EKS-ORC-00191

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ORC-00191

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/CDKL	464.1	1.5E-139	13	297	285

Status

Unreviewed

Ensembl Protein

ENSOCUP00000009278

UniProt Accession

G1SZY8;

Protein Name

Protein Synonyms/Alias

Gene Name

CDKL5

Gene Synonyms/Alias

CDKL5;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSOCUG00000010775	ENSOCUP00000009278	ENSOCUT00000010781

Organism

Oryctolagus cuniculus

Functional Description

Protein Length

905

Protein Sequence
(FASTA)

MKIPNIGNVM NKFEILGVVG EGAYGVVLKC RHKETHEIVA IKKFKDSEEN EEVKETTLRE 60

LKMLRTLKQE NIVELKEAFR RRGKLYLVFE YVEKNMLELL EEMPNGVPPE KVKSYIYQLI 120

KAIHWCHKND IVHRDIKPEN LLISHNDVLK LCDFGFARNL SEGNNANYTE YVATRWYRSP 180

ELLLGAPYGK SVDMWSVGCI LGELSDGQPL FPGESEIDQL FTIQKVLGPL PSEQMKLFYS 240

NPRFHGLRFP AVNHPQSLER RYLGILNSVL LDLMKNLLQL DPADRYLTEQ CLNHPTFQTQ 300

RLLDRSPSRS AKRKPYHVES STLSNRNQAS KSTALQSHHR SNSKDIQNLS VVLPRADEGL 360

PANESFLNGN LAGATLSPMH TKSYQAGTQP GSASKDLTNN NIPHLLSPKD AKSKTEFDFN 420

IDPKPSEGPG TKYLKSSSRS QQNRHSFMES SQSKAGTLQP SEKQSRHSYI DTIPQSSRSP 480

SYRTKAKSHG ALSDSKSVSN LSETRAQVAE SNTSRYFPSS CLDLNSPTSP TPTRHSDTRT 540

LLSPSGRNNR SEGTLDSRRT TTRHSKTMEE LKLPEHMDSS HSHSLSAPHE SFSYGLGYTS 600

PFSSQQRPHR HSMYVTRDKV RAKGLDGSLS IGQGMAARAN SLQLLSPQPG EQLPPEMTVA 660

SPSVKESSRE GTASFHPGQK SEGGVYHDPH SDDGTAPKEN RHLYNDPVPR RVGSFYRVPS 720

PRPDNSFHEN NVSTRVSSLP SESSSGTNHS KRQTAFDPWK SPENISHSEQ LKEKEKQGFF 780

RSMKKKKKKS QAVPNSDGPD LLTLQKAIHS ASTTSSRPKE WRPEKISDLQ TQSQPLKSLR 840

KLLHLSSASN HPASSDPRFQ PLTTQQAKNS FSEIRIHPLS QASGGSSNIR QEPTPKGRPT 900

LQLPG 905

Nucleotide Sequence
(FASTA)

