EKS-ORC-00438

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ORC-00438

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/MAPK	415.9	8.5E-125	67	362	296

Status

Unreviewed

Ensembl Protein

ENSOCUP00000009184

UniProt Accession

G1SZR5;

Protein Name

Protein Synonyms/Alias

Gene Name

MAPK10

Gene Synonyms/Alias

MAPK10;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSOCUG00000010663	ENSOCUP00000009184	ENSOCUT00000010659

Organism

Oryctolagus cuniculus

Functional Description

Protein Length

467

Protein Sequence
(FASTA)

QVFMSLHFLY YCSEPTLDVK LAFCQGFDKQ VDVSYIAKYY NMSKSKVDNQ FYSVEVGDST 60

FTVLKRYQNL KPIGSGAQGI VCAAYDAVLD RNVAIKKLSR PFQNQTHAKR AYRELVLMKC 120

VNHKNIISLL NVFTPQKTLE EFQDVYLVME LMDANLCQVI QMELDHERMS YLLYQMLCGI 180

KHLHSAGIIH RDLKPSNIVV KSDCTLKILD FGLARTACSS FMMTPYVVTR YYRAPEVILG 240

MGYKENVDIW SVGCIMGEMV RHKILFPGRD YIDQWNKVIE QLGTPCPEFM KKLQPTVRNY 300

VENRPKYAGL TFPKLFPDSL FPADSEHNKL KASQARDLLS KMLVIDPAKR ISVDDALQHP 360

YINVWYDPAE VEAPPPQIYD KQLDEREHTI DEWKELIYKE VMNSEEKTKN GVVKGQPSPS 420

GAAVNSSESL HPSSSVNDIS SMSTDQTLAS DTDSSLEASA GPLGCCR 467

Nucleotide Sequence
(FASTA)

