EKS-ORC-00344
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-ORC-00344
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Src448.47.6E-135278527250
StatusUnreviewed
Ensembl ProteinENSOCUP00000008260
UniProt AccessionG1SXH7;
Protein Name
Protein Synonyms/Alias
Gene NameSRC
Gene Synonyms/Alias SRC;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSOCUG00000009585ENSOCUP00000008260ENSOCUT00000009583
OrganismOryctolagus cuniculus
Functional Description
Protein Length544
Protein Sequence
(FASTA)
MGSSKSKPRD ASQRRRSLEP ARERPTEGPD GAFPSTQTPN KPASADGHRG PSAAFAPAAA 60
EPKLFGGFNS SDTVTSPQRA GPLAGGVTTF VALYDYESRT ETDLSFKKGE RLQIVNNTWV 120
PLPLREGDWW LAHSLSTGQT GYIPSNYVAP SDSIQAEEWY FGKITRRESE RLLLNAENPR 180
GTFLVRESET TKGAYCLSVS DFDNAKGLNV KHYKIRKLDS GGFYITSRTQ FSSLQQLVAY 240
YSKHADGLCH RLTTVCPTSK PQTQGLAKDA WEIPRESLRL EVKLGQGCFG EVWMGTWNGT 300
TRVAIKTLKP GTMSPEAFLQ EAQVMKKLRH EKLVQLYAVV SEEPIYIVTE YMSKGSLLDF 360
LKGETGKYLR LPQLVDMAAQ IASGMAYVER MNYVHRDLRA ANILVGENLV CKVADFGLAR 420
LIEDNEYTAR QGAKFPIKWT APEAALYGRF TIKSDVWSFG ILLTELTTKG RVPYPGMVNR 480
EVLDQVERGY RMPCPPECPE SLHDLMCQCW RKEPEERPTF EYLQAFLEDY FTSTEPQYQP 540
GENL 544
Nucleotide Sequence
(FASTA)
ATGGGCAGCA GCAAGAGCAA GCCCAGGGAC GCGAGCCAGC GGCGCCGCAG CCTGGAGCCG 60
GCCCGAGAGC GCCCCACGGA GGGGCCCGAC GGCGCCTTCC CCAGCACGCA GACCCCCAAC 120
AAGCCGGCCT CCGCCGACGG CCACCGCGGC CCCAGCGCCG CCTTCGCCCC TGCTGCCGCC 180
GAGCCCAAAC TCTTCGGGGG CTTCAACTCT TCGGACACCG TCACCTCCCC GCAGAGGGCC 240
GGGCCGCTGG CTGGCGGGGT GACCACCTTC GTGGCCCTCT ACGACTATGA GTCCCGGACG 300
GAGACCGACC TGTCCTTCAA GAAGGGGGAG CGGCTGCAGA TCGTCAACAA CACGTGGGTG 360
CCCCTTCCCC TCCGGGAGGG AGACTGGTGG CTGGCCCACT CGCTCAGCAC GGGACAGACC 420
GGCTACATCC CCAGCAACTA CGTGGCGCCC TCCGACTCCA TCCAGGCCGA GGAGTGGTAC 480
TTCGGCAAGA TTACCAGGCG GGAGTCGGAG CGGTTACTGC TCAATGCAGA AAACCCAAGG 540
GGGACCTTCC TGGTGCGCGA GAGTGAGACC ACGAAAGGTG CCTACTGCCT GTCAGTGTCG 600
GACTTCGACA ACGCCAAGGG CCTCAACGTG AAGCACTACA AGATCCGCAA GCTGGACAGC 660
GGCGGCTTCT ACATCACCTC CCGCACGCAG TTCAGCAGCC TGCAGCAGCT CGTGGCCTAC 720
TACTCCAAGC ACGCCGACGG CCTGTGCCAC CGCCTCACCA CCGTGTGCCC CACGTCCAAG 780
CCGCAGACTC AGGGCCTGGC CAAGGACGCC TGGGAGATCC CCCGCGAGTC GCTGCGGCTG 840
GAGGTCAAAC TGGGCCAGGG CTGCTTCGGC GAGGTGTGGA TGGGGACCTG GAACGGCACC 900
ACCAGGGTGG CCATCAAAAC CCTGAAGCCC GGCACCATGT CCCCGGAGGC CTTCCTGCAG 960
GAGGCACAGG TCATGAAGAA GCTGCGGCAC GAGAAGCTGG TGCAGCTGTA CGCCGTGGTG 1020
TCCGAGGAGC CCATCTACAT CGTCACAGAG TACATGAGCA AGGGGAGCTT GCTGGACTTC 1080
CTCAAGGGAG AGACGGGCAA GTACCTCCGG CTGCCGCAGC TGGTGGACAT GGCTGCGCAG 1140
ATCGCCTCAG GCATGGCGTA CGTGGAGCGG ATGAACTACG TGCACCGGGA CCTCCGAGCC 1200
GCCAACATCC TGGTGGGGGA GAACCTGGTG TGCAAGGTGG CTGACTTCGG GCTGGCCCGG 1260
CTCATCGAAG ACAACGAGTA CACGGCCCGG CAAGGTGCCA AGTTCCCCAT CAAGTGGACA 1320
GCTCCGGAGG CTGCACTCTA TGGCCGGTTC ACCATCAAGT CAGACGTGTG GTCCTTTGGC 1380
ATCCTGCTGA CGGAGCTCAC CACAAAGGGA CGGGTGCCCT ACCCCGGGAT GGTGAACCGC 1440
GAGGTGCTGG ACCAGGTGGA GCGGGGCTAC CGGATGCCCT GCCCGCCCGA GTGCCCCGAG 1500
TCCCTGCATG ACCTCATGTG CCAGTGCTGG CGGAAGGAGC CGGAGGAGCG GCCCACCTTC 1560
GAGTACCTGC AGGCCTTCCT GGAGGACTAC TTCACGTCCA CCGAGCCCCA GTACCAGCCT 1620
GGAGAGAACC TA 1632
Domain Profile
S: 1     lklvkklGeGqfGevwlgkwkgsvkvavktlkegtlspeafleeaqilkklrheklvkly  60
         l+l+ klG+G+fGevw+g+w+g+++va+ktlk+gt+speafl+eaq++kklrheklv+ly
Q: 278   LRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLY  337
