EKS-ORC-00293

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ORC-00293

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
STE/STE20	356.2	1.2E-106	30	294	265

Status

Unreviewed

Ensembl Protein

ENSOCUP00000008802

UniProt Accession

G1SYU6;

Protein Name

Protein Synonyms/Alias

Gene Name

MINK1

Gene Synonyms/Alias

MINK1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSOCUG00000010204	ENSOCUP00000008802	ENSOCUT00000010211

Organism

Oryctolagus cuniculus

Functional Description

Protein Length

1308

Protein Sequence
(FASTA)

RGDPSPACSC TSQLSVSLSL KKEKDPAGIF ELVEVVGNGT YGQVYKGRHV KTGQLAAIKV 60

MDVTEDEEEE IKQEINMLKK YSHHRNIATY YGAFIKKSPP GNDDQLWLVM EFCGAGSVTD 120

LVKNTKGNAL KEDCIAYICR EILRGLAHLH AHKVIHRDIK GQNVLLTENA EVKLVDFGVS 180

AQLDRTVGRR NTFIGTPYWM APEVIACDEN PDATYDYRSD IWSLGITAIE MAEGAPPLCD 240

MHPMRALFLI PRNPPPRLKS KKWSKKFIDF IDTCLIKTYL SRPPTEQLLK FPFIRDQPTE 300

RQVRIQLKDH IDRSRKKRGE KEETEYEYSG SEEEDDSHGE EGEPSSIMNV PGESTLRREF 360

LRLQQENKSN SEALRDPEAH IKHLLHQRQR RIEEQKEERR RVEEQKKNLR ESLLQKSRVQ 420

FCQLRSVQAA QQQEITASQT LPGGGSPPQR RGSLGVQGLL GAPAPLLFES SLVRNLVKAE 480

REQILPGDRK PLYHYGRGVN PADKPAWARE VEERTRMNKQ QNSPLAKTKP SSTGPEPPAP 540

QASPSPPGPL SQTPPMQRPV EPQEGPHKSL VAHRVPLKPY AAPVPRSQSL QDQPTRNLAA 600

FPASHDPDPA VAAPAATPSA RGAVIRQNSD PTSEGPGPSP NPPAWVRPDN EAPPKVPQRT 660

SSIATALNTS GAAGSRPAQA VRARPRSNSA WQIYLQRRAE RGAPKPPGPP AQPPGPPNAS 720

SNPDLRRSDP GWERSDSVLP ASHGHLPQAG SLERNRVGAT TKLDSSPVLS PGNKAKPDDH 780

RSRPGRPADF VLLKERTLDE APRPPKKAMD YSSSSEEVES SEDDDEEGDG EPAEGSRDTP 840

GGRSDGDTDS VSTMVVLDVE ETAGTQPPYG GGTMLVQRTP EEKRSLLHSD STRPPENSKG 900

QSPPSKDGSS DYQSRGLVKA PGKSSFTMFV DLGLYQPGGS GDTIPITALV GGEGARLDQL 960

QYDVRKGSVV NVNPTNTRAH SETPEIRKYK KRFNSEILCA ALWGGPGKKV GTENGLKAER 1020

KLTGKVSALL GRRRFQQMDV LEGLNLLIPI SGKRNKLRVY YLSWLRNKIL HNDPEVEKKQ 1080

GWTTVGDMEG CGHYRVVKYE RIKFLVIALK SSVEVYAWAP KPYHKFMAFK SFADLPHRPL 1140

LVDLTVEEGQ RLKVIYGSSA GFHAVDVDSG NSYDIYIPVH IQSQITPHAI IFLPNTDGME 1200

MLLCYEDEGV YVNTYGRIIK DVVLQWGEMP TSVAYICSNQ IMGWGEKAIE IRSVETGHLD 1260

GVFMHKRAQR LKFLCERNDK VVFFASVRSG GSSQVYFMTL NRNCIMNW 1308

Nucleotide Sequence
(FASTA)

