRKCVHK KSSQAFAVKI ISKRMEANTQ KEITALKLCE GHPNIVKLHE 60
VFHDQLHTFL VMELLSGGEL FERIKKKQHF SETEASYIMR KLVSAVSHMH DVGVVHRDLK 120
PENLLFTDEN DNLEIKVIDF GFARLKPPDN QPLKTPCFTL HYAAPELLNH NGYDESCDLW 180
SLGVILYTML SGQVPFQSHD RSLTCTSAVE IMKKIKKGDF SFEGEAWKNV SQEAKDLIQG 240
LLTVDPNKRL KMSGLRYNEW L 261
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00156
EKS-ANC-00159
EKS-BOT-00163
EKS-CAE-00125
EKS-CAJ-00167
EKS-CAF-00170
EKS-CAP-00162
EKS-CII-00093
EKS-CIS-00194
EKS-DAR-00452
EKS-DIO-00087
EKS-DRM-00077
EKS-EQC-00162
EKS-FEC-00153
EKS-GAG-00140
EKS-GAA-00192
EKS-GOG-00163
EKS-HOS-00169
EKS-ICT-00158
EKS-LAC-00173
EKS-LOA-00162
EKS-MAM-00160
EKS-MAE-00060
EKS-MEG-00130
EKS-MOD-00162
EKS-MUM-00169
EKS-MUP-00167
EKS-MYL-00173
EKS-NOL-00156
EKS-ORN-00202
EKS-ORA-00141
EKS-ORL-00189
EKS-OTG-00170
EKS-PAT-00153
EKS-PES-00145
EKS-PEM-00087
EKS-POA-00160
EKS-RAN-00161
EKS-SAH-00157
EKS-SUS-00141
EKS-TAG-00191
EKS-TAR-00209
EKS-TEN-00202
EKS-XET-00152
EKS-XIM-00197
Gene Ontology
GO:0005737; C:cytoplasm
GO:0005634; C:nucleus
GO:0005524; F:ATP binding
GO:0000287; F:magnesium ion binding
GO:0004674; F:protein serine/threonine kinase activity
GO:0043990; P:histone H2A-S1 phosphorylation
GO:0043987; P:histone H3-S10 phosphorylation
GO:0043988; P:histone H3-S28 phosphorylation
GO:0070498; P:interleukin-1-mediated signaling pathway
GO:0007243; P:intracellular protein kinase cascade
GO:0045892; P:negative regulation of transcription, DNA-dependent
GO:0035066; P:positive regulation of histone acetylation
GO:0033129; P:positive regulation of histone phosphorylation
GO:0051092; P:positive regulation of NF-kappaB transcription factor activity
GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter
GO:0009605; P:response to external stimulus
GO:0006950; P:response to stress
KEGG
InterPros
IPR000961; AGC-kinase_C.
IPR011009; Kinase-like_dom.
IPR017892; Pkinase_C.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR016239; Ribosomal_S6_kinase_II.
IPR002290; Ser/Thr_dual-sp_kinase_dom.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF00069; Pkinase; 2.
PF00433; Pkinase_C; 1.
SMARTs
SM00133; S_TK_X; 1.
SM00220; S_TKc; 2.
Prosites
PS51285; AGC_KINASE_CTER; 1.
PS00107; PROTEIN_KINASE_ATP; 2.
PS50011; PROTEIN_KINASE_DOM; 2.
PS00108; PROTEIN_KINASE_ST; 2.
Prints
Created Date20-Feb-2013