EPS-ORC-00027

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EPS-ORC-00027

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
PPM/PP2C	185.9	1.4E-54	783	1029	247

Status

Unreviewed

Ensembl Protein

ENSOCUP00000008595

UniProt Accession

G1SYB0;

Protein Name

Protein Synonyms/Alias

Gene Name

PHLPP2

Gene Synonyms/Alias

PHLPP2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSOCUG00000009972	ENSOCUP00000008595	ENSOCUT00000009977
ENSOCUG00000009972	ENSOCUP00000019541	ENSOCUT00000029494

Organism

Oryctolagus cuniculus

Functional Description

Protein Length

1321

Protein Sequence
(FASTA)

MKRNGSRSCL TRRSRFGSRE RDWLREDVKR GCVYLYGAET STATTATASS TSCSSSSSDL 60

HLVLCTVETP ASEICAGEGR ESLYIQLHGD LVRRLEPTER PLQIVYDYLS RLGFDDPVRI 120

QEEATNPDLG CMIRFYGEKP CQLDHLDRIL LSGIYNVRKG KTQLHKWAER LVVLCGTCLI 180

VSSVKDCQTG KVHILPLVGG KVEEVKRRQH CLAFSSAGAQ AQTYHVSFET LAEYQRWQRQ 240

ASKVVSQRIS TVDLSCYSLE EVPEHLFYSQ DITYLNLRHN FMQLERPGGL DTLYKFSQLK 300

GLNLSHNKLG FFPVLLCEIS TLTELNLSCN GFHDLPSEIG NLLNLQTLCL DGNFLTTLPE 360

ELGNLQQLSS LGISFNNFSQ IPEVYEKLTL VDKVVMAGNH LEVLSLGVLN RMSHVKHVDL 420

RMNHLKTMVA ENLEGNKHIT HMDLRDNQLT DLDLSSLCSL EQLHCERNQL RELTLSGFSL 480

RTLYANSNKL TAVNVYPVPS LLTTLELSRN LLECVPDWAC DAKKIEIIDV SYNVLTEVPM 540

RILSSLSLRK LMMGHNHIQN LPALVEHIPL EVLDIQHNGL TRLPDTLFSR ALNLRYLNAS 600

ANSLECLPSA CAAGESLSVL QLLYLTSNRL TDQCIPVLVG FPHLRVLHLA NNQLQTFPAS 660

KLNKLEQLEE LNLSGNKLKT IPTTIANCKR LHTLVAHSNN ISIFPEILQL PQIQFVDLSC 720

NDLTEILIPE ALPATLQDLD LTGNTNLVLE HKTLDIFSHI TTLKIDQKPL PTTDSTITST 780

FWSHGLAEMA GQRNKLCVSA LAMDNLAEGV GAVYGMFDGD RNEELPRLLQ CTMADVLLEE 840

VQQSAHDTVF MASTFLVSHR KLGMAGQKLG SSALLCYIRP DTVDPTSSFN LTVANVGTCQ 900

AVLCRSGKPV PLSKVFSLEQ DPEEAQRVKD QKAIITEDNK VNGVTCCTRL LGCAYLYPWI 960

LPKPYISSTP LTIQDELLIL GNKALWEHLS YAEAVNAVRH VQDPLAAAKK LCTLAQSYGC 1020

QDNVGAMVVY LNIGEEGCTC EMNGLTLPGP VGFASSTTIK DAPKPTTPSS SSGIASEFSS 1080

ETSTSEVSSE VGSTASDEHN TVGLEAGLLP RPERRCSLHP TPTSGVFQRQ PSCATFSSNQ 1140

SDNGLDSDDD QPVEGVITNG SKVEVEVDIH CCRGRDLESS PTLRESSPTP CPEEPSRGLC 1200

FGIRRQNSVN SGILLPMSKD KMELQKSPST SCLYGKKLSN GSIVPLEDSL NLIEVATEVP 1260

KRKTGYFAAP TQLEPEDQFV VPRDLEEEVK EQMKQHQESR PEPEPSEEDR TEPPEEFDTA 1320

L 1321

Nucleotide Sequence
(FASTA)

