EKS-ORC-00281
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-ORC-00281
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/EGFR496.02.5E-149723980258
StatusUnreviewed
Ensembl ProteinENSOCUP00000009117
UniProt AccessionG1SZL0;
Protein Name
Protein Synonyms/Alias
Gene NameERBB2
Gene Synonyms/Alias ERBB2;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSOCUG00000010569ENSOCUP00000024078ENSOCUT00000028863
ENSOCUG00000010569ENSOCUP00000023626ENSOCUT00000025969
ENSOCUG00000010569ENSOCUP00000009117ENSOCUT00000010577
OrganismOryctolagus cuniculus
Functional Description
Protein Length1258
Protein Sequence
(FASTA)
VSTMELAAWY RWGLLLALLP PGTAGTQVCT GTDMKLRFPA SPETHLDMLR YLYQGCQVVQ 60
GNLELTYLPA NASLSFLQDI QEVQGYVLIA HNQVRHIPLQ RLRIVRGTQL FEDNFALAVL 120
DNGDPRDNAT PAAGAPPGGL RELRLRSLTE ILKGGVLIQR NPQLCYQDTI LWQDIFHKNN 180
QLALTRINAS RARTCPPCSP ACQASGCWGE SPEDCQSLTR TICAGGCARC KGQLPTDCCH 240
EQCAAGCTGP KHSDCLACLH FNHSGICELH CPALVTYNTD TFESMPNPEG RYTFGASCVT 300
TCPYNYLSTD VGSCTLVCPL HNQEVTAEDG TQRCEKCSKP CARVCYGLGM EHLREVRAVT 360
SANIQEFAGC KKIFGSLAFL PESFEGDPAS ATAPLLPEQL RVFGTLEEIT GYLYIAAWPD 420
SLPDLSVFQN LQVIRGRVLH DGAYSLTLQG LGIRWLGLRS LRELGSGLAL IHRNPHLCFV 480
HTVPWEQLFR NPHQALLHSG NQPEDECAGK GQACYPLCAH GHCWGPGPTQ CVNCSQFLRG 540
QECVEECRVL QGLPREYVSD RHCLPCHPEC QPQNGSVTCF GSEADQCVAC AHYKDPPSCV 600
ARCPSGVKPD LSYMPVWKFP DEEGTCQPCP INCTHACVDL DDKGCPAEQR ASPVTSIIAA 660
VVGILLVVVM GSVLGIFIKR RRQKIRKYTM RRLLQETELV EPLTPSGAMP NQAQMRILKE 720
TELRKVKVLG SGAFGTVYKG IWIPDGENVK IPVAIKVLRE NTSPKANKEI LDEAYVMAGV 780
GSPYVSRLLG ICLTSTVQLV TQLMPYGCLL DHVREHRGRL GSQDLLNWCV QIAKGMSYLE 840
DVRLVHRDLA ARNVLVKSPN HVKITDFGLA RLLDIDETEY HADGGKVPIK WMALESILRR 900
RFTHQSDVWS YGVTVWELMT FGAKPYDGIP AREIPDLLEK GERLPQPPIC TIDVYMIMVK 960
CWMIDSECRP RFRELVAEFS RMARDPQRFV VIQNEDLGPA SPLDSTFYRS LLEDDDMGDL 1020
VDAEEYLVPQ QGFFCPDPAP GAGGTAHRRH RSSSTRSGGG ELPLGLEPTE EEPPRSPLAP 1080
SEGAGSDVFD GDLGMGAAKG LQSLPPHDPN PLQRYSEDPT GPLPPDTDGY VAPLTCSPQP 1140
EYVNQPEVRP QPPSPLEGPA PPARPAGATL ERPKTLSPGK NGVVKDVFAF GGAVENPEYL 1200
APRGGAAPQP HSPPAFSPAF DNLYYWDQDP AERGSPPSTF EGTPTAENPE YLGLDVPV 1258
Nucleotide Sequence
(FASTA)
GTGAGCACCA TGGAGCTGGC GGCCTGGTAC CGCTGGGGGC TCCTCCTCGC CCTTTTGCCC 60
CCCGGAACCG CGGGCACCCA AGTGTGCACC GGCACAGACA TGAAGCTGCG GTTCCCGGCC 120
AGTCCCGAGA CCCACCTGGA CATGCTTCGC TACCTCTACC AGGGCTGTCA GGTGGTGCAG 180
GGGAACCTGG AACTCACCTA CCTGCCCGCC AATGCCAGTC TCTCCTTCCT GCAGGACATC 240
CAGGAGGTAC AGGGCTACGT GCTCATCGCC CACAACCAGG TGCGGCACAT CCCGCTGCAG 300
AGGCTGCGCA TCGTGCGAGG CACCCAGCTC TTCGAGGACA ACTTCGCCCT GGCCGTGCTG 360
GACAATGGAG ACCCGCGGGA CAACGCCACG CCAGCCGCGG GGGCCCCCCC GGGAGGGCTG 420
CGGGAGCTGC GGCTTCGGAG CCTCACAGAG ATCCTGAAGG GAGGGGTCTT GATCCAGCGG 480
