EKS-ORC-00370

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ORC-00370

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
STE/STE11	325.2	4.1E-97	1086	1350	265

Status

Unreviewed

Ensembl Protein

ENSOCUP00000007905

UniProt Accession

G1TPU2;

Protein Name

Protein Synonyms/Alias

Gene Name

MAP3K1

Gene Synonyms/Alias

MAP3K1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSOCUG00000009155	ENSOCUP00000007905	ENSOCUT00000009160
ENSOCUG00000009155	ENSOCUP00000019030	ENSOCUT00000025073

Organism

Oryctolagus cuniculus

Functional Description

Protein Length

1355

Protein Sequence
(FASTA)

AISCCLPDRE MENKETLKGL HKMDDRPEER MIREKLKATC MPAWKHEWLE RRNRRGPVVV 60

KPIPIKGDGS EMSNLAAECQ GEGQVGAASP APKGRRSPSP SSSPSGRIVK SESPGVRRKR 120

VSPVPFQSGR ITPPRRAPSP DGFSPYSPEE TNRRVNKVMR ARLYLLQQIG PNSFLIGGDS 180

PDNKYRVFIG PQNCSCGRGT FCIHLLFVML RVFQLEPSDP MLWRKTLKNF EVESLFQKYH 240

SRRSSRIKAP SRNTIQKFVS RMSNSHTLSS SSTSTSSSEN SIKDEEEQMC PICLLGMLDE 300

ESLTVCEDGC RNKLHHHCMS IWAEECRRNR EPLICPLCRS KWRSHDFYSH ELSSPVDSPS 360

SLRTAQQQTL QQPPLAGSQR RTQESNFNLT HYGTQQIPPA YKDLAEPWIQ VFGMELVGCL 420

FSRNWNVREM ALRRLSHDVS GALLLANGES TGNSGGSGGS SPSVGAASGS PQASVSGDVV 480

EACCNVLSVV CADPVYKVYV AALKTLRAML VYTPCHSLAE RIKLQRLLRP VVDTILVKCA 540

DANSRTSQLS ISTLLELCKG QAGELAVGRE ILKAGSIGIG GVDYVLNCIL GNQIESNNWQ 600

ELLGRLCLVD RLLLEFPAEF YPHIVSTDVS QAEPVEIRYK KLLSLLTFAL QSIDNSHSMV 660

GKLSRRIYLS SARMVTAVPH VFSKLLEMLT VSSSTHFTRM RRRLLAIADE VEIAEAIQLD 720

MEDGLGRRQD SFLQASVPNS YPETTENGSR ECTAHTEKTG KGLCAAKLSA SSEDISDRLA 780

SISLGLPCSA TTEQPKPVIQ TKGRPHSQCL NSSPLSHHSQ LGFPALSTPS SSAPSGPAGT 840

VTDVCKHRPQ GFVPCKIPSA SPQTQRKFSL QFQRNCCENK DSDKLSPIFT QSRPLPSSNI 900

HRPKPSRPTP GNTSKQGDAS KNGMTLDLST TSKCDDSIGS SSHGSNAVIP SDETVFTPVE 960

EKGRLDVNTE LNSSIEDLLE ASMPSSDTTV TFKSEVAVLS PEKAENDDTY KDDVNHNQKC 1020

KEKMEAEEEE ALAIAMAMSA SQDALPIVPQ LQVENGEDII IIQQDTPETL PGHTKAKQPY 1080

REDTEWLKGQ QIGLGAFSSC YQAQDVGTGT LMAVKQVTYV RNTSSEQEEV VEALREEIRM 1140

MSHLNHPNII RMLGATCEKS NYNLFIEWMA GGSVAHLLSK YGAFKESVVI NYTEQLLRGL 1200

SYLHENQIIH RDVKGANLLI DSTGQRLRIA DFGAAARLAS KGTGAGEFQG QLLGTIAFMA 1260

PEVLRGQQYG RSCDVWSVGC AIIEMACAKP PWNAEKHSNH LALIFKIASA TTAPSIPSHL 1320

SPGLRDVALR CLELQPQDRP PSRELLKHPV FRTTW 1355

Nucleotide Sequence
(FASTA)

