EKS-ORC-00116

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ORC-00116

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Met	455.2	7.7E-137	1042	1300	259

Status

Unreviewed

Ensembl Protein

ENSOCUP00000020795

UniProt Accession

G1SX27;

Protein Name

Protein Synonyms/Alias

Gene Name

MST1R

Gene Synonyms/Alias

MST1R;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSOCUG00000009360	ENSOCUP00000008078	ENSOCUT00000009366
ENSOCUG00000009360	ENSOCUP00000020795	ENSOCUT00000023339

Organism

Oryctolagus cuniculus

Functional Description

Protein Length

1322

Protein Sequence
(FASTA)

ATGDKVWAPG WEGRALPAVP EAGGDRRCLR SPYEASRDFD VEYKLPSFSA GGPVQAMATF 60

EGGADGSAVF VATRNRLQVL GPDLQSVGSL ATGPAGDPGC QTCSACDPGS QDPPGDTDMQ 120

VLVLEPGLPA LVSCGSSLQG RCFLHELELG GAVPHLAAPA CLFSAHHNQP EDCPDCVASP 180

LGTRVVVVEQ GQASYFYVAS SLDPAVAASF SPRSVSIRRL KADASGFEPG FPALSVLPKH 240

LASYRIEYVH SFRAGAFVYL LTVQPTSVAD APGALHTRLA RLNAAEPELG DYRELVLDCR 300

FAPKRRRRGA AEGGQPFPVL RAAHSAPVGA QLATELSVPE GQEVLFGVFS TGKDGSPGSG 360

LASVVCAFPI DLMDKLIDEE TVQCLSGFWA CRHWSSTHRV LRAVGLRKPG GLGATRRVPE 420

FISTFQRVDL FNGLLGPVQV TALHVTRHGN VTVAHMGTTD GRILQVELAR SLNYLLYVSN 480

FSLGSSGQPI QRDVSRLGDY LLFASGDQVF QVPIRGPGCR HFLTCGRCLR AQRFMGCGWC 540

GNVCGRQEEC PGSWQQDHCP PELTEFYPHS GPLRGSTRLT LCGSNFYLHP SGLAPEGTYR 600

VTVGHSPCQL LPKDTSHLSL TMTNMPPGKH FRIDGTSVLG GFSFTEPVLT AVQPLFGPRA 660

GGTCLTLEGR GLSVGSSRAV LLNGTECLLE RVSEGQLVCT TPPGAATASV PLRLQVGGAE 720

VPGSWTFHYR EDPVVLGISP NCGYTGSRVT IHGQHLTSAQ YLVLSFNDGH RAVENKEGGC 780

TSLLSSSPLH AEPRRLGEPR VGGLANSHVG PSSVRGGFRS SFEVGVGPGA GREGDPEYIG 840

LGAVADCVDV NVTVGGESCQ HELRGDVVVC PLPSSLQLDK DGAPLQVCVD GACHDLGRVV 900

RPGPQGIPQS TLLGVLLALL VLVAALATAL IFNYRWKKKQ QVLSPNLDDL ASLDQTPGAV 960

ALPLLRSGSD YRSGAGPPLL PTSLSFCLPT AAPAGSESFS DSGDGTCVPL LQTESILLRD 1020

LDPALLAEVK DVLIPYKQVV THSDQVIGKG HFGVVYHGEY TDKAQNRIHC AIKSLSRIAD 1080

AQEVEAFLRE GLLMRSLHHP NVLALIGIVL PPEGLPQVLL PYMHHGDLLQ FIRSPQRNPT 1140

VKDLISFGLQ VARGMEYLAD QKFVHRDLAA RNCMLDESFT VKVADFGLAR DVLDKEYYSV 1200

QQHRHARLPV KWMALESLQT YRFTTKSDVW SFGVLLWELL TRGAPPYPHI DPFDLPSFLA 1260

QGRRLPQPEY CPDSLYLVMQ RCWEADPAAR PSFGVLVGEV EQVVAALLGD HYVQLSAAYV 1320

NL 1322

Nucleotide Sequence
(FASTA)

