EKS-ORC-00279

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ORC-00279

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/EGFR	502.6	2.3E-151	642	899	258

Status

Unreviewed

Ensembl Protein

ENSOCUP00000008439

UniProt Accession

G1SXY0;

Protein Name

Protein Synonyms/Alias

Gene Name

ERBB4

Gene Synonyms/Alias

ERBB4;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSOCUG00000009790	ENSOCUP00000008439	ENSOCUT00000009795

Organism

Oryctolagus cuniculus

Functional Description

Protein Length

1232

Protein Sequence
(FASTA)

FQSIREVTGY VLVALNQFRY LPLENLRIIR GTKLYEDRYA LAIFLNYRKD GNFGLQELGL 60

KNLTEILNGG VYVDQNKFLC YADTIHWQDI VRNPWPSNLT LVSTNGSSGC GRCHKSCTGR 120

CWGPTENHCQ TLTRTVCAEQ CDGRCYGPYV SDCCHRECAG GCSGPKDTDC FACMNFNDSG 180

ACVTQCPQTF VYNPTTFQLE HNFNAKYTYG AFCVKKCPHN FVVDSSSCVR ACPSSKMEVE 240

ENGIKMCKPC TDICPKACDG IGTGSLMSAQ TVDSSNIDKF INCTKINGNL IFLVTGIHGD 300

PYNAIEAIDP EKLNVFRTVR EITGFLNIQS WPPNMTDFSV FSNLVTIGGR VLYSGLSLLI 360

LKQQGITSLQ FQSLKEISAG NIYITDNSNL CYYHTINWTT LFSTINQRIV IRDNRKAENC 420

TAEGMVCNHL CSNDGCWGPG PDQCLSCRRF SRGRICIESC NLYDGEFREF ENGSICVECD 480

PQCEKMEDGL LTCHGPGPDN CTKCSHFKDG PNCVEKCPDG VQGANSFIFK YADQDRECHP 540

CHPNCTQGCN GPTSHDCIYY PWTGHSTLPQ HARTPLIAAG VIGGLFILVI VGLTFAVYVR 600

RKSIKKKRAL RRFLETELVE PLTPSGTAPN QAQLRILKET ELKRVKVLGS GAFGTVYKGI 660

WVPEGETVKI PVAIKILNET TGPKANVEFM DEALIMASMD HPHLVRLLGV CLSPTIQLVT 720

QLMPHGCLLD YVHEHKDNIG SQLLLNWCVQ IAKGMMYLEE RRLVHRDLAA RNVLVKSPNH 780

VKITDFGLAR LLEGDEKEYN ADGGKMPIKW MALECIHYRK FTHQSDVWSY GVTIWELMTF 840

GGKPYDGIPT REIPDLLEKG ERLPQPPICT IDVYMVMVKC WMIDADSRPK FKELAAEFSR 900

MARDPQRYLV IQGDDRMKLP SPNDSKFFQN LLDEEDLEDM MDAEEYLVPQ AFNIPPPIYT 960

SRARIDSNRS EIGHSPPPAY TPMSGNQFVY RDGGFTAEQG VSVPYRATTS TIPEAPVAQG 1020

ATAEIFDDSC CNGTLRKPVA PHIQEDSSTQ RYSADPTVFA PERSPRGELD EEGYMTPMRD 1080

KPKQEYLNPV EENPFVSRRK NGELQALDNP EYHKASSGPP KAEDEYVNEP LYLNTFANAL 1140

GNAEYLKNNV LSVPEKAKKA FDNPDYWNHS LPPRSTLQHP DYLQEYSTKY FYKQNGRIRP 1200

IVAENPEYLS EFSLKPGTVL PPPPYRHRNT VV 1232

Nucleotide Sequence
(FASTA)

