EKS-ORC-00413

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ORC-00413

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
AGC/DMPK	494.7	7.4E-149	66	332	267

Status

Unreviewed

Ensembl Protein

ENSOCUP00000008907

UniProt Accession

G1SZ34;

Protein Name

Protein Synonyms/Alias

Gene Name

CDC42BPB

Gene Synonyms/Alias

CDC42BPB;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSOCUG00000010323	ENSOCUP00000008907	ENSOCUT00000010340
ENSOCUG00000010323	ENSOCUP00000022096	ENSOCUT00000025563

Organism

Oryctolagus cuniculus

Functional Description

Protein Length

1503

Protein Sequence
(FASTA)

EQLLLDGPWR NESALSVETL LDVLVCLYTE CSHSALRRDK YVAEFLEWAK PFTQLVKEMQ 60

LHREDFEIIK VIGRGAFGEV AVVKMKNTER IYAMKILNKW EMLKRAETAC FREERDVLVN 120

GDCQWITTLH YAFQDENYLY LVMDYYVGGD LLTLLSKFED KLPEDMARFY IGEMVLAIDS 180

IHQLHYVHRD IKPDNVLLDV NGHIRLADFG SCLKMSDDGT VQSSVAVGTP DYISPEILQA 240

MEDGMGAYGP ECDWWSLGVC MYEMLYGETP FYAESLVETY GKIMNHEERF QFPSHVTDVS 300

EEAKDLIQRL ICSRERRLGQ NGIEDFKKHA FFEGLNWENI RNLEAPYIPD VSSPSDTSNF 360

DVDDDVLRNT EILPPGSHTG FSGLHLPFIG FTFTTESCFS DRGCLKSTMQ THTLTEDEDV 420

QRDLENSLQV EAYERRIRRL AQEKLELSRK LQESTQTVQS LHGSTRALSS SNRDKEIKKL 480

NEEIERLRSK VADSSRLERQ LEDTVSLRQE HEDCTQRLKG LEKQCRAARQ EKEDLHKQLV 540

EASERLKSQA KELRDAHQQR KLALQEFSEL NERMAELRSQ KQKVSRQLRD REEEVEVAMQ 600

KMDSLRQEMR KSEKLRKELE AQLEDAVAEA SKERKLREHS ESFSKQVERE LEALKVKQGG 660

RGPGAALEHQ QEISKIKSEL EKKVLFYEEE LVRREASHVL EVKSVRKEAH DSESQQLALQ 720

KEVLMLKDKL EKAKRERHTE MEEAVGTVRD KYERERTMLL DENKKLTAEN EKLCSFVDKL 780

TAQNRQLEGE LQDLASKKES AAHWEAQIAE IIQWVSDEKD ARGYLQALAS KMAEELEALR 840

SSSLGSRTLD PLWKVRRSQK LDMSARLELQ SALEAEIRAK QLVQEELRKV KDANLSFESK 900

LKDSEARNRG LLEEMENLKK KMEENLRADP GLKLPDFQDA IFEYFNTAPL AHDLTFRSSS 960

ASEQEAQAAK PEASPSVAAS TEQQEDLARP PQRMPAVPLP TTPALALAGP KPKAHQFSIK 1020

SFSSPTQCSH CTSLMVGLIR QGYACEVCSF ACHVSCRDSA PQVCPIPPEQ SKRPLGVDVQ 1080

RGIGTAYKGY VKVPKPSGVK KGWQRAYAVV CDCKLFLYDL PEGKSAQPGV VASQVLDLRD 1140

EEFSVSSVLA SDVIHATRRD VPCIFRVTAS LLGTPSKTSA LLILTENENE KRKWVGILEG 1200

LQSILHKNRL RNQVVHVPQE AYDSSLPLIK AVLAAAIVDG DRIAVGLEEG LYVIEVTRDV 1260

IVRAADCKKV HQIELAPREK MVVLLCGRSH HVHLYPWSSL DGAEGSFDIK LPETKGCQLI 1320

ATATLKGSSA TCLFVAVKRL VLCYEIQRTK PFHRKFSELA APGHVQWMAV FKDRLCVGYP 1380

SGFSLLSIQG DGQALNLVNP NDPSLTFLSQ QSFDALCAVE LTSEEYLLCF SHMGLYVDPQ 1440

GRRSRMQELM WPAAPVACSC SPSHVTVYSE YGVDVFDVRT MEWVQTIGLR RIRPLNSDGS 1500

LNL 1503

Nucleotide Sequence
(FASTA)

