EKS-ORC-00280
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-ORC-00280
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/EGFR497.01.2E-149712969258
StatusUnreviewed
Ensembl ProteinENSOCUP00000009041
UniProt AccessionG1SZE4;
Protein Name
Protein Synonyms/Alias
Gene NameEGFR
Gene Synonyms/Alias EGFR;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSOCUG00000010481ENSOCUP00000009041ENSOCUT00000010492
OrganismOryctolagus cuniculus
Functional Description
Protein Length1210
Protein Sequence
(FASTA)
MRPSGPVGPA LLALLAALLQ AGQALEEKRV CQGTSNKLTQ LGPFEDHFLS LQRMFNSCEV 60
VLGNLEITYV QRNHDLSFLK TIQEVAGYVL IALNTVESIP LESLQIIRGN VLYENTYALA 120
VLSNYGANKT GLRELPMRNL QEILHGAVRF SNNPVLCNVE TIQWRDIVHG DFLSNMSLDM 180
QNPLGSCQKC DPSCPNGSCW GAGGENCQRL TKIICAQQCS GRCRGKSPSD CCHNQCAAGC 240
TGPRESDCLV CRKFRDEATC KDTCPPLMLY NPTTYQMDVN PEGKYSFGAT CVKKCPRNYV 300
VTDHGSCVRA CGPDSYEVEE DGVRKCKKCE GPCRKVCNGI GIGEFKDTLS INATNIKHFK 360
NCTSISGDLH ILPVAFRGDS FTRTPPLDPE ELDILKTVRE ITGFLLIQAW PENKTDLHAF 420
ENLEIIRGRT KQHGQFSLAV VGLDITSLGL RSLQEISDGD VIVSGNRDLC YANTINWKKL 480
FGTSSQKTKI INNRGDKDCK AAGHVCDPLC SSEGCWGPEP RDCVSCRNVS RGKECVERCN 540
VLEGEPREFV ENSECIQCHP ECLPQAMNIT CTGRGPDNCI KCAHFIDGPH CVKTCPAGVM 600
GENDTLVWKF ADAGRICRLC HPNCTYGCAG PGLEGCATNG PKIPSIATGV VGGLFLLVVL 660
GLGIGLFMRR RHIVRKRTLR RLLQERELVE PLTPSGEAPN QALLRILKET EFKKLKVLGS 720
GAFGTVYKGL WIPEGEKVKI PVAIKELREA TSPKANKEIL DEAYVMASVD NPHVCRLLGI 780
CLTSTVQLVT QLMPFGCLLD YVREHKDNIG SQHLLNWCVQ IAKGMNYLED RRLVHRDLAA 840
RNVLVKTPQH VKITDFGLAK LLGAEEKEYH AEGGKVPIKW MALESILHRI YTHQSDVWSY 900
GVTVWELMTF GSKPYDGIPA SEIASVLEKG ERLPQPPICT IDVYMIMVKC WMIDADSRPK 960
FRELIVEFSK MARDPQRYLV IQGDERMHLP SPTDSNFYRA LMDEEDMGDV IDADEYLIPQ 1020
QGFFNSPSTS RTPLLSSLSA TSNSSTMACV DRNGVCSCPV KEDSLLQRYS SDPTGGVTED 1080
SMDDTFLPVP EYINQYIPKR PAGSVQNPVY HNQPLHPAPG RDPHYQDPHS SAVGNPEYLN 1140
TTQPPCPNGI FDSPTPWAQK GSHQMSLDNP DYQQDFFPKD GKLNGIFKGP TAENAEYLRV 1200
APPGREFTTA 1210
Nucleotide Sequence
(FASTA)
ATGCGACCCT CGGGGCCGGT CGGGCCCGCG CTCCTGGCGC TGCTGGCCGC GCTCCTGCAG 60
GCGGGACAGG CGCTGGAGGA GAAGAGAGTT TGCCAGGGCA CAAGCAACAA GCTGACCCAG 120
CTGGGCCCTT TTGAGGACCA CTTCCTGAGC CTGCAGAGGA TGTTCAACAG CTGTGAGGTG 180
GTGCTGGGGA ACCTGGAGAT CACCTACGTG CAGAGGAACC ACGACCTCTC CTTCTTAAAG 240
ACCATCCAGG AGGTGGCTGG CTACGTGCTC ATTGCCCTCA ACACCGTGGA GAGCATCCCT 300
TTGGAGAGCC TGCAAATCAT CCGAGGAAAC GTGCTGTATG AGAACACCTA CGCCTTAGCC 360
GTTCTGTCCA ACTACGGAGC CAACAAGACC GGGCTGAGGG AGCTGCCCAT GCGGAACTTG 420
CAGGAAATCC TTCATGGAGC TGTGCGATTC AGCAACAACC CTGTCCTGTG CAATGTGGAG 480
ACCATCCAGT GGCGGGACAT TGTTCACGGT GACTTTCTGA GCAACATGTC TCTGGACATG 540
CAGAACCCCC TGGGCAGCTG CCAGAAGTGT GACCCAAGCT GTCCCAATGG AAGCTGCTGG 600
GGCGCAGGCG GCGAGAACTG CCAGAGACTG ACCAAAATCA TCTGCGCCCA GCAGTGCTCT 660
