EKS-ORC-00109

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ORC-00109

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Other/NAK	393.4	6.0E-118	46	309	264

Status

Unreviewed

Ensembl Protein

ENSOCUP00000008235

UniProt Accession

G1SXF7;

Protein Name

Protein Synonyms/Alias

Gene Name

AAK1

Gene Synonyms/Alias

AAK1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSOCUG00000009550	ENSOCUP00000008235	ENSOCUT00000009553
ENSOCUG00000009550	ENSOCUP00000021715	ENSOCUT00000025834

Organism

Oryctolagus cuniculus

Functional Description

Protein Length

959

Protein Sequence
(FASTA)

MKKFFDSRRE QGSSGLGSGS SGGGGSTSGL GSGYIGRVFG IGRQQVTVDE VLAEGGFAIV 60

FLVRTSNGMK CALKRMFVNN EHDLQVCKRE IQIMRDLSGH KNIVGYIDSS INSVSSGDVW 120

EVLILMDFCR GGQVVNLMNQ RLQTGFTENE VLQIFCDTCE AVARLHQCKT PIIHRDLKVE 180

NILLHDRGHY VLCDFGSATN KFQNPQTEGV NAVEDEIKKY TTLSYRAPEM VNLYSGKIIT 240

TKADIWALGC LLYKLCYFTL PFGESQVAIC DGSFTIPDNS RYSQDMHCLI RYMLEPDPDK 300

RPDIYQVSYF SFKLLKKECP IPNVQNSSIP AKLPEPVKAS EAAAKKTQPK ARLTDPIPTT 360

ETSIAPRQRP KAGQTQPNPG ILPIQPALTP RKRATVQPPP QAAGSSNQPG LLASVPQPKA 420

QPQPSQPLPQ PQPKQPQAPP TPQQTPSTQA QGLPTQAQAT PQHQQQLFLK QQPAQQPAQQ 480

PAPQQPASPP HFLPLCPAQF QAVHPTTQQP AIAQFPVVSQ GGSQQQLIQN FYQQQQQQQQ 540

QQQQLATALH QQQLMTQQAA LQQKAAVAAI QQPQAQPTVA TQPSPAQEPA IQAPVRQQPK 600

VQTTPPPAIQ GQKLGSLTPP SSPKTQRAGH RRILSDVTHS AVFGVPASKS TQLLQAAAAE 660

ASLNKSKSAT TTPSGSPRTS QQNVYNPAEG STWNPFDDDN FSKLTAEELL NKDFAKLGEG 720

KHPEKLGGSA ESLLPGFQSA QGDAFATPPF SAGTAEKRKG GQTVDSGLPL LSVSDPFIPL 780

QVPDAPEKLI EGLKSPDTSL LLPDLLPMTD PFGSTSDAVT EKADVAVESL IPGLEPPVPQ 840

RLPSQTESVT SNRTDSLTGE DSLLDCSLLA NPTTDLLEEF APIAISAPAH KAAEDSNLIS 900

GFDVPEGSDK VAEDEFDPIP VLITKNPQGG HSRNSSGSSE SSLPNLARSL LLVDQLIDL 959

Nucleotide Sequence
(FASTA)

