EKS-ORC-00347
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-ORC-00347
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Src438.57.6E-132260509250
StatusUnreviewed
Ensembl ProteinENSOCUP00000008404
UniProt AccessionG1TX61;
Protein Name
Protein Synonyms/Alias
Gene NameHCK
Gene Synonyms/Alias HCK;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSOCUG00000009751ENSOCUP00000021661ENSOCUT00000029921
ENSOCUG00000009751ENSOCUP00000008404ENSOCUT00000009756
OrganismOryctolagus cuniculus
Functional Description
Protein Length524
Protein Sequence
(FASTA)
LGGRSSCEDP GCPPSEERAP RMGCMKSKFL QGGRKISKTE PSTNLHTTVY VPDPTSSIKP 60
GSSSSHDKPP GLAEGSEDII VVALFDYEAI HREDLSFQKG DQLVVLEESG EWWKARSLAT 120
QEEGYIPSNY VARVNSLETE EWFFKGISRK DAERHLLAAG NMLGSFMIRD SETTKGSYSL 180
SVRDYDPQQG DTVKHYKIRT LDSGGFYVSP RSTFGTLQEL VAHYQKQRDG LCQQLSVPCV 240
AAKPQKPWEK DAWEIPRDSL KLEKKLGAGQ FGEVWMATYN KHTKVAVKTM KPGSMSVEAF 300
LAEANLMKTL QHDKLVRLHA VVTQEPIYII TEFMAKGSLL DFLKSEDGSQ QPLPKLIDFA 360
AQIAEGMAYI EQRNYIHRDL RAANILVSAS LVCKIADFGL ARVIEDTEYT AREGAKFPIK 420
WTAPEAINFG SFTIKSDVWS FGILLMEIIT YGRIPYPGMS NPEVIRALEH GYRMPRPEHC 480
PEELYSIMMR CWKNRPEERP TFEYIQSVLD DFYTATESQY QQQP 524
Nucleotide Sequence
(FASTA)
CTGGGGGGGC GCTCGAGCTG CGAGGATCCG GGCTGCCCGC CAAGCGAAGA GCGGGCGCCT 60
AGGATGGGGT GCATGAAGTC CAAGTTCCTC CAGGGTGGAC GCAAAATCTC AAAAACCGAG 120
CCCAGCACGA ACCTGCACAC AACTGTGTAT GTGCCGGATC CCACATCCTC CATCAAGCCG 180
GGGTCCAGCA GCAGCCATGA CAAACCCCCG GGACTTGCAG AGGGTTCTGA GGACATCATT 240
GTGGTTGCCT TGTTTGACTA CGAGGCCATT CACCGCGAAG ACCTCAGCTT CCAGAAGGGA 300
GACCAGCTCG TGGTCCTGGA GGAGTCTGGG GAGTGGTGGA AGGCTCGTTC CCTGGCCACC 360
CAGGAAGAGG GCTACATCCC GAGCAACTAC GTGGCCCGCG TTAACTCTCT GGAGACGGAG 420
GAGTGGTTCT TCAAGGGCAT CAGCCGCAAG GATGCAGAGC GCCACCTCCT GGCTGCCGGT 480
AACATGCTGG GCTCCTTCAT GATCCGAGAC AGTGAGACCA CCAAAGGGAG CTACTCCTTG 540
TCCGTGCGAG ACTACGACCC GCAGCAAGGG GACACAGTGA AGCACTACAA GATCCGCACC 600
CTGGACAGCG GGGGCTTCTA CGTCTCCCCG CGGAGCACCT TCGGCACCCT GCAGGAGCTG 660
GTGGCCCACT ATCAGAAGCA GAGAGACGGG CTCTGCCAGC AGCTGTCAGT GCCCTGCGTG 720
GCCGCAAAGC CACAGAAGCC ATGGGAGAAA GACGCCTGGG AAATCCCACG GGACTCCCTC 780
AAGCTGGAGA AGAAGCTTGG AGCTGGGCAG TTTGGGGAGG TCTGGATGGC CACCTACAAC 840
AAGCACACCA AGGTGGCAGT GAAGACCATG AAGCCGGGGA GCATGTCGGT GGAGGCCTTC 900
CTGGCAGAGG CCAACCTGAT GAAAACTCTG CAGCATGACA AGCTGGTGAG GCTGCACGCG 960
GTGGTCACCC AGGAGCCCAT CTACATCATC ACGGAGTTCA TGGCCAAAGG AAGCCTGCTG 1020
GACTTCCTGA AGAGTGAAGA CGGCAGCCAG CAGCCCTTGC CGAAGCTCAT TGACTTTGCA 1080
GCCCAGATTG CAGAAGGCAT GGCCTACATC GAGCAGAGGA ACTACATCCA CCGAGACCTC 1140
CGAGCTGCCA ACATCCTGGT GTCTGCGTCA CTGGTGTGTA AGATTGCTGA CTTCGGCCTG 1200
GCACGGGTCA TCGAGGACAC GGAGTACACG GCTCGGGAAG GGGCGAAGTT CCCCATCAAG 1260
TGGACGGCTC CCGAAGCCAT CAACTTTGGC TCCTTCACCA TCAAGTCTGA CGTCTGGTCC 1320
TTTGGCATCC TGCTGATGGA GATCATCACC TACGGCCGCA TCCCTTACCC AGGGATGTCC 1380
AACCCCGAGG TGATCCGGGC GCTGGAACAC GGGTACCGGA TGCCGCGACC AGAGCACTGC 1440
CCCGAGGAGC TCTACAGCAT CATGATGCGC TGCTGGAAGA ACCGCCCGGA GGAGCGGCCC 1500
ACCTTCGAGT ACATCCAGAG TGTGCTGGAT GACTTCTACA CGGCCACAGA GAGCCAGTAC 1560
CAGCAGCAGC CGTGA 1575
Domain Profile
S: 1     lklvkklGeGqfGevwlgkwkgsvkvavktlkegtlspeafleeaqilkklrheklvkly  60
         lkl+kklG+GqfGevw++++++++kvavkt+k+g++s eafl+ea+++k+l+h+klv+l+
Q: 260   LKLEKKLGAGQFGEVWMATYNKHTKVAVKTMKPGSMSVEAFLAEANLMKTLQHDKLVRLH  319