GGACGCTGCC GCGGCAAGTC CCCCAGCGAC TGCTGCCACA ACCAGTGTGC TGCTGGCTGC 720
ACAGGCCCAC GGGAGAGCGA CTGCTTGGTC TGCCGTAAAT TCAGAGACGA AGCCACATGC 780
AAGGACACCT GCCCACCTCT CATGCTGTAC AACCCCACCA CATATCAGAT GGATGTCAAC 840
CCCGAGGGAA AATACAGCTT TGGTGCCACC TGTGTCAAGA AATGTCCCCG TAACTACGTG 900
GTGACAGATC ATGGCTCCTG TGTCCGGGCC TGTGGTCCTG ACAGCTACGA GGTGGAGGAA 960
GATGGCGTCC GCAAGTGTAA GAAGTGCGAG GGGCCTTGTC GCAAAGTTTG TAATGGGATA 1020
GGAATTGGTG AATTTAAAGA CACGTTGTCC ATAAATGCCA CAAACATCAA ACACTTCAAA 1080
AACTGCACGT CCATCAGTGG TGATCTGCAC ATCCTGCCGG TGGCATTCAG GGGGGATTCC 1140
TTCACCCGCA CCCCGCCCCT GGACCCCGAG GAGCTGGACA TCCTGAAAAC CGTGCGGGAG 1200
ATCACAGGGT TTCTACTGAT TCAGGCGTGG CCAGAAAACA AGACTGACCT CCATGCCTTT 1260
GAGAACCTAG AAATCATCCG TGGCAGGACA AAGCAGCATG GTCAGTTTTC TCTTGCGGTT 1320
GTCGGCCTGG ACATAACATC CCTGGGACTG CGCTCCCTCC AAGAGATTAG CGATGGAGAC 1380
GTGATCGTTT CAGGAAACCG AGACCTGTGC TATGCAAACA CAATAAACTG GAAAAAGCTT 1440
TTTGGAACCT CCAGCCAGAA AACCAAAATT ATCAACAACC GGGGAGACAA GGACTGCAAG 1500
GCCGCTGGCC ACGTCTGTGA CCCGCTGTGC TCATCGGAGG GCTGCTGGGG CCCCGAGCCC 1560
AGGGACTGTG TCTCCTGCCG GAATGTCAGC CGTGGCAAGG AGTGTGTGGA GAGGTGCAAC 1620
GTTCTGGAGG GTGAGCCCAG GGAGTTTGTG GAGAACTCTG AGTGCATTCA GTGCCATCCG 1680
GAATGTCTGC CCCAGGCCAT GAACATCACC TGCACAGGAC GGGGTCCAGA TAACTGCATC 1740
AAGTGTGCAC ACTTCATCGA TGGCCCTCAC TGCGTCAAGA CCTGCCCAGC AGGAGTCATG 1800
GGGGAAAACG ACACCCTGGT CTGGAAGTTT GCCGACGCTG GACGCATCTG CCGCCTGTGC 1860
CACCCAAACT GCACCTATGG CTGTGCTGGG CCAGGTCTCG AAGGCTGTGC AACAAATGGG 1920
CCCAAAATCC CCTCCATCGC CACGGGGGTC GTGGGCGGCC TCTTCCTGCT GGTGGTGCTG 1980
GGCCTCGGCA TCGGCCTCTT CATGCGCAGG CGCCACATTG TCCGGAAGCG CACATTGCGC 2040
CGACTGCTGC AGGAGAGAGA GCTCGTGGAG CCTCTTACAC CCAGTGGGGA GGCCCCCAAC 2100
CAAGCCCTCC TGAGGATTTT AAAGGAAACA GAATTCAAGA AGCTCAAAGT CCTGGGCTCT 2160
GGAGCGTTTG GCACCGTGTA TAAGGGACTC TGGATTCCAG AAGGCGAGAA AGTTAAAATC 2220
CCTGTGGCCA TCAAGGAGTT AAGAGAAGCC ACGTCTCCAA AGGCCAACAA GGAGATCCTG 2280
GATGAGGCCT ACGTGATGGC CAGCGTGGAC AACCCCCATG TGTGTCGCCT CCTGGGCATC 2340
TGCCTGACCT CCACTGTGCA GCTCGTCACA CAGCTCATGC CCTTCGGTTG CCTGCTGGAC 2400
TACGTCCGAG AGCACAAAGA CAACATCGGC TCCCAGCACC TGCTCAACTG GTGTGTGCAG 2460
ATTGCAAAGG GCATGAACTA CCTGGAGGAC CGGCGTCTGG TGCACCGCGA CCTGGCTGCC 2520
AGGAATGTGC TGGTAAAGAC ACCGCAACAC GTCAAGATCA CAGATTTTGG GCTGGCCAAG 2580
CTGCTCGGTG CAGAGGAGAA AGAATACCAT GCAGAGGGGG GCAAGGTCCC CATCAAGTGG 2640
ATGGCTTTGG AATCGATTTT ACACCGGATT TACACCCACC AGAGTGATGT CTGGAGCTAC 2700
GGAGTCACCG TTTGGGAGTT GATGACCTTT GGGTCCAAGC CTTACGACGG AATCCCTGCC 2760
AGTGAGATCG CGTCTGTGCT GGAGAAAGGA GAACGACTTC CACAGCCCCC CATCTGCACT 2820
ATTGACGTCT ACATGATCAT GGTCAAGTGC TGGATGATAG ATGCTGACAG TCGCCCAAAG 2880
TTCCGGGAGT TGATTGTGGA ATTTTCCAAA ATGGCCCGAG ACCCTCAGCG TTACCTTGTC 2940
