EKS-ORC-00016

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ORC-00016

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/InsR	512.7	2.1E-154	981	1248	268

Status

Unreviewed

Ensembl Protein

ENSOCUP00000009205

UniProt Accession

G1SZT0;

Protein Name

Tyrosine-protein kinase receptor

Protein Synonyms/Alias

Gene Name

INSRR

Gene Synonyms/Alias

INSRR;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSOCUG00000010677	ENSOCUP00000009205	ENSOCUT00000010688

Organism

Oryctolagus cuniculus

Functional Description

Protein Length

1303

Protein Sequence
(FASTA)

MAVLSPWPLG ACLLGILLSL GFGLDTLEVC PSLDIRSEVA ELRRLENCSV VEGHLQILLM 60

FTATGEDFRR LSFPRLTQVT DYLLLFRVYG LESLRDLFPN LAVIRGARLF LGYALVIFEM 120

PHLRDVGLPA LGAVLRGAVR VEKNQELCHL STIDWGLLQP APGANHIVGN KLGEECADVC 180

PGVLGASGEP CARTTFSGHT DYRCWTSSHC QRVCPCPHGL ACTARGECCH AECLGGCSQP 240

EDPRACVACR HLYFQGACLR ACPPGTYQHE SWRCVTAEDC ASLRAVPGRT STFGIHQGSC 300

LAQCPPGFTR NGSSIFCHKC EGLCPKECKV GTKTIDSIQA AQDLAGCTHV EGSLILNLRQ 360

GYNLEPELQR SLGLVETITG FLKIKHSFAL VSLSFFKNLK LIRGDAMVDG NYTLYVLDNQ 420

NLQQLGSWVA TGLTIPVGKI YFAFNPRLCL ELIYRLEEVT GTRGRQNKAE INPRTNGDRA 480

SCQTRTLRFV SNVTEANRIL LRWERYEPQE ARDLLSFIVY YKESPFQNAT EHVGPDACGA 540

QSWNLLDVEL PLSRTQEPGV TLAPLKPWTQ YAVFVRAITL TTAEDSPHPG AQSPIVYLRT 600

LPAAPTVPQE VISTSNSSSH LLVRWKPPTQ RNGNNTYYLV LWQRLAEDAD LYLNDYCHRG 660

GLRLPTSNTD PRFDREDGEL EAETEPGCCP CQHPHPGQVV PPLEAQEASF QKKFENFLHN 720

AITIPKSPWK VTSINKSPQS DSGRHRRSAG TLRLGGNSSD FEIQEDKVPR ERAVLSGLRH 780

FTEYRIDIHA CNHAAHTVGC SAVTFVFART MPHREADGIP GKVAWEAASR SSVLLRWLEP 840

PDPNGLVLKY EIKYRRLGEE ATVLCVSRLR YAKFGGVHLA LLPPGNYSAR VRATSLAGNG 900

SWTESVAFYI PGPAEEEDSG GLHVLLTVTP VGLMLLIVLA ALGLFYGKKR NSTLYTSVNP 960

EYFSASEMYV PDEWEVPREQ ISIIRELGQG SFGMVYEGLV QGLEAGEEST PVALKTVNEL 1020

ASPRERIEFL KEASVMKAFK CHHVVRLLGV VSQGQPTLVI MELMTRGDLK SHLRSLRPEA 1080

ENNPGLPRPA LGDMMQMAGE IADGMAYLAA NKFVHRDLAA RNCMVSQDLT VKIGDFGMTR 1140

DVYETDYYRK GGKGLLPVRW MAPESLKDGV FTTHSDVWSF GVVLWEIVTL AEQPYQGLSN 1200

EQVLKFVMDG GVLEELESCP LQLQELMSRC WQQNPRLRPT FTHILDSIQE ELRPSFRLLS 1260

FYYSPACRGA RGSLLPADAE PDSSPNPKGP SLDCSPQNGG PRA 1303

Nucleotide Sequence
(FASTA)

