EKS-ORC-00099
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-ORC-00099
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Tec488.44.3E-147402652251
StatusUnreviewed
Ensembl ProteinENSOCUP00000009153
UniProt AccessionG1SZN9;
Protein Name
Protein Synonyms/Alias
Gene NameBTK
Gene Synonyms/Alias BTK;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSOCUG00000010621ENSOCUP00000009153ENSOCUT00000010622
OrganismOryctolagus cuniculus
Functional Description
Protein Length659
Protein Sequence
(FASTA)
MAAVILESIF LKRSQQKKKT SPLNFKKRLF LLTVQKLSYY EYDFERGRRG SKKGSIDVEK 60
ITCVETVVPE KNPPPERQIL RRGEESSETE QISIIERFPY PFQVVYDEGP LYVFSPTEEL 120
RKRWIHQLKN VIRYNSDLVQ KYHPCFWIDG QYLCCSQTAK NAMGCQILEN RNGSLKPGSS 180
HRKTKKPLPP TPEEDQILKK PLPPEPTAAP VSTSELKKVV ALYDYMPMNA NDLQLRKGDE 240
YFILEESNLP WWRARDKNGQ EGYIPSNYVT EAEDSIEMYE WYSKHMTRSQ AEQLLKQEGK 300
EGGFIVRDSS KAGKYTVSVF AKSTGDPQGV IRHYVVCSTP QSQYYLAEKH LFSTIPELIN 360
YHQHNSAGLI SRLKYPVSQQ NKNAPSTAGL GYGSWEIDPK DLTFLKELGT GQFGVVKYGK 420
WRGRYDVAIK MIREGSMSED EFIEEAKVMM NLSHEKLVQL YGVCTKQRPI FIITEYMANG 480
CLLNYLREMR HRFQTQQLLE MCKDVCEAME YLESKQFLHR DLAARNCLVN DQGVVKVSDF 540
GLSRYVLDDE YTSSVGSKFP VRWSPPEVLM YSKFSSKSDI WAFGVLMWEI YSLGKMPYER 600
FTNSETAEHI AQGLRLYRPH LASERVYTIM YSCWHEKADE RPTFKILLSN ILDVMDEES 659
Nucleotide Sequence
(FASTA)
ATGGCTGCAG TGATACTGGA GAGCATCTTT CTGAAGCGTT CCCAGCAGAA AAAGAAAACA 60
TCACCCTTAA ACTTCAAGAA GCGCCTCTTT CTCTTGACTG TGCAGAAACT TTCCTACTAT 120
GAGTATGACT TTGAACGTGG GAGAAGAGGC AGTAAGAAGG GTTCAATAGA TGTTGAGAAG 180
ATCACCTGTG TTGAAACAGT GGTGCCTGAA AAAAACCCTC CCCCTGAAAG ACAGATTCTG 240
AGAAGGGGTG AAGAGTCCAG TGAAACGGAA CAGATTTCCA TCATTGAAAG GTTCCCTTAT 300
CCCTTCCAGG TTGTGTATGA TGAAGGGCCT CTTTATGTCT TCTCCCCAAC TGAAGAACTG 360
AGGAAACGTT GGATTCACCA GCTCAAAAAT GTAATCCGGT ACAACAGTGA TCTGGTTCAG 420
AAATACCACC CTTGCTTCTG GATCGATGGG CAGTATCTCT GCTGCTCTCA GACAGCCAAA 480
AATGCTATGG GCTGCCAAAT TTTGGAGAAC AGGAATGGAA GCTTAAAACC AGGGAGTTCT 540
CACAGAAAGA CAAAAAAGCC TCTTCCTCCA ACGCCTGAGG AGGACCAGAT CTTGAAAAAG 600
CCACTGCCCC CTGAGCCAAC AGCAGCACCA GTCAGCACAA GTGAGCTGAA AAAGGTGGTA 660
GCCCTTTATG ATTACATGCC GATGAATGCC AATGACCTAC AACTGCGCAA GGGTGATGAG 720
TATTTTATCT TGGAGGAGAG CAACTTACCA TGGTGGCGAG CACGGGATAA AAACGGGCAG 780
GAAGGCTACA TTCCTAGTAA CTATGTCACC GAAGCAGAAG ACTCCATAGA AATGTATGAG 840
TGGTATTCCA AACACATGAC TCGGAGTCAA GCTGAGCAAC TGCTCAAGCA AGAGGGGAAA 900