ATGAAGATTC CTAACATTGG TAATGTGATG AATAAATTTG AGATCCTTGG GGTTGTAGGA 60

GAAGGAGCGT ATGGAGTTGT ACTTAAATGC AGACATAAGG AAACACATGA AATTGTGGCA 120

ATTAAGAAAT TCAAGGACAG TGAAGAGAAT GAAGAAGTCA AGGAAACGAC TTTACGAGAG 180

CTTAAAATGC TTCGCACTCT CAAACAGGAA AACATTGTGG AGCTGAAGGA AGCCTTTCGT 240

CGCAGGGGGA AATTGTACTT GGTGTTTGAA TATGTTGAAA AAAATATGCT TGAGTTGCTG 300

GAAGAAATGC CAAATGGAGT TCCACCTGAA AAAGTAAAAA GTTACATCTA TCAACTAATC 360

AAAGCTATTC ACTGGTGCCA TAAGAACGAT ATTGTTCATA GAGATATAAA GCCAGAAAAC 420

CTTTTAATCA GCCACAATGA TGTTCTGAAA CTGTGCGACT TTGGCTTTGC TAGAAATCTA 480

TCAGAAGGCA ACAATGCTAA CTATACAGAG TATGTGGCCA CCAGGTGGTA TCGATCCCCA 540

GAGCTCTTAC TTGGAGCTCC CTATGGAAAA TCTGTAGACA TGTGGTCTGT GGGCTGTATT 600

CTTGGGGAGC TTAGTGATGG ACAGCCATTA TTTCCTGGAG AAAGTGAAAT TGACCAACTT 660

TTTACCATAC AGAAAGTGCT AGGACCTCTT CCTTCTGAGC AGATGAAACT CTTCTACAGT 720

AATCCTCGCT TCCATGGGCT TCGGTTTCCA GCTGTTAACC ATCCTCAGTC ATTGGAGAGA 780

AGATACCTTG GAATTTTGAA TAGTGTTTTA CTTGATCTAA TGAAGAATTT ACTGCAGTTG 840

GACCCAGCTG ACAGATACTT GACAGAACAG TGTTTGAATC ATCCTACATT TCAGACCCAG 900

AGACTTTTGG ATCGTTCCCC TTCAAGGTCA GCAAAAAGAA AACCTTACCA TGTGGAAAGC 960

AGCACATTGT CTAATAGAAA CCAAGCCAGT AAAAGTACTG CTTTACAGTC TCACCACAGA 1020

TCTAACAGCA AGGACATCCA GAACCTAAGT GTGGTTCTGC CCCGGGCTGA TGAAGGCCTC 1080

CCTGCCAACG AAAGCTTCCT AAATGGAAAC CTCGCTGGAG CTACCCTCAG TCCAATGCAC 1140

ACCAAAAGCT ACCAAGCAGG CACTCAGCCT GGGTCTGCCA GCAAAGATCT CACTAACAAC 1200

AACATACCAC ACCTTCTCAG CCCAAAAGAC GCCAAGTCAA AAACAGAGTT CGACTTTAAT 1260

ATTGACCCAA AGCCTTCAGA AGGCCCGGGC ACGAAGTACC TCAAGTCAAG CAGTAGATCT 1320

CAGCAGAACC GGCACTCATT TATGGAAAGC TCTCAGAGCA AAGCCGGGAC ACTGCAGCCC 1380

AGTGAGAAGC AGAGCCGGCA CAGCTATATC GACACCATAC CCCAGTCCTC GAGGAGTCCT 1440

TCCTATAGAA CCAAGGCCAA AAGCCACGGG GCGCTGAGTG ACTCCAAGTC TGTGAGCAAC 1500

CTTTCTGAAA CCAGGGCCCA AGTCGCAGAG TCCAATACCA GTAGATACTT CCCATCCAGC 1560

TGCTTGGACT TGAACTCTCC CACCAGCCCA ACCCCCACCA GGCACAGTGA CACAAGAACT 1620

TTGCTCAGCC CTTCAGGGAG AAATAACCGC AGTGAGGGCA CTCTGGACTC ACGCAGAACC 1680

ACAACCAGGC ATTCTAAAAC GATGGAGGAG TTGAAGCTGC CCGAACACAT GGACAGCAGC 1740

CATTCCCATT CACTGTCTGC ACCTCATGAA TCCTTTTCTT ACGGACTGGG CTATACCAGC 1800

CCCTTCTCTT CTCAGCAGCG TCCTCACAGA CATTCCATGT ACGTGACCCG AGACAAAGTC 1860

AGAGCCAAAG GCTTGGACGG AAGCTTGAGC ATCGGGCAAG GGATGGCAGC CAGAGCCAAC 1920

AGCTTGCAGC TCTTATCACC CCAGCCTGGA GAGCAGCTCC CTCCAGAGAT GACCGTGGCC 1980

AGCCCTTCCG TTAAAGAGTC CTCCAGAGAA GGCACTGCAT CTTTCCATCC TGGGCAGAAG 2040

TCTGAGGGTG GAGTGTATCA TGACCCACAC TCCGATGACG GCACAGCCCC CAAAGAAAAT 2100

CGACATCTGT ACAATGACCC TGTCCCCAGA AGAGTTGGTA GCTTTTACAG AGTGCCATCA 2160

CCACGCCCAG ACAATTCTTT TCATGAAAAT AATGTGTCAA CTAGAGTCTC TTCCCTACCA 2220