AACCCCCAGC TCTGCTACCA GGACACGATT CTGTGGCAGG ACATCTTCCA CAAGAACAAC 540
CAGCTGGCCC TCACGCGGAT AAATGCCAGC CGTGCCCGGA CCTGCCCACC CTGTTCTCCA 600
GCTTGTCAAG CCTCCGGCTG CTGGGGAGAA AGTCCCGAGG ACTGTCAGAG CCTGACACGC 660
ACCATTTGTG CCGGAGGCTG TGCCCGCTGC AAGGGCCAGC TGCCCACGGA CTGTTGCCAT 720
GAGCAGTGCG CCGCCGGCTG CACGGGCCCC AAGCACTCCG ACTGCCTGGC CTGCCTGCAC 780
TTCAACCACA GTGGCATCTG CGAGCTGCAC TGCCCGGCCC TGGTCACCTA CAACACGGAC 840
ACCTTTGAGT CCATGCCCAA CCCCGAGGGC CGTTACACCT TCGGCGCCAG CTGTGTGACC 900
ACCTGTCCCT ACAACTACCT GTCTACGGAC GTGGGCTCCT GCACCTTGGT CTGTCCCCTG 960
CACAACCAAG AGGTGACGGC TGAGGACGGG ACACAGCGGT GTGAGAAATG CAGCAAGCCC 1020
TGTGCACGAG TGTGCTACGG CCTGGGCATG GAGCACCTGC GGGAGGTGCG GGCGGTCACG 1080
AGTGCCAACA TCCAGGAGTT CGCCGGCTGC AAGAAGATCT TTGGGAGCCT GGCATTTCTG 1140
CCAGAGAGCT TTGAAGGGGA CCCAGCCTCT GCCACCGCCC CCCTCCTGCC TGAGCAGCTC 1200
AGAGTGTTTG GGACCCTGGA GGAGATAACA GGTTACCTGT ACATTGCGGC CTGGCCAGAC 1260
AGCCTGCCGG ATCTCAGCGT CTTCCAGAAC CTTCAAGTCA TCCGGGGACG AGTTCTGCAT 1320
GACGGCGCCT ACTCGCTGAC CCTGCAAGGC CTGGGCATCC GCTGGCTGGG GCTGCGCTCG 1380
CTGCGGGAGC TGGGCAGTGG CCTGGCCCTC ATCCACCGCA ACCCCCACCT CTGCTTCGTG 1440
CACACGGTGC CCTGGGAGCA GCTCTTCCGG AACCCGCACC AGGCGCTGCT GCACAGCGGC 1500
AATCAGCCAG AGGACGAGTG TGCGGGCAAG GGCCAGGCCT GCTACCCGCT GTGCGCCCAT 1560
GGGCACTGCT GGGGGCCGGG GCCCACCCAG TGCGTCAACT GCAGCCAGTT CCTTCGGGGC 1620
CAGGAGTGCG TGGAGGAATG CCGAGTGCTA CAGGGGCTCC CCAGGGAGTA TGTCAGTGAC 1680
AGGCACTGTC TGCCGTGTCA CCCCGAGTGT CAGCCCCAGA ATGGCTCGGT CACCTGCTTT 1740
GGATCGGAGG CCGACCAGTG TGTGGCCTGT GCCCACTACA AGGACCCTCC CTCCTGCGTG 1800
GCTCGCTGCC CCAGCGGGGT GAAACCCGAC CTGTCCTACA TGCCCGTCTG GAAGTTCCCG 1860
GATGAGGAAG GCACATGCCA GCCGTGCCCC ATCAACTGCA CCCATGCCTG CGTGGACCTG 1920
GATGACAAAG GCTGCCCCGC GGAGCAGAGA GCCAGCCCTG TCACGTCCAT CATCGCTGCT 1980
GTGGTGGGCA TTCTGCTGGT CGTGGTCATG GGGTCAGTCC TCGGGATCTT CATCAAGCGA 2040
AGGCGGCAGA AGATCCGGAA GTACACCATG CGGAGGCTGC TGCAGGAAAC GGAGCTGGTG 2100
GAGCCACTAA CACCCAGCGG AGCGATGCCC AACCAGGCTC AGATGCGGAT CCTGAAGGAG 2160
ACGGAGCTGA GGAAGGTGAA GGTGCTTGGA TCAGGAGCTT TCGGCACAGT GTACAAGGGC 2220
ATCTGGATCC CCGATGGGGA GAATGTGAAA ATCCCGGTGG CCATCAAAGT GTTGCGGGAA 2280
AACACATCCC CTAAAGCCAA CAAAGAGATC CTGGACGAAG CATACGTGAT GGCAGGGGTG 2340
GGCTCCCCCT ATGTGTCCCG CCTCCTGGGC ATCTGCTTGA CGTCCACGGT GCAGCTGGTG 2400
ACACAGCTGA TGCCCTACGG CTGCCTCCTG GACCATGTCC GTGAACACCG CGGGCGCCTG 2460
GGCTCACAGG ACTTACTGAA CTGGTGTGTG CAAATTGCCA AGGGGATGAG CTACTTGGAA 2520
GACGTGCGGC TCGTGCACAG GGACCTGGCT GCACGGAACG TGCTGGTCAA GAGCCCCAAC 2580
CACGTCAAGA TCACAGACTT CGGGCTGGCT CGGCTGCTGG ACATTGACGA GACAGAGTAC 2640
CACGCGGACG GGGGCAAGGT GCCCATCAAG TGGATGGCGT TGGAGTCCAT TCTCCGCCGG 2700
CGGTTCACCC ACCAGAGTGA TGTGTGGAGC TACGGGGTGA CTGTCTGGGA GCTGATGACT 2760
