EKS-ORC-00250

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ORC-00250

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/DYRK	471.9	1.2E-141	207	520	314

Status

Unreviewed

Ensembl Protein

ENSOCUP00000025593

UniProt Accession

G1SY75;

Protein Name

Protein Synonyms/Alias

Gene Name

DYRK2

Gene Synonyms/Alias

DYRK2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSOCUG00000009934	ENSOCUP00000025593	ENSOCUT00000027558
ENSOCUG00000009934	ENSOCUP00000008554	ENSOCUT00000009932

Organism

Oryctolagus cuniculus

Functional Description

Protein Length

586

Protein Sequence
(FASTA)

PSFVSSRAWL PGRGGDSAVR QLQASGVGTG PPSPIALPPL RASNAAATAH TIGGSKHTMN 60

DHLHISSHSH GQIQVQQLFE DNSNKRTVLT TQPNGLTTVG KTSLPVVPER QLESIHRRQG 120

SSTSLKSIEG MGKVKATPMT PEQAMKQYMQ KLTAFEHHEI FSYPEIYFLG PNAKKRQGMT 180

GGPNNGGYDD DQGSYVQVPH DHVAYRYEVL KVIGKGSFGQ VVKAYDHKVH QHVALKMVRN 240

EKRFHRQAAE EIRILEHLRK QDKDNAMNVI HMLENFTFRN HICMTFELLS MNLYELIKKN 300

KFQGFSLPLV RKFAHSILQC LDALHKNRII HCDLKPENIL LKQQGRSGIK VIDFGSSCYE 360

HQRVYTYIQS RFYRAPEVIL GARYGMPIDM WSLGCILAEL LTGYPLLPGE DEGDQLACMI 420

ELLGMPSQKL LDASKRAKNF VSSKGYPRYC TVTTLSDGNV VLNGGRSRRG KLRGPPESRE 480

WGNALKGCDD PLFLDFLKQC LEWDPAVRMT PGQALRHPWL RRRLPKPPTG EKTSVKRITE 540

SSGAITSISK LPPPSSSASK LRTNLAQMTD ANGNIQQRTV LPKLVS 586

Nucleotide Sequence
(FASTA)