ATGAAACGCA ATGGAAGCAG AAGTTGTTTG ACTAGGAGAA GTAGGTTTGG TTCTCGAGAA 60

AGAGACTGGC TGAGAGAAGA TGTGAAGAGA GGCTGCGTTT ACCTGTATGG CGCAGAGACC 120

AGCACTGCCA CTACAGCCAC CGCCTCCTCT ACTTCCTGCT CCTCCTCCTC CTCTGACTTA 180

CATCTTGTCC TTTGCACAGT GGAGACACCA GCGTCAGAAA TATGTGCTGG AGAGGGAAGA 240

GAAAGTCTAT ATATACAGCT TCATGGAGAC CTGGTCAGGA GACTGGAGCC TACTGAACGA 300

CCTCTTCAGA TTGTTTATGA TTACTTGTCC AGGCTGGGAT TCGACGATCC TGTGCGCATA 360

CAAGAGGAGG CTACTAATCC TGATCTTGGC TGTATGATTC GATTTTATGG TGAAAAGCCA 420

TGCCAGCTGG ATCATCTGGA TCGGATCCTG CTGTCTGGTA TATACAACGT GCGTAAGGGA 480

AAGACCCAGC TGCATAAGTG GGCTGAACGC CTAGTTGTCC TCTGTGGTAC CTGCCTTATT 540

GTTTCCTCAG TGAAAGATTG TCAGACTGGA AAGGTGCACA TTTTGCCTCT GGTTGGGGGA 600

AAGGTAGAAG AAGTGAAGCG CCGGCAACAC TGCCTTGCAT TCAGCTCAGC TGGAGCCCAA 660

GCCCAGACCT ATCATGTCAG CTTTGAGACT TTGGCTGAGT ACCAGAGATG GCAGCGGCAG 720

GCATCCAAGG TGGTGTCGCA GCGCATCAGC ACTGTGGATC TCTCATGTTA CAGCCTCGAG 780

GAGGTTCCGG AGCATCTCTT CTACAGTCAA GATATCACCT ACCTCAACTT GCGACACAAC 840

TTCATGCAGT TAGAAAGACC AGGGGGCCTC GACACACTCT ACAAATTTTC TCAGCTGAAG 900

GGCCTGAACT TATCCCATAA TAAGCTTGGA TTCTTTCCTG TGTTGCTATG TGAGATCTCT 960

ACTCTGACTG AGCTCAACCT CTCCTGTAAT GGATTTCATG ACCTGCCAAG TGAAATTGGA 1020

AATCTGCTAA ATCTTCAAAC CCTTTGTCTT GATGGCAACT TTCTGACTAC TTTACCTGAA 1080

GAATTGGGAA ATCTGCAACA ACTTTCCTCC CTGGGAATTT CCTTCAACAA CTTTAGTCAA 1140

ATTCCTGAGG TTTATGAGAA ACTCACTTTG GTGGATAAAG TTGTTATGGC AGGAAATCAC 1200

CTGGAAGTCC TAAGCCTAGG GGTGCTGAAC CGCATGAGCC ATGTCAAGCA CGTGGATTTA 1260

AGGATGAATC ATTTGAAAAC CATGGTTGCT GAAAATCTGG AGGGAAATAA ACATATCACC 1320

CACATGGATT TGCGGGACAA TCAGCTGACT GACTTGGATC TCAGCTCCTT GTGTAGCTTG 1380

GAGCAGCTGC ATTGTGAGCG GAACCAGCTG AGGGAGCTGA CACTGAGTGG CTTCTCCCTT 1440

CGAACTCTCT ATGCCAATTC GAACAAGCTG ACAGCAGTAA ATGTGTATCC AGTTCCTAGT 1500

CTTCTCACTA CCCTGGAACT CTCCCGAAAT CTGCTAGAAT GTGTCCCTGA CTGGGCCTGT 1560

GATGCAAAGA AGATAGAAAT AATAGATGTG AGTTATAATG TTCTCACAGA GGTTCCTATG 1620

AGAATTCTGA GTAGTTTGAG TCTTAGAAAA CTGATGATGG GACACAATCA CATCCAAAAC 1680

CTTCCAGCGC TGGTGGAGCA CATCCCACTT GAGGTCCTGG ATATTCAGCA TAATGGACTC 1740

ACCAGGCTGC CAGATACCCT CTTCTCCAGG GCTTTAAACC TCAGATACCT GAATGCATCT 1800

GCAAACAGTC TGGAGTGTTT GCCATCTGCT TGTGCTGCCG GCGAGAGTCT GAGCGTGCTG 1860

CAGCTGCTCT ATCTGACCAG CAATCGCCTG ACTGATCAGT GCATACCTGT CTTGGTTGGG 1920

TTCCCGCACC TGCGAGTCTT GCACCTTGCC AACAATCAAC TACAGACCTT TCCTGCAAGC 1980