GAGCAGCTGC TCCTGGACGG GCCGTGGCGC AACGAGAGCG CCCTGAGCGT GGAGACGCTG 60

CTCGACGTGC TCGTGTGCCT GTACACCGAG TGCAGCCACT CGGCCCTGCG GCGCGACAAG 120

TACGTGGCCG AGTTCCTCGA GTGGGCTAAA CCGTTCACAC AGCTGGTGAA AGAAATGCAG 180

CTTCATCGAG AAGACTTTGA GATAATTAAA GTGATCGGAA GAGGCGCTTT TGGTGAGGTT 240

GCTGTTGTCA AAATGAAGAA CACTGAACGA ATTTATGCCA TGAAGATCCT CAACAAGTGG 300

GAGATGCTTA AAAGAGCAGA GACCGCTTGT TTCCGAGAGG AGCGGGACGT GCTGGTGAAC 360

GGCGACTGCC AGTGGATCAC CACGCTGCAC TACGCTTTTC AGGACGAGAA CTACCTGTAC 420

TTGGTCATGG ATTACTACGT GGGGGGCGAT CTGCTGACCC TGCTCAGCAA GTTTGAGGAC 480

AAGCTTCCGG AGGACATGGC GAGGTTCTAC ATCGGTGAGA TGGTGCTGGC CATCGACTCC 540

ATCCACCAGC TCCATTACGT GCACAGGGAC ATCAAGCCTG ACAACGTACT TTTGGACGTG 600

AACGGCCACA TCCGCCTGGC CGACTTCGGG TCGTGCTTGA AGATGAGCGA CGATGGAACT 660

GTCCAGTCCT CTGTGGCCGT GGGCACACCT GACTACATCT CCCCAGAGAT CCTGCAGGCC 720

ATGGAGGACG GCATGGGCGC GTACGGGCCC GAGTGTGACT GGTGGTCCCT GGGCGTCTGC 780

ATGTACGAGA TGCTGTATGG AGAAACCCCC TTTTATGCCG AGTCGCTGGT GGAGACCTAC 840

GGCAAGATCA TGAACCATGA GGAGCGATTT CAGTTCCCCT CCCATGTCAC GGATGTCTCT 900

GAAGAAGCCA AGGACCTCAT CCAGAGGTTG ATCTGCAGCA GAGAGCGCCG GCTGGGGCAG 960

AACGGGATAG AGGACTTCAA AAAGCACGCG TTCTTTGAAG GCCTGAACTG GGAAAACATC 1020

CGGAACCTGG AAGCCCCGTA CATCCCTGAC GTGAGCAGTC CTTCTGACAC CTCCAACTTC 1080

GACGTGGATG ACGACGTGCT GAGAAACACT GAAATCCTAC CTCCCGGTTC TCACACAGGT 1140

TTTTCTGGAT TACATTTGCC ATTCATTGGT TTCACATTCA CAACAGAAAG CTGTTTCTCT 1200

GATCGAGGCT GTCTGAAGAG CACCATGCAG ACCCACACGT TAACCGAGGA CGAGGACGTG 1260

CAGCGAGACC TGGAGAACAG CCTGCAGGTC GAGGCCTACG AGAGGAGGAT CCGCAGGCTG 1320

GCGCAGGAGA AGCTGGAGCT GAGCCGGAAG CTGCAAGAGT CCACCCAGAC CGTGCAGTCT 1380

CTTCACGGCT CCACTCGGGC CCTGAGCAGT TCCAACCGAG ACAAAGAAAT CAAAAAGCTC 1440

AACGAAGAGA TTGAACGTCT GAGGAGTAAG GTAGCAGATT CGAGCAGGCT GGAGCGGCAG 1500

CTGGAGGACA CGGTCTCGCT TCGCCAGGAG CACGAGGACT GCACGCAGCG GCTGAAGGGC 1560

CTGGAGAAGC AGTGCCGCGC GGCGCGGCAG GAGAAGGAGG ACCTGCACAA GCAACTGGTG 1620

GAAGCGTCAG AGCGGCTGAA ATCCCAGGCC AAAGAACTCA GAGACGCGCA TCAGCAGCGG 1680

AAGCTGGCCC TGCAGGAGTT TTCCGAGCTC AACGAGCGCA TGGCGGAGCT CCGCTCCCAG 1740

AAGCAGAAGG TGTCCCGGCA GCTGCGGGAC CGAGAGGAGG AGGTGGAGGT GGCCATGCAG 1800