AGAGGGGACC CATCTCCAGC TTGCAGCTGC ACCTCTCAGC TTTCTGTCTC TCTCTCCCTC 60

AAGAAAGAGA AGGACCCTGC TGGGATCTTT GAGCTGGTGG AAGTGGTCGG CAATGGAACC 120

TACGGACAGG TGTACAAGGG TCGGCATGTC AAGACCGGGC AGCTGGCTGC CATCAAGGTC 180

ATGGACGTCA CGGAGGACGA GGAGGAAGAG ATCAAACAGG AGATCAATAT GCTGAAAAAA 240

TACTCTCACC ACCGCAACAT CGCCACCTAC TATGGGGCCT TCATCAAGAA GAGCCCCCCT 300

GGAAACGACG ACCAGCTCTG GCTGGTGATG GAGTTCTGTG GTGCTGGCTC CGTGACTGAC 360

CTGGTGAAGA ACACCAAGGG GAACGCCCTG AAGGAGGACT GCATCGCCTA CATCTGCCGG 420

GAGATTCTCA GGGGTCTGGC GCATCTCCAC GCACACAAGG TGATTCATCG AGACATCAAG 480

GGGCAGAACG TGCTGCTGAC CGAGAACGCT GAGGTTAAGC TAGTGGATTT TGGGGTGAGC 540

GCTCAGCTGG ATCGCACCGT GGGCAGGCGG AACACTTTCA TTGGGACCCC GTACTGGATG 600

GCCCCAGAGG TCATTGCCTG TGATGAGAAC CCCGATGCCA CCTACGATTA CAGGAGTGAC 660

ATCTGGTCTC TAGGAATCAC AGCCATCGAG ATGGCGGAGG GAGCCCCCCC TCTGTGCGAC 720

ATGCACCCCA TGCGAGCCCT CTTCCTCATC CCTCGGAACC CCCCGCCCCG GCTCAAGTCC 780

AAGAAGTGGT CGAAGAAGTT CATCGATTTC ATCGACACCT GTCTCATCAA GACTTACCTG 840

AGCCGCCCAC CCACGGAGCA GCTACTCAAG TTTCCCTTCA TCCGTGACCA GCCCACAGAG 900

CGGCAGGTCC GCATCCAGCT CAAGGACCAC ATCGACCGTT CCCGGAAGAA GCGGGGTGAG 960

AAAGAGGAGA CCGAGTACGA GTACAGCGGC AGTGAGGAGG AAGACGACAG CCACGGAGAG 1020

GAAGGAGAGC CAAGCTCCAT CATGAACGTG CCCGGGGAGT CCACGCTGCG CCGGGAGTTC 1080

CTGCGGCTCC AGCAGGAGAA CAAGAGCAAC TCGGAGGCGC TGCGCGACCC CGAGGCGCAC 1140

ATCAAGCACC TGCTGCACCA GCGGCAGCGG CGCATCGAGG AGCAGAAGGA GGAGCGGCGG 1200

CGCGTGGAGG AGCAAAAAAA GAACTTGCGA GAAAGCCTGC TCCAAAAGAG CCGTGTGCAG 1260

TTCTGTCAGC TCCGTAGCGT TCAGGCGGCA CAGCAACAGG AAATCACAGC TAGCCAGACG 1320

CTTCCCGGAG GAGGCAGCCC ACCGCAGAGG CGCGGGTCCC TGGGAGTGCA AGGGCTCCTC 1380

GGAGCGCCTG CCCCACTGTT GTTTGAGAGC TCTTTGGTCA GAAACCTTGT GAAAGCCGAG 1440

CGGGAGCAGA TCCTGCCCGG GGACAGGAAG CCCCTCTACC ACTATGGCCG GGGCGTCAAC 1500

CCTGCCGACA AACCAGCCTG GGCCCGAGAG GTGGAAGAGA GAACCAGGAT GAACAAGCAG 1560

CAGAACTCTC CCTTGGCCAA GACCAAGCCG AGCAGCACGG GACCTGAGCC CCCTGCCCCC 1620

CAGGCCTCCC CCAGCCCCCC AGGACCCCTG TCCCAAACTC CTCCTATGCA GAGGCCGGTG 1680

GAGCCCCAGG AGGGACCGCA CAAGAGCCTG GTGGCACACC GGGTCCCACT GAAGCCATAT 1740

GCAGCACCTG TACCCCGATC CCAGTCCCTG CAGGACCAGC CCACCCGAAA CCTGGCTGCC 1800

TTCCCAGCCT CCCACGACCC AGACCCTGCC GTCGCCGCAC CTGCTGCCAC GCCCAGTGCC 1860

CGCGGAGCTG TCATCCGCCA GAATTCAGAC CCCACCTCTG AAGGGCCTGG GCCCAGCCCC 1920

AACCCCCCAG CCTGGGTCCG GCCAGACAAT GAGGCCCCGC CCAAGGTGCC TCAGAGGACC 1980

TCGTCCATCG CCACTGCCCT TAACACCAGT GGGGCCGCAG GGTCCCGGCC AGCGCAGGCT 2040