GAAGGAGGTT TTATTGTCAG AGACTCCAGC AAAGCTGGAA AATACACCGT GTCTGTGTTT 960
GCTAAATCTA CAGGGGACCC GCAAGGAGTG ATACGCCATT ATGTTGTGTG CTCCACGCCT 1020
CAGAGCCAGT ATTACCTGGC TGAGAAGCAC CTTTTCAGCA CCATCCCCGA GCTCATTAAC 1080
TATCATCAGC ATAACTCTGC AGGACTCATA TCCAGGCTCA AATATCCAGT GTCTCAACAA 1140
AACAAGAACG CACCTTCCAC TGCAGGCCTG GGCTACGGAT CTTGGGAAAT CGATCCAAAG 1200
GACCTGACCT TCTTGAAGGA GCTGGGGACT GGACAATTTG GGGTAGTGAA GTATGGAAAG 1260
TGGAGAGGCC GATATGACGT GGCCATCAAG ATGATCAGAG AAGGCTCTAT GTCTGAGGAT 1320
GAGTTCATTG AAGAAGCCAA AGTTATGATG AACCTTTCCC ATGAGAAGCT GGTGCAGTTG 1380
TATGGCGTGT GCACCAAGCA GCGCCCCATC TTCATCATCA CTGAGTACAT GGCCAATGGC 1440
TGCCTCCTGA ACTACCTGAG AGAGATGCGC CATCGCTTCC AGACTCAGCA GCTGTTGGAG 1500
ATGTGCAAGG ATGTCTGCGA AGCCATGGAA TACCTGGAGT CAAAGCAGTT CCTTCACCGA 1560
GACCTGGCAG CTCGAAACTG TTTAGTAAAC GATCAAGGAG TGGTGAAAGT GTCTGACTTC 1620
GGCCTGTCCA GGTACGTCCT GGATGATGAA TACACAAGCT CAGTAGGCTC TAAGTTTCCA 1680
GTCCGGTGGT CTCCACCAGA AGTCCTCATG TATAGCAAGT TCAGCAGCAA ATCTGACATT 1740
TGGGCTTTTG GGGTTTTGAT GTGGGAAATC TACTCCCTGG GGAAGATGCC CTATGAAAGA 1800
TTTACTAACA GTGAGACCGC TGAACACATC GCCCAAGGCC TGCGTCTCTA CAGGCCTCAC 1860
CTGGCTTCAG AGAGGGTGTA CACCATTATG TACAGCTGCT GGCATGAGAA AGCAGATGAA 1920
CGTCCCACTT TCAAAATTCT CCTGAGCAAC ATTCTAGACG TCATGGATGA AGAATCCTGA 1980
Domain Profile
S: 1     ltllkelgsgqfgvvklgkwrakidvaikaikegamseedfieeakvmmklshpklvqly  60
         lt+lkelg+gqfgvvk+gkwr+++dvaik+i+eg+mse++fieeakvmm+lsh+klvqly
Q: 402   LTFLKELGTGQFGVVKYGKWRGRYDVAIKMIREGSMSEDEFIEEAKVMMNLSHEKLVQLY  461
         79**********************************************************
S: 61    gvclkqkpiyivteylengcllnylrekkkklekelllemckdvcegmeylerksfihrd  120
         gvc+kq+pi+i+tey++ngcllnylre+++++++++llemckdvce+meyle+k+f+hrd
Q: 462   GVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRD  521
         ************************************************************
S: 121   laarnclvdeelvvkvsdfglaryvlddqyvssvgakfpvkwsppevlsyskyssksdvw  180
         laarnclv+++ vvkvsdfgl+ryvldd+y+ssvg+kfpv+wsppevl+ysk+ssksd+w
Q: 522   LAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIW  581
         ************************************************************
S: 181   afgvlmwevfsegklpyekksnsevvekvsrglrlyrpklaskkvyevmkscwkekpeer  240
         afgvlmwe++s+gk+pye+++nse++e++++glrlyrp+las++vy++m+scw+ek++er
