EKS-ORC-00263

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ORC-00263

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/STKR	451.7	1.2E-135	195	482	288

Status

Unreviewed

Ensembl Protein

ENSOCUP00000007947

UniProt Accession

G1SWR9;

Protein Name

Protein Synonyms/Alias

Gene Name

ACVR1C

Gene Synonyms/Alias

ACVR1C;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSOCUG00000009208	ENSOCUP00000007947	ENSOCUT00000009206

Organism

Oryctolagus cuniculus

Functional Description

Protein Length

493

Protein Sequence
(FASTA)

MTPALLSALR QALLLLAAAA ELSAGLKCVC LLCDSSNFTC QTEGACWASV MLTNGKEQVI 60

KSCVSLPELN AQVFCHSSNN VTKTECCFTD FCNNITLHLP TASPNAPKLG PMELTVVIIV 120

PVCLLSIAAM LTVWACQGRQ CTYRRKKRQN VEEPLSECNL VNAGKTLKDL IYDVTASGSG 180

SGLPLLVQRT IARTIVLQEI VGKGRFGEVW HGRWCGEDVA VKIFSSRDER SWFREAEIYQ 240

TVMLRHENIL GFIAADNKDN GTWTQLWLVS EYHEQGSLYD YLNRNIVTVA GMIKLALSIA 300

SGLAHLHMEI VGTQGKPAIA HRDIKSKNIL VKKCETCAIA DLGLAVKHDS ILNTIDIPQN 360

PKVGTKRYMA PEMLDDTMNV NIFESFKRAD IYSVGLVYWE IARRCSVGGI VEEYQLPYYD 420

MVPSDPSIEE MRKVVCDQNL RPSIPNQWQS CEALRVMGRI MRECWYANGA ARLTALRIKK 480

TISQLCVKED CKA 493

Nucleotide Sequence
(FASTA)