         68999*******************************************************
S: 61    avvseeePiyivtelmakGslldflkeeegkklklpklvdlaaqvaeGmayleeknlihr  120
         avvse ePiyivte+m+kGslldflk e+gk+l+lp+lvd+aaq+a+Gmay+e++n++hr
Q: 338   AVVSE-EPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNYVHR  396
         ****9.******************************************************
S: 121   dlaarnvlvgeslvvkvadfGlarlieddeytakegaklPikWtaPeaiklgkftiksdv  180
         dl+a+n+lvge+lv+kvadfGlarlied+eyta++gak+PikWtaPea+ +g+ftiksdv
Q: 397   DLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDV  456
         ************************************************************
S: 181   WsfGillteivtkGkvPypGmtneevleqvergyrlprpeecpeelyelllecwkkdpee  240
         WsfGillte++tkG+vPypGm n+evl+qvergyr+p+p ecpe+l++l+++cw+k+pee
Q: 457   WSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQCWRKEPEE  516
         ************************************************************
S: 241   rPtfetlqevl  251
         rPtfe+lq++l
Q: 517   RPTFEYLQAFL  527
         *******9876
Domain Sequence
(FASTA)
LRLEVKLGQG CFGEVWMGTW NGTTRVAIKT LKPGTMSPEA FLQEAQVMKK LRHEKLVQLY 60
AVVSEEPIYI VTEYMSKGSL LDFLKGETGK YLRLPQLVDM AAQIASGMAY VERMNYVHRD 120
LRAANILVGE NLVCKVADFG LARLIEDNEY TARQGAKFPI KWTAPEAALY GRFTIKSDVW 180
SFGILLTELT TKGRVPYPGM VNREVLDQVE RGYRMPCPPE CPESLHDLMC QCWRKEPEER 240
PTFEYLQAFL 250
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; SH3 domain; Transferase; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00340
EKS-ANC-00356
EKS-BOT-00366
EKS-CAJ-00371
EKS-CAF-00367
EKS-CAP-00399
EKS-CII-00206
EKS-CIS-00121
EKS-DAR-00747
EKS-DIO-00054
EKS-EQC-00357
EKS-FEC-00354
EKS-GAG-00310
EKS-GAA-00450
EKS-GOG-00366
EKS-HOS-00372
EKS-ICT-00347
EKS-LAC-00383
EKS-LOA-00375
EKS-MAM-00366
EKS-MEG-00302
EKS-MIM-00048
EKS-MOD-00355
EKS-MUM-00398
EKS-MUP-00360
EKS-MYL-00367
EKS-NOL-00334
EKS-ORN-00475
EKS-ORL-00435
EKS-OTG-00369
EKS-PAT-00346
EKS-PES-00326
EKS-POA-00356
EKS-RAN-00380
EKS-SAH-00337
EKS-SUS-00323
EKS-TAG-00439
EKS-TAR-00470
EKS-TEN-00465
EKS-XET-00482
EKS-XIM-00463
Gene Ontology
GO:0005901; C:caveola
GO:0005770; C:late endosome
GO:0005764; C:lysosome
GO:0005743; C:mitochondrial inner membrane
GO:0005524; F:ATP binding
GO:0020037; F:heme binding
GO:0004713; F:protein tyrosine kinase activity
GO:0060444; P:branching involved in mammary gland duct morphogenesis
GO:0016477; P:cell migration
GO:0030900; P:forebrain development
GO:0007243; P:intracellular protein kinase cascade
GO:2001237; P:negative regulation of extrinsic apoptotic signaling pathway
GO:2001243; P:negative regulation of intrinsic apoptotic signaling pathway
GO:0048477; P:oogenesis
GO:0018108; P:peptidyl-tyrosine phosphorylation
GO:0090263; P:positive regulation of canonical Wnt receptor signaling pathway
GO:0033146; P:regulation of intracellular estrogen receptor signaling pathway
GO:0070555; P:response to interleukin-1
GO:0060065; P:uterus development
KEGG
InterPros
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980; SH2.
IPR001452; SH3_domain.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
Pfam
PF07714; Pkinase_Tyr; 1.
PF00017; SH2; 1.
PF00018; SH3_1; 1.
SMARTs
SM00252; SH2; 1.
SM00326; SH3; 1.
SM00219; TyrKc; 1.
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS50001; SH2; 1.
PS50002; SH3; 1.
Prints
PR00401; SH2DOMAIN.
PR00452; SH3DOMAIN.
PR00109; TYRKINASE.
Created Date20-Feb-2013