TTTGGGGCCA AACCTTACGA TGGGATCCCA GCCCGGGAAA TCCCTGACCT GCTGGAGAAG 2820
GGGGAGCGGC TGCCCCAGCC CCCCATCTGC ACCATCGATG TCTACATGAT CATGGTCAAA 2880
TGTTGGATGA TTGACTCGGA ATGCCGGCCC AGATTCCGGG AGTTGGTGGC TGAATTCTCC 2940
CGCATGGCCA GGGACCCCCA GCGCTTTGTG GTCATCCAGA ATGAGGACCT GGGCCCCGCC 3000
AGCCCGTTGG ACAGCACCTT CTACCGCTCG TTGCTGGAGG ATGATGACAT GGGGGACCTG 3060
GTGGACGCTG AGGAGTACCT GGTGCCCCAG CAGGGCTTCT TCTGCCCAGA CCCTGCTCCG 3120
GGCGCTGGGG GTACAGCCCA CCGCAGGCAC CGCAGCTCGT CCACCCGGAG TGGTGGCGGT 3180
GAGCTGCCGT TGGGGCTGGA GCCCACCGAA GAGGAGCCCC CCAGGTCTCC ACTGGCCCCC 3240
TCAGAAGGGG CTGGCTCCGA CGTATTCGAT GGCGACCTGG GGATGGGGGC AGCCAAGGGG 3300
CTGCAGAGCC TCCCGCCACA CGACCCCAAC CCTCTGCAAC GGTACAGTGA GGACCCCACA 3360
GGACCCCTGC CCCCGGACAC TGACGGCTAC GTTGCCCCCC TGACCTGCAG CCCCCAGCCC 3420
GAGTATGTGA ACCAGCCAGA GGTCCGGCCG CAGCCCCCCT CGCCCCTGGA GGGCCCTGCA 3480
CCGCCTGCCC GGCCAGCCGG GGCCACCCTG GAAAGGCCCA AGACTCTCTC CCCCGGGAAG 3540
AATGGGGTTG TCAAAGACGT TTTTGCCTTT GGGGGTGCCG TGGAGAACCC CGAGTACTTG 3600
GCACCCCGGG GAGGGGCTGC CCCTCAGCCC CACTCTCCTC CTGCCTTCAG CCCAGCCTTT 3660
GACAACCTCT ATTATTGGGA CCAGGACCCA GCAGAGCGGG GGTCCCCACC CAGCACCTTT 3720
GAAGGGACCC CTACGGCAGA GAACCCCGAG TACCTGGGCC TGGACGTGCC GGTGTGA 3777
Domain Profile
S: 1     lkklkvlGsGafGtvykGiwipegenvkipvaikvleektgkkankelldealvlasldh  60
         l+k+kvlGsGafGtvykGiwip+genvkipvaikvl+e+t++kanke+ldea+v+a + +
Q: 723   LRKVKVLGSGAFGTVYKGIWIPDGENVKIPVAIKVLRENTSPKANKEILDEAYVMAGVGS  782
         69**********************************************************
S: 61    anlvrllglclsstlqlvtqllplGclldyvrehkdklGsqellnwcvqiakGmsyleek  120
         ++++rllg+cl+st+qlvtql+p+Gclld+vreh+++lGsq+llnwcvqiakGmsyle+ 
Q: 783   PYVSRLLGICLTSTVQLVTQLMPYGCLLDHVREHRGRLGSQDLLNWCVQIAKGMSYLEDV  842
         ************************************************************
S: 121   rlvhrdlaarnvlvkspnhvkitdfGlaklleadekelkaeggkvpikwlalesilkrky  180
         rlvhrdlaarnvlvkspnhvkitdfGla+ll+ de+e++a+ggkvpikw+alesil+r++
Q: 843   RLVHRDLAARNVLVKSPNHVKITDFGLARLLDIDETEYHADGGKVPIKWMALESILRRRF  902
         ************************************************************
S: 181   thqsdvwsyGvtvwelltfGakpydgipakeipdllekGerlaqppictidvymvlvkcw  240
         thqsdvwsyGvtvwel+tfGakpydgipa+eipdllekGerl+qppictidvym++vkcw
Q: 903   THQSDVWSYGVTVWELMTFGAKPYDGIPAREIPDLLEKGERLPQPPICTIDVYMIMVKCW  962
         ************************************************************
S: 241   midaesrpkfkelaeefs  258
         mid+e+rp+f+el++efs
Q: 963   MIDSECRPRFRELVAEFS  980
         ****************96
Domain Sequence
(FASTA)
LRKVKVLGSG AFGTVYKGIW IPDGENVKIP VAIKVLRENT SPKANKEILD EAYVMAGVGS 60
PYVSRLLGIC LTSTVQLVTQ LMPYGCLLDH VREHRGRLGS QDLLNWCVQI AKGMSYLEDV 120