AAGATGGACT CGCTGCGGCA GGAGATGCGC AAGTCCGAGA AGCTCAGGAA AGAGCTGGAG 1860

GCTCAGCTCG AAGACGCCGT CGCCGAGGCC TCCAAGGAAC GCAAGCTTCG TGAGCACAGC 1920

GAGAGCTTCT CCAAGCAGGT GGAGCGCGAG CTGGAGGCCC TCAAGGTGAA GCAGGGCGGC 1980

CGGGGGCCGG GGGCGGCCCT GGAACATCAG CAGGAGATCT CCAAGATCAA GTCTGAGCTG 2040

GAGAAGAAAG TCTTGTTTTA CGAAGAGGAG TTGGTCCGGC GCGAGGCCTC GCACGTGCTG 2100

GAGGTGAAGA GTGTGAGGAA GGAGGCTCAT GACTCCGAGA GCCAGCAGCT GGCCCTGCAG 2160

AAGGAGGTGC TGATGCTGAA AGACAAGCTG GAGAAGGCGA AACGCGAGCG GCACACTGAG 2220

ATGGAGGAGG CGGTGGGCAC CGTCAGAGAC AAGTACGAGC GGGAGAGAAC GATGCTGCTT 2280

GATGAAAACA AGAAGTTAAC AGCTGAGAAT GAAAAGCTTT GTTCCTTTGT GGACAAACTC 2340

ACGGCTCAAA ACAGACAGCT GGAGGGCGAG CTGCAGGACC TGGCCTCCAA GAAGGAGTCC 2400

GCCGCGCACT GGGAAGCCCA GATCGCGGAA ATCATTCAGT GGGTCAGCGA CGAGAAGGAC 2460

GCCCGGGGCT ACCTTCAGGC TCTGGCTTCT AAGATGGCGG AGGAGCTCGA GGCTCTGCGG 2520

AGCTCCAGCC TGGGGTCCAG GACACTGGAC CCGCTTTGGA AAGTCCGACG CAGTCAGAAG 2580

CTGGACATGT CTGCACGGCT GGAGTTGCAG TCTGCGCTTG AGGCAGAGAT CCGGGCCAAG 2640

CAGCTGGTGC AGGAGGAGCT GAGGAAGGTC AAAGATGCAA ATCTCTCCTT CGAGAGCAAA 2700

CTGAAGGACT CCGAAGCCAG AAACAGGGGG TTACTGGAAG AGATGGAGAA TTTGAAGAAG 2760

AAGATGGAGG AGAACTTGAG AGCAGACCCT GGGCTCAAAC TTCCAGACTT TCAGGATGCT 2820

ATTTTTGAGT ACTTCAACAC TGCACCTCTT GCACATGACC TGACGTTCAG AAGCAGCTCA 2880

GCCAGTGAGC AGGAAGCGCA GGCTGCAAAG CCGGAGGCCT CGCCCTCTGT GGCCGCCAGC 2940

ACCGAGCAGC AGGAGGACCT GGCGCGACCG CCACAGAGGA TGCCCGCTGT GCCGCTGCCC 3000

ACCACGCCGG CCCTCGCCCT GGCTGGACCA AAGCCCAAGG CCCACCAGTT CAGCATCAAG 3060

TCCTTCTCCA GCCCCACACA GTGCAGCCAC TGCACCTCCC TGATGGTCGG CCTCATTCGC 3120

CAGGGCTACG CCTGCGAGGT GTGTTCCTTT GCGTGCCACG TCTCCTGCAG AGACAGCGCC 3180

CCCCAGGTGT GCCCCATCCC TCCCGAGCAG TCCAAGAGGC CTCTTGGCGT GGACGTACAG 3240

AGGGGCATAG GAACAGCCTA CAAGGGCTAC GTCAAGGTCC CAAAGCCCAG CGGGGTGAAG 3300

AAGGGCTGGC AGCGGGCGTA CGCGGTGGTG TGCGACTGCA AGCTCTTCCT GTACGACCTG 3360

CCTGAGGGGA AGTCCGCCCA GCCCGGGGTC GTCGCCAGCC AGGTCCTGGA CCTCAGAGAC 3420

GAAGAGTTTT CTGTGAGCTC AGTCCTGGCC TCAGATGTCA TCCACGCCAC GCGCCGAGAC 3480

GTCCCGTGTA TATTCAGGGT GACGGCCTCT CTCTTAGGTA CACCTTCCAA GACCAGCGCC 3540