GCCATCAGCT GCTGCCTACC AGATCGCGAG ATGGAGAATA AAGAAACTCT CAAAGGGCTA 60

CACAAGATGG ATGATCGCCC AGAAGAGCGG ATGATCAGGG AGAAACTGAA GGCAACATGC 120

ATGCCGGCCT GGAAGCACGA GTGGCTGGAA AGGAGAAATA GGAGAGGCCC TGTGGTGGTA 180

AAACCAATCC CTATTAAAGG AGATGGATCC GAAATGAGTA ACTTGGCCGC TGAATGTCAA 240

GGAGAGGGCC AGGTGGGCGC TGCGTCTCCA GCCCCCAAAG GCCGGCGCAG CCCGTCTCCC 300

AGCAGCTCCC CTTCAGGTCG CATAGTGAAA TCCGAATCGC CAGGAGTAAG GAGAAAAAGA 360

GTTTCTCCGG TGCCTTTTCA GAGTGGCCGG ATCACACCAC CCCGGAGAGC GCCCTCACCA 420

GATGGCTTCT CACCATACAG CCCCGAGGAA ACAAACCGCC GTGTGAACAA GGTGATGCGG 480

GCCAGGCTGT ACTTGCTGCA GCAAATAGGA CCCAACTCTT TCCTGATTGG AGGGGACAGC 540

CCGGACAATA AATACCGCGT GTTTATAGGG CCACAGAACT GCAGCTGTGG GCGTGGAACA 600

TTTTGTATCC ATCTGTTGTT TGTTATGCTC CGGGTGTTTC AACTAGAACC TTCAGACCCA 660

ATGCTGTGGA GAAAAACCTT AAAGAATTTT GAGGTTGAGA GTTTGTTCCA GAAATATCAC 720

AGTAGGCGTA GCTCAAGGAT CAAAGCTCCA TCTCGTAACA CCATCCAGAA GTTTGTTTCA 780

CGCATGTCAA ATTCTCATAC ATTGTCATCA TCTAGTACTT CTACATCTAG TTCAGAAAAC 840

AGCATAAAAG ATGAAGAGGA GCAAATGTGT CCTATCTGCT TGTTGGGCAT GCTGGACGAG 900

GAGAGCCTGA CAGTGTGTGA GGATGGCTGC AGGAACAAGC TGCACCACCA CTGCATGTCC 960

ATATGGGCAG AAGAATGTAG AAGAAATAGA GAACCTTTAA TATGTCCCCT TTGTAGATCT 1020

AAGTGGCGGT CCCATGATTT TTATAGCCAC GAGTTGTCGA GCCCTGTGGA TTCCCCCTCT 1080

TCCCTTCGAA CTGCACAGCA ACAAACCCTA CAGCAGCCAC CTTTGGCTGG ATCACAAAGA 1140

AGGACTCAAG AGAGCAACTT CAACCTTACT CACTATGGAA CTCAGCAGAT CCCACCTGCT 1200

TACAAAGATC TGGCTGAGCC ATGGATTCAG GTGTTTGGAA TGGAACTCGT TGGCTGCTTA 1260

TTTTCTAGAA ACTGGAATGT CAGAGAGATG GCCCTCAGGC GTCTTTCCCA TGATGTTAGT 1320

GGGGCCCTGC TGTTGGCAAA TGGGGAGAGC ACTGGAAATT CCGGGGGCAG CGGTGGCAGC 1380

AGTCCGAGCG TGGGAGCCGC CAGTGGGTCT CCACAGGCCA GCGTCTCTGG GGACGTGGTG 1440

GAGGCGTGCT GCAACGTCTT GTCGGTGGTC TGCGCCGACC CTGTCTACAA AGTGTACGTT 1500

GCTGCTTTAA AAACATTGCG AGCTATGCTG GTGTACACTC CTTGCCACAG TCTGGCAGAA 1560

AGAATCAAGC TCCAGAGACT CCTCCGACCA GTTGTTGACA CCATCCTCGT CAAGTGTGCT 1620

GATGCCAACA GCCGCACAAG TCAGTTGTCC ATATCAACAC TGTTGGAATT GTGCAAAGGC 1680

CAAGCAGGAG AGTTGGCAGT TGGTAGAGAA ATACTTAAAG CTGGATCCAT TGGAATTGGT 1740

GGTGTTGATT ATGTCTTAAA TTGTATTCTT GGAAACCAAA TTGAATCAAA CAACTGGCAA 1800

GAACTCCTGG GCCGCCTTTG TCTTGTAGAT AGACTGTTGT TGGAGTTTCC TGCTGAATTT 1860

TATCCTCATA TTGTCAGTAC TGACGTCTCA CAAGCTGAGC CTGTTGAAAT CAGGTATAAG 1920

AAGCTGCTGT CCCTCTTAAC CTTTGCTTTG CAGTCCATTG ATAATTCCCA CTCAATGGTG 1980

GGTAAACTCT CCCGAAGGAT CTACTTGAGT TCTGCGAGGA TGGTGACCGC AGTGCCCCAC 2040

GTGTTTTCAA AGCTGTTGGA GATGCTGACC GTCTCCAGCT CTACTCACTT CACCAGGATG 2100

CGCCGCCGGC TGCTGGCTAT TGCGGATGAG GTGGAAATTG CTGAGGCCAT CCAGCTAGAC 2160