ATGGCAGTGC TCAGCCCGTG GCCCTTGGGA GCATGCCTGC TTGGGATCCT TCTCTCCTTG 60

GGATTTGGCC TCGACACTCT AGAGGTGTGC CCCAGCCTGG ACATCCGCTC CGAGGTGGCA 120

GAGCTGCGGC GGCTGGAGAA CTGCAGCGTG GTGGAGGGCC ACCTGCAGAT CCTGCTCATG 180

TTCACGGCCA CGGGGGAGGA CTTCCGCCGC CTCAGCTTCC CCCGCCTCAC CCAGGTCACG 240

GACTACCTGC TGCTCTTCCG TGTCTACGGC CTGGAGAGCC TGCGGGACCT CTTCCCCAAC 300

CTGGCGGTGA TCCGCGGCGC CCGCCTCTTC CTGGGCTACG CGCTGGTTAT CTTCGAGATG 360

CCGCACCTGC GCGACGTGGG GCTGCCAGCG TTGGGGGCCG TGCTGCGTGG GGCGGTGCGC 420

GTGGAGAAGA ACCAGGAGCT CTGCCACCTC TCCACCATCG ACTGGGGCCT GCTGCAGCCT 480

GCGCCCGGTG CCAATCACAT TGTGGGCAAC AAACTGGGCG AAGAGTGTGC CGACGTGTGC 540

CCGGGTGTGC TGGGGGCCTC TGGTGAGCCC TGTGCCAGAA CCACCTTCAG TGGGCACACA 600

GACTACAGGT GCTGGACCTC CAGCCACTGC CAGAGAGTGT GTCCCTGCCC CCACGGGCTG 660

GCCTGCACAG CAAGGGGCGA GTGTTGCCAC GCCGAGTGCC TGGGGGGCTG CAGCCAGCCT 720

GAAGACCCTC GTGCCTGTGT AGCCTGCCGC CACCTCTACT TCCAGGGTGC CTGCCTCCGC 780

GCCTGCCCTC CAGGTACCTA CCAGCATGAG TCCTGGCGCT GTGTCACGGC CGAGGACTGC 840

GCCAGCCTGC GCGCCGTGCC TGGCCGCACC TCCACCTTCG GCATCCACCA AGGCAGTTGC 900

CTGGCGCAGT GCCCCCCAGG CTTCACCCGT AATGGCAGCA GCATCTTCTG CCACAAGTGT 960

GAGGGGCTGT GTCCCAAAGA GTGCAAGGTA GGCACCAAGA CCATCGACTC CATCCAAGCA 1020

GCACAGGACC TGGCGGGCTG CACCCACGTG GAGGGAAGCC TCATCCTCAA CCTGCGGCAG 1080

GGCTACAACC TGGAGCCGGA GCTGCAGCGC AGCCTGGGGC TGGTCGAGAC CATCACCGGC 1140

TTCCTCAAAA TCAAGCACTC CTTTGCCCTC GTATCCCTGA GCTTCTTCAA GAACCTCAAA 1200

CTGATCCGGG GGGATGCCAT GGTGGACGGG AACTACACTC TGTATGTGCT GGACAACCAG 1260

AACCTACAGC AGCTGGGGTC CTGGGTGGCC ACTGGCCTCA CCATCCCGGT GGGCAAGATC 1320

TACTTTGCCT TCAACCCGCG CCTCTGCCTG GAGCTCATCT ACCGCTTGGA GGAGGTGACA 1380

GGCACGAGAG GGCGGCAGAA CAAGGCTGAG ATCAACCCGC GCACCAACGG GGACCGCGCC 1440

TCCTGCCAGA CTCGCACCTT GCGCTTCGTG TCCAACGTGA CGGAGGCAAA CCGCATCCTG 1500

CTCCGCTGGG AGCGCTACGA GCCTCAGGAG GCCCGCGACC TGCTCAGCTT CATCGTATAC 1560

TACAAGGAGT CCCCATTCCA GAATGCCACG GAGCACGTGG GTCCAGATGC CTGTGGCGCC 1620

CAGAGCTGGA ACCTGTTGGA TGTGGAGCTG CCCCTTAGTC GCACCCAGGA GCCAGGGGTG 1680

ACCCTGGCCC CCCTCAAACC CTGGACACAG TATGCAGTGT TTGTGCGGGC CATCACGCTG 1740

ACCACCGCAG AGGACAGCCC CCATCCGGGG GCCCAGAGCC CCATCGTCTA CCTGCGCACC 1800

CTGCCTGCAG CACCCACGGT GCCCCAAGAG GTCATCTCCA CGTCCAACTC CTCCTCCCAC 1860

CTCCTGGTGC GCTGGAAGCC ACCCACGCAG CGCAACGGAA ACAACACCTA CTACCTGGTG 1920

CTGTGGCAGC GGCTGGCAGA GGACGCCGAC CTCTACCTCA ACGACTACTG CCACCGCGGT 1980

GGCTTGCGGC TGCCCACCAG CAACACCGAC CCGCGCTTCG ACCGTGAGGA CGGGGAACTT 2040

GAGGCCGAGA CGGAGCCGGG CTGCTGCCCT TGCCAGCACC CACACCCTGG GCAGGTCGTG 2100

CCCCCGCTGG AAGCGCAAGA GGCTTCGTTC CAAAAGAAGT TTGAGAACTT TCTACACAAT 2160