ATGAAGAAGT TTTTCGACTC CCGGCGCGAG CAGGGAAGCT CTGGCCTGGG CTCGGGCTCC 60

AGCGGAGGAG GGGGCAGCAC GTCGGGCCTG GGCAGTGGCT ACATCGGAAG GGTCTTCGGC 120

ATCGGGCGAC AGCAGGTCAC CGTGGACGAG GTGCTGGCGG AAGGTGGATT CGCTATTGTG 180

TTCCTGGTGA GGACAAGCAA TGGGATGAAG TGTGCCTTGA AACGCATGTT TGTCAACAAT 240

GAGCATGATC TGCAGGTGTG CAAAAGAGAA ATCCAGATAA TGAGGGACCT GTCAGGTCAC 300

AAGAACATTG TGGGTTACAT TGACTCAAGT ATCAACAGTG TGAGTAGTGG TGATGTCTGG 360

GAAGTTCTCA TTCTTATGGA CTTCTGTCGA GGAGGCCAGG TGGTGAACCT GATGAACCAG 420

CGCCTACAAA CAGGTTTCAC AGAGAATGAA GTGCTCCAGA TATTTTGTGA TACTTGTGAA 480

GCTGTTGCCC GCCTGCATCA GTGCAAAACT CCCATCATCC ACCGTGACCT GAAGGTTGAA 540

AATATCCTCT TGCATGATCG AGGCCATTAT GTCCTGTGTG ACTTTGGAAG TGCCACCAAC 600

AAATTCCAGA ATCCACAAAC TGAGGGAGTC AATGCAGTAG AAGATGAGAT TAAGAAATAT 660

ACAACACTGT CCTATCGAGC ACCAGAAATG GTCAACCTGT ACAGTGGCAA AATCATCACT 720

ACGAAGGCAG ACATTTGGGC TCTTGGATGT TTGTTGTATA AATTATGCTA CTTCACTTTG 780

CCATTTGGGG AGAGTCAGGT GGCGATTTGT GATGGAAGCT TCACAATTCC TGATAACTCT 840

CGATATTCTC AAGACATGCA CTGCCTAATT AGGTATATGT TGGAGCCAGA CCCCGACAAA 900

AGACCAGATA TTTACCAGGT CTCCTACTTC TCATTTAAAC TGCTCAAGAA AGAATGCCCA 960

ATTCCAAATG TACAGAACTC CTCCATTCCT GCAAAGCTTC CTGAACCAGT GAAAGCCAGT 1020

GAGGCAGCTG CAAAAAAGAC CCAGCCAAAG GCCAGACTGA CAGATCCCAT TCCCACCACA 1080

GAGACTTCAA TTGCACCCCG CCAGAGGCCT AAAGCTGGGC AGACTCAGCC AAACCCAGGA 1140

ATCCTTCCCA TCCAGCCAGC GTTGACACCT CGCAAGAGGG CCACAGTGCA GCCCCCACCT 1200

CAGGCTGCAG GATCCAGCAA TCAGCCTGGC CTTTTGGCCA GTGTTCCCCA ACCAAAAGCC 1260

CAACCCCAAC CTAGCCAGCC TCTGCCACAG CCTCAGCCCA AACAGCCACA GGCTCCGCCT 1320

ACCCCACAGC AGACGCCTTC CACTCAGGCC CAGGGTCTGC CCACTCAGGC CCAGGCTACT 1380

CCTCAGCACC AGCAGCAGCT CTTCCTCAAG CAGCAGCCAG CGCAGCAGCC AGCGCAGCAG 1440

CCAGCGCCAC AACAGCCAGC GTCACCTCCT CATTTCTTGC CACTTTGTCC TGCTCAGTTT 1500

CAGGCAGTAC ATCCAACAAC CCAGCAACCA GCCATTGCTC AGTTCCCGGT GGTATCCCAA 1560

GGAGGCTCTC AACAGCAGCT CATACAGAAT TTCTACCAGC AGCAGCAACA GCAGCAGCAG 1620

CAGCAGCAGC AGCTGGCCAC AGCCCTGCAT CAACAACAGC TGATGACTCA GCAGGCTGCC 1680

TTGCAGCAAA AGGCCGCCGT GGCAGCCATC CAGCAGCCCC AGGCACAGCC GACTGTAGCC 1740

ACACAGCCAT CCCCTGCCCA GGAGCCAGCG ATTCAAGCCC CAGTGAGACA ACAACCAAAA 1800

GTTCAGACAA CCCCACCTCC TGCTATCCAG GGGCAGAAAC TTGGATCTCT CACTCCTCCA 1860

TCATCCCCCA AAACCCAGCG TGCTGGGCAC AGGCGGATTC TCAGTGATGT AACCCACAGT 1920

GCGGTCTTTG GGGTCCCTGC CAGCAAATCA ACCCAGCTGC TCCAAGCAGC TGCAGCGGAG 1980

GCCAGTCTCA ATAAGTCCAA GTCTGCAACC ACCACTCCAT CAGGCTCTCC TCGGACCTCC 2040

CAACAAAACG TTTATAATCC CGCAGAAGGT TCTACGTGGA ATCCCTTTGA TGATGACAAT 2100

TTCTCCAAAC TTACAGCTGA AGAACTGCTA AACAAGGACT TTGCCAAGCT GGGGGAAGGC 2160

AAACATCCTG AGAAGCTCGG AGGCTCAGCC GAGAGTTTGC TCCCAGGTTT TCAGTCAGCT 2220

CAAGGCGATG CTTTTGCCAC TCCACCATTT TCTGCAGGAA CCGCTGAGAA AAGGAAGGGT 2280

GGGCAGACTG TGGATTCTGG CCTCCCACTT CTAAGCGTCT CTGATCCTTT CATTCCTCTT 2340