ATGGAAGACG GCCTGGGACG CCGCCAGGAC AGCTTTCTGC AGGCATCTGT CCCTAACAGC 2220

TATCCCGAAA CCACAGAGAA CGGCTCCCGT GAGTGCACAG CCCATACAGA GAAAACTGGA 2280

AAAGGATTGT GTGCTGCAAA ATTGAGTGCC AGCTCAGAGG ACATTTCTGA CAGACTGGCC 2340

AGCATTTCAC TGGGACTTCC TTGTTCAGCA ACAACAGAGC AGCCAAAGCC AGTGATTCAG 2400

ACAAAAGGCA GACCCCACAG TCAGTGTTTG AACTCTTCTC CTTTATCTCA TCATTCGCAA 2460

TTAGGGTTCC CAGCCTTATC AACCCCTTCC TCCTCGGCCC CATCTGGACC AGCCGGCACT 2520

GTAACAGATG TCTGTAAGCA TAGACCTCAG GGATTCGTTC CCTGCAAAAT ACCCTCTGCA 2580

TCTCCTCAGA CACAACGCAA GTTTTCTCTA CAATTCCAGA GAAACTGTTG TGAAAACAAA 2640

GACTCAGATA AACTCTCCCC AATCTTTACT CAATCGAGAC CCCTGCCCTC CAGTAACATA 2700

CACAGGCCAA AGCCATCTCG ACCTACGCCA GGTAATACAA GTAAACAGGG AGATGCCTCA 2760

AAAAATGGCA TGACACTTGA TCTGAGCACT ACTTCCAAAT GTGACGACAG CATTGGCAGT 2820

AGCAGCCATG GTAGTAATGC TGTTATACCC AGTGATGAGA CAGTGTTCAC CCCAGTCGAG 2880

GAGAAAGGCA GATTAGATGT CAATACAGAG CTCAACTCCA GTATCGAGGA CCTTCTTGAA 2940

GCTTCCATGC CTTCTAGTGA CACAACAGTA ACCTTCAAGT CAGAAGTTGC TGTCCTGTCT 3000

CCTGAAAAGG CTGAGAATGA TGACACCTAC AAAGATGATG TAAATCATAA TCAGAAGTGC 3060

AAAGAGAAGA TGGAAGCTGA GGAAGAAGAA GCTTTAGCCA TTGCCATGGC AATGTCAGCA 3120

TCGCAGGATG CCCTCCCCAT AGTTCCTCAA CTGCAGGTTG AAAACGGAGA AGATATCATC 3180

ATTATCCAAC AGGATACACC AGAAACTCTA CCAGGACATA CCAAAGCAAA ACAGCCTTAC 3240

AGAGAAGACA CCGAGTGGCT GAAGGGGCAG CAGATAGGCC TTGGAGCGTT TTCTTCTTGT 3300

TATCAGGCTC AAGATGTGGG AACTGGAACT TTAATGGCTG TTAAACAGGT GACATATGTC 3360

AGAAACACGT CCTCTGAGCA GGAGGAAGTG GTGGAAGCCC TGCGAGAAGA GATCAGAATG 3420

ATGAGCCATC TGAATCACCC GAACATCATC AGGATGTTGG GAGCCACGTG TGAGAAGAGC 3480

AACTATAATC TCTTCATTGA GTGGATGGCA GGGGGATCTG TGGCCCATTT GCTGAGTAAA 3540

TACGGAGCCT TTAAGGAATC AGTCGTTATT AATTATACTG AGCAGCTGCT TCGTGGCCTG 3600

TCCTACCTCC ATGAGAACCA GATCATTCAC AGAGATGTCA AAGGTGCCAA TTTGCTGATT 3660

GACAGCACAG GTCAGAGACT GAGAATTGCA GATTTTGGAG CTGCAGCCAG GTTGGCATCG 3720

AAAGGCACTG GTGCAGGAGA GTTTCAGGGA CAGTTACTGG GGACGATCGC ATTCATGGCA 3780

CCTGAGGTAC TAAGAGGTCA GCAGTATGGT AGGAGCTGTG ACGTCTGGAG TGTTGGCTGT 3840

GCTATTATAG AAATGGCTTG CGCAAAACCA CCTTGGAATG CAGAAAAACA CTCCAATCAT 3900

CTTGCTTTAA TATTTAAGAT CGCTAGTGCA ACTACTGCTC CATCCATCCC GTCACATCTG 3960

TCACCCGGGT TACGGGACGT GGCCCTGCGC TGCTTAGAAC TGCAACCTCA GGACAGGCCT 4020

CCCTCAAGAG AGCTACTGAA GCACCCCGTC TTCCGTACCA CGTGGTAG 4068

Domain Profile

S: 1     wqkrevigkGsfgsvyaaldvdtgellavKeveikpekksekk.evkalkeEikllkelk  59

         w k+++ig G+f+s+y+a+dv tg+l+avK+v++ ++++se++ +v+al+eEi+++++l+

Q: 1086  WLKGQQIGLGAFSSCYQAQDVGTGTLMAVKQVTYVRNTSSEQEeVVEALREEIRMMSHLN  1145

         899*******************************999998887699**************