AAACTAAATA AATTGGAGCA GTTGGAGGAA CTGAACTTAA GTGGCAACAA GCTTAAGACG 2040

ATTCCCACAA CTATAGCAAA CTGCAAAAGA CTGCACACCC TTGTTGCACA CTCCAACAAC 2100

ATCAGCATTT TCCCAGAAAT CCTGCAATTG CCTCAGATCC AGTTTGTAGA TCTAAGTTGC 2160

AATGACTTGA CAGAAATACT CATTCCAGAG GCTCTGCCTG CTACACTACA AGACCTTGAC 2220

CTGACTGGAA ATACAAATCT GGTTCTGGAA CACAAGACGC TAGACATATT TAGCCATATC 2280

ACAACACTAA AAATTGATCA GAAACCTTTG CCAACCACAG ATTCTACCAT TACATCAACC 2340

TTCTGGAGCC ACGGACTGGC TGAGATGGCA GGACAGAGAA ATAAGCTGTG TGTATCTGCT 2400

CTAGCTATGG ATAACTTGGC AGAGGGTGTG GGAGCCGTGT ATGGCATGTT TGACGGCGAC 2460

CGGAACGAGG AGCTCCCTCG CCTGCTGCAG TGCACGATGG CAGACGTGCT GTTGGAAGAG 2520

GTACAGCAGT CAGCACATGA CACCGTTTTC ATGGCGAGCA CCTTCTTGGT GTCTCACAGG 2580

AAACTAGGAA TGGCTGGGCA GAAGCTGGGC TCCTCCGCTC TCCTGTGCTA CATTCGCCCT 2640

GACACTGTTG ATCCAACAAG CAGTTTTAAC CTGACTGTGG CCAACGTTGG CACCTGCCAA 2700

GCAGTCCTGT GCCGAAGTGG GAAGCCAGTG CCACTCTCTA AAGTCTTCAG CCTGGAACAG 2760

GATCCAGAGG AAGCGCAAAG AGTGAAGGAC CAAAAAGCCA TCATAACAGA GGACAACAAA 2820

GTGAATGGGG TAACTTGCTG TACCAGGTTG CTGGGCTGTG CGTACCTCTA CCCTTGGATC 2880

CTCCCCAAGC CCTACATATC GTCCACTCCT CTTACCATTC AGGATGAGCT GCTGATTCTG 2940

GGAAACAAGG CATTGTGGGA ACACTTGTCA TATGCAGAAG CTGTTAACGC AGTGCGTCAT 3000

GTACAAGACC CACTAGCAGC AGCCAAGAAG CTGTGCACAT TAGCCCAGAG CTATGGTTGC 3060

CAGGACAATG TGGGGGCAAT GGTGGTTTAT TTGAACATTG GTGAGGAAGG GTGCACTTGT 3120

GAAATGAATG GACTGACGCT CCCGGGTCCT GTGGGATTTG CTTCAAGCAC CACCATCAAG 3180

GACGCTCCCA AGCCAACCAC TCCTTCGTCT AGTAGCGGCA TCGCCTCTGA ATTTAGCAGT 3240

GAGACGTCCA CCTCCGAGGT GAGCAGTGAA GTAGGCTCTA CCGCTTCTGA CGAGCATAAC 3300

ACTGTGGGCC TAGAGGCTGG CTTGCTTCCA AGGCCAGAGA GGCGCTGCAG CCTCCATCCA 3360

ACACCCACCT CTGGGGTATT TCAGCGCCAG CCTTCTTGTG CAACCTTCTC CAGTAATCAG 3420

TCTGACAATG GCCTAGACAG TGATGATGAC CAGCCTGTTG AAGGGGTCAT AACCAATGGC 3480

AGCAAGGTCG AAGTAGAGGT GGATATCCAC TGCTGCAGAG GAAGAGATCT TGAGAGCTCG 3540

CCTACTCTTC GGGAGAGTTC TCCCACCCCC TGTCCTGAGG AACCTTCTAG AGGCTTGTGT 3600

TTTGGAATCC GCAGACAGAA CAGTGTGAAT AGTGGCATCC TTCTCCCAAT GAGCAAGGAC 3660

AAGATGGAGT TACAGAAGTC CCCCTCCACT TCCTGTCTCT ATGGGAAGAA ACTCTCCAAC 3720

GGTTCCATTG TGCCCCTGGA AGACAGCCTG AATCTCATTG AAGTGGCCAC GGAAGTACCC 3780

AAGAGGAAAA CTGGCTATTT TGCTGCCCCC ACTCAGCTGG AACCAGAGGA TCAGTTTGTT 3840

GTGCCTCGTG ACCTGGAGGA GGAAGTGAAG GAGCAAATGA AACAGCATCA GGAGAGCAGA 3900

CCTGAGCCCG AGCCCAGCGA GGAGGATCGG ACTGAGCCCC CGGAGGAGTT TGACACGGCG 3960

CTG 3963