         689*********************************************************
S: 61    avvseeePiyivtelmakGslldflkeeegkklklpklvdlaaqvaeGmayleeknlihr  120
         avv++ ePiyi+te+makGslldflk+e+g++++lpkl+d+aaq+aeGmay+e++n+ihr
Q: 320   AVVTQ-EPIYIITEFMAKGSLLDFLKSEDGSQQPLPKLIDFAAQIAEGMAYIEQRNYIHR  378
         ****9.******************************************************
S: 121   dlaarnvlvgeslvvkvadfGlarlieddeytakegaklPikWtaPeaiklgkftiksdv  180
         dl+a+n+lv+ slv+k+adfGlar+ied eyta+egak+PikWtaPeai++g+ftiksdv
Q: 379   DLRAANILVSASLVCKIADFGLARVIEDTEYTAREGAKFPIKWTAPEAINFGSFTIKSDV  438
         ************************************************************
S: 181   WsfGillteivtkGkvPypGmtneevleqvergyrlprpeecpeelyelllecwkkdpee  240
         WsfGill+ei+t+G++PypGm+n ev++++e+gyr+prpe+cpeely+++++cwk++pee
Q: 439   WSFGILLMEIITYGRIPYPGMSNPEVIRALEHGYRMPRPEHCPEELYSIMMRCWKNRPEE  498
         ************************************************************
S: 241   rPtfetlqevl  251
         rPtfe++q+vl
Q: 499   RPTFEYIQSVL  509
         *******9976
Domain Sequence
(FASTA)
LKLEKKLGAG QFGEVWMATY NKHTKVAVKT MKPGSMSVEA FLAEANLMKT LQHDKLVRLH 60
AVVTQEPIYI ITEFMAKGSL LDFLKSEDGS QQPLPKLIDF AAQIAEGMAY IEQRNYIHRD 120
LRAANILVSA SLVCKIADFG LARVIEDTEY TAREGAKFPI KWTAPEAINF GSFTIKSDVW 180
SFGILLMEII TYGRIPYPGM SNPEVIRALE HGYRMPRPEH CPEELYSIMM RCWKNRPEER 240
PTFEYIQSVL 250
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; SH3 domain; Transferase; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Petromyzon marinus"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00343
EKS-ANC-00359
EKS-BOT-00369
EKS-CAJ-00373
EKS-CAF-00370
EKS-CAP-00404
EKS-DAR-00749
EKS-EQC-00360
EKS-FEC-00356
EKS-GAG-00313
EKS-GAA-00451
EKS-GOG-00360
EKS-HOS-00375
EKS-ICT-00350
EKS-LOA-00378
EKS-MAM-00369
EKS-MEG-00306
EKS-MOD-00358
EKS-MUM-00401
EKS-MUP-00363
EKS-MYL-00369
EKS-NOL-00337
EKS-OCP-00073
EKS-ORN-00478
EKS-ORL-00440
EKS-OTG-00371
EKS-PAT-00354
EKS-PEM-00194
EKS-PTV-00094
EKS-RAN-00383
EKS-SAH-00339
EKS-TAG-00442
EKS-TAR-00474
EKS-XIM-00467
Gene Ontology
GO:0005884; C:actin filament
GO:0005901; C:caveola
GO:0031234; C:extrinsic to internal side of plasma membrane
GO:0005925; C:focal adhesion
GO:0005764; C:lysosome
GO:0005524; F:ATP binding
GO:0004713; F:protein tyrosine kinase activity
GO:0050830; P:defense response to Gram-positive bacterium
GO:0043066; P:negative regulation of apoptotic process
GO:0018108; P:peptidyl-tyrosine phosphorylation
GO:0006909; P:phagocytosis
GO:2000251; P:positive regulation of actin cytoskeleton reorganization
GO:0008284; P:positive regulation of cell proliferation
GO:0046777; P:protein autophosphorylation
GO:0008360; P:regulation of cell shape
GO:0050764; P:regulation of phagocytosis
GO:0071801; P:regulation of podosome assembly
GO:0051090; P:regulation of sequence-specific DNA binding transcription factor activity
KEGG
InterPros
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980; SH2.
IPR001452; SH3_domain.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
Pfam
PF07714; Pkinase_Tyr; 1.
PF00017; SH2; 1.
PF00018; SH3_1; 1.
SMARTs
SM00252; SH2; 1.
SM00326; SH3; 1.
SM00219; TyrKc; 1.
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS50001; SH2; 1.
PS50002; SH3; 1.
Prints
PR00401; SH2DOMAIN.
PR00452; SH3DOMAIN.
PR00109; TYRKINASE.
Created Date20-Feb-2013