TTTCAGTCTA TTCGAGAAGT CACAGGCTAT GTATTAGTGG CTCTGAACCA GTTCCGTTAC 60

CTGCCTCTGG AGAATTTGCG CATTATTCGT GGGACAAAAC TTTATGAGGA TCGATATGCT 120

TTGGCAATAT TTCTAAACTA CAGAAAAGAT GGAAACTTTG GACTTCAGGA ACTTGGATTA 180

AAGAACTTGA CAGAAATCCT GAATGGGGGT GTCTATGTGG ACCAGAACAA ATTCCTTTGT 240

TATGCAGACA CAATTCATTG GCAAGACATT GTTCGGAATC CATGGCCTTC GAATTTGACT 300

CTGGTGTCAA CAAATGGTAG CTCAGGATGT GGGCGTTGCC ATAAGTCCTG TACTGGCCGA 360

TGCTGGGGAC CTACAGAAAA TCATTGCCAG ACTTTGACAA GGACAGTGTG TGCGGAACAA 420

TGTGATGGCA GGTGCTACGG GCCCTACGTC AGTGACTGCT GTCATCGAGA ATGTGCAGGG 480

GGCTGCTCAG GACCTAAGGA CACCGATTGC TTTGCCTGCA TGAATTTCAA TGACAGTGGA 540

GCATGTGTTA CTCAGTGTCC CCAAACCTTT GTCTACAATC CAACCACTTT TCAGTTGGAG 600

CACAACTTCA ATGCGAAGTA CACCTATGGC GCGTTCTGTG TCAAGAAATG CCCACATAAT 660

TTTGTGGTAG ATTCCAGTTC TTGTGTACGT GCCTGCCCTA GTTCCAAGAT GGAAGTAGAA 720

GAAAATGGAA TTAAGATGTG CAAACCTTGT ACTGACATTT GCCCAAAAGC TTGTGATGGT 780

ATTGGCACAG GATCGTTGAT GTCAGCCCAG ACTGTGGATT CTAGTAACAT TGACAAATTC 840

ATAAACTGCA CCAAGATCAA TGGGAATTTG ATTTTCCTTG TCACTGGTAT TCATGGGGAT 900

CCATACAATG CAATTGAAGC TATAGACCCA GAGAAACTGA ATGTCTTTCG GACAGTCAGA 960

GAGATAACAG GTTTTTTGAA CATACAATCA TGGCCCCCAA ACATGACTGA CTTCAGTGTT 1020

TTTTCCAACC TGGTCACCAT TGGTGGGAGA GTACTCTATA GTGGCCTCTC CTTGCTTATC 1080

CTCAAGCAAC AAGGCATCAC CTCTCTGCAG TTCCAGTCGC TAAAGGAAAT CAGTGCAGGA 1140

AACATCTATA TCACGGACAA CAGCAACCTG TGTTACTATC ATACCATTAA CTGGACAACG 1200

CTCTTCAGCA CGATCAACCA ACGAATAGTG ATCCGGGACA ATAGGAAAGC TGAAAATTGT 1260

ACTGCTGAAG GAATGGTGTG CAACCACCTG TGTTCAAATG ATGGCTGCTG GGGACCTGGG 1320

CCGGACCAGT GCCTGTCATG CCGCCGCTTT AGCAGAGGAA GGATCTGCAT TGAGTCTTGT 1380

AACCTCTATG ATGGCGAATT TCGGGAGTTT GAGAATGGCT CCATCTGTGT GGAGTGTGAC 1440

CCTCAATGTG AGAAGATGGA AGATGGCCTC CTCACATGCC ACGGACCGGG ACCTGACAAC 1500

TGTACAAAGT GCTCTCATTT TAAGGATGGT CCAAACTGTG TGGAAAAATG TCCAGATGGC 1560

GTACAAGGGG CAAACAGTTT CATTTTCAAG TATGCTGATC AGGATCGGGA GTGCCACCCA 1620

TGCCACCCCA ACTGCACCCA AGGGTGTAAC GGTCCCACTA GTCATGACTG CATTTACTAC 1680

CCATGGACGG GCCATTCCAC TTTACCACAA CATGCTAGAA CTCCCCTGAT TGCAGCTGGA 1740

GTCATTGGTG GGCTTTTTAT CCTGGTCATT GTGGGCCTGA CATTTGCAGT GTATGTTAGA 1800

AGGAAGAGCA TCAAAAAGAA AAGAGCCTTG AGAAGATTCC TGGAAACAGA GTTGGTGGAG 1860

CCCTTGACTC CCAGTGGCAC AGCACCTAAT CAAGCTCAAC TTCGGATTCT GAAAGAAACT 1920

GAGCTCAAGA GAGTGAAAGT CCTTGGCTCT GGTGCTTTTG GAACCGTTTA TAAAGGTATT 1980

TGGGTACCTG AAGGAGAAAC GGTGAAGATT CCCGTGGCTA TTAAGATTCT TAATGAGACA 2040

ACTGGTCCCA AGGCCAATGT GGAGTTCATG GATGAAGCTC TGATAATGGC AAGTATGGAC 2100

CATCCACACC TAGTCCGGTT ACTAGGTGTG TGTCTGAGCC CAACCATCCA GCTGGTTACC 2160

CAACTTATGC CCCATGGCTG CCTATTGGAT TATGTTCATG AACACAAGGA TAACATTGGC 2220

TCACAGCTGC TGCTTAACTG GTGTGTCCAG ATAGCTAAGG GAATGATGTA CCTGGAAGAA 2280

AGACGGCTTG TTCATCGGGA TTTGGCAGCC CGTAATGTTT TAGTAAAATC TCCAAACCAT 2340