GCCATCACCA TCCCCAAATC CCCTTGGAAG GTCACGTCCA TCAATAAGAG TCCCCAAAGC 2220

GACTCGGGGC GGCACCGCCG GTCCGCCGGG ACCCTCCGAC TCGGGGGCAA CAGTTCGGAT 2280

TTCGAGATCC AGGAGGACAA GGTGCCCCGG GAGCGAGCGG TGCTGAGTGG CTTGCGCCAC 2340

TTCACCGAAT ACCGGATCGA CATCCACGCC TGCAACCACG CAGCGCACAC CGTGGGCTGC 2400

AGCGCCGTCA CCTTCGTCTT TGCCCGCACG ATGCCGCACA GAGAGGCCGA TGGTATCCCC 2460

GGGAAGGTGG CCTGGGAGGC TGCCAGCCGG AGCAGCGTCC TCCTGCGCTG GCTTGAGCCC 2520

CCGGACCCAA ACGGACTGGT CCTCAAGTAC GAGATCAAGT ACCGCCGCCT GGGAGAGGAA 2580

GCCACTGTGC TGTGCGTGTC CCGTCTGCGG TATGCCAAGT TCGGTGGGGT CCACCTGGCC 2640

CTGCTGCCCC CTGGCAACTA CTCTGCCCGG GTTCGAGCGA CCTCACTGGC TGGCAATGGC 2700

TCCTGGACAG AGAGTGTGGC CTTCTACATC CCTGGCCCAG CAGAGGAGGA GGACTCCGGG 2760

GGCCTGCATG TGCTCCTCAC CGTCACCCCC GTGGGCCTCA TGCTGCTCAT CGTCCTCGCC 2820

GCCCTGGGTC TCTTCTATGG AAAGAAGAGA AACAGCACCC TGTATACCTC TGTGAACCCA 2880

GAGTACTTCA GCGCCTCTGA GATGTACGTG CCTGACGAGT GGGAGGTGCC TCGGGAGCAG 2940

ATCTCCATAA TCCGGGAACT GGGCCAGGGC TCCTTCGGGA TGGTCTATGA GGGGCTGGTG 3000

CAAGGCCTTG AGGCTGGGGA GGAGTCCACG CCCGTGGCCC TGAAGACGGT GAATGAGCTG 3060

GCCAGCCCAC GGGAGCGCAT CGAGTTCCTC AAGGAAGCGT CTGTCATGAA GGCATTCAAG 3120

TGTCATCATG TGGTACGTCT CCTAGGTGTG GTGTCTCAGG GTCAGCCAAC TCTGGTCATC 3180

ATGGAGTTGA TGACCCGTGG AGACCTCAAG AGCCATCTTC GATCTTTGCG ACCTGAGGCA 3240

GAGAACAACC CTGGGCTCCC ACGGCCAGCT CTGGGCGATA TGATGCAGAT GGCTGGTGAG 3300

ATCGCAGATG GCATGGCCTA CCTTGCCGCC AACAAGTTTG TGCACCGAGA CCTGGCAGCC 3360

CGCAACTGCA TGGTGTCCCA GGACCTGACC GTCAAGATTG GGGACTTCGG GATGACTCGG 3420

GACGTGTATG AGACAGATTA TTACCGCAAG GGTGGGAAGG GGCTGCTGCC TGTGCGCTGG 3480

ATGGCCCCCG AGTCCCTCAA GGATGGAGTC TTCACCACCC ACTCGGATGT CTGGTCCTTC 3540

GGTGTGGTGC TCTGGGAGAT CGTGACGCTG GCTGAGCAGC CCTACCAGGG CCTCTCCAAC 3600

GAGCAGGTGC TCAAGTTCGT CATGGACGGC GGGGTCCTGG AGGAGCTGGA GAGCTGTCCC 3660

CTTCAGCTGC AGGAGCTGAT GAGCCGCTGC TGGCAGCAGA ACCCGCGCCT GCGTCCAACC 3720

TTCACCCACA TCCTGGACAG CATACAGGAG GAGCTTCGGC CCTCCTTCCG CCTGCTTTCC 3780

TTCTACTACA GCCCAGCGTG CCGGGGTGCC CGGGGCTCCC TGCTGCCCGC CGACGCAGAG 3840

CCCGACTCCT CACCCAACCC CAAAGGGCCC TCCCTGGACT GCAGCCCCCA AAACGGGGGG 3900

CCCAGGGCA 3909

Domain Profile

S: 1     ivllrelGqGsfGmvyeGvakdvvkgeeetrvaiktvneaassrerieflkeasvmkefk  60

         i+++relGqGsfGmvyeG+ +++++gee+t+va+ktvne as rerieflkeasvmk+fk

Q: 981   ISIIRELGQGSFGMVYEGLVQGLEAGEESTPVALKTVNELASPRERIEFLKEASVMKAFK  1040

         6799********************************************************

S: 61    thhvvrllGvvskgqpalvvmelmkkGdlksylrslrpeeeneaalappaldkliqmaae  120