GCCACTGGGG ACAAGGTGTG GGCGCCAGGC TGGGAAGGGC GGGCCCTGCC CGCGGTGCCT 60

GAGGCCGGCG GGGACCGGAG GTGCCTGCGC TCCCCATACG AGGCTTCCCG CGACTTTGAC 120

GTGGAGTACA AGCTGCCCAG CTTCTCAGCA GGCGGCCCGG TGCAGGCCAT GGCGACCTTC 180

GAAGGCGGCG CGGATGGGAG TGCGGTGTTC GTGGCCACAC GCAATCGCCT ACAGGTGCTC 240

GGGCCTGACC TACAATCTGT CGGGAGCCTG GCCACGGGCC CTGCCGGGGA CCCTGGCTGC 300

CAGACGTGTT CAGCCTGTGA CCCGGGGTCC CAGGACCCAC CGGGTGACAC CGATATGCAG 360

GTGTTGGTAC TGGAGCCGGG GCTGCCCGCG CTGGTCAGCT GCGGCTCGAG CCTGCAGGGC 420

CGCTGCTTCC TGCATGAGCT GGAGCTGGGC GGGGCAGTGC CGCACCTGGC AGCGCCTGCC 480

TGTCTCTTCT CAGCCCACCA CAACCAGCCC GAGGACTGCC CAGATTGTGT GGCCAGCCCA 540

CTGGGCACCC GCGTGGTCGT GGTCGAGCAG GGCCAGGCCT CCTACTTTTA CGTGGCGTCC 600

TCCCTGGACC CAGCTGTGGC TGCCAGCTTT AGCCCCCGCT CGGTGTCCAT CCGGCGCCTC 660

AAGGCCGATG CCTCGGGATT CGAACCTGGT TTTCCGGCTC TGTCGGTGCT GCCCAAGCAC 720

CTCGCCTCTT ACCGGATCGA ATACGTGCAC AGCTTCCGCG CGGGAGCCTT CGTCTACTTG 780

CTGACCGTGC AGCCGACCAG CGTGGCGGAC GCGCCGGGCG CCCTGCACAC GCGTCTGGCG 840

AGGCTCAACG CCGCCGAGCC CGAGCTGGGC GACTATCGCG AGCTGGTCCT CGACTGCCGC 900

TTCGCACCTA AACGCCGGCG TCGCGGGGCC GCAGAGGGCG GGCAGCCCTT CCCGGTGCTG 960

CGGGCCGCCC ACTCGGCTCC CGTGGGCGCC CAGCTGGCCA CTGAGCTGAG CGTCCCCGAG 1020

GGCCAGGAAG TGCTCTTCGG CGTCTTCTCC ACCGGCAAGG ACGGCAGCCC TGGCTCGGGC 1080

CTGGCCTCAG TGGTCTGTGC CTTCCCCATC GACCTGATGG ACAAGCTGAT CGACGAAGAG 1140

ACTGTGCAAT GTTTGTCTGG GTTCTGGGCA TGCAGACACT GGAGCAGTAC CCACCGTGTG 1200

CTCAGAGCGG TTGGCCTCAG GAAGCCTGGG GGGCTCGGGG CTACACGTAG GGTCCCTGAG 1260

TTCATCAGCA CCTTCCAACG TGTGGACCTG TTCAATGGAC TGCTGGGCCC AGTGCAGGTC 1320

ACCGCACTGC ATGTCACACG CCATGGCAAC GTCACCGTGG CCCACATGGG CACAACTGAT 1380

GGGCGTATCC TGCAGGTGGA GCTGGCCAGG TCACTCAACT ACTTGCTGTA TGTGTCCAAC 1440

TTCTCACTGG GCAGCAGTGG GCAGCCCATT CAGCGGGATG TCAGTCGCCT AGGGGACTAC 1500

CTACTCTTCG CCTCTGGGGA CCAGGTCTTC CAGGTACCTA TCCGGGGCCC TGGCTGCCGC 1560

CACTTCCTCA CCTGTGGACG CTGCCTGCGG GCACAACGTT TTATGGGCTG TGGCTGGTGT 1620

GGGAACGTGT GTGGCCGGCA GGAAGAGTGT CCTGGCTCCT GGCAACAGGA CCACTGCCCA 1680

CCTGAGCTCA CTGAGTTCTA CCCCCACAGT GGACCCCTAC GGGGCAGCAC GAGGCTGACC 1740

CTGTGTGGCT CTAACTTCTA CCTGCACCCG TCCGGTCTGG CACCTGAGGG AACCTACCGG 1800

GTCACTGTGG GCCACAGTCC CTGCCAGCTG CTGCCCAAGG ACACCTCACA CCTCAGCCTT 1860

ACCATGACCA ACATGCCGCC CGGCAAGCAC TTCCGGATAG ATGGCACCTC TGTGCTGGGA 1920

GGCTTCTCTT TCACGGAGCC GGTGCTGACA GCAGTGCAAC CCCTGTTTGG CCCTCGGGCG 1980

GGGGGCACCT GTCTCACCCT TGAGGGCCGG GGCCTGTCTG TAGGCTCCAG CCGGGCTGTG 2040

CTGCTCAATG GAACCGAGTG CCTGTTGGAA CGGGTCAGTG AGGGGCAGCT TGTATGCACC 2100

ACACCCCCTG GGGCTGCCAC GGCCAGCGTC CCCCTTCGCC TGCAGGTGGG GGGTGCCGAG 2160