GTCCGTGCCA GACCTCGCAG CAACTCCGCC TGGCAGATCT ACCTGCAAAG GCGGGCAGAG 2100

CGGGGCGCCC CCAAGCCTCC AGGGCCCCCT GCTCAGCCCC CTGGCCCGCC CAACGCCTCT 2160

AGTAACCCTG ACCTCAGGAG GAGCGATCCT GGCTGGGAGC GCTCGGACAG CGTCCTCCCG 2220

GCTTCTCATG GGCACCTCCC GCAGGCTGGC TCGCTGGAGC GAAACCGAGT GGGAGCTACC 2280

ACCAAACTGG ACAGCTCCCC AGTGCTGTCC CCCGGGAACA AAGCCAAGCC CGATGACCAC 2340

CGCTCTCGGC CAGGCCGGCC CGCAGATTTT GTGCTGCTGA AAGAGCGGAC CCTGGACGAG 2400

GCCCCGCGGC CGCCCAAAAA AGCCATGGAC TACTCCTCGT CCAGCGAGGA GGTGGAGAGC 2460

AGCGAGGACG ACGACGAGGA GGGCGACGGC GAGCCTGCGG AGGGCAGCAG AGACACCCCC 2520

GGGGGCCGCA GCGACGGAGA CACAGACAGC GTCAGCACCA TGGTGGTCCT CGACGTGGAG 2580

GAGACGGCCG GGACCCAGCC CCCCTACGGG GGCGGCACGA TGCTGGTGCA GCGCACCCCG 2640

GAGGAGAAGC GAAGCCTGCT GCACTCAGAC AGCACTCGCC CACCGGAGAA CAGCAAAGGC 2700

CAGAGCCCCC CCTCAAAGGA TGGAAGCAGT GACTACCAGT CCCGTGGCCT GGTCAAGGCC 2760

CCCGGCAAGA GCTCCTTCAC CATGTTTGTG GATCTAGGGC TCTACCAGCC CGGAGGCAGT 2820

GGGGACACCA TCCCCATCAC AGCCCTGGTG GGTGGAGAGG GCGCTCGGCT GGATCAGCTG 2880

CAGTACGACG TGAGGAAGGG CTCCGTGGTC AACGTGAATC CCACCAACAC CCGCGCCCAC 2940

AGCGAGACCC CCGAGATCCG CAAGTACAAG AAGCGTTTCA ACTCGGAGAT CCTCTGTGCC 3000

GCCCTCTGGG GTGGGCCTGG TAAAAAGGTG GGCACGGAGA ATGGGCTCAA GGCAGAGCGA 3060

AAATTGACGG GCAAGGTGTC CGCCCTCTTA GGGCGGCGCC GCTTCCAGCA GATGGACGTG 3120

CTGGAGGGGC TCAACCTGCT CATCCCCATC TCAGGGAAGA GGAACAAACT GCGGGTGTAT 3180

TACCTGTCCT GGCTCCGGAA CAAGATTCTG CACAATGACC CGGAAGTGGA GAAGAAGCAG 3240

GGCTGGACCA CTGTGGGGGA CATGGAGGGC TGTGGCCACT ACCGCGTGGT GAAGTACGAG 3300

CGCATCAAGT TCCTGGTCAT TGCCCTGAAG AGCTCCGTGG AGGTGTATGC CTGGGCCCCC 3360

AAGCCCTACC ACAAATTCAT GGCCTTCAAG TCCTTTGCCG ACCTCCCGCA CCGCCCTCTG 3420

CTGGTCGACC TCACGGTGGA GGAGGGGCAG CGGCTCAAGG TCATCTACGG CTCCAGCGCC 3480

GGCTTCCACG CTGTGGATGT GGACTCGGGG AACAGCTACG ACATCTACAT CCCCGTGCAC 3540

ATTCAGAGCC AGATCACACC CCACGCCATC ATCTTCCTCC CCAACACCGA CGGCATGGAG 3600

ATGCTGCTGT GCTACGAGGA CGAGGGTGTC TACGTCAACA CGTACGGGCG GATCATCAAG 3660

GACGTGGTGC TGCAGTGGGG CGAGATGCCC ACCTCTGTGG CCTACATCTG CTCCAACCAG 3720

ATCATGGGCT GGGGTGAGAA AGCCATCGAG ATCCGCTCCG TGGAGACGGG CCACCTGGAC 3780

GGGGTCTTCA TGCACAAACG AGCCCAGAGG CTCAAGTTCC TGTGTGAGCG GAACGACAAG 3840

GTGGTGTTTT TTGCCTCCGT CCGCTCTGGG GGCAGCAGCC AGGTTTACTT CATGACTCTG 3900

AACCGGAACT GCATCATGAA CTGGTGA 3927

Domain Profile

S: 1     yelleeigkGalgkvylarekktgelvaikkinlekqekleelqkeisvlkklkh.pniv  59

         +el+e++g+G++g+vy++r++ktg+l+aik++++++ +++ee+++ei++lkk++h +ni