GTGAAAATCA CAGATTTTGG ACTGGCCAGA CTCTTGGAAG GAGATGAAAA AGAGTATAAT 2400

GCTGATGGAG GAAAGATGCC AATCAAATGG ATGGCTTTGG AGTGTATACA TTATAGGAAA 2460

TTCACCCACC AGAGTGACGT TTGGAGCTAT GGAGTAACTA TATGGGAACT GATGACCTTT 2520

GGAGGAAAAC CCTATGATGG AATTCCAACC CGAGAAATTC CTGATTTATT AGAGAAAGGA 2580

GAACGTTTGC CTCAGCCTCC CATCTGCACT ATCGATGTTT ACATGGTCAT GGTCAAATGT 2640

TGGATGATTG ATGCCGACAG TAGACCTAAA TTCAAGGAAC TGGCTGCTGA ATTTTCAAGG 2700

ATGGCCCGAG ACCCTCAAAG ATATCTTGTT ATTCAGGGTG ATGATCGCAT GAAGCTTCCC 2760

AGTCCAAATG ACAGCAAGTT CTTTCAGAAC CTCTTGGATG AAGAAGACTT AGAAGATATG 2820

ATGGATGCTG AGGAGTATCT GGTCCCTCAG GCTTTCAACA TCCCACCTCC CATCTATACT 2880

TCCAGAGCAA GAATTGACTC AAATAGGAGT GAAATTGGAC ACAGCCCTCC TCCTGCCTAC 2940

ACCCCTATGT CAGGAAACCA GTTTGTGTAC CGAGATGGGG GTTTCACTGC AGAACAAGGA 3000

GTTTCTGTGC CCTATAGAGC CACGACCAGC ACAATCCCAG AAGCTCCAGT TGCTCAGGGT 3060

GCCACAGCTG AAATTTTTGA TGATTCCTGT TGTAACGGCA CCCTACGCAA GCCGGTGGCA 3120

CCCCATATCC AAGAGGACAG CAGCACCCAG AGGTACAGTG CTGACCCCAC TGTGTTTGCC 3180

CCAGAACGGA GCCCACGAGG AGAACTGGAT GAAGAAGGTT ACATGACTCC TATGAGAGAC 3240

AAACCCAAAC AAGAATACCT GAATCCTGTG GAAGAGAATC CTTTTGTTTC TCGAAGAAAA 3300

AATGGAGAAC TTCAAGCTTT GGATAATCCT GAGTATCACA AGGCTTCTAG TGGTCCACCC 3360

AAGGCAGAGG ATGAGTACGT GAATGAGCCA TTGTACCTCA ACACATTTGC CAATGCCTTG 3420

GGGAATGCGG AGTACCTGAA GAACAACGTA CTGTCTGTGC CAGAGAAGGC CAAGAAAGCA 3480

TTTGACAACC CTGACTACTG GAACCACAGC CTGCCGCCTC GGAGCACCCT TCAGCACCCA 3540

GACTACCTGC AGGAGTACAG CACAAAATAT TTTTATAAAC AGAATGGACG GATCCGGCCC 3600

ATTGTGGCAG AGAATCCTGA ATACCTCTCT GAGTTCTCAC TGAAGCCAGG CACTGTGCTG 3660

CCTCCTCCAC CCTACAGACA CCGGAATACT GTGGTA 3696

Domain Profile

S: 1     lkklkvlGsGafGtvykGiwipegenvkipvaikvleektgkkankelldealvlasldh  60

         lk++kvlGsGafGtvykGiw+pege+vkipvaik+l+e+tg+kan e++deal++as+dh

Q: 642   LKRVKVLGSGAFGTVYKGIWVPEGETVKIPVAIKILNETTGPKANVEFMDEALIMASMDH  701

         699*********************************************************

S: 61    anlvrllglclsstlqlvtqllplGclldyvrehkdklGsqellnwcvqiakGmsyleek  120

         ++lvrllg+cls t+qlvtql+p+Gclldyv+ehkd++Gsq llnwcvqiakGm+ylee+

Q: 702   PHLVRLLGVCLSPTIQLVTQLMPHGCLLDYVHEHKDNIGSQLLLNWCVQIAKGMMYLEER  761

         ************************************************************

S: 121   rlvhrdlaarnvlvkspnhvkitdfGlaklleadekelkaeggkvpikwlalesilkrky  180

         rlvhrdlaarnvlvkspnhvkitdfGla+lle deke++a+ggk+pikw+ale+i++rk+

Q: 762   RLVHRDLAARNVLVKSPNHVKITDFGLARLLEGDEKEYNADGGKMPIKWMALECIHYRKF  821

         ************************************************************

S: 181   thqsdvwsyGvtvwelltfGakpydgipakeipdllekGerlaqppictidvymvlvkcw  240

         thqsdvwsyGvt+wel+tfG kpydgip++eipdllekGerl+qppictidvymv+vkcw

Q: 822   THQSDVWSYGVTIWELMTFGGKPYDGIPTREIPDLLEKGERLPQPPICTIDVYMVMVKCW  881