CCCTCTTTTG TCTCCTCCCG TGCGTGGCTC CCAGGCCGAG GAGGGGACAG CGCCGTTCGT 60

CAGCTTCAGG CTAGCGGAGT GGGGACCGGC CCGCCCTCCC CCATCGCCCT GCCGCCTCTC 120

CGGGCCAGCA ACGCGGCCGC CACGGCCCAC ACGATTGGCG GCAGTAAGCA CACCATGAAT 180

GATCACCTGC ACATCAGCAG CCACAGCCAC GGACAGATCC AGGTTCAGCA GCTGTTTGAG 240

GACAACAGTA ACAAGCGGAC CGTGCTCACG ACACAACCAA ATGGGCTTAC AACAGTGGGT 300

AAAACAAGCT TGCCAGTGGT GCCAGAGCGG CAGCTGGAGA GCATTCATAG ACGGCAGGGG 360

AGCTCCACCT CTCTCAAGTC CATCGAAGGC ATGGGAAAGG TGAAAGCCAC ACCCATGACA 420

CCCGAACAAG CAATGAAGCA ATACATGCAA AAACTCACAG CCTTCGAACA CCATGAGATT 480

TTCAGCTACC CTGAAATATA TTTCTTGGGT CCAAACGCAA AGAAGCGCCA GGGCATGACG 540

GGCGGGCCCA ACAACGGTGG CTACGATGAT GACCAGGGAT CGTATGTGCA GGTGCCCCAT 600

GACCATGTGG CTTACAGGTA CGAGGTCCTC AAGGTCATTG GGAAGGGGAG CTTTGGGCAG 660

GTGGTCAAGG CGTACGATCA CAAAGTCCAC CAGCACGTGG CCCTAAAGAT GGTGCGGAAC 720

GAGAAGCGCT TTCACCGGCA GGCGGCCGAG GAGATCCGCA TCCTGGAGCA CCTGCGCAAG 780

CAGGACAAAG ACAACGCCAT GAACGTCATC CACATGCTGG AGAACTTCAC CTTCCGCAAC 840

CACATCTGCA TGACCTTTGA GCTGCTGAGC ATGAACCTCT ATGAGCTCAT CAAGAAGAAC 900

AAATTCCAGG GCTTCAGCCT GCCCTTGGTC CGCAAGTTTG CCCACTCGAT TCTGCAGTGC 960

TTGGATGCTT TGCACAAAAA CAGGATCATT CACTGTGACC TTAAGCCCGA GAATATTTTG 1020

TTAAAGCAGC AGGGTAGAAG CGGCATCAAA GTGATCGATT TTGGCTCCAG CTGCTACGAG 1080

CATCAGCGTG TCTACACGTA CATCCAGTCG CGCTTTTACC GGGCTCCCGA GGTGATTCTG 1140

GGGGCCAGGT ACGGCATGCC CATCGACATG TGGAGCCTGG GCTGCATTCT GGCAGAGCTC 1200

CTGACGGGCT ACCCCCTCTT GCCTGGGGAA GACGAAGGGG ACCAGCTGGC TTGTATGATT 1260

GAGCTGTTGG GCATGCCCTC CCAGAAACTG CTGGATGCAT CCAAACGAGC CAAAAATTTC 1320

GTGAGCTCCA AGGGTTATCC CCGTTACTGC ACTGTCACGA CTCTCTCTGA CGGCAACGTG 1380

GTCCTCAATG GAGGCCGTTC CCGGAGAGGG AAGCTGAGGG GTCCACCCGA GAGCAGAGAG 1440

TGGGGGAATG CACTGAAAGG GTGCGACGAT CCCCTCTTCC TTGACTTCTT AAAACAGTGT 1500

TTGGAGTGGG ATCCTGCCGT GCGCATGACC CCGGGCCAGG CTTTGCGGCA CCCCTGGCTG 1560

AGAAGGCGGT TGCCCAAGCC TCCGACCGGG GAGAAGACCT CAGTGAAGCG GATAACCGAG 1620

AGCTCTGGTG CTATCACGTC GATTTCCAAG TTACCTCCAC CTTCCAGCTC AGCGTCCAAA 1680

CTGAGGACTA ATTTGGCACA GATGACAGAT GCCAATGGGA ATATTCAGCA GAGGACAGTG 1740

TTGCCAAAAC TCGTGAGCTG A 1761

Domain Profile

S: 1     yevlevigkGsfgqVvkaldkktkeivaikiiknkkrfarqaqeEveiLeklnkkdkeek  60

         yevl+vigkGsfgqVvka+d+k +++va+k+++n+krf+rqa+eE++iLe+l+k+dk+++

Q: 207   YEVLKVIGKGSFGQVVKAYDHKVHQHVALKMVRNEKRFHRQAAEEIRILEHLRKQDKDNA  266

         9***********************************************************

S: 61    ynvvrllelfvfrnhlclvfellsqnLyellkknkfsglslklvrklaqqilkaLklLke  120

         +nv+++le f+frnh+c++fells+nLyel+kknkf+g+sl lvrk+a++il++L++L++

Q: 267   MNVIHMLENFTFRNHICMTFELLSMNLYELIKKNKFQGFSLPLVRKFAHSILQCLDALHK  326

         ************************************************************

S: 121   lkiiHaDlKPeNillvekkrsevkviDFGsssavsqkeiytyiqsrfYraPEiilglkyd  180

         ++iiH+DlKPeNill++++rs +kviDFGss++++q+ +ytyiqsrfYraPE+ilg++y

Q: 327   NRIIHCDLKPENILLKQQGRSGIKVIDFGSSCYEHQR-VYTYIQSRFYRAPEVILGARYG  385

         *************************************.**********************

S: 181   eaiDmWSlGcvlaElftGkpLfpGenevdqlalivevlglppekllekakkakkfftkke  240

         + iDmWSlGc+laEl+tG+pL+pGe+e dqla+++e+lg+p++kll+++k+ak+f+++k+

Q: 386   MPIDMWSLGCILAELLTGYPLLPGEDEGDQLACMIELLGMPSQKLLDASKRAKNFVSSKG  445

         ************************************************************

S: 241   apkyilktkksdrkkklvlnvkkaakkrkaplskelgealkekedklfkdllkrmleldp  300

         +p+y+++t+ sd +++l+ ++++++k r +p+s+e+g+alk ++d lf d+lk++le+dp

Q: 446   YPRYCTVTTLSDGNVVLNGGRSRRGKLRGPPESREWGNALKGCDDPLFLDFLKQCLEWDP  505

         ************************************************************

S: 301   akRitpkealkhpfv  315

         a R+tp +al+hp++

Q: 506   AVRMTPGQALRHPWL  520

         **************6

Domain Sequence
(FASTA)

YEVLKVIGKG SFGQVVKAYD HKVHQHVALK MVRNEKRFHR QAAEEIRILE HLRKQDKDNA 60

MNVIHMLENF TFRNHICMTF ELLSMNLYEL IKKNKFQGFS LPLVRKFAHS ILQCLDALHK 120

NRIIHCDLKP ENILLKQQGR SGIKVIDFGS SCYEHQRVYT YIQSRFYRAP EVILGARYGM 180

PIDMWSLGCI LAELLTGYPL LPGEDEGDQL ACMIELLGMP SQKLLDASKR AKNFVSSKGY 240

PRYCTVTTLS DGNVVLNGGR SRRGKLRGPP ESREWGNALK GCDDPLFLDF LKQCLEWDPA 300

VRMTPGQALR HPWL 314

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dasypus novemcinctus"; ?>Drosophila melanogaster"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tupaia belangeri"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005737	; C:cytoplasm
GO:0005634	; C:nucleus
GO:0030529	; C:ribonucleoprotein complex
GO:0000151	; C:ubiquitin ligase complex
GO:0005524	; F:ATP binding
GO:0000287	; F:magnesium ion binding
GO:0030145	; F:manganese ion binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0004713	; F:protein tyrosine kinase activity
GO:0042771	; P:intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
GO:0045725	; P:positive regulation of glycogen biosynthetic process
GO:0007224	; P:smoothened signaling pathway

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013