Domain Profile

S: 2     lvgvvsvngrrnemedavtsspnflkspekkdrlaffgvyDGhggsevakfcseklheil  61

         ++g++++ g+rn+++ ++ +++n+++  +     a++g++DG++++e  + +++++ ++l

Q: 783   SHGLAEMAGQRNKLCVSALAMDNLAEGVG-----AVYGMFDGDRNEELPRLLQCTMADVL  837

         6899***********99999888888766.....59************************

S: 62    aeelesseseerkvkkalakaFlstdeelkvleeksldidksGstavvalikds......  115

          ee++    ++++ + ++a++Fl  +++l       ++ +k Gs+a++++i+++

Q: 838   LEEVQ----QSAHDTVFMASTFLVSHRKL------GMAGQKLGSSALLCYIRPDtvdpts  887

         ***99....88999999************......89***************9999999*

S: 116   ..klyvanvGdSravLcrngkavelssdHkpsre.dEleRieeaggsvilkdgaRvlGvL  172

           +l+vanvG ++avLcr+gk+v+ls+ ++ +++ +E +R++++++ +++++  +v+Gv+

Q: 888   sfNLTVANVGTCQAVLCRSGKPVPLSKVFSLEQDpEEAQRVKDQKAIITEDN--KVNGVT  945

         ******************************99866**********9999998..******

S: 173   avsRalGdlylkpyvtpePevtshrltsedefliLasDGlwdvvsneeavslvrdvlekk  232

         +++R lG+ yl+p++ p+P ++s++lt +de liL+ + lw+++s  eav++vr+v +

Q: 946   CCTRLLGCAYLYPWILPKPYISSTPLTIQDELLILGNKALWEHLSYAEAVNAVRHVQD--  1003

         **********************************************************..

S: 233   eaeqeaakkLvklalargskdnvsaivv  260

           + +aakkL++la+++g++dnv a+vv

Q: 1004  --PLAAAKKLCTLAQSYGCQDNVGAMVV  1029

         ..************************97

Domain Sequence
(FASTA)

SHGLAEMAGQ RNKLCVSALA MDNLAEGVGA VYGMFDGDRN EELPRLLQCT MADVLLEEVQ 60

QSAHDTVFMA STFLVSHRKL GMAGQKLGSS ALLCYIRPDT VDPTSSFNLT VANVGTCQAV 120

LCRSGKPVPL SKVFSLEQDP EEAQRVKDQK AIITEDNKVN GVTCCTRLLG CAYLYPWILP 180

KPYISSTPLT IQDELLILGN KALWEHLSYA EAVNAVRHVQ DPLAAAKKLC TLAQSYGCQD 240

NVGAMVV 247

Keyword

Complete proteome; Leucine-rich repeat; Reference proteome; Repeat.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Saccharomyces cerevisiae"; ?>

Gene Ontology

GO:0005737	; C:cytoplasm
GO:0003824	; F:catalytic activity
GO:0005543	; F:phospholipid binding
GO:0008152	; P:metabolic process

KEGG

InterPros

IPR001611	; Leu-rich_rpt.
IPR025875	; Leu-rich_rpt_4.
IPR003591	; Leu-rich_rpt_typical-subtyp.
IPR011993	; PH_like_dom.
IPR001849	; Pleckstrin_homology.
IPR001932	; PP2C-like.

Pfam

PF00560	; LRR_1; 1.
PF12799	; LRR_4; 1.
PF00481	; PP2C; 1.

SMARTs

SM00369	; LRR_TYP; 1.
SM00332	; PP2Cc; 1.

Prosites

PS51450	; LRR; 16.
PS50003	; PH_DOMAIN; 1.

Prints

Created Date

20-Feb-2013