CTGCTCATTC TGACAGAGAA TGAGAACGAG AAGAGGAAGT GGGTGGGGAT TCTAGAAGGA 3600

CTGCAGTCCA TCCTCCACAA AAACCGGCTG AGGAACCAGG TGGTGCACGT GCCGCAGGAA 3660

GCCTACGACA GCTCGCTGCC GCTCATCAAG GCCGTGCTGG CGGCGGCCAT CGTGGATGGA 3720

GACCGGATAG CAGTTGGCCT GGAAGAGGGA CTGTACGTCA TTGAGGTCAC CCGAGACGTG 3780

ATCGTCCGCG CCGCCGACTG TAAGAAAGTG CACCAGATCG AGCTTGCTCC CCGAGAGAAG 3840

ATGGTCGTCC TCCTGTGTGG CCGCAGCCAC CACGTGCACC TCTACCCGTG GTCCTCTCTG 3900

GATGGAGCGG AAGGCAGCTT TGATATCAAG CTCCCGGAAA CCAAAGGCTG CCAGCTCATA 3960

GCCACGGCCA CCCTGAAGGG GAGCTCTGCG ACCTGCCTCT TCGTGGCCGT GAAGCGGCTG 4020

GTCCTCTGCT ATGAGATCCA GAGGACTAAG CCCTTCCACA GGAAGTTCAG TGAGCTCGCG 4080

GCCCCCGGAC ACGTGCAGTG GATGGCCGTG TTCAAGGACA GGCTGTGTGT TGGCTACCCT 4140

TCTGGGTTCT CTCTGTTGAG CATCCAGGGA GACGGGCAGG CTCTCAACCT GGTAAATCCC 4200

AATGACCCCT CGCTTACGTT CCTCTCACAA CAGTCTTTTG ATGCCCTTTG TGCTGTGGAA 4260

CTCACAAGTG AGGAGTACCT GCTTTGCTTC AGCCACATGG GACTGTACGT GGACCCACAA 4320

GGCCGGAGGT CACGCATGCA GGAGCTCATG TGGCCTGCGG CTCCTGTCGC CTGTAGTTGC 4380

AGCCCTTCCC ACGTCACGGT GTACAGCGAG TATGGCGTCG ACGTCTTTGA CGTGCGCACC 4440

ATGGAGTGGG TGCAGACCAT CGGCTTGCGG AGGATAAGAC CACTGAACTC CGACGGCTCC 4500

CTCAACCTC 4509

Domain Profile

S: 1     feilkviGrGafgevavvrekatekvyamkilkklellkraesaffreerdvlvkadsew  60

         fei+kviGrGafgevavv++k+te++yamkil+k+e+lkrae+a+freerdvlv++d++w

Q: 66    FEIIKVIGRGAFGEVAVVKMKNTERIYAMKILNKWEMLKRAETACFREERDVLVNGDCQW  125

         89**********************************************************

S: 61    ivqlqyafqdekylylvmeylvGGdlltllskyedklpeelarfylaelvlaldsvhelg  120

         i++l+yafqde+ylylvm+y+vGGdlltllsk+edklpe++arfy+ e+vla+ds+h+l+

Q: 126   ITTLHYAFQDENYLYLVMDYYVGGDLLTLLSKFEDKLPEDMARFYIGEMVLAIDSIHQLH  185

         ************************************************************

S: 121   yvhrdikpdnilldksGhikladfGsclklnedgtvkssvavGtpdyispevlkaleegk  180

         yvhrdikpdn+lld++Ghi+ladfGsclk+++dgtv+ssvavGtpdyispe+l+a+e+g+

Q: 186   YVHRDIKPDNVLLDVNGHIRLADFGSCLKMSDDGTVQSSVAVGTPDYISPEILQAMEDGM  245

         ************************************************************

S: 181   geygkecdwwslGvilyellvgetpfyaeslvetyskilnhkeslkfpede.kvseeakd  239