GTTCCCGGCT CCTGGACCTT CCACTACCGG GAAGACCCTG TCGTGCTGGG CATCAGCCCC 2220

AACTGTGGCT ACACTGGCTC CCGTGTTACC ATCCATGGCC AGCATCTGAC TTCGGCACAG 2280

TACCTCGTGC TGTCATTCAA TGATGGGCAC AGGGCAGTGG AGAACAAGGA GGGAGGCTGC 2340

ACCAGTCTCC TGAGCTCCAG CCCACTCCAT GCTGAGCCCA GGAGACTGGG GGAGCCACGG 2400

GTGGGAGGCC TGGCTAACTC TCATGTGGGT CCCAGCAGTG TGAGGGGCGG CTTCCGGAGC 2460

AGCTTCGAGG TAGGTGTGGG GCCGGGGGCA GGGAGAGAGG GGGATCCAGA GTATATTGGG 2520

CTGGGCGCTG TGGCTGACTG TGTGGACGTG AACGTGACCG TGGGAGGCGA AAGCTGCCAG 2580

CATGAGCTCC GAGGAGACGT GGTTGTCTGC CCTCTGCCCT CCTCCCTGCA GCTTGACAAG 2640

GATGGCGCCC CATTGCAGGT CTGCGTGGAT GGTGCATGTC ACGACCTGGG CAGAGTGGTG 2700

CGGCCAGGCC CACAGGGAAT CCCACAGAGC ACGCTCCTTG GTGTCCTGCT GGCCTTGCTT 2760

GTGCTTGTGG CCGCCCTGGC CACCGCACTT ATCTTTAACT ATCGGTGGAA GAAGAAGCAG 2820

CAAGTCCTTT CTCCCAACCT GGATGACCTG GCATCCCTGG ACCAGACTCC TGGAGCCGTG 2880

GCCCTGCCTC TTCTCCGCTC GGGTTCTGAC TACAGAAGTG GTGCTGGGCC ACCCCTTCTC 2940

CCCACAAGCC TCTCATTCTG TCTCCCCACA GCAGCCCCTG CCGGCAGTGA GTCCTTCTCA 3000

GACAGCGGGG ATGGGACCTG TGTCCCGCTG CTGCAGACAG AGTCCATTCT GCTCAGAGAC 3060

CTGGACCCTG CACTCCTGGC CGAGGTCAAG GATGTACTGA TTCCCTACAA GCAGGTGGTC 3120

ACCCACAGTG ACCAAGTCAT TGGCAAAGGT CACTTTGGAG TTGTCTACCA CGGAGAATAC 3180

ACAGACAAGG CTCAGAACCG AATCCACTGT GCCATCAAGT CACTGAGTCG CATCGCCGAC 3240

GCACAGGAGG TGGAGGCCTT CCTGCGAGAG GGGCTGCTCA TGCGCAGCTT GCACCACCCC 3300

AACGTGCTGG CCCTCATCGG CATCGTGCTG CCCCCCGAGG GGCTGCCCCA GGTGCTGCTG 3360

CCCTACATGC ACCACGGAGA CCTGCTCCAG TTCATCCGCT CACCTCAGCG GAACCCCACT 3420

GTGAAGGACC TCATCAGCTT CGGCCTGCAG GTAGCCCGTG GCATGGAGTA CCTGGCAGAC 3480

CAGAAGTTTG TGCACAGGGA CCTGGCTGCT CGGAACTGCA TGCTGGACGA GTCATTCACG 3540

GTCAAGGTGG CTGACTTCGG TCTAGCCCGT GATGTCCTGG ACAAGGAGTA CTACAGTGTT 3600

CAGCAGCACC GCCATGCTCG CCTGCCAGTC AAGTGGATGG CACTGGAGAG CCTGCAGACC 3660

TACAGATTCA CCACCAAGTC TGATGTGTGG TCCTTTGGCG TGCTGCTGTG GGAACTGCTG 3720

ACTCGAGGCG CCCCCCCGTA CCCCCACATT GACCCTTTTG ACCTCCCCAG CTTCCTGGCT 3780

CAGGGCCGGC GCCTGCCTCA GCCTGAGTAT TGCCCCGATT CTCTCTACCT AGTGATGCAG 3840

CGATGCTGGG AGGCGGACCC GGCGGCACGA CCCAGCTTTG GAGTGCTCGT GGGGGAAGTG 3900

GAGCAGGTCG TGGCCGCCCT GCTTGGAGAC CACTATGTGC AGCTCTCTGC CGCCTACGTG 3960

AACCTG 3966

Domain Profile

S: 2     dkeeviGkGhfGvvykgelsdsaskkikvavksleritdiekveeflreglvmkeldhpn  61

         ++++viGkGhfGvvy+ge++d+a+++i++a+ksl+ri+d ++ve+flregl+m+ l+hpn

Q: 1042  HSDQVIGKGHFGVVYHGEYTDKAQNRIHCAIKSLSRIADAQEVEAFLREGLLMRSLHHPN  1101

         789*********************************************************

S: 62    vlsllGialddeglplvvlpymkkGdlksfirneernltvkdllefalqvakgmeylask  121

         vl+l+Gi+l++eglp v+lpym++Gdl +fir+++rn+tvkdl++f+lqva+gmeyla++

