EKS-ORC-00348
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-ORC-00348
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Src436.92.4E-131263510248
StatusUnreviewed
Ensembl ProteinENSOCUP00000007706
UniProt AccessionG1SW58;
Protein Name
Protein Synonyms/Alias
Gene NameFGR
Gene Synonyms/Alias FGR;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSOCUG00000008922ENSOCUP00000007706ENSOCUT00000008924
OrganismOryctolagus cuniculus
Functional Description
Protein Length527
Protein Sequence
(FASTA)
MGCVFCKKLE PGPKEDVGLE GNFRASGAAD RYGPDPTQGR PASSFAHIPN YNNFTPQPSS 60
HTFLGGGTVK GISGSGVTLF IALYDYEART EDDLTFTKGE KFHILNNTEG DWWEARSLSS 120
GQTGYIPSNY VAPVDSIQAE EWYFGKIGRK DAERQLLSPG NPQGTFLIRE SETTKGAYSL 180
SIRDWDQSRG DHVKHYKIRK LDTGGYYITT RAQFDSVQEL VKHYMEVNDG LCHLLTVACA 240
TMKPQTLGLA KDAWEISRAS IGLERRLGSG CFGDVWLGTW NGSTKVAVKT LKPGTMSPKA 300
FLEEAQVMKL LRHHKLVQLY AVVSEEPIYI VTEFMCHGSL LEFLKDQEGQ DLRLPQLVDM 360
AAQVAEGMAY VERMNYIHRD LRAANILVGE RLVCKIADFG LARLIEDDEY NPRQGTKFPI 420
KWTAPEAALF GKFTIKSDVW SFGILLTELI SKGRVPYPGM NNREVLEQVE HGYHMPCPPG 480
CPESLYEIME QTWRLDPEER PTFEYLQSFL EDYFTSTEPQ YQPGDQP 527
Nucleotide Sequence
(FASTA)
ATGGGCTGTG TGTTCTGCAA GAAGCTGGAG CCGGGGCCCA AGGAGGATGT GGGCCTGGAA 60
GGAAACTTCA GGGCCTCTGG GGCTGCCGAC CGCTATGGCC CTGACCCCAC CCAGGGCCGG 120
CCGGCCTCCT CCTTTGCACA CATCCCCAAC TACAACAACT TTACCCCTCA GCCCTCCAGC 180
CACACCTTCC TTGGTGGGGG CACCGTCAAG GGCATCTCAG GCTCTGGGGT GACCCTGTTC 240
ATTGCCCTGT ATGACTATGA GGCCCGGACA GAAGATGACC TCACCTTCAC CAAGGGCGAG 300
AAGTTCCACA TCCTGAACAA CACTGAAGGA GACTGGTGGG AGGCCCGGTC CCTCAGCTCT 360
GGACAAACTG GCTACATTCC CAGCAATTAC GTGGCCCCCG TGGACTCCAT CCAGGCTGAA 420
GAGTGGTACT TCGGAAAGAT CGGGAGGAAG GATGCAGAGA GGCAGCTGCT GTCCCCAGGC 480
AACCCCCAGG GGACCTTCCT CATTCGGGAG AGTGAGACCA CCAAAGGCGC CTACTCGCTG 540
TCCATCCGTG ACTGGGACCA GAGCAGAGGT GATCACGTGA AGCATTATAA GATCCGCAAG 600
CTGGACACGG GTGGCTACTA CATCACCACG CGGGCCCAGT TCGACTCAGT GCAGGAGCTG 660
GTGAAGCACT ACATGGAGGT GAACGATGGG CTGTGCCACC TGCTCACGGT GGCCTGTGCC 720
ACCATGAAGC CGCAGACCCT GGGCCTGGCC AAGGACGCCT GGGAGATCAG CCGTGCCTCC 780
ATCGGACTGG AGCGCCGGCT GGGCAGCGGC TGCTTCGGGG ATGTGTGGCT GGGCACGTGG 840
AACGGCAGCA CAAAGGTGGC GGTGAAGACG CTGAAGCCGG GCACCATGTC CCCGAAGGCC 900
TTCCTGGAGG AGGCGCAGGT CATGAAGCTG CTGCGGCACC ACAAGCTGGT GCAGCTGTAT 960
GCCGTGGTGT CCGAGGAGCC CATCTACATC GTGACCGAGT TCATGTGCCA CGGTAGCTTG 1020
CTGGAGTTCC TCAAGGACCA GGAGGGCCAG GATTTGAGGC TGCCCCAGTT GGTGGACATG 1080
GCAGCCCAGG TAGCTGAGGG CATGGCCTAC GTGGAGCGCA TGAATTATAT CCACCGGGAC 1140
CTGAGGGCGG CCAACATCCT GGTGGGGGAG CGCCTGGTGT GCAAGATCGC AGACTTCGGT 1200
CTGGCCCGTC TCATCGAGGA CGACGAGTAC AACCCTCGGC AAGGGACCAA GTTTCCCATC 1260
AAGTGGACGG CTCCAGAGGC GGCCCTCTTC GGCAAGTTCA CCATCAAGTC AGATGTGTGG 1320
TCCTTTGGGA TCTTGCTCAC CGAGCTCATC AGCAAGGGCC GAGTCCCATA CCCAGGTATG 1380
AATAACCGGG AAGTGCTGGA GCAGGTGGAG CACGGCTACC ACATGCCGTG TCCCCCAGGC 1440
TGCCCCGAGT CCCTGTACGA GATCATGGAG CAGACCTGGC GGCTGGACCC GGAGGAGAGA 1500
CCCACCTTCG AGTACCTGCA GTCCTTCCTG GAGGACTACT TCACCTCCAC AGAACCGCAG 1560
TACCAGCCCG GGGACCAGCC CTAG 1584
Domain Profile
S: 3     lvkklGeGqfGevwlgkwkgsvkvavktlkegtlspeafleeaqilkklrheklvklyav  62
         l+++lG+G+fG+vwlg+w+gs+kvavktlk+gt+sp+afleeaq++k lrh+klv+lyav
Q: 263   LERRLGSGCFGDVWLGTWNGSTKVAVKTLKPGTMSPKAFLEEAQVMKLLRHHKLVQLYAV  322