CAGGTATTTA TGAGCCTCCA TTTCTTATAC TACTGCAGTG AACCAACCTT GGATGTGAAA 60

CTTGCCTTTT GTCAGGGATT TGATAAACAA GTGGATGTGT CATATATTGC CAAATATTAC 120

AACATGAGCA AAAGCAAAGT GGACAACCAG TTCTACAGTG TGGAAGTGGG AGACTCAACC 180

TTCACAGTTC TCAAGCGCTA CCAGAACCTA AAGCCTATTG GCTCTGGGGC TCAGGGAATA 240

GTTTGTGCTG CCTATGATGC TGTCCTTGAC AGAAATGTGG CCATTAAGAA GCTCAGCAGA 300

CCCTTTCAGA ACCAAACGCA TGCCAAGAGA GCTTACCGGG AGCTGGTCCT CATGAAGTGT 360

GTGAACCATA AAAACATTAT TAGTTTATTA AATGTCTTCA CACCCCAGAA AACGCTGGAG 420

GAATTCCAAG ATGTCTACCT GGTCATGGAA CTGATGGACG CCAACTTGTG TCAGGTGATT 480

CAGATGGAAT TAGACCATGA GCGAATGTCT TACCTGCTCT ATCAGATGTT GTGTGGCATT 540

AAGCACCTCC ACTCTGCTGG AATTATCCAC AGGGATTTAA AACCCAGTAA CATTGTAGTC 600

AAATCCGATT GCACGTTGAA AATCCTCGAC TTTGGACTGG CCAGGACAGC ATGCTCCAGC 660

TTCATGATGA CTCCGTATGT GGTGACACGT TATTACAGAG CCCCAGAGGT CATCCTGGGA 720

ATGGGCTACA AGGAGAATGT GGATATATGG TCTGTGGGAT GCATTATGGG AGAAATGGTT 780

CGCCACAAAA TCCTCTTTCC AGGAAGGGAC TATATCGACC AGTGGAACAA AGTCATTGAG 840

CAACTAGGAA CGCCGTGTCC AGAATTCATG AAGAAATTGC AGCCTACAGT AAGAAACTAT 900

GTGGAGAACC GGCCCAAGTA TGCGGGACTC ACCTTCCCCA AGCTCTTTCC AGATTCCCTC 960

TTCCCAGCAG ACTCCGAGCA CAATAAGCTC AAAGCCAGCC AAGCCAGGGA CTTGTTGTCA 1020

AAGATGCTAG TGATTGACCC AGCAAAGAGG ATATCGGTGG ATGACGCCTT ACAGCATCCT 1080

TACATCAACG TCTGGTATGA CCCCGCCGAA GTGGAAGCGC CTCCACCTCA GATATACGAC 1140

AAGCAGCTGG ATGAAAGAGA ACACACCATT GACGAGTGGA AAGAACTTAT CTACAAGGAA 1200

GTAATGAATT CAGAAGAAAA GACTAAGAAT GGCGTAGTGA AAGGACAGCC TTCTCCTTCA 1260

GGTGCAGCAG TGAACAGCAG TGAGAGTCTC CATCCATCCT CGTCTGTCAA CGACATCTCC 1320

TCCATGTCCA CCGACCAGAC CCTGGCGTCT GACACTGACA GCAGCCTGGA AGCCTCGGCA 1380

GGACCCCTGG GTTGTTGCAG G 1401

Domain Profile

S: 1     yeslkplgeGaygvvvsavdkrteervaikklsrpfqketsakrtlRElkllkelkheNi  60

         y++lkp+g+Ga+g+v++a+d+  +++vaikklsrpfq++t+akr++REl l+k+++h+Ni

Q: 67    YQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNI  126

         899*********************************************************

S: 61    iklldvftpeeeleelkdvYlvtelmetdLkkviksqklsdehiklllyqilrglkylHs  120

         i+ll+vftp+++lee++dvYlv+elm+++L++vi+++ l++e++++llyq+l+g+k+lHs

Q: 127   ISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQME-LDHERMSYLLYQMLCGIKHLHS  185

         ************************************9.**********************

S: 121   anviHrDlKPsNllvnedcelkildFGlarsadkekekklteyvatrwYraPeillslke  180

         a++iHrDlKPsN++v++dc+lkildFGlar+a ++ +  +t+yv+tr+YraPe++l  +

Q: 186   AGIIHRDLKPSNIVVKSDCTLKILDFGLARTACSSFM--MTPYVVTRYYRAPEVILG-MG  242

         ********************************99976..*****************9.99

S: 181   ytkavDiWsvGCIlaElltgkplfpgkdeidqlekilevlgtpseeflkkieseearnyi  240

         y+++vDiWsvGCI++E++++k+lfpg+d+idq++k++e+lgtp  ef+kk++  ++rny+

Q: 243   YKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQP-TVRNYV  301

         *****************************************************.5*****

S: 241   kslpkkkkkdfeelfpk............aseealdLleklLvldpdkRisveeaLehpY  288

         +++pk++  +f +lfp+            + ++a+dLl+k+Lv+dp kRisv++aL+hpY

Q: 302   ENRPKYAGLTFPKLFPDslfpadsehnklKASQARDLLSKMLVIDPAKRISVDDALQHPY  361

         *****************************99*****************************

S: 289   l  289

Q: 362   I  362

Domain Sequence
(FASTA)

YQNLKPIGSG AQGIVCAAYD AVLDRNVAIK KLSRPFQNQT HAKRAYRELV LMKCVNHKNI 60

ISLLNVFTPQ KTLEEFQDVY LVMELMDANL CQVIQMELDH ERMSYLLYQM LCGIKHLHSA 120

GIIHRDLKPS NIVVKSDCTL KILDFGLART ACSSFMMTPY VVTRYYRAPE VILGMGYKEN 180

VDIWSVGCIM GEMVRHKILF PGRDYIDQWN KVIEQLGTPC PEFMKKLQPT VRNYVENRPK 240

YAGLTFPKLF PDSLFPADSE HNKLKASQAR DLLSKMLVID PAKRISVDDA LQHPYI 296

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Danio rerio"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005739	; C:mitochondrion
GO:0005886	; C:plasma membrane
GO:0005524	; F:ATP binding
GO:0004707	; F:MAP kinase activity
GO:0000165	; P:MAPK cascade

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR003527	; MAP_kinase_CS.
IPR008351	; MAPK_JNK.
IPR000719	; Prot_kinase_cat_dom.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS01351	; MAPK; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

PR01772

; JNKMAPKINASE.

Created Date

20-Feb-2013