CAAGTACCTG ATGCTCCAGA AAAACTAATT GAGGGACTCA AATCTCCTGA CACTTCTCTC 2400

CTGCTCCCTG ACCTTTTGCC TATGACAGAT CCTTTTGGTA GCACTTCCGA TGCTGTAACT 2460

GAAAAAGCTG ATGTTGCTGT TGAGAGTCTC ATACCAGGAC TGGAGCCCCC AGTTCCCCAG 2520

CGCCTCCCAT CTCAGACGGA ATCTGTGACT TCAAACCGCA CAGATTCTCT CACCGGGGAG 2580

GATTCCTTGC TTGATTGCTC TCTCCTTGCT AACCCTACTA CTGACCTTCT GGAAGAGTTT 2640

GCCCCCATAG CAATCTCTGC TCCAGCCCAT AAAGCTGCAG AAGATAGTAA TCTCATCTCA 2700

GGTTTTGATG TCCCTGAGGG CTCGGACAAG GTGGCGGAGG ATGAGTTTGA CCCAATTCCT 2760

GTTTTGATAA CCAAAAACCC GCAAGGTGGG CACTCTAGAA ACAGCAGTGG GAGCTCTGAG 2820

TCCAGTCTTC CCAACCTAGC CAGGTCTTTA CTGCTGGTGG ATCAGCTCAT AGACCTG 2877

Domain Profile

S: 1     vriekvlaeGGfalvylaedastgekyalKrilvneeedleeikrEieimkklsghkniv  60

         v++++vlaeGGfa+v+l++ +s+g k+alKr++vn+e+dl+ +krEi+im++lsghkniv

Q: 46    VTVDEVLAEGGFAIVFLVR-TSNGMKCALKRMFVNNEHDLQVCKREIQIMRDLSGHKNIV  104

         6899***************.99**************************************

S: 61    klvdssvkeekdngskevlllleyckkgslvdllnkrlekgelseaeilkilldvtrava  120

          ++dss+++ ++++++evl+l+++c+ g++v+l+n+rl++g ++e+e+l+i++d+++ava

Q: 105   GYIDSSINSVSSGDVWEVLILMDFCRGGQVVNLMNQRLQTG-FTENEVLQIFCDTCEAVA  163

         ************9***************************9.******************

S: 121   alHalsvpliHRDlkveNillsdegelvlcDlGSattaileveskqelsalqeeiekntt  180

         +lH++++p+iHRDlkveNill+d+g++vlcD+GSat+++++++ +++++a+++ei+k+tt

Q: 164   RLHQCKTPIIHRDLKVENILLHDRGHYVLCDFGSATNKFQNPQ-TEGVNAVEDEIKKYTT  222

         *******************************************.9***************

S: 181   lsyrsPElidlysnlvideksDiWaLGcllYklcffesPfeesvklailngkysiPensr  240

         lsyr+PE+++lys+++i++k+DiWaLGcllYklc+f+ Pf+es ++ai++g+++iP+nsr

Q: 223   LSYRAPEMVNLYSGKIITTKADIWALGCLLYKLCYFTLPFGES-QVAICDGSFTIPDNSR  281

         *******************************************.****************

S: 241   yseklkslikkmlevdpeeRptiaqvle  268

         ys+++++li++mle+dp++Rp+i+qv++

Q: 282   YSQDMHCLIRYMLEPDPDKRPDIYQVSY  309

         **************************87

Domain Sequence
(FASTA)

VTVDEVLAEG GFAIVFLVRT SNGMKCALKR MFVNNEHDLQ VCKREIQIMR DLSGHKNIVG 60

YIDSSINSVS SGDVWEVLIL MDFCRGGQVV NLMNQRLQTG FTENEVLQIF CDTCEAVARL 120

HQCKTPIIHR DLKVENILLH DRGHYVLCDF GSATNKFQNP QTEGVNAVED EIKKYTTLSY 180

RAPEMVNLYS GKIITTKADI WALGCLLYKL CYFTLPFGES QVAICDGSFT IPDNSRYSQD 240

MHCLIRYMLE PDPDKRPDIY QVSY 264

Keyword

Complete proteome; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0045747	; P:positive regulation of Notch signaling pathway
GO:0050821	; P:protein stabilization
GO:2000369	; P:regulation of clathrin-mediated endocytosis
GO:0032880	; P:regulation of protein localization

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

Prosites

PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013