         ************************************************************

S: 241   midaesrpkfkelaeefs  258

         mida+srpkfkela+efs

Q: 882   MIDADSRPKFKELAAEFS  899

         ****************96

Domain Sequence
(FASTA)

LKRVKVLGSG AFGTVYKGIW VPEGETVKIP VAIKILNETT GPKANVEFMD EALIMASMDH 60

PHLVRLLGVC LSPTIQLVTQ LMPHGCLLDY VHEHKDNIGS QLLLNWCVQI AKGMMYLEER 120

RLVHRDLAAR NVLVKSPNHV KITDFGLARL LEGDEKEYNA DGGKMPIKWM ALECIHYRKF 180

THQSDVWSYG VTIWELMTFG GKPYDGIPTR EIPDLLEKGE RLPQPPICTI DVYMVMVKCW 240

MIDADSRPKF KELAAEFS 258

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Phosphoprotein; Reference proteome; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Equus caballus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016323	; C:basolateral plasma membrane
GO:0016021	; C:integral to membrane
GO:0005739	; C:mitochondrion
GO:0005524	; F:ATP binding
GO:0004716	; F:receptor signaling protein tyrosine kinase activity
GO:0044212	; F:transcription regulatory region DNA binding
GO:0004714	; F:transmembrane receptor protein tyrosine kinase activity
GO:0006915	; P:apoptotic process
GO:0061026	; P:cardiac muscle tissue regeneration
GO:0045165	; P:cell fate commitment
GO:0021551	; P:central nervous system morphogenesis
GO:0009880	; P:embryonic pattern specification
GO:0007507	; P:heart development
GO:0007595	; P:lactation
GO:0060749	; P:mammary gland alveolus development
GO:0060644	; P:mammary gland epithelial cell differentiation
GO:0043066	; P:negative regulation of apoptotic process
GO:0008285	; P:negative regulation of cell proliferation
GO:0001755	; P:neural crest cell migration
GO:0021889	; P:olfactory bulb interneuron differentiation
GO:0018108	; P:peptidyl-tyrosine phosphorylation
GO:0060045	; P:positive regulation of cardiac muscle cell proliferation
GO:0070374	; P:positive regulation of ERK1 and ERK2 cascade
GO:0043552	; P:positive regulation of phosphatidylinositol 3-kinase activity
GO:2000366	; P:positive regulation of STAT protein import into nucleus
GO:0045893	; P:positive regulation of transcription, DNA-dependent
GO:0042523	; P:positive regulation of tyrosine phosphorylation of Stat5 protein
GO:0046777	; P:protein autophosphorylation
GO:0030334	; P:regulation of cell migration
GO:0023014	; P:signal transduction by phosphorylation
GO:0007169	; P:transmembrane receptor protein tyrosine kinase signaling pathway

KEGG

InterPros

IPR000494	; EGF_rcpt_L.
IPR006211	; Furin-like_Cys-rich_dom.
IPR006212	; Furin_repeat.
IPR009030	; Growth_fac_rcpt.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.
IPR016245	; Tyr_kinase_EGF/ERB/XmrK_rcpt.

Pfam

PF00757	; Furin-like; 1.
PF07714	; Pkinase_Tyr; 1.
PF01030	; Recep_L_domain; 2.

SMARTs

SM00261	; FU; 5.
SM00219	; TyrKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013