RLVHRDLAAR NVLVKSPNHV KITDFGLARL LDIDETEYHA DGGKVPIKWM ALESILRRRF 180
THQSDVWSYG VTVWELMTFG AKPYDGIPAR EIPDLLEKGE RLPQPPICTI DVYMIMVKCW 240
MIDSECRPRF RELVAEFS 258
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Phosphoprotein; Reference proteome; Transferase; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00280
EKS-ANC-00289
EKS-BOT-00298
EKS-CAJ-00305
EKS-CAF-00305
EKS-CAP-00334
EKS-DAR-00646
EKS-EQC-00290
EKS-FEC-00284
EKS-GAA-00370
EKS-GOG-00296
EKS-HOS-00305
EKS-ICT-00281
EKS-LAC-00310
EKS-LOA-00309
EKS-MAM-00302
EKS-MOD-00293
EKS-MUM-00330
EKS-MUP-00296
EKS-MYL-00300
EKS-NOL-00275
EKS-ORN-00389
EKS-ORL-00360
EKS-OTG-00303
EKS-PAT-00284
EKS-RAN-00315
EKS-SAH-00280
EKS-SUS-00262
EKS-TAR-00391
EKS-TEN-00386
EKS-XET-00372
EKS-XIM-00379
Gene Ontology
GO:0016324; C:apical plasma membrane
GO:0016323; C:basolateral plasma membrane
GO:0010008; C:endosome membrane
GO:0016021; C:integral to membrane
GO:0043235; C:receptor complex
GO:0005524; F:ATP binding
GO:0004716; F:receptor signaling protein tyrosine kinase activity
GO:0004714; F:transmembrane receptor protein tyrosine kinase activity
GO:0007507; P:heart development
GO:0008045; P:motor neuron axon guidance
GO:0042552; P:myelination
GO:0033088; P:negative regulation of immature T cell proliferation in thymus
GO:0007528; P:neuromuscular junction development
GO:0007422; P:peripheral nervous system development
GO:0014065; P:phosphatidylinositol 3-kinase cascade
GO:0045785; P:positive regulation of cell adhesion
GO:0030307; P:positive regulation of cell growth
GO:0050679; P:positive regulation of epithelial cell proliferation
GO:0043406; P:positive regulation of MAP kinase activity
GO:0032321; P:positive regulation of Rho GTPase activity
GO:0045943; P:positive regulation of transcription from RNA polymerase I promoter
GO:0045945; P:positive regulation of transcription from RNA polymerase III promoter
GO:0045727; P:positive regulation of translation
GO:0070372; P:regulation of ERK1 and ERK2 cascade
GO:0032886; P:regulation of microtubule-based process
GO:0023014; P:signal transduction by phosphorylation
GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway
GO:0042060; P:wound healing
KEGG
InterPros
IPR021157; Cyt_c1_TM_anchor_C.
IPR000494; EGF_rcpt_L.
IPR006211; Furin-like_Cys-rich_dom.
IPR006212; Furin_repeat.
IPR009030; Growth_fac_rcpt.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR016245; Tyr_kinase_EGF/ERB/XmrK_rcpt.
Pfam
PF00757; Furin-like; 1.
PF07714; Pkinase_Tyr; 1.
PF01030; Recep_L_domain; 2.
SMARTs
SM00261; FU; 3.
SM00219; TyrKc; 1.
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
Prints
PR00109; TYRKINASE.
Created Date20-Feb-2013