ATTCAGGGGG ATGAGCGGAT GCATTTGCCA AGCCCTACAG ATTCCAATTT TTACCGTGCC 3000
CTGATGGACG AAGAAGACAT GGGCGACGTC ATAGATGCTG ACGAGTACCT CATTCCTCAG 3060
CAGGGCTTCT TCAACAGCCC CTCCACATCA CGGACGCCGC TCTTAAGCTC TCTGAGTGCG 3120
ACCAGCAACA GTTCCACCAT GGCTTGTGTG GATAGGAACG GGGTATGTAG CTGTCCTGTC 3180
AAGGAAGACA GCCTCCTGCA GCGGTACAGC TCAGACCCCA CTGGTGGCGT GACTGAGGAC 3240
AGCATGGATG ACACGTTTCT CCCAGTGCCT GAATACATAA ACCAGTACAT TCCCAAGAGG 3300
CCTGCAGGCT CTGTGCAGAA CCCTGTCTAC CATAACCAGC CTCTGCACCC GGCTCCGGGC 3360
AGAGACCCCC ACTACCAGGA TCCCCACAGC AGCGCAGTGG GAAACCCTGA ATATCTCAAC 3420
ACCACCCAGC CTCCCTGTCC CAATGGCATC TTTGACAGCC CCACCCCCTG GGCCCAGAAG 3480
GGCAGCCACC AAATGAGCCT GGACAACCCC GATTACCAGC AAGACTTTTT TCCCAAGGAT 3540
GGCAAGCTGA ATGGCATCTT CAAGGGTCCT ACGGCTGAAA ACGCAGAATA CCTAAGGGTA 3600
GCACCACCAG GCCGTGAATT TACCACAGCG 3630
Domain Profile
S: 1     lkklkvlGsGafGtvykGiwipegenvkipvaikvleektgkkankelldealvlasldh  60
         +kklkvlGsGafGtvykG+wipege+vkipvaik+l+e+t++kanke+ldea+v+as+d+
Q: 712   FKKLKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDN  771
         599*********************************************************
S: 61    anlvrllglclsstlqlvtqllplGclldyvrehkdklGsqellnwcvqiakGmsyleek  120
         ++++rllg+cl+st+qlvtql+p+Gclldyvrehkd++Gsq+llnwcvqiakGm+yle++
Q: 772   PHVCRLLGICLTSTVQLVTQLMPFGCLLDYVREHKDNIGSQHLLNWCVQIAKGMNYLEDR  831
         ************************************************************
S: 121   rlvhrdlaarnvlvkspnhvkitdfGlaklleadekelkaeggkvpikwlalesilkrky  180
         rlvhrdlaarnvlvk+p+hvkitdfGlakll a+eke++aeggkvpikw+alesil+r+y
Q: 832   RLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIY  891
         ************************************************************
S: 181   thqsdvwsyGvtvwelltfGakpydgipakeipdllekGerlaqppictidvymvlvkcw  240
         thqsdvwsyGvtvwel+tfG+kpydgipa+ei ++lekGerl+qppictidvym++vkcw
Q: 892   THQSDVWSYGVTVWELMTFGSKPYDGIPASEIASVLEKGERLPQPPICTIDVYMIMVKCW  951
         ************************************************************
S: 241   midaesrpkfkelaeefs  258
         mida+srpkf+el+ efs
Q: 952   MIDADSRPKFRELIVEFS  969
         ****************96
Domain Sequence
(FASTA)
FKKLKVLGSG AFGTVYKGLW IPEGEKVKIP VAIKELREAT SPKANKEILD EAYVMASVDN 60
PHVCRLLGIC LTSTVQLVTQ LMPFGCLLDY VREHKDNIGS QHLLNWCVQI AKGMNYLEDR 120
RLVHRDLAAR NVLVKTPQHV KITDFGLAKL LGAEEKEYHA EGGKVPIKWM ALESILHRIY 180
THQSDVWSYG VTVWELMTFG SKPYDGIPAS EIASVLEKGE RLPQPPICTI DVYMIMVKCW 240
MIDADSRPKF RELIVEFS 258
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Phosphoprotein; Reference proteome; Transferase; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona savignyi"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-ANC-00290
EKS-BOT-00297
EKS-CAJ-00304