TCTGAGAGCA GTTCTGGAAC TAACCATTCA AAAAGACAAA CAGCATTTGA TCCATGGAAA 2280

AGTCCCGAAA ATATTAGTCA CTCCGAACAA CTCAAGGAGA AGGAGAAGCA AGGCTTTTTC 2340

AGGTCAATGA AAAAGAAAAA GAAGAAATCT CAAGCAGTGC CCAATTCTGA TGGCCCTGAT 2400

CTTCTGACAT TACAGAAAGC CATTCACTCT GCTAGCACTA CAAGCAGCAG ACCCAAGGAG 2460

TGGCGCCCTG AGAAGATCTC GGATCTACAG ACCCAAAGCC AGCCACTAAA ATCCCTGCGC 2520

AAGCTGTTAC ATCTCTCTTC AGCCTCCAAT CACCCGGCGT CCTCAGACCC CCGCTTCCAG 2580

CCCTTAACAA CTCAGCAAGC CAAAAATTCC TTCTCAGAAA TTCGGATTCA CCCCCTGAGC 2640

CAGGCCTCTG GTGGGAGTAG CAACATCCGG CAGGAGCCCA CGCCAAAGGG CAGGCCAACT 2700

CTCCAGCTGC CGGGT 2715

Domain Profile

S: 1     yeklgkvGeGsyGvvlkcrnkdtgqivaikkfleseddkevkkialreikllkqlkhenl  60

         +e lg+vGeG+yGvvlkcr+k+t++ivaikkf++se+++evk+++lre+k+l++lk+en+

Q: 13    FEILGVVGEGAYGVVLKCRHKETHEIVAIKKFKDSEENEEVKETTLRELKMLRTLKQENI  72

         799*********************************************************

S: 61    vnllevfrrkkklylvfeyvdktvldelerypnGveeelvkkilyqilkaiefchknnii  120

         v+l+e+frr+ klylvfeyv+k++l+ le++pnGv+ e+vk+++yq++kai++chkn+i+

Q: 73    VELKEAFRRRGKLYLVFEYVEKNMLELLEEMPNGVPPEKVKSYIYQLIKAIHWCHKNDIV  132

         ************************************************************

S: 121   hrdikpenilisksgvvklcdfGfarlla.apgdvytdyvatrwyrapellvgdtkyGks  179

         hrdikpen+lis+++v+klcdfGfar+l+ +++++yt+yvatrwyr+pell+g + yGks

Q: 133   HRDIKPENLLISHNDVLKLCDFGFARNLSeGNNANYTEYVATRWYRSPELLLG-APYGKS  191

         ****************************98999********************.9*****

S: 180   vdvwaiGcllaelltGeplfpgksdvdqlykirktlGeliprhqkifsknevfaGvklpe  239

         vd+w++Gc+l el++G+plfpg+s++dql++i+k+lG+l ++++k+f++n++f+G+++p+

Q: 192   VDMWSVGCILGELSDGQPLFPGESEIDQLFTIQKVLGPLPSEQMKLFYSNPRFHGLRFPA  251

         ************************************************************

S: 240   vedleslekkyp.klnevlldllkkclkldpaerlsceellkheyf  284

         v++++sle++y   ln+vlldl+k++l+ldpa+r+++e++l+h++f

Q: 252   VNHPQSLERRYLgILNSVLLDLMKNLLQLDPADRYLTEQCLNHPTF  297

         ***********9899****************************998

Domain Sequence
(FASTA)

FEILGVVGEG AYGVVLKCRH KETHEIVAIK KFKDSEENEE VKETTLRELK MLRTLKQENI 60

VELKEAFRRR GKLYLVFEYV EKNMLELLEE MPNGVPPEKV KSYIYQLIKA IHWCHKNDIV 120

HRDIKPENLL ISHNDVLKLC DFGFARNLSE GNNANYTEYV ATRWYRSPEL LLGAPYGKSV 180

DMWSVGCILG ELSDGQPLFP GESEIDQLFT IQKVLGPLPS EQMKLFYSNP RFHGLRFPAV 240

NHPQSLERRY LGILNSVLLD LMKNLLQLDP ADRYLTEQCL NHPTF 285

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005737	; C:cytoplasm
GO:0005634	; C:nucleus
GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0046777	; P:protein autophosphorylation

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013