         89**********************************************************
S: 63    vseeePiyivtelmakGslldflkeeegkklklpklvdlaaqvaeGmayleeknlihrdl  122
         vse ePiyivte+m +Gsll+flk++eg+ l+lp+lvd+aaqvaeGmay+e++n+ihrdl
Q: 323   VSE-EPIYIVTEFMCHGSLLEFLKDQEGQDLRLPQLVDMAAQVAEGMAYVERMNYIHRDL  381
         **9.********************************************************
S: 123   aarnvlvgeslvvkvadfGlarlieddeytakegaklPikWtaPeaiklgkftiksdvWs  182
         +a+n+lvge+lv+k+adfGlarlieddey++++g+k+PikWtaPea+ +gkftiksdvWs
Q: 382   RAANILVGERLVCKIADFGLARLIEDDEYNPRQGTKFPIKWTAPEAALFGKFTIKSDVWS  441
         ************************************************************
S: 183   fGillteivtkGkvPypGmtneevleqvergyrlprpeecpeelyelllecwkkdpeerP  242
         fGillte+++kG+vPypGm+n+evleqve+gy++p+p  cpe+lye+++++w+ dpeerP
Q: 442   FGILLTELISKGRVPYPGMNNREVLEQVEHGYHMPCPPGCPESLYEIMEQTWRLDPEERP  501
         ************************************************************
S: 243   tfetlqevl  251
         tfe+lq++l
Q: 502   TFEYLQSFL  510
         ******986
Domain Sequence
(FASTA)
LERRLGSGCF GDVWLGTWNG STKVAVKTLK PGTMSPKAFL EEAQVMKLLR HHKLVQLYAV 60
VSEEPIYIVT EFMCHGSLLE FLKDQEGQDL RLPQLVDMAA QVAEGMAYVE RMNYIHRDLR 120
AANILVGERL VCKIADFGLA RLIEDDEYNP RQGTKFPIKW TAPEAALFGK FTIKSDVWSF 180
GILLTELISK GRVPYPGMNN REVLEQVEHG YHMPCPPGCP ESLYEIMEQT WRLDPEERPT 240
FEYLQSFL 248
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; SH3 domain; Transferase; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Equus caballus"; ?>Felis catus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Ornithorhynchus anatinus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>
EKS-AIM-00344
EKS-BOT-00371
EKS-CAJ-00374
EKS-CAF-00373
EKS-CAP-00403
EKS-EQC-00362
EKS-FEC-00357
EKS-GOG-00361
EKS-HOS-00377
EKS-ICT-00349
EKS-LOA-00379
EKS-MAM-00370
EKS-MUM-00402
EKS-MUP-00364
EKS-ORA-00323
EKS-OTG-00373
EKS-PAT-00350
EKS-POA-00360
EKS-RAN-00385
EKS-SAH-00341
Gene Ontology
GO:0015629; C:actin cytoskeleton
GO:0032587; C:ruffle membrane
GO:0005524; F:ATP binding
GO:0004715; F:non-membrane spanning protein tyrosine kinase activity
GO:0050830; P:defense response to Gram-positive bacterium
GO:0007229; P:integrin-mediated signaling pathway
GO:0018108; P:peptidyl-tyrosine phosphorylation
GO:0030335; P:positive regulation of cell migration
GO:0050715; P:positive regulation of cytokine secretion
GO:0043306; P:positive regulation of mast cell degranulation
GO:0043552; P:positive regulation of phosphatidylinositol 3-kinase activity
GO:0014068; P:positive regulation of phosphatidylinositol 3-kinase cascade
GO:0046777; P:protein autophosphorylation
GO:0008360; P:regulation of cell shape
GO:0045088; P:regulation of innate immune response
GO:0050764; P:regulation of phagocytosis
GO:0045859; P:regulation of protein kinase activity
KEGG
InterPros
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980; SH2.
IPR001452; SH3_domain.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
Pfam
PF07714; Pkinase_Tyr; 1.
PF00017; SH2; 1.
PF00018; SH3_1; 1.
SMARTs
SM00252; SH2; 1.
SM00326; SH3; 1.
SM00219; TyrKc; 1.
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS50001; SH2; 1.
PS50002; SH3; 1.
Prints
PR00401; SH2DOMAIN.
PR00452; SH3DOMAIN.
PR00109; TYRKINASE.
Created Date20-Feb-2013