EKS-CAF-00304
EKS-CAP-00333
EKS-CIS-00072
EKS-DRM-00152
EKS-EQC-00289
EKS-FEC-00283
EKS-GAG-00251
EKS-GAA-00368
EKS-GOG-00295
EKS-HOS-00304
EKS-ICT-00280
EKS-LOA-00308
EKS-MAM-00301
EKS-MEG-00239
EKS-MOD-00292
EKS-MUM-00329
EKS-MUP-00295
EKS-NOL-00274
EKS-ORN-00386
EKS-ORA-00262
EKS-ORL-00359
EKS-OTG-00304
EKS-PAT-00283
EKS-PES-00265
EKS-POA-00289
EKS-RAN-00314
EKS-SAH-00279
EKS-TAG-00314
EKS-TAR-00390
EKS-TEN-00385
EKS-XET-00371
EKS-XIM-00378
Gene Ontology
GO:0016323; C:basolateral plasma membrane
GO:0030139; C:endocytic vesicle
GO:0005768; C:endosome
GO:0016021; C:integral to membrane
GO:0045121; C:membrane raft
GO:0048471; C:perinuclear region of cytoplasm
GO:0005524; F:ATP binding
GO:0005006; F:epidermal growth factor-activated receptor activity
GO:0030235; F:nitric-oxide synthase regulator activity
GO:0004716; F:receptor signaling protein tyrosine kinase activity
GO:0000902; P:cell morphogenesis
GO:0008283; P:cell proliferation
GO:0016337; P:cell-cell adhesion
GO:0021795; P:cerebral cortex cell migration
GO:0048546; P:digestive tract morphogenesis
GO:0001892; P:embryonic placenta development
GO:0001942; P:hair follicle development
GO:0060571; P:morphogenesis of an epithelial fold
GO:0043066; P:negative regulation of apoptotic process
GO:0042177; P:negative regulation of protein catabolic process
GO:0035413; P:positive regulation of catenin import into nucleus
GO:0030335; P:positive regulation of cell migration
GO:0031659; P:positive regulation of cyclin-dependent protein kinase activity involved in G1/S
GO:0045739; P:positive regulation of DNA repair
GO:0045740; P:positive regulation of DNA replication
GO:0050679; P:positive regulation of epithelial cell proliferation
GO:0048146; P:positive regulation of fibroblast proliferation
GO:0043406; P:positive regulation of MAP kinase activity
GO:0045429; P:positive regulation of nitric oxide biosynthetic process
GO:0051897; P:positive regulation of protein kinase B signaling cascade
GO:0046777; P:protein autophosphorylation
GO:0050999; P:regulation of nitric-oxide synthase activity
GO:0050730; P:regulation of peptidyl-tyrosine phosphorylation
GO:0070141; P:response to UV-A
GO:0007435; P:salivary gland morphogenesis
GO:0023014; P:signal transduction by phosphorylation
KEGG
InterPros
IPR000494; EGF_rcpt_L.
IPR006211; Furin-like_Cys-rich_dom.
IPR006212; Furin_repeat.
IPR009030; Growth_fac_rcpt.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR016245; Tyr_kinase_EGF/ERB/XmrK_rcpt.
Pfam
PF00757; Furin-like; 1.
PF07714; Pkinase_Tyr; 1.
PF01030; Recep_L_domain; 2.
SMARTs
SM00261; FU; 4.
SM00219; TyrKc; 1.
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
Prints
PR00109; TYRKINASE.
Created Date20-Feb-2013