S: 60    HenivkyyGveveeeelkiflEyvegGslssllekygkleesvikkytkqileglayLHe  119

         H+ni++++G+++e++++++f+E+++gGs+++ll+kyg+++esv+ +yt+q+l+gl+yLHe

Q: 1146  HPNIIRMLGATCEKSNYNLFIEWMAGGSVAHLLSKYGAFKESVVINYTEQLLRGLSYLHE  1205

         ************************************************************

S: 120   kkivHRDiKgaNillds.sgvvklsDFGaskrlaelntkaae.lesltGtlaymaPEvik  177

         ++i+HRD+KgaN+l+ds  + ++++DFGa++rla++ t a+e + +l Gt+a+maPEv++

Q: 1206  NQIIHRDVKGANLLIDStGQRLRIADFGAAARLASKGTGAGEfQGQLLGTIAFMAPEVLR  1265

         *****************7789******************9996779*************9

S: 178   kkekgygrkaDiWslgcvviemltgkrPfa..eldeelaimfkvgakktkPeipeklsee  235

         ++  +ygr++D+Ws+gc++iem+++k+P++  +++++la++fk+++++t+P+ip++ls+

Q: 1266  GQ--QYGRSCDVWSVGCAIIEMACAKPPWNaeKHSNHLALIFKIASATTAPSIPSHLSPG  1323

         98..8************************87678899***********************

S: 236   gkdflekcleldpkkrpsaeeLLkhef  262

          +d+  +clel+p++rp ++eLLkh++

Q: 1324  LRDVALRCLELQPQDRPPSRELLKHPV  1350

         *************************86

Domain Sequence
(FASTA)

WLKGQQIGLG AFSSCYQAQD VGTGTLMAVK QVTYVRNTSS EQEEVVEALR EEIRMMSHLN 60

HPNIIRMLGA TCEKSNYNLF IEWMAGGSVA HLLSKYGAFK ESVVINYTEQ LLRGLSYLHE 120

NQIIHRDVKG ANLLIDSTGQ RLRIADFGAA ARLASKGTGA GEFQGQLLGT IAFMAPEVLR 180

GQQYGRSCDV WSVGCAIIEM ACAKPPWNAE KHSNHLALIF KIASATTAPS IPSHLSPGLR 240

DVALRCLELQ PQDRPPSREL LKHPV 265

Keyword

ATP-binding; Complete proteome; Metal-binding; Nucleotide-binding; Reference proteome; Zinc; Zinc-finger.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ornithorhynchus anatinus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Vicugna pacos"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0008545	; F:JUN kinase kinase activity
GO:0004674	; F:protein serine/threonine kinase activity
GO:0008270	; F:zinc ion binding
GO:0008637	; P:apoptotic mitochondrial changes
GO:0043010	; P:camera-type eye development
GO:0071260	; P:cellular response to mechanical stimulus
GO:0030838	; P:positive regulation of actin filament polymerization
GO:0030334	; P:regulation of cell migration
GO:0007179	; P:transforming growth factor beta receptor signaling pathway
GO:0042060	; P:wound healing

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.
IPR001841	; Znf_RING.
IPR013083	; Znf_RING/FYVE/PHD.
IPR007527	; Znf_SWIM.

Pfam

PF00069	; Pkinase; 1.
PF04434	; SWIM; 1.

SMARTs

SM00184	; RING; 1.
SM00220	; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.
PS50089	; ZF_RING_2; 1.
PS50966	; ZF_SWIM; 1.

Prints

Created Date

20-Feb-2013