ATGACCCCGG CGCTCCTCTC TGCGCTCCGC CAGGCTCTCC TGCTGCTCGC CGCGGCCGCA 60

GAGCTCTCGG CAGGATTGAA GTGTGTGTGT CTTTTGTGTG ACTCTTCAAA CTTTACCTGC 120

CAAACAGAAG GAGCATGTTG GGCATCAGTC ATGCTAACCA ATGGAAAAGA ACAGGTGATC 180

AAGTCCTGTG TATCCCTCCC AGAATTAAAT GCTCAAGTCT TCTGCCATAG TTCCAACAAT 240

GTTACCAAAA CTGAGTGCTG CTTCACAGAT TTTTGCAACA ATATAACACT GCACCTTCCA 300

ACAGCATCAC CAAATGCCCC CAAACTTGGA CCCATGGAGT TGACTGTTGT TATTATTGTG 360

CCTGTTTGCC TGCTGTCCAT AGCTGCCATG CTGACAGTAT GGGCGTGCCA AGGACGACAG 420

TGCACCTACA GAAGGAAAAA GAGACAGAAT GTGGAGGAAC CACTATCTGA GTGCAATCTG 480

GTAAATGCTG GCAAAACCCT CAAAGATCTG ATTTATGATG TGACTGCCTC TGGATCTGGC 540

TCTGGTCTTC CTCTGTTGGT TCAAAGAACA ATTGCGAGGA CAATTGTACT TCAGGAAATT 600

GTGGGAAAAG GTAGATTTGG TGAGGTGTGG CATGGAAGAT GGTGCGGGGA GGATGTGGCC 660

GTCAAGATAT TCTCCTCCAG GGATGAAAGA TCTTGGTTTC GTGAGGCAGA AATTTACCAG 720

ACTGTTATGC TGCGACATGA AAACATCCTT GGCTTCATCG CTGCTGACAA CAAAGATAAT 780

GGAACTTGGA CTCAACTTTG GCTTGTATCT GAATATCATG AACAAGGCTC CTTATATGAT 840

TATTTGAATA GAAACATAGT GACAGTGGCT GGAATGATAA AACTGGCACT TTCAATAGCT 900

AGTGGTCTGG CTCACCTCCA TATGGAGATT GTTGGTACAC AAGGTAAACC TGCTATTGCT 960

CATAGAGACA TAAAATCAAA GAATATCTTA GTGAAAAAAT GCGAAACTTG TGCCATAGCA 1020

GACTTGGGGT TGGCTGTGAA GCATGATTCA ATCCTGAACA CTATAGACAT TCCTCAGAAT 1080

CCTAAAGTGG GAACCAAAAG GTATATGGCT CCTGAAATGC TTGATGATAC AATGAATGTG 1140

AATATCTTTG AGTCCTTCAA ACGAGCTGAC ATCTATTCTG TTGGTCTGGT TTACTGGGAA 1200

ATAGCCCGGA GGTGTTCAGT TGGAGGAATT GTGGAGGAGT ACCAGTTGCC TTATTATGAT 1260

ATGGTGCCTT CAGATCCCTC AATAGAGGAA ATGAGGAAGG TTGTTTGTGA CCAGAATCTC 1320

CGACCAAGTA TCCCAAACCA GTGGCAAAGC TGTGAAGCAC TCCGAGTCAT GGGGAGAATA 1380

ATGCGTGAGT GCTGGTATGC CAATGGGGCA GCCCGCCTGA CTGCCCTCCG TATTAAGAAG 1440

ACCATCTCTC AACTTTGTGT CAAAGAAGAC TGCAAAGCC 1479

Domain Profile

S: 1     lklleligkGrygeVwkaklrgeevAvKifstedeaswkrEkeiyqtvllrhenilqfia  60

         + l+e++gkGr+geVw++++ ge+vAvKifs++de+sw+rE+eiyqtv+lrhenil+fia

Q: 195   IVLQEIVGKGRFGEVWHGRWCGEDVAVKIFSSRDERSWFREAEIYQTVMLRHENILGFIA  254

         5789********************************************************

S: 61    adkkeedsltelllvteyhekgsLsdyLkretldveellrlalslasGlahLHeeivgtk  120

         ad+k+++++t+l+lv+eyhe+gsL+dyL+r++++v  +++lals+asGlahLH+eivgt+

Q: 255   ADNKDNGTWTQLWLVSEYHEQGSLYDYLNRNIVTVAGMIKLALSIASGLAHLHMEIVGTQ  314

         ************************************************************

S: 121   gkkKpaiaHRDlkskNilvkkdltcciaDlGLalkleeekeeldlaansqvGtkRYmaPE  180

         g  KpaiaHRD+kskNilvkk +tc+iaDlGLa+k+++  +++d+ +n +vGtkRYmaPE

Q: 315   G--KPAIAHRDIKSKNILVKKCETCAIADLGLAVKHDSILNTIDIPQNPKVGTKRYMAPE  372

         *..*********************************************************

S: 181   vleealnlkdfeafkraDvYslgLvlWEvasRceevdeeveeyklpfeevvgsdPsleem  240

         +l++++n++ fe+fkraD+Ys+gLv+WE+a+Rc+  +++veey+lp++++v+sdPs+eem

Q: 373   MLDDTMNVNIFESFKRADIYSVGLVYWEIARRCSV-GGIVEEYQLPYYDMVPSDPSIEEM  431

         **********************************9.************************

S: 241   kevvvekklrPkipeawkkkealkelsklleecWdadpeaRltalrvkkrl  291

         ++vv++++lrP+ip++w+++eal+++ ++++ecW+a+++aRltalr+kk++

Q: 432   RKVVCDQNLRPSIPNQWQSCEALRVMGRIMRECWYANGAARLTALRIKKTI  482

         ************************************************986

Domain Sequence
(FASTA)

IVLQEIVGKG RFGEVWHGRW CGEDVAVKIF SSRDERSWFR EAEIYQTVML RHENILGFIA 60

ADNKDNGTWT QLWLVSEYHE QGSLYDYLNR NIVTVAGMIK LALSIASGLA HLHMEIVGTQ 120

GKPAIAHRDI KSKNILVKKC ETCAIADLGL AVKHDSILNT IDIPQNPKVG TKRYMAPEML 180

DDTMNVNIFE SFKRADIYSV GLVYWEIARR CSVGGIVEEY QLPYYDMVPS DPSIEEMRKV 240

VCDQNLRPSI PNQWQSCEAL RVMGRIMREC WYANGAARLT ALRIKKTI 288

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0048179	; C:activin receptor complex
GO:0016361	; F:activin receptor activity, type I
GO:0005524	; F:ATP binding
GO:0005024	; F:transforming growth factor beta-activated receptor activity
GO:0030154	; P:cell differentiation
GO:0019915	; P:lipid storage
GO:0008285	; P:negative regulation of cell proliferation
GO:0046676	; P:negative regulation of insulin secretion
GO:0038092	; P:nodal signaling pathway
GO:0043280	; P:positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0002021	; P:response to dietary excess
GO:0009749	; P:response to glucose stimulus
GO:0032868	; P:response to insulin stimulus

KEGG

InterPros

IPR000472	; Activin_rcpt.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR008271	; Ser/Thr_kinase_AS.
IPR003605	; TGF_beta_rcpt_GS.

Pfam

PF01064	; Activin_recp; 1.
PF00069	; Pkinase; 1.
PF08515	; TGF_beta_GS; 1.

SMARTs

SM00467

; GS; 1.

Prosites

PS51256	; GS; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013