Q: 1102  VLALIGIVLPPEGLPQVLLPYMHHGDLLQFIRSPQRNPTVKDLISFGLQVARGMEYLADQ  1161

         ************************************************************

S: 122   kfvhrdlaarnclldekltvkvadfGlardvldkelyvveeerdarlpvkwlaleslqtf  181

         kfvhrdlaarnc+lde++tvkvadfGlardvldke+y+v+++r+arlpvkw+aleslqt+

Q: 1162  KFVHRDLAARNCMLDESFTVKVADFGLARDVLDKEYYSVQQHRHARLPVKWMALESLQTY  1221

         ************************************************************

S: 182   kqfttksdvwsfGvllwelltrgatpysevasfdltlylkegrrlrkpeycpdklydvml  241

         + fttksdvwsfGvllwelltrga+py+++++fdl  +l++grrl++peycpd+ly vm+

Q: 1222  R-FTTKSDVWSFGVLLWELLTRGAPPYPHIDPFDLPSFLAQGRRLPQPEYCPDSLYLVMQ  1280

         *.**********************************************************

S: 242   kcwkakpaerpqfsdlvsii  261

         +cw+a+pa+rp+f  lv  +

Q: 1281  RCWEADPAARPSFGVLVGEV  1300

         *************9998765

Domain Sequence
(FASTA)

HSDQVIGKGH FGVVYHGEYT DKAQNRIHCA IKSLSRIADA QEVEAFLREG LLMRSLHHPN 60

VLALIGIVLP PEGLPQVLLP YMHHGDLLQF IRSPQRNPTV KDLISFGLQV ARGMEYLADQ 120

KFVHRDLAAR NCMLDESFTV KVADFGLARD VLDKEYYSVQ QHRHARLPVK WMALESLQTY 180

RFTTKSDVWS FGVLLWELLT RGAPPYPHID PFDLPSFLAQ GRRLPQPEYC PDSLYLVMQR 240

CWEADPAARP SFGVLVGEV 259

Keyword

ATP-binding; Complete proteome; Disulfide bond; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Felis catus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryzias latipes"; ?>Pan troglodytes"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016021	; C:integral to membrane
GO:0005886	; C:plasma membrane
GO:0001725	; C:stress fiber
GO:0005524	; F:ATP binding
GO:0004713	; F:protein tyrosine kinase activity
GO:0004872	; F:receptor activity
GO:0007275	; P:multicellular organismal development
GO:0043406	; P:positive regulation of MAP kinase activity
GO:0051897	; P:positive regulation of protein kinase B signaling cascade
GO:0009615	; P:response to virus

KEGG

InterPros

IPR013783	; Ig-like_fold.
IPR014756	; Ig_E-set.
IPR002909	; IPT_TIG_rcpt.
IPR011009	; Kinase-like_dom.
IPR003659	; Plexin-like.
IPR016201	; Plexin-like_fold.
IPR002165	; Plexin_repeat.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001627	; Semaphorin/CD100_Ag.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.
IPR015943	; WD40/YVTN_repeat-like_dom.

Pfam

PF07714	; Pkinase_Tyr; 1.
PF01437	; PSI; 1.
PF01403	; Sema; 1.
PF01833	; TIG; 2.

SMARTs

SM00429	; IPT; 3.
SM00423	; PSI; 1.
SM00630	; Sema; 1.
SM00219	; TyrKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS51004	; SEMA; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013