         +hhvvrllGvvs+gqp+lv+melm++Gdlks+lrslrpe+en+++l++pal++++qma+e

Q: 1041  CHHVVRLLGVVSQGQPTLVIMELMTRGDLKSHLRSLRPEAENNPGLPRPALGDMMQMAGE  1100

         ************************************************************

S: 121   iadGmayleakkfvhrdlaarncmvaedltvkiGdfGmtrdiyetdyyrkggkgllpvrw  180

         iadGmayl+a+kfvhrdlaarncmv++dltvkiGdfGmtrd+yetdyyrkggkgllpvrw

Q: 1101  IADGMAYLAANKFVHRDLAARNCMVSQDLTVKIGDFGMTRDVYETDYYRKGGKGLLPVRW  1160

         ************************************************************

S: 181   mspeslkdGvftsksdvwsfGvvlweivtlaeqpyqGlsneqvlkfvldggvlekpencp  240

         m+peslkdGvft++sdvwsfGvvlweivtlaeqpyqGlsneqvlkfv+dggvle++e+cp

Q: 1161  MAPESLKDGVFTTHSDVWSFGVVLWEIVTLAEQPYQGLSNEQVLKFVMDGGVLEELESCP  1220

         ************************************************************

S: 241   elltelmrlcwqynpklrpsfleivell  268

          +l+elm++cwq np+lrp+f++i++++

Q: 1221  LQLQELMSRCWQQNPRLRPTFTHILDSI  1248

         ************************9976

Domain Sequence
(FASTA)

ISIIRELGQG SFGMVYEGLV QGLEAGEEST PVALKTVNEL ASPRERIEFL KEASVMKAFK 60

CHHVVRLLGV VSQGQPTLVI MELMTRGDLK SHLRSLRPEA ENNPGLPRPA LGDMMQMAGE 120

IADGMAYLAA NKFVHRDLAA RNCMVSQDLT VKIGDFGMTR DVYETDYYRK GGKGLLPVRW 180

MAPESLKDGV FTTHSDVWSF GVVLWEIVTL AEQPYQGLSN EQVLKFVMDG GVLEELESCP 240

LQLQELMSRC WQQNPRLRPT FTHILDSI 268

Keyword

ATP-binding; Complete proteome; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Equus caballus"; ?>Felis catus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Xenopus tropicalis"; ?>

Gene Ontology

GO:0016021	; C:integral to membrane
GO:0005524	; F:ATP binding
GO:0004714	; F:transmembrane receptor protein tyrosine kinase activity
GO:0031532	; P:actin cytoskeleton reorganization
GO:0071469	; P:cellular response to alkalinity
GO:0030238	; P:male sex determination
GO:0046777	; P:protein autophosphorylation
GO:0007169	; P:transmembrane receptor protein tyrosine kinase signaling pathway

KEGG

InterPros

IPR000494	; EGF_rcpt_L.
IPR003961	; Fibronectin_type3.
IPR006211	; Furin-like_Cys-rich_dom.
IPR006212	; Furin_repeat.
IPR009030	; Growth_fac_rcpt.
IPR013783	; Ig-like_fold.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.
IPR016246	; Tyr_kinase_insulin-like_rcpt.
IPR002011	; Tyr_kinase_rcpt_2_CS.

Pfam

PF00757	; Furin-like; 1.
PF07714	; Pkinase_Tyr; 1.
PF01030	; Recep_L_domain; 2.

SMARTs

SM00060	; FN3; 3.
SM00261	; FU; 1.
SM00219	; TyrKc; 1.

Prosites

PS50853	; FN3; 4.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS00239	; RECEPTOR_TYR_KIN_II; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013