         g yg+ecdwwslGv++ye+l+getpfyaeslvety+ki+nh+e+++fp+++ +vseeakd

Q: 246   GAYGPECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMNHEERFQFPSHVtDVSEEAKD  305

         **************************************************99********

S: 240   likklltsreerlgregiedlkkhpff  266

         li++l++sre+rlg++gied+kkh+ff

Q: 306   LIQRLICSRERRLGQNGIEDFKKHAFF  332

         **************************9

Domain Sequence
(FASTA)

FEIIKVIGRG AFGEVAVVKM KNTERIYAMK ILNKWEMLKR AETACFREER DVLVNGDCQW 60

ITTLHYAFQD ENYLYLVMDY YVGGDLLTLL SKFEDKLPED MARFYIGEMV LAIDSIHQLH 120

YVHRDIKPDN VLLDVNGHIR LADFGSCLKM SDDGTVQSSV AVGTPDYISP EILQAMEDGM 180

GAYGPECDWW SLGVCMYEML YGETPFYAES LVETYGKIMN HEERFQFPSH VTDVSEEAKD 240

LIQRLICSRE RRLGQNGIED FKKHAFF 267

Keyword

ATP-binding; Complete proteome; Kinase; Metal-binding; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase; Zinc; Zinc-finger.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0042641	; C:actomyosin
GO:0005524	; F:ATP binding
GO:0046872	; F:metal ion binding
GO:0005543	; F:phospholipid binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0005083	; F:small GTPase regulator activity
GO:0031532	; P:actin cytoskeleton reorganization
GO:0031032	; P:actomyosin structure organization
GO:0016477	; P:cell migration
GO:0035556	; P:intracellular signal transduction

KEGG

InterPros

IPR000961	; AGC-kinase_C.
IPR001180	; Citron.
IPR020454	; DAG/PE-bd.
IPR011009	; Kinase-like_dom.
IPR014930	; Myotonic_dystrophy_kinase_coil.
IPR011993	; PH_like_dom.
IPR017892	; Pkinase_C.
IPR001849	; Pleckstrin_homology.
IPR002219	; Prot_Kinase_C-like_PE/DAG-bd.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.
IPR026611	; Ser/Thr_kinase_MRCK.

Pfam

PF00130	; C1_1; 1.
PF00780	; CNH; 1.
PF08826	; DMPK_coil; 1.
PF00069	; Pkinase; 1.
PF00433	; Pkinase_C; 1.

SMARTs

SM00109	; C1; 1.
SM00036	; CNH; 1.
SM00233	; PH; 1.
SM00133	; S_TK_X; 1.
SM00220	; S_TKc; 1.

Prosites

PS51285	; AGC_KINASE_CTER; 1.
PS50219	; CNH; 1.
PS50003	; PH_DOMAIN; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.
PS00479	; ZF_DAG_PE_1; 1.
PS50081	; ZF_DAG_PE_2; 1.

Prints

PR00008

; DAGPEDOMAIN.

Created Date

20-Feb-2013