Q: 582   AFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASERVYTIMYSCWHEKADER  641
         ************************************************************
S: 241   ptfkellsale  251
         ptfk lls++ 
Q: 642   PTFKILLSNIL  652
         ********996
Domain Sequence
(FASTA)
LTFLKELGTG QFGVVKYGKW RGRYDVAIKM IREGSMSEDE FIEEAKVMMN LSHEKLVQLY 60
GVCTKQRPIF IITEYMANGC LLNYLREMRH RFQTQQLLEM CKDVCEAMEY LESKQFLHRD 120
LAARNCLVND QGVVKVSDFG LSRYVLDDEY TSSVGSKFPV RWSPPEVLMY SKFSSKSDIW 180
AFGVLMWEIY SLGKMPYERF TNSETAEHIA QGLRLYRPHL ASERVYTIMY SCWHEKADER 240
PTFKILLSNI L 251
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; SH3 domain; Transferase; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00098
EKS-ANC-00100
EKS-BOT-00108
EKS-CAJ-00109
EKS-CAF-00109
EKS-CAP-00103
EKS-DAR-00355
EKS-EQC-00104
EKS-FEC-00102
EKS-GAG-00088
EKS-GAA-00127
EKS-GOG-00108
EKS-HOS-00110
EKS-ICT-00102
EKS-LAC-00112
EKS-LOA-00102
EKS-MAM-00103
EKS-MEG-00083
EKS-MOD-00109
EKS-MUM-00109
EKS-MUP-00110
EKS-MYL-00121
EKS-NOL-00100
EKS-ORN-00132
EKS-ORA-00087
EKS-ORL-00124
EKS-OTG-00109
EKS-PAT-00098
EKS-PES-00092
EKS-PEM-00054
EKS-POA-00100
EKS-PTV-00097
EKS-RAN-00109
EKS-SAH-00100
EKS-SOA-00057
EKS-SUS-00094
EKS-TAR-00136
EKS-TEN-00126
EKS-XET-00090
EKS-XIM-00130
Gene Ontology
GO:0031410; C:cytoplasmic vesicle
GO:0005829; C:cytosol
GO:0045121; C:membrane raft
GO:0005634; C:nucleus
GO:0005886; C:plasma membrane
GO:0005524; F:ATP binding
GO:0005547; F:phosphatidylinositol-3,4,5-trisphosphate binding
GO:0004713; F:protein tyrosine kinase activity
GO:0048469; P:cell maturation
GO:0007249; P:I-kappaB kinase/NF-kappaB cascade
GO:0018108; P:peptidyl-tyrosine phosphorylation
KEGG
InterPros
IPR011009; Kinase-like_dom.
IPR011993; PH_like_dom.
IPR001849; Pleckstrin_homology.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980; SH2.
IPR001452; SH3_domain.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR001562; Znf_Btk_motif.
Pfam
PF00779; BTK; 1.
PF00169; PH; 1.
PF07714; Pkinase_Tyr; 1.
PF00017; SH2; 1.
PF00018; SH3_1; 1.
SMARTs
SM00107; BTK; 1.
SM00233; PH; 1.
SM00252; SH2; 1.
SM00326; SH3; 1.
SM00219; TyrKc; 1.
Prosites
PS50003; PH_DOMAIN; 1.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS50001; SH2; 1.
PS50002; SH3; 1.
PS51113; ZF_BTK; 1.
Prints
PR00401; SH2DOMAIN.
PR00452; SH3DOMAIN.
PR00402; TECBTKDOMAIN.
PR00109; TYRKINASE.
Created Date20-Feb-2013