Q: 30    FELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE-DEEEEIKQEINMLKKYSHhRNIA  88

         899********************************8.999*************998****

S: 60    eylesflk......eeelwlvmeylagGslsdlvkeelkselkEeqiayilrevlkaLey  113

         +y+++f+k      +++lwlvme++ +Gs++dlvk+++ + lkE+ iayi+re+l++L++

Q: 89    TYYGAFIKksppgnDDQLWLVMEFCGAGSVTDLVKNTKGNALKEDCIAYICREILRGLAH  148

         *************99*********************************************

S: 114   lHskkviHrdikakniLlteegeVkLsdfgvaaqlektrkkrktvvgtpywmAPEviaqe  173

         lH++kviHrdik++n+Llte++eVkL+dfgv+aql++t+ +r+t++gtpywmAPEvia++

Q: 149   LHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACD  208

         ************************************************************

S: 174   ...ekgYdekaDiwslGItaielaegepPfkdleplkallkilkneppklkskkkfskef  230

            + +Yd+++DiwslGItaie+aeg+pP++d++p++al++i++n+pp+lksk k+sk+f

Q: 209   enpDATYDYRSDIWSLGITAIEMAEGAPPLCDMHPMRALFLIPRNPPPRLKSK-KWSKKF  267

         999999********************************************888.******

S: 231   kefvekclqknpekRpsasellkhkFl  257

          +f+++cl k + +Rp +++llk +F+

Q: 268   IDFIDTCLIKTYLSRPPTEQLLKFPFI  294

         *************************97

Domain Sequence
(FASTA)

FELVEVVGNG TYGQVYKGRH VKTGQLAAIK VMDVTEDEEE EIKQEINMLK KYSHHRNIAT 60

YYGAFIKKSP PGNDDQLWLV MEFCGAGSVT DLVKNTKGNA LKEDCIAYIC REILRGLAHL 120

HAHKVIHRDI KGQNVLLTEN AEVKLVDFGV SAQLDRTVGR RNTFIGTPYW MAPEVIACDE 180

NPDATYDYRS DIWSLGITAI EMAEGAPPLC DMHPMRALFL IPRNPPPRLK SKKWSKKFID 240

FIDTCLIKTY LSRPPTEQLL KFPFI 265

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Equus caballus"; ?>Felis catus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>

Gene Ontology

GO:0005794	; C:Golgi apparatus
GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0005083	; F:small GTPase regulator activity
GO:0031532	; P:actin cytoskeleton reorganization
GO:0045060	; P:negative thymic T cell selection
GO:0046330	; P:positive regulation of JNK cascade
GO:0046777	; P:protein autophosphorylation
GO:0030334	; P:regulation of cell migration
GO:0022407	; P:regulation of cell-cell adhesion
GO:0001952	; P:regulation of cell-matrix adhesion

KEGG

InterPros

IPR001180	; Citron.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00780	; CNH; 1.
PF00069	; Pkinase; 1.

SMARTs

SM00036	; CNH; 1.
SM00220	; S_TKc; 1.

